P25183 (RCC1_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Regulator of chromosome condensation

Gene names

Name:

rcc1

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	424 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds to the chromatin. RCC1/Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA By similarity.
Subcellular location	Nucleus. Cytoplasm. Note: Becomes dispersed throughout the cytoplasm during mitosis.
Sequence similarities	Contains 7 RCC1 repeats.

Ontologies

Keywords
Biological process	Cell cycle Cell division Mitosis
Cellular component	Cytoplasm Nucleus
Domain	Repeat
Molecular function	Guanine-nucleotide releasing factor
Gene Ontology (GO)
Biological process	cell division Inferred from electronic annotation. Source: UniProtKB-KW mitosis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	guanyl-nucleotide exchange factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 424	424	Regulator of chromosome condensation		PRO_0000206631
Regions
	Repeat	40 – 90	51	RCC1 1
	Repeat	91 – 142	52	RCC1 2
	Repeat	144 – 195	52	RCC1 3
	Repeat	197 – 262	66	RCC1 4
	Repeat	263 – 316	54	RCC1 5
	Repeat	317 – 367	51	RCC1 6
	Repeat	368 – 421	54	RCC1 7
Natural variations
	Natural variant	27 – 30	4	Missing in clone lambda