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P25241

- T3RE_BACC1

UniProt

P25241 - T3RE_BACC1

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Protein
Type III restriction-modification system Bce10987IP enzyme res
Gene
res, t3res, BCE_1019
Organism
Bacillus cereus (strain ATCC 10987)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

This protein cuts the DNA outside of the recognition site. May also act as a helicase involved in unwinding DNA at the cleavage site. Protein only required for restriction but needs the presence of the modification enzyme By similarity.

Catalytic activityi

Endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates.

Cofactori

Magnesium By similarity.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. Type III site-specific deoxyribonuclease activity Source: UniProtKB-EC
  4. helicase activity Source: UniProtKB-KW

GO - Biological processi

  1. DNA restriction-modification system Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Helicase, Hydrolase, Nuclease

Keywords - Biological processi

Restriction system

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.1.21.5. 648.

Protein family/group databases

REBASEi2841. BceSI.

Names & Taxonomyi

Protein namesi
Recommended name:
Type III restriction-modification system Bce10987IP enzyme res (EC:3.1.21.5)
Gene namesi
Name:res
Synonyms:t3res
Ordered Locus Names:BCE_1019
OrganismiBacillus cereus (strain ATCC 10987)
Taxonomic identifieri222523 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000002527: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 987987Type III restriction-modification system Bce10987IP enzyme res
PRO_0000077376Add
BLAST

Interactioni

Subunit structurei

Contains two different subunits: res and mod.

Protein-protein interaction databases

STRINGi222523.BCE_1019.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini886 – 97489VRR-NUC
Add
BLAST

Sequence similaritiesi

Contains 1 VRR-NUC domain.

Phylogenomic databases

eggNOGiCOG3587.
HOGENOMiHOG000218980.
KOiK01156.
OMAiRANQREN.
OrthoDBiEOG6MPWQ7.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR006935. Helicase/UvrB_dom.
IPR027417. P-loop_NTPase.
IPR014883. VRR_NUC.
[Graphical view]
PfamiPF04851. ResIII. 1 hit.
PF08774. VRR_NUC. 1 hit.
[Graphical view]
SMARTiSM00990. VRR_NUC. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 4 hits.

Sequencei

Sequence statusi: Complete.

P25241-1 [UniParc]FASTAAdd to Basket

« Hide

MKILLEELPH QEESLKAILE NFTGIDNAAN DSDVDYVYAN PLIRGRYNEI    50
SNIDVKMETG TGKTYVYTRL MYEMHQQYGI FKFVIVVPSP AIKEGAKNFI 100
QSDYAKQHFS QFYENVRIEL NVINAGDFKS KSGRRNFPAQ LLNFVEGSRQ 150
NSNTIEVLLI NADMLRSKSM RNNDYDQTLI GGTTSPIEAI QDTRPVVIID 200
EPHRFPRDKA NYQSIEAIKP QVIIRFGATF PEVTTGKGSN KITKKDYYRK 250
KPQFDLNAIE SFNNGLVKGI DIYYPNLTEE QAKNRYVVDS VKAKELVLKQ 300
NSKSWILHVG DNLAEVDSGF EGDIEYAGSK MLSNELELEK GMTLIPGTYR 350
STYQELIIKD AIDKHFEIEQ ANFLRANQRE NNVPRIKTLS LFFIDSITSY 400
RQDDGWLKAT FERLLKEKLS RLVAEYEFKR LPREKEYLEF LRATQSSLAS 450
DNQNVHAGYF GEDRGSGDES IQAEVDDILK NKEKLLSFKD ENGNWQTRRF 500
LFSKWTLREG WDNPNVFVIA KLRTSGSDNS KIQEVGRGLR LPVDETGHRI 550
QQDEWPTRLA FLIGYDEKDF AQKLIGEINS DAKLQLNEEK LTEDMIQLIV 600
TKRKKVNPEF TDERLLEHLD NLGIINRKNE FKESIDIGGV QKSGFEWLVE 650
LYPELNTNRL REGKVIDTKK HSIKVRVKLR KENWEKVKEL WQQFSNRYML 700
EFQRIPETIS FMAEQIVGNH SLYEREVPMQ MKESLHASDD NESVVLREQE 750
NEYQRIYLPG MAYGKFVKRI NIATGIPIKE IHANLFKLMK SSLKGDARYL 800
SELSLNNIIR EFKKRFDEIF AQAYEYKKLD FQARTAIYNP EMDSFVDDIN 850
AEVIGVNIDE QAQEDNRYLY ELPPMRYDSV TPERDLLRHG YNDKVTVFGK 900
LPRRAIQVPK YTGGSTTPDF IYMIEKDNDS SVYVLVETKA ENMRLEDQRI 950
IDIQKKFFDT LKEHHIEFIE ATSAQQVYSI IRKLSEE 987
Length:987
Mass (Da):114,787
Last modified:May 24, 2004 - v2
Checksum:i1D0D6CF4112407FC
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti410 – 46253TFERL…GYFGE → GDYQFIETKAPTGYDLNAKP IPFTITKGQAQVTSVTALNS LTTGSMELMKVDM in CAA43125. 1 Publication
Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ007510 Genomic DNA. Translation: CAB40612.1.
AE017194 Genomic DNA. Translation: AAS39950.1.
X60713 Genomic DNA. Translation: CAA43125.1.
PIRiS15518. JC1116.
RefSeqiNP_977342.1. NC_003909.8.
WP_000698184.1. NC_003909.8.

