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Protein

Myelin basic protein

Gene

MBP

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin basic protein
Short name:
MBP
Gene namesi
Name:MBP
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
Proteomesi
  • UP000005447 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Keywords - Diseasei

Autoimmune encephalomyelitis

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001589881 – 167Myelin basic proteinAdd BLAST167

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylalanineBy similarity1
Modified residuei7PhosphoserineBy similarity1
Modified residuei12PhosphoserineBy similarity1
Modified residuei14PhosphotyrosineBy similarity1
Modified residuei17PhosphothreonineBy similarity1
Modified residuei19PhosphoserineBy similarity1
Modified residuei20PhosphothreonineBy similarity1
Modified residuei25CitrullineBy similarity1
Modified residuei31CitrullineBy similarity1
Modified residuei35PhosphothreonineBy similarity1
Modified residuei40PhosphoserineBy similarity1
Modified residuei43Omega-N-methylarginineBy similarity1
Modified residuei49Omega-N-methylarginineBy similarity1
Modified residuei56PhosphoserineBy similarity1
Modified residuei67PhosphothreonineBy similarity1
Modified residuei69PhosphotyrosineBy similarity1
Modified residuei76PhosphoserineBy similarity1
Modified residuei94PhosphothreonineBy similarity1
Modified residuei97PhosphothreonineBy similarity1
Modified residuei102Deamidated glutamineBy similarity1
Modified residuei106Omega-N-methylarginine; alternateBy similarity1
Modified residuei106Symmetric dimethylarginine; alternateBy similarity1
Modified residuei114PhosphoserineBy similarity1
Modified residuei121N6-acetyllysineBy similarity1
Modified residuei129CitrullineBy similarity1
Modified residuei144Deamidated glutamineBy similarity1
Modified residuei156CitrullineBy similarity1
Modified residuei158PhosphoserineBy similarity1
Modified residuei162Phosphoserine; by UHMK1By similarity1
Modified residuei167CitrullineBy similarity1

Post-translational modificationi

At least 5 charge isomers; C1 (the most cationic, least modified, and most abundant form), C2, C3, C4 and C5 (the least cationic form); are produced as a result of optional post-translational modifications such as phosphorylation of serine or threonine residues, deamidation of glutamine or asparagine residues, citrullination and methylation of arginine residues. C1 and C2 are unphosphorylated, C3 and C4 are monophosphorylated and C5 is phosphorylated at two positions (PubMed:51849).1 Publication
Phosphorylated by TAOK2, VRK2, MAPK11, MAPK12, MAPK14 and MINK1.By similarity

Keywords - PTMi

Acetylation, Citrullination, Methylation, Phosphoprotein

Proteomic databases

PRIDEiP25188.

Expressioni

Tissue specificityi

Found in both the central and the peripheral nervous system.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000007579.

Structurei

3D structure databases

ProteinModelPortaliP25188.
SMRiP25188.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni45 – 87Induces experimental autoimmune encephalomyelitis (EAE) 1Add BLAST43
Regioni114 – 122Induces experimental autoimmune encephalomyelitis (EAE) 29

Sequence similaritiesi

Belongs to the myelin basic protein family.Curated

Phylogenomic databases

eggNOGiENOG410IIUJ. Eukaryota.
ENOG4111PMJ. LUCA.
HOGENOMiHOG000293395.
HOVERGENiHBG008347.
InParanoidiP25188.

Family and domain databases

InterProiIPR000548. Myelin_BP.
[Graphical view]
PANTHERiPTHR11429. PTHR11429. 1 hit.
PfamiPF01669. Myelin_MBP. 1 hit.
[Graphical view]
PRINTSiPR00212. MYELINMBP.
PROSITEiPS00569. MYELIN_MBP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25188-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ASQKRPSQRH GSKYLATAST MDHARHGFLP RHRDTGILDS IGRFFGSDRA
60 70 80 90 100
APKRGSGKDS HHAARTTHYG SLPQKSQRSQ DENPVVHFFK NIVTPRTPPP
110 120 130 140 150
SQGKGRGLSL SRFSWGAEGQ KPGFGYGGRA DYKSKGFKGA HDAQGTLSKI
160
FKLGGRDSRS GSPMARR
Length:167
Mass (Da):18,213
Last modified:May 1, 1992 - v1
Checksum:i866D31F1E5ACFEA6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF074337 mRNA. Translation: AAC26130.1.
PIRiA37246.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF074337 mRNA. Translation: AAC26130.1.
PIRiA37246.

3D structure databases

ProteinModelPortaliP25188.
SMRiP25188.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000007579.

Proteomic databases

PRIDEiP25188.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410IIUJ. Eukaryota.
ENOG4111PMJ. LUCA.
HOGENOMiHOG000293395.
HOVERGENiHBG008347.
InParanoidiP25188.

Family and domain databases

InterProiIPR000548. Myelin_BP.
[Graphical view]
PANTHERiPTHR11429. PTHR11429. 1 hit.
PfamiPF01669. Myelin_MBP. 1 hit.
[Graphical view]
PRINTSiPR00212. MYELINMBP.
PROSITEiPS00569. MYELIN_MBP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMBP_CAVPO
AccessioniPrimary (citable) accession number: P25188
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: November 2, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.