Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Nuclear transcription factor Y subunit beta

Gene

NFYB

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi57 – 637By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-GGA-2426168. Activation of gene expression by SREBF (SREBP).

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear transcription factor Y subunit beta
Alternative name(s):
CAAT box DNA-binding protein subunit B
Nuclear transcription factor Y subunit B
Short name:
NF-YB
Gene namesi
Name:NFYB
ORF Names:RCJMB04_7n24
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 205205Nuclear transcription factor Y subunit betaPRO_0000204612Add
BLAST

Proteomic databases

PaxDbiP25207.

Interactioni

Subunit structurei

Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding (By similarity).By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000020733.

Structurei

3D structure databases

ProteinModelPortaliP25207.
SMRiP25207. Positions 55-141.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 5050A domainAdd
BLAST
Regioni51 – 14090B domainAdd
BLAST
Regioni84 – 9512Subunit association domain (SAD)By similarityAdd
BLAST
Regioni141 – 20161C domainAdd
BLAST

Domaini

Can be divided into 3 domains: the weakly conserved A domain, the highly conserved B domain thought to be involved in subunit interaction and DNA binding, and the Glu-rich C domain.

Sequence similaritiesi

Belongs to the NFYB/HAP3 subunit family.Curated

Phylogenomic databases

eggNOGiKOG0869. Eukaryota.
COG2036. LUCA.
GeneTreeiENSGT00550000074689.
HOGENOMiHOG000211832.
HOVERGENiHBG008864.
InParanoidiP25207.
KOiK08065.
OMAiIAGDYIG.
OrthoDBiEOG7RNK2W.
PhylomeDBiP25207.
TreeFamiTF314521.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR003958. CBFA_NFYB_domain.
IPR009072. Histone-fold.
IPR003956. Transcrpt_fac_NFYB/HAP3_CS.
[Graphical view]
PfamiPF00808. CBFD_NFYB_HMF. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00685. NFYB_HAP3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25207-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGDSSTTDA SQLGIAGDYI GGSHYVIQPH DDTEDSMNDH EDTNGSKESF
60 70 80 90 100
REQDIYLPIA NVARIMKNAI PQTGKIAKDA KECVQECVSE FISFITSEAS
110 120 130 140 150
ERCHQEKRKT INGEDILFAM STLGFDSYVE PLKLYLQKFR EAMKGEKGIG
160 170 180 190 200
GTVTTGDGLS EELTEEAFTN QLPAGLITTD GQQQNVMVYT TSYQQISGVQ

QIQFS
Length:205
Mass (Da):22,585
Last modified:August 30, 2005 - v2
Checksum:iC68BEBBE27049AD2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719889 mRNA. Translation: CAG31548.1.
X59713 mRNA. Translation: CAA42233.1. Sequence problems.
PIRiS24469.
RefSeqiNP_990600.1. NM_205269.1.
UniGeneiGga.1264.

Genome annotation databases

EnsembliENSGALT00000020762; ENSGALP00000020733; ENSGALG00000012717.
GeneIDi396205.
KEGGigga:396205.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719889 mRNA. Translation: CAG31548.1.
X59713 mRNA. Translation: CAA42233.1. Sequence problems.
PIRiS24469.
RefSeqiNP_990600.1. NM_205269.1.
UniGeneiGga.1264.

3D structure databases

ProteinModelPortaliP25207.
SMRiP25207. Positions 55-141.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000020733.

Proteomic databases

PaxDbiP25207.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000020762; ENSGALP00000020733; ENSGALG00000012717.
GeneIDi396205.
KEGGigga:396205.

Organism-specific databases

CTDi4801.

Phylogenomic databases

eggNOGiKOG0869. Eukaryota.
COG2036. LUCA.
GeneTreeiENSGT00550000074689.
HOGENOMiHOG000211832.
HOVERGENiHBG008864.
InParanoidiP25207.
KOiK08065.
OMAiIAGDYIG.
OrthoDBiEOG7RNK2W.
PhylomeDBiP25207.
TreeFamiTF314521.

Enzyme and pathway databases

ReactomeiR-GGA-2426168. Activation of gene expression by SREBF (SREBP).

Miscellaneous databases

NextBioi20816257.
PROiP25207.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR003958. CBFA_NFYB_domain.
IPR009072. Histone-fold.
IPR003956. Transcrpt_fac_NFYB/HAP3_CS.
[Graphical view]
PfamiPF00808. CBFD_NFYB_HMF. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00685. NFYB_HAP3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.
  2. "Evolutionary variation of the CCAAT-binding transcription factor NF-Y."
    Li X.-Y., Mantovani R., Hooft van Huijsduijnen R., Andre I., Benoist C., Mathis D.
    Nucleic Acids Res. 20:1087-1091(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-151.

Entry informationi

Entry nameiNFYB_CHICK
AccessioniPrimary (citable) accession number: P25207
Secondary accession number(s): Q5ZL45
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: August 30, 2005
Last modified: November 11, 2015
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.