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Protein

Antimicrobial protein CAP18

Gene

CAP18

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

CAP18 binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Has antibiotic activity.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial

Protein family/group databases

TCDBi1.C.33.1.6. the cathelicidin (cathelicidin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Antimicrobial protein CAP18
Alternative name(s):
18 kDa cationic protein
18 kDa lipopolysaccharide-binding protein
CAP18-A
Cleaved into the following chain:
Gene namesi
Name:CAP18
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence analysisAdd
BLAST
Chaini30 – 171142Antimicrobial protein CAP18PRO_0000004754Add
BLAST
Chaini135 – 17137Antimicrobial protein CAP7PRO_0000004755Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi85 ↔ 96By similarity
Disulfide bondi107 ↔ 124By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Neutrophils.

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000013325.

Structurei

Secondary structure

1
171
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi136 – 16530Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1LYPNMR-A135-166[»]
ProteinModelPortaliP25230.
SMRiP25230. Positions 30-128, 135-166.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP25230.

Family & Domainsi

Sequence similaritiesi

Belongs to the cathelicidin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J18R. Eukaryota.
ENOG41119S0. LUCA.
HOGENOMiHOG000093184.
HOVERGENiHBG006116.
InParanoidiP25230.
KOiK13916.

Family and domain databases

InterProiIPR001894. Cathelicidin.
IPR018216. Cathelicidin_CS.
IPR022746. Cathlecidin_C.
[Graphical view]
PANTHERiPTHR10206. PTHR10206. 1 hit.
PfamiPF12153. CAP18_C. 1 hit.
[Graphical view]
PROSITEiPS00946. CATHELICIDINS_1. 1 hit.
PS00947. CATHELICIDINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25230-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METHKHGPSL AWWSLLLLLL GLLMPPAIAQ DLTYREAVLR AVDAFNQQSS
60 70 80 90 100
EANLYRLLSM DPQQLEDAKP YTPQPVSFTV KETECPRTTW KLPEQCDFKE
110 120 130 140 150
DGLVKRCVGT VTRYQAWDSF DIRCNRAQES PEPTGLRKRL RKFRNKIKEK
160 170
LKKIGQKIQG FVPKLAPRTD Y
Length:171
Mass (Da):19,805
Last modified:May 1, 1992 - v1
Checksum:iD7BF2103BCFB13C4
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti157 – 1571K → D.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73998 mRNA. Translation: AAA31187.1.
PIRiJQ1171.
RefSeqiNP_001075774.1. NM_001082305.1.
UniGeneiOcu.1839.

Genome annotation databases

GeneIDi100009142.
KEGGiocu:100009142.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73998 mRNA. Translation: AAA31187.1.
PIRiJQ1171.
RefSeqiNP_001075774.1. NM_001082305.1.
UniGeneiOcu.1839.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1LYPNMR-A135-166[»]
ProteinModelPortaliP25230.
SMRiP25230. Positions 30-128, 135-166.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000013325.

Protein family/group databases

TCDBi1.C.33.1.6. the cathelicidin (cathelicidin) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100009142.
KEGGiocu:100009142.

Organism-specific databases

CTDi820.

Phylogenomic databases

eggNOGiENOG410J18R. Eukaryota.
ENOG41119S0. LUCA.
HOGENOMiHOG000093184.
HOVERGENiHBG006116.
InParanoidiP25230.
KOiK13916.

Miscellaneous databases

EvolutionaryTraceiP25230.

Family and domain databases

InterProiIPR001894. Cathelicidin.
IPR018216. Cathelicidin_CS.
IPR022746. Cathlecidin_C.
[Graphical view]
PANTHERiPTHR10206. PTHR10206. 1 hit.
PfamiPF12153. CAP18_C. 1 hit.
[Graphical view]
PROSITEiPS00946. CATHELICIDINS_1. 1 hit.
PS00947. CATHELICIDINS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAP18_RABIT
AccessioniPrimary (citable) accession number: P25230
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: May 11, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.