P25183 (RCC1_XENLA) Reviewed, UniProtKB/Swiss-Prot
Last modified
November 16, 2011.
Version 64.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Regulator of chromosome condensation | ||
| Gene names |
| ||
| Organism | Xenopus laevis (African clawed frog) | ||
| Taxonomic identifier | 8355 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Protein attributes
| Sequence length | 424 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds to the chromatin. RCC1/Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA By similarity. |
| Subcellular location | Nucleus. Cytoplasm. Note: Becomes dispersed throughout the cytoplasm during mitosis. |
| Sequence similarities | Contains 7 RCC1 repeats. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Cell cycle Cell division Mitosis |
| Cellular component | Cytoplasm Nucleus |
| Domain | Repeat |
| Molecular function | Guanine-nucleotide releasing factor |
| Gene Ontology (GO) | |
| Biological process | cell division Inferred from electronic annotation. Source: UniProtKB-KW mitosisInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleusInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | guanyl-nucleotide exchange factor activity Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 424 | 424 | Regulator of chromosome condensation | PRO_0000206631 | |||||
Regions | |||||||||
| Repeat | 40 – 90 | 51 | RCC1 1 | ||||||
| Repeat | 91 – 142 | 52 | RCC1 2 | ||||||
| Repeat | 144 – 195 | 52 | RCC1 3 | ||||||
| Repeat | 197 – 262 | 66 | RCC1 4 | ||||||
| Repeat | 263 – 316 | 54 | RCC1 5 | ||||||
| Repeat | 317 – 367 | 51 | RCC1 6 | ||||||
| Repeat | 368 – 421 | 54 | RCC1 7 | ||||||
Natural variations | |||||||||
| Natural variant | 27 – 30 | 4 | Missing in clone lambda O-23. | ||||||
Sequences
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References
| [1] | "Cloning of Xenopus RCC1 cDNA, a homolog of the human RCC1 gene: complementation of tsBN2 mutation and identification of the product." Nishitani H., Kobayashi H., Ohtsubo M., Nishimoto T. J. Biochem. 107:228-235(1990) [PubMed: 2361953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | D00679 mRNA. Translation: BAA00586.1. D00646 mRNA. Translation: BAA00542.1. |
| PIR | I51559. |
| RefSeq | NP_001081229.1. NM_001087760.1. |
| UniGene | Xl.29555. |
3D structure databases | |
| ProteinModelPortal | P25183. |
| SMR | P25183. Positions 31-423. |
| ModBase | Search... |
Proteomic databases | |
| PRIDE | P25183. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 397722. |
| KEGG | xla:397722. |
Organism-specific databases | |
| CTD | 397722. |
| Xenbase | XB-GENE-6252622. rcc1. |
Phylogenomic databases | |
| HOVERGEN | HBG017712. |
Family and domain databases | |
| InterPro | IPR000408. Reg_chr_condens. IPR009091. Reg_csome_cond/b-lactamase_inh. [Graphical view] |
| Gene3D | G3DSA:2.130.10.30. Reg_csome_cond/b-lactamase_inh. 1 hit. |
| KO | K11493. |
| Pfam | PF00415. RCC1. 7 hits. [Graphical view] |
| PRINTS | PR00633. RCCNDNSATION. |
| SUPFAM | SSF50985. RCC1/BLIP-II. 1 hit. |
| PROSITE | PS00625. RCC1_1. 1 hit. PS00626. RCC1_2. 5 hits. PS50012. RCC1_3. 7 hits. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | RCC1_XENLA | ||||||||
| Accession | Primary (citable) accession number: P25183 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

Clusters with