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Protein

Alpha-1-acid glycoprotein

Gene

ORM1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain (By similarity). Appears to function in modulating the activity of the immune system during the acute-phase reaction.By similarity

GO - Biological processi

Keywordsi

Biological processAcute phase, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1-acid glycoprotein
Alternative name(s):
Orosomucoid
Short name:
OMD
Gene namesi
Name:ORM1
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18By similarityAdd BLAST18
ChainiPRO_000001786719 – 201Alpha-1-acid glycoproteinAdd BLAST183

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi25N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi33N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi87N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi90 ↔ 183By similarity
Glycosylationi93N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi169N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP25227.

Expressioni

Gene expression databases

BgeeiENSOCUG00000004625.

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000003988.

Structurei

3D structure databases

ProteinModelPortaliP25227.
SMRiP25227.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Contains a beta-barrel that binds various ligands in its interior.By similarity

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWZI. Eukaryota.
ENOG4111C49. LUCA.
GeneTreeiENSGT00390000012130.
HOGENOMiHOG000125170.
HOVERGENiHBG000035.
InParanoidiP25227.
KOiK17308.
OMAiQRENGTI.
OrthoDBiEOG091G0NAQ.
TreeFamiTF343791.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiView protein in InterPro
IPR001500. A1A_glycop.
IPR012674. Calycin.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
PANTHERiPTHR11967. PTHR11967. 1 hit.
PfamiView protein in Pfam
PF00061. Lipocalin. 1 hit.
PIRSFiPIRSF036899. AGP. 1 hit.
PRINTSiPR00708. A1AGLPROTEIN.
SUPFAMiSSF50814. SSF50814. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25227-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALPWALAVL SLLPLLHAQD PACANFSTSP ITNATLDQLS HKWFFTASAF
60 70 80 90 100
RNPKYKQLVQ HTQAAFFYFT AIKEEDTLLL REYITTNNTC FYNSSIVRVQ
110 120 130 140 150
RENGTLSKHD GIRNSVADLL LLRDPGSFLL VFFAGKEQDK GMSFYTDKPK
160 170 180 190 200
ASPEQLEEFY EALTCLGMNK TEVVYTDWTK DLCEPLEKQH EEERKKEKAE

S
Length:201
Mass (Da):23,028
Last modified:May 1, 1992 - v1
Checksum:i97DC40E41C7DAC4D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58727 mRNA. Translation: CAA41559.1.
M93344 Genomic DNA. No translation available.
PIRiJH0617.
RefSeqiNP_001095165.1. NM_001101695.1.
UniGeneiOcu.2068.

Genome annotation databases

EnsembliENSOCUT00000004621; ENSOCUP00000003988; ENSOCUG00000004625.
GeneIDi100009268.
KEGGiocu:100009268.

Similar proteinsi

Entry informationi

Entry nameiA1AG_RABIT
AccessioniPrimary (citable) accession number: P25227
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: August 30, 2017
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families