Genome annotation databases

EnsemblBacteriaiAAS39950; AAS39950; BCE_1019.
GeneIDi2750767.
KEGGibca:BCE_1019.
PATRICi18850934. VBIBacCer118379_0972.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ007510 Genomic DNA. Translation: CAB40612.1 .
AE017194 Genomic DNA. Translation: AAS39950.1 .
X60713 Genomic DNA. Translation: CAA43125.1 .
PIRi S15518. JC1116.
RefSeqi NP_977342.1. NC_003909.8.
WP_000698184.1. NC_003909.8.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 222523.BCE_1019.

Protein family/group databases

REBASEi 2841. BceSI.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAS39950 ; AAS39950 ; BCE_1019 .
GeneIDi 2750767.
KEGGi bca:BCE_1019.
PATRICi 18850934. VBIBacCer118379_0972.

Phylogenomic databases

eggNOGi COG3587.
HOGENOMi HOG000218980.
KOi K01156.
OMAi RANQREN.
OrthoDBi EOG6MPWQ7.

Enzyme and pathway databases

BRENDAi 3.1.21.5. 648.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR006935. Helicase/UvrB_dom.
IPR027417. P-loop_NTPase.
IPR014883. VRR_NUC.
[Graphical view ]
Pfami PF04851. ResIII. 1 hit.
PF08774. VRR_NUC. 1 hit.
[Graphical view ]
SMARTi SM00990. VRR_NUC. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 4 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome organization is not conserved between Bacillus cereus and Bacillus subtilis."
    Oekstad O.A., Hegna I.K., Lindbaeck T., Rishovd A.-L., Kolstoe A.-B.
    Microbiology 145:621-631(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The genome sequence of Bacillus cereus ATCC 10987 reveals metabolic adaptations and a large plasmid related to Bacillus anthracis pXO1."
    Rasko D.A., Ravel J., Oekstad O.A., Helgason E., Cer R.Z., Jiang L., Shores K.A., Fouts D.E., Tourasse N.J., Angiuoli S.V., Kolonay J.F., Nelson W.C., Kolstoe A.-B., Fraser C.M., Read T.D.
    Nucleic Acids Res. 32:977-988(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 10987.
  3. "A type-III DNA restriction and modification system in Bacillus cereus?"
    Hegna I.K., Karlstroem E.S., Lopez R., Kristensen T., Kolstoe A.-B.
    Gene 114:149-150(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 410-821.

Entry informationi

Entry nameiT3RE_BACC1
AccessioniPrimary (citable) accession number: P25241
Secondary accession number(s): Q9XBI5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 24, 2004
Last modified: September 3, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Restriction enzymes and methylases
    Classification of restriction enzymes and methylases and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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