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Protein

Modification methylase HgiBI

Gene

hgiBIM

Organism
Herpetosiphon aurantiacus (Herpetosiphon giganteus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This methylase recognizes the double-stranded sequence GGWCC, causes specific methylation on C-? on both strands, and protects the DNA from cleavage by the HgiBI endonuclease.

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei75PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processRestriction system
LigandS-adenosyl-L-methionine

Protein family/group databases

REBASEi3414 M.HgiBI

Names & Taxonomyi

Protein namesi
Recommended name:
Modification methylase HgiBI (EC:2.1.1.37)
Short name:
M.HgiBI
Alternative name(s):
Cytosine-specific methyltransferase HgiBI
Gene namesi
Name:hgiBIM
OrganismiHerpetosiphon aurantiacus (Herpetosiphon giganteus)
Taxonomic identifieri65 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaHerpetosiphonalesHerpetosiphonaceaeHerpetosiphon

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000878851 – 437Modification methylase HgiBIAdd BLAST437

Structurei

3D structure databases

ProteinModelPortaliP25262
SMRiP25262
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 431SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd BLAST428

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation

Family and domain databases

InterProiView protein in InterPro
IPR018117 C5_DNA_meth_AS
IPR001525 C5_MeTfrase
IPR031303 C5_meth_CS
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF00145 DNA_methylase, 1 hit
PRINTSiPR00105 C5METTRFRASE
SUPFAMiSSF53335 SSF53335, 2 hits
TIGRFAMsiTIGR00675 dcm, 1 hit
PROSITEiView protein in PROSITE
PS00094 C5_MTASE_1, 1 hit
PS00095 C5_MTASE_2, 1 hit
PS51679 SAM_MT_C5, 1 hit

Sequencei

Sequence statusi: Complete.

P25262-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQQFRFIDLF AGIGGFRLGL EAVGGVCVAS AEIDQQAIKV YRQNWPTDGV
60 70 80 90 100
DHNLGDITAI QQLPAHDVLV GGVPCQPWSI AGKNQAFDDP RGQLWADVIR
110 120 130 140 150
LVQINQPKAF IFENVKGLVD PRNRLCLEII LDSFKDLGYS VFYKLLNSFD
160 170 180 190 200
FGVAQNRDRV FIVGIQQKLD LNGFSFPEYT ESEQRLYHIL DNLEVPETKL
210 220 230 240 250
ESIPIQRNLF GERIDVGYNK LTPRGAFNDF FILNDIRNGP TSIHSWEIYP
260 270 280 290 300
TTEREKQICM IIMRNRRNSR YGDCDGNPMS YQDIAELVAG LAEKELQTLV
310 320 330 340 350
EKRILRQYPD GKYEFFNRRL SGGIDGTYRI FLPNARFFGT LTARGMHDEI
360 370 380 390 400
AEISVSGANA EEYKHNFIQQ VLIPKRYRKI TVSEAARLQG FPGSFQFHSN
410 420 430
QSANFRLIGN SVAPPVIVAL GKALQCVKLF EQELCEV
Length:437
Mass (Da):49,627
Last modified:May 1, 1992 - v1
Checksum:i70A658159D8D23AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55137 Genomic DNA Translation: CAA38927.1
PIRiS22307

Similar proteinsi

Entry informationi

Entry nameiMTB1_HERAU
AccessioniPrimary (citable) accession number: P25262
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: March 28, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Restriction enzymes and methylases
    Classification of restriction enzymes and methylases and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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