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Protein

Alpha-1-acid glycoprotein

Gene

ORM1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain (By similarity). Appears to function in modulating the activity of the immune system during the acute-phase reaction.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Acute phase, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1-acid glycoprotein
Alternative name(s):
Orosomucoid
Short name:
OMD
Gene namesi
Name:ORM1
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818By similarityAdd
BLAST
Chaini19 – 201183Alpha-1-acid glycoproteinPRO_0000017867Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi25 – 251N-linked (GlcNAc...)Sequence analysis
Glycosylationi33 – 331N-linked (GlcNAc...)Sequence analysis
Glycosylationi87 – 871N-linked (GlcNAc...)Sequence analysis
Disulfide bondi90 ↔ 183By similarity
Glycosylationi93 – 931N-linked (GlcNAc...)Sequence analysis
Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence analysis
Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000003988.

Structurei

3D structure databases

ProteinModelPortaliP25227.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Contains a beta-barrel that binds various ligands in its interior.By similarity

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWZI. Eukaryota.
ENOG4111C49. LUCA.
GeneTreeiENSGT00390000012130.
HOGENOMiHOG000125170.
HOVERGENiHBG000035.
InParanoidiP25227.
KOiK17308.
OMAiEYQTRQD.
OrthoDBiEOG091G0NAQ.
TreeFamiTF343791.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR001500. A1A_glycop.
IPR012674. Calycin.
IPR011038. Calycin-like.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PANTHERiPTHR11967. PTHR11967. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PIRSFiPIRSF036899. AGP. 1 hit.
PRINTSiPR00708. A1AGLPROTEIN.
SUPFAMiSSF50814. SSF50814. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25227-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALPWALAVL SLLPLLHAQD PACANFSTSP ITNATLDQLS HKWFFTASAF
60 70 80 90 100
RNPKYKQLVQ HTQAAFFYFT AIKEEDTLLL REYITTNNTC FYNSSIVRVQ
110 120 130 140 150
RENGTLSKHD GIRNSVADLL LLRDPGSFLL VFFAGKEQDK GMSFYTDKPK
160 170 180 190 200
ASPEQLEEFY EALTCLGMNK TEVVYTDWTK DLCEPLEKQH EEERKKEKAE

S
Length:201
Mass (Da):23,028
Last modified:May 1, 1992 - v1
Checksum:i97DC40E41C7DAC4D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58727 mRNA. Translation: CAA41559.1.
M93344 Genomic DNA. No translation available.
PIRiJH0617.
RefSeqiNP_001095165.1. NM_001101695.1.
UniGeneiOcu.2068.

Genome annotation databases

EnsembliENSOCUT00000004621; ENSOCUP00000003988; ENSOCUG00000004625.
GeneIDi100009268.
KEGGiocu:100009268.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58727 mRNA. Translation: CAA41559.1.
M93344 Genomic DNA. No translation available.
PIRiJH0617.
RefSeqiNP_001095165.1. NM_001101695.1.
UniGeneiOcu.2068.

3D structure databases

ProteinModelPortaliP25227.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000003988.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOCUT00000004621; ENSOCUP00000003988; ENSOCUG00000004625.
GeneIDi100009268.
KEGGiocu:100009268.

Organism-specific databases

CTDi5004.

Phylogenomic databases

eggNOGiENOG410IWZI. Eukaryota.
ENOG4111C49. LUCA.
GeneTreeiENSGT00390000012130.
HOGENOMiHOG000125170.
HOVERGENiHBG000035.
InParanoidiP25227.
KOiK17308.
OMAiEYQTRQD.
OrthoDBiEOG091G0NAQ.
TreeFamiTF343791.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR001500. A1A_glycop.
IPR012674. Calycin.
IPR011038. Calycin-like.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PANTHERiPTHR11967. PTHR11967. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PIRSFiPIRSF036899. AGP. 1 hit.
PRINTSiPR00708. A1AGLPROTEIN.
SUPFAMiSSF50814. SSF50814. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiA1AG_RABIT
AccessioniPrimary (citable) accession number: P25227
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: September 7, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.