ID   RCC1_XENLA              Reviewed;         424 AA.
AC   P25183;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1992, sequence version 1.
DT   01-SEP-2009, entry version 58.
DE   RecName: Full=Regulator of chromosome condensation;
GN   Name=rcc1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae;
OC   Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=90299858; PubMed=2361953;
RA   Nishitani H., Kobayashi H., Ohtsubo M., Nishimoto T.;
RT   "Cloning of Xenopus RCC1 cDNA, a homolog of the human RCC1 gene:
RT   complementation of tsBN2 mutation and identification of the product.";
RL   J. Biochem. 107:228-235(1990).
CC   -!- FUNCTION: Promotes the exchange of Ran-bound GDP by GTP. Involved
CC       in the regulation of onset of chromosome condensation in the S
CC       phase. Binds to the chromatin. RCC1/Ran complex (together with
CC       other proteins) acts as a component of a signal transmission
CC       pathway that detects unreplicated DNA (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Becomes dispersed
CC       throughout the cytoplasm during mitosis.
CC   -!- SIMILARITY: Contains 7 RCC1 repeats.
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DR   EMBL; D00679; BAA00586.1; -; mRNA.
DR   EMBL; D00646; BAA00542.1; -; mRNA.
DR   PIR; I51559; I51559.
DR   RefSeq; NP_001081229.1; -.
DR   UniGene; Xl.29555; -.
DR   HSSP; P18754; 1I2M.
DR   SMR; P25183; 31-423.
DR   PRIDE; P25183; -.
DR   GeneID; 397722; -.
DR   KEGG; xla:397722; -.
DR   CTD; 397722; -.
DR   HOVERGEN; P25183; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007067; P:mitosis; IEA:UniProtKB-KW.
DR   InterPro; IPR000408; Reg_chr_condens.
DR   InterPro; IPR009091; Reg_csome_cond/b-lactamase_inh.
DR   Gene3D; G3DSA:2.130.10.30; Reg_csome_cond/b-lactamase_inh; 1.
DR   Pfam; PF00415; RCC1; 7.
DR   PRINTS; PR00633; RCCNDNSATION.
DR   PROSITE; PS00625; RCC1_1; 1.
DR   PROSITE; PS00626; RCC1_2; 5.
DR   PROSITE; PS50012; RCC1_3; 7.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Cytoplasm;
KW   Guanine-nucleotide releasing factor; Mitosis; Nucleus; Repeat.
FT   CHAIN         1    424       Regulator of chromosome condensation.
FT                                /FTId=PRO_0000206631.
FT   REPEAT       40     90       RCC1 1.
FT   REPEAT       91    142       RCC1 2.
FT   REPEAT      144    195       RCC1 3.
FT   REPEAT      197    262       RCC1 4.
FT   REPEAT      263    316       RCC1 5.
FT   REPEAT      317    367       RCC1 6.
FT   REPEAT      368    421       RCC1 7.
FT   VARIANT      27     30       Missing (in clone lambda O-23).
SQ   SEQUENCE   424 AA;  45071 MW;  DCF77FCCEBAB6639 CRC64;
     MKGKKTLKRT IAAEESNGTS DVKKTKALPI VTHPSHGTVG GQVLTLGQGD VGQLGLGEDI
     MERKKPALVT LTEDIVQAAA GGMHTVCLGA SGSIYTFGCN DEGALGRDTS EEGSEMQPGK
     VELAEKVVQV SAGDSHTAAL TEDGRVFVFG SFRDNNGVIG LLEPMKKSMV PVQVQINTPV
     IKIASGNDHL VLLTVDGDLY TSGCGEQGQL GRVPERFTNR GGRKGLERLL VPQCIHLKAK
     GSGRVHFQDV FCGAYFTFAV SQEGHVYGFG LSNYHQLGTK NTQACYAPQN LTSFKNSTKS
     WIGFSGGQHH TVCVDSEGKA YSLGRAEYGR LGLGENAEEQ SEPTPIPDLP KINSVASGAS
     VSYAVSTDGC VFAWGMGTNL QLGTGEEEDV WSPEQMTGKH LEDREVLSVS SGGQHTVLLV
     RKRS
//