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Protein

Modification methylase HgiCI

Gene

hgiCIM

Organism
Herpetosiphon aurantiacus (Herpetosiphon giganteus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This methylase recognizes the double-stranded sequence GGYRCC, causes specific methylation on C-5 on both strands, and protects the DNA from cleavage by the HgiCI endonuclease.

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei75PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processRestriction system
LigandS-adenosyl-L-methionine

Protein family/group databases

REBASEi3415 M.HgiCI

Names & Taxonomyi

Protein namesi
Recommended name:
Modification methylase HgiCI (EC:2.1.1.37)
Short name:
M.HgiCI
Alternative name(s):
Cytosine-specific methyltransferase HgiCI
Gene namesi
Name:hgiCIM
OrganismiHerpetosiphon aurantiacus (Herpetosiphon giganteus)
Taxonomic identifieri65 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaHerpetosiphonalesHerpetosiphonaceaeHerpetosiphon

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000878861 – 420Modification methylase HgiCIAdd BLAST420

Structurei

3D structure databases

ProteinModelPortaliP25263
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 417SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd BLAST416

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation

Family and domain databases

InterProiView protein in InterPro
IPR018117 C5_DNA_meth_AS
IPR001525 C5_MeTfrase
IPR031303 C5_meth_CS
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF00145 DNA_methylase, 1 hit
PRINTSiPR00105 C5METTRFRASE
SUPFAMiSSF53335 SSF53335, 2 hits
TIGRFAMsiTIGR00675 dcm, 1 hit
PROSITEiView protein in PROSITE
PS00094 C5_MTASE_1, 1 hit
PS00095 C5_MTASE_2, 1 hit
PS51679 SAM_MT_C5, 1 hit

Sequencei

Sequence statusi: Complete.

P25263-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKFIDLFAG IGGMRLGFEQ AMHELGIETA CVLSSEIDKH AQTTYAMNFH
60 70 80 90 100
EQSQGDITQI QDFPSFDFLL AGFPCQPFSY AGKQKGFGDT RGTLFFEIER
110 120 130 140 150
ILKAYRPKGF LLENVRGLTT HDKGRTFKTI LQKLHELNYG VYLILNSSNF
160 170 180 190 200
QVPQNRLRVY IVGLDQSQPE LTITSHIGAT DSHKFKQLSN QASLFDTNKI
210 220 230 240 250
MLVRDILEDH PLDKYNCSTD FVNKLLAFIG HPIKLNGKRL IDYRNGNSIH
260 270 280 290 300
SWELGIKGEC TSDEIQFMNA LIANRRKKHF GAHQDGKKLT IEQIKTFFEH
310 320 330 340 350
DDLDSIMQSL ITKGYLQEVN GRFNPVAGNM SFEVFKFLDP DSVSITLVSS
360 370 380 390 400
DAHKIGVVHQ NRIRRITPRE CARLQGFPDS FQFHPKDSLA YRQFGNSVSV
410 420
PVVKAVILDL FKSADLASCF
Length:420
Mass (Da):47,641
Last modified:November 1, 1995 - v2
Checksum:iEDB427C9D66CD971
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55138 Genomic DNA Translation: CAA38933.1
PIRiS19707

Similar proteinsi

Entry informationi

Entry nameiMTC1_HERAU
AccessioniPrimary (citable) accession number: P25263
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: November 1, 1995
Last modified: March 28, 2018
This is version 78 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

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