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Protein

Nuclear transcription factor Y subunit beta

Gene

NFYB

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi57 – 63By similarity7

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-GGA-2426168. Activation of gene expression by SREBF (SREBP).

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear transcription factor Y subunit beta
Alternative name(s):
CAAT box DNA-binding protein subunit B
Nuclear transcription factor Y subunit B
Short name:
NF-YB
Gene namesi
Name:NFYB
ORF Names:RCJMB04_7n24
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002046121 – 205Nuclear transcription factor Y subunit betaAdd BLAST205

Proteomic databases

PaxDbiP25207.

Expressioni

Gene expression databases

BgeeiENSGALG00000012717.

Interactioni

Subunit structurei

Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding (By similarity).By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000020733.

Structurei

3D structure databases

ProteinModelPortaliP25207.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 50A domainAdd BLAST50
Regioni51 – 140B domainAdd BLAST90
Regioni84 – 95Subunit association domain (SAD)By similarityAdd BLAST12
Regioni141 – 201C domainAdd BLAST61

Domaini

Can be divided into 3 domains: the weakly conserved A domain, the highly conserved B domain thought to be involved in subunit interaction and DNA binding, and the Glu-rich C domain.

Sequence similaritiesi

Belongs to the NFYB/HAP3 subunit family.Curated

Phylogenomic databases

eggNOGiKOG0869. Eukaryota.
COG2036. LUCA.
GeneTreeiENSGT00550000074689.
HOGENOMiHOG000211832.
HOVERGENiHBG008864.
InParanoidiP25207.
KOiK08065.
OMAiIAGDYIG.
OrthoDBiEOG091G0Y4D.
PhylomeDBiP25207.
TreeFamiTF314521.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR003958. CBFA_NFYB_domain.
IPR009072. Histone-fold.
IPR003956. Transcrpt_fac_NFYB/HAP3_CS.
[Graphical view]
PfamiPF00808. CBFD_NFYB_HMF. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00685. NFYB_HAP3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25207-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGDSSTTDA SQLGIAGDYI GGSHYVIQPH DDTEDSMNDH EDTNGSKESF
60 70 80 90 100
REQDIYLPIA NVARIMKNAI PQTGKIAKDA KECVQECVSE FISFITSEAS
110 120 130 140 150
ERCHQEKRKT INGEDILFAM STLGFDSYVE PLKLYLQKFR EAMKGEKGIG
160 170 180 190 200
GTVTTGDGLS EELTEEAFTN QLPAGLITTD GQQQNVMVYT TSYQQISGVQ

QIQFS
Length:205
Mass (Da):22,585
Last modified:August 30, 2005 - v2
Checksum:iC68BEBBE27049AD2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719889 mRNA. Translation: CAG31548.1.
X59713 mRNA. Translation: CAA42233.1. Sequence problems.
PIRiS24469.
RefSeqiNP_990600.1. NM_205269.1.
UniGeneiGga.1264.

Genome annotation databases

EnsembliENSGALT00000065187; ENSGALP00000051245; ENSGALG00000041193.
ENSGALT00000070018; ENSGALP00000056991; ENSGALG00000041193.
ENSGALT00000076295; ENSGALP00000056060; ENSGALG00000041193.
GeneIDi396205.
KEGGigga:396205.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719889 mRNA. Translation: CAG31548.1.
X59713 mRNA. Translation: CAA42233.1. Sequence problems.
PIRiS24469.
RefSeqiNP_990600.1. NM_205269.1.
UniGeneiGga.1264.

3D structure databases

ProteinModelPortaliP25207.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000020733.

Proteomic databases

PaxDbiP25207.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000065187; ENSGALP00000051245; ENSGALG00000041193.
ENSGALT00000070018; ENSGALP00000056991; ENSGALG00000041193.
ENSGALT00000076295; ENSGALP00000056060; ENSGALG00000041193.
GeneIDi396205.
KEGGigga:396205.

Organism-specific databases

CTDi4801.

Phylogenomic databases

eggNOGiKOG0869. Eukaryota.
COG2036. LUCA.
GeneTreeiENSGT00550000074689.
HOGENOMiHOG000211832.
HOVERGENiHBG008864.
InParanoidiP25207.
KOiK08065.
OMAiIAGDYIG.
OrthoDBiEOG091G0Y4D.
PhylomeDBiP25207.
TreeFamiTF314521.

Enzyme and pathway databases

ReactomeiR-GGA-2426168. Activation of gene expression by SREBF (SREBP).

Miscellaneous databases

PROiP25207.

Gene expression databases

BgeeiENSGALG00000012717.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR003958. CBFA_NFYB_domain.
IPR009072. Histone-fold.
IPR003956. Transcrpt_fac_NFYB/HAP3_CS.
[Graphical view]
PfamiPF00808. CBFD_NFYB_HMF. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00685. NFYB_HAP3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNFYB_CHICK
AccessioniPrimary (citable) accession number: P25207
Secondary accession number(s): Q5ZL45
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: August 30, 2005
Last modified: November 30, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.