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P25248

- ACEA_BRANA

UniProt

P25248 - ACEA_BRANA

Protein

Isocitrate lyase

Gene
N/A
Organism
Brassica napus (Rape)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 May 1992)
      Previous versions | rss
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    • Comment

    Functioni

    Involved in storage lipid mobilization during the growth of higher plant seedling.

    Catalytic activityi

    Isocitrate = succinate + glyoxylate.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei213 – 2131Curated

    GO - Molecular functioni

    1. isocitrate lyase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-UniPathway
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Glyoxylate bypass, Tricarboxylic acid cycle

    Enzyme and pathway databases

    UniPathwayiUPA00703; UER00719.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate lyase (EC:4.1.3.1)
    Short name:
    ICL
    Short name:
    Isocitrase
    Short name:
    Isocitratase
    OrganismiBrassica napus (Rape)
    Taxonomic identifieri3708 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeBrassiceaeBrassica

    Subcellular locationi

    GO - Cellular componenti

    1. glyoxysome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Glyoxysome, Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 576576Isocitrate lyasePRO_0000068802Add
    BLAST

    Expressioni

    Developmental stagei

    Expressed maximally during postgerminative growth.

    Interactioni

    Subunit structurei

    Homotetramer.

    Structurei

    3D structure databases

    ProteinModelPortaliP25248.
    SMRiP25248. Positions 9-535.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi574 – 5763Microbody targeting signalSequence Analysis

    Sequence similaritiesi

    Family and domain databases

    Gene3Di3.20.20.60. 2 hits.
    InterProiIPR006254. Isocitrate_lyase.
    IPR018523. Isocitrate_lyase_ph_CS.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    [Graphical view]
    PANTHERiPTHR21631:SF3. PTHR21631:SF3. 1 hit.
    PfamiPF00463. ICL. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001362. Isocit_lyase. 1 hit.
    SUPFAMiSSF51621. SSF51621. 1 hit.
    TIGRFAMsiTIGR01346. isocit_lyase. 1 hit.
    PROSITEiPS00161. ISOCITRATE_LYASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P25248-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAASFSVPSM IMEEEGRFEA EVAEVQTWWS SERFKLTRRP YTARDVVALR    50
    GHLKQGYASN EMAKKLWRTL KSHQANGTAS RTFGALDPVQ VTMMAKHLDT 100
    IYVSGWQCSS THTSTNEPGP DLADYPYDTV PNKVEHLFFA QQYHDRKQRE 150
    ARMSMSREER AKTPFVDYLK PIIADGDTGF GGTTATVKLC KLFVERGAAG 200
    VHIEDQSSVT KKCGHMAGKV LVAVSEHINR LVAARLQFDV MGTETVLVAR 250
    TDAVAATLIQ SNIDSRDHQF ILGVTNPSLR GKSLSSLLAE GMAVGNNGPA 300
    LQAIEDQWLS SARLMTFSDA VVEALKRMNL SENEKSRRVN EWLNHARYEN 350
    CLSNEQGREL AAKLGVTDLF WDWDLPRTRE GFYRFQGSVT AAVVRGWAFA 400
    QIADLIWMET ASPDLNECTQ FAEGVKSKTP EVMLAYNLSP SFNWDASGMT 450
    DQQMMEFIPR IARLGYCWQF ITLAGFHADA LVVDTFAKDY ARRGMLAYVE 500
    RIQREERSNG VDTLAHQKWS GANYYDRYLK TVQGGISSTA AMGKGVTEEQ 550
    FKETWTRPGA AGMGEGTSLV VAKSRM 576
    Length:576
    Mass (Da):64,326
    Last modified:May 1, 1992 - v1
    Checksum:i81A87701A4ACC350
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti75 – 751A → V in CAA73792. 1 PublicationCurated
    Sequence conflicti177 – 1771D → G in CAA73792. 1 PublicationCurated
    Sequence conflicti256 – 2561A → P in CAA73792. 1 PublicationCurated
    Sequence conflicti278 – 2781S → N in CAA73792. 1 PublicationCurated
    Sequence conflicti340 – 3401N → T in CAA73792. 1 PublicationCurated
    Sequence conflicti344 – 3441N → I in CAA73792. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L08482 Genomic DNA. Translation: AAA32992.1.
    Y13356 mRNA. Translation: CAA73792.1.
    PIRiJQ1105. WZRPI.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L08482 Genomic DNA. Translation: AAA32992.1 .
    Y13356 mRNA. Translation: CAA73792.1 .
    PIRi JQ1105. WZRPI.

    3D structure databases

    ProteinModelPortali P25248.
    SMRi P25248. Positions 9-535.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00703 ; UER00719 .

    Family and domain databases

    Gene3Di 3.20.20.60. 2 hits.
    InterProi IPR006254. Isocitrate_lyase.
    IPR018523. Isocitrate_lyase_ph_CS.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    [Graphical view ]
    PANTHERi PTHR21631:SF3. PTHR21631:SF3. 1 hit.
    Pfami PF00463. ICL. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001362. Isocit_lyase. 1 hit.
    SUPFAMi SSF51621. SSF51621. 1 hit.
    TIGRFAMsi TIGR01346. isocit_lyase. 1 hit.
    PROSITEi PS00161. ISOCITRATE_LYASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Coordinate expression of transcriptionally regulated isocitrate lyase and malate synthase genes in Brassica napus L."
      Comai L., Dietrich R.A., Maslyar D.J., Baden C.S., Harada J.J.
      Plant Cell 1:293-300(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "Two classes of isocitrate lyase genes are expressed during late embryogeny and postgermination in Brassica napus L."
      Zhang J.Z., Gomez-Pedrozo M., Baden C.S., Harada J.J.
      Mol. Gen. Genet. 238:177-184(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. Olesen C., Thomsen K.K., Svendsen I., Brandt A.
      Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Global.
      Tissue: Cotyledon.

    Entry informationi

    Entry nameiACEA_BRANA
    AccessioniPrimary (citable) accession number: P25248
    Secondary accession number(s): O04910
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: May 1, 1992
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3