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P25248

- ACEA_BRANA

UniProt

P25248 - ACEA_BRANA

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Protein
Isocitrate lyase
Gene
N/A
Organism
Brassica napus (Rape)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in storage lipid mobilization during the growth of higher plant seedling.

Catalytic activityi

Isocitrate = succinate + glyoxylate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei213 – 2131 Inferred

GO - Molecular functioni

  1. isocitrate lyase activity Source: UniProtKB-EC

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-UniPathway
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00703; UER00719.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate lyase (EC:4.1.3.1)
Short name:
ICL
Short name:
Isocitrase
Short name:
Isocitratase
OrganismiBrassica napus (Rape)
Taxonomic identifieri3708 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeBrassiceaeBrassica

Subcellular locationi

GO - Cellular componenti

  1. glyoxysome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Glyoxysome, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 576576Isocitrate lyase
PRO_0000068802Add
BLAST

Expressioni

Developmental stagei

Expressed maximally during postgerminative growth.

Interactioni

Subunit structurei

Homotetramer.

Structurei

3D structure databases

ProteinModelPortaliP25248.
SMRiP25248. Positions 9-535.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi574 – 5763Microbody targeting signal Reviewed prediction

Sequence similaritiesi

Family and domain databases

Gene3Di3.20.20.60. 2 hits.
InterProiIPR006254. Isocitrate_lyase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PANTHERiPTHR21631:SF3. PTHR21631:SF3. 1 hit.
PfamiPF00463. ICL. 1 hit.
[Graphical view]
PIRSFiPIRSF001362. Isocit_lyase. 1 hit.
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR01346. isocit_lyase. 1 hit.
PROSITEiPS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25248-1 [UniParc]FASTAAdd to Basket

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MAASFSVPSM IMEEEGRFEA EVAEVQTWWS SERFKLTRRP YTARDVVALR    50
GHLKQGYASN EMAKKLWRTL KSHQANGTAS RTFGALDPVQ VTMMAKHLDT 100
IYVSGWQCSS THTSTNEPGP DLADYPYDTV PNKVEHLFFA QQYHDRKQRE 150
ARMSMSREER AKTPFVDYLK PIIADGDTGF GGTTATVKLC KLFVERGAAG 200
VHIEDQSSVT KKCGHMAGKV LVAVSEHINR LVAARLQFDV MGTETVLVAR 250
TDAVAATLIQ SNIDSRDHQF ILGVTNPSLR GKSLSSLLAE GMAVGNNGPA 300
LQAIEDQWLS SARLMTFSDA VVEALKRMNL SENEKSRRVN EWLNHARYEN 350
CLSNEQGREL AAKLGVTDLF WDWDLPRTRE GFYRFQGSVT AAVVRGWAFA 400
QIADLIWMET ASPDLNECTQ FAEGVKSKTP EVMLAYNLSP SFNWDASGMT 450
DQQMMEFIPR IARLGYCWQF ITLAGFHADA LVVDTFAKDY ARRGMLAYVE 500
RIQREERSNG VDTLAHQKWS GANYYDRYLK TVQGGISSTA AMGKGVTEEQ 550
FKETWTRPGA AGMGEGTSLV VAKSRM 576
Length:576
Mass (Da):64,326
Last modified:May 1, 1992 - v1
Checksum:i81A87701A4ACC350
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti75 – 751A → V in CAA73792. 1 Publication
Sequence conflicti177 – 1771D → G in CAA73792. 1 Publication
Sequence conflicti256 – 2561A → P in CAA73792. 1 Publication
Sequence conflicti278 – 2781S → N in CAA73792. 1 Publication
Sequence conflicti340 – 3401N → T in CAA73792. 1 Publication
Sequence conflicti344 – 3441N → I in CAA73792. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L08482 Genomic DNA. Translation: AAA32992.1.
Y13356 mRNA. Translation: CAA73792.1.
PIRiJQ1105. WZRPI.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L08482 Genomic DNA. Translation: AAA32992.1 .
Y13356 mRNA. Translation: CAA73792.1 .
PIRi JQ1105. WZRPI.

3D structure databases

ProteinModelPortali P25248.
SMRi P25248. Positions 9-535.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00703 ; UER00719 .

Family and domain databases

Gene3Di 3.20.20.60. 2 hits.
InterProi IPR006254. Isocitrate_lyase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view ]
PANTHERi PTHR21631:SF3. PTHR21631:SF3. 1 hit.
Pfami PF00463. ICL. 1 hit.
[Graphical view ]
PIRSFi PIRSF001362. Isocit_lyase. 1 hit.
SUPFAMi SSF51621. SSF51621. 1 hit.
TIGRFAMsi TIGR01346. isocit_lyase. 1 hit.
PROSITEi PS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Coordinate expression of transcriptionally regulated isocitrate lyase and malate synthase genes in Brassica napus L."
    Comai L., Dietrich R.A., Maslyar D.J., Baden C.S., Harada J.J.
    Plant Cell 1:293-300(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Two classes of isocitrate lyase genes are expressed during late embryogeny and postgermination in Brassica napus L."
    Zhang J.Z., Gomez-Pedrozo M., Baden C.S., Harada J.J.
    Mol. Gen. Genet. 238:177-184(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Olesen C., Thomsen K.K., Svendsen I., Brandt A.
    Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Global.
    Tissue: Cotyledon.

Entry informationi

Entry nameiACEA_BRANA
AccessioniPrimary (citable) accession number: P25248
Secondary accession number(s): O04910
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: May 14, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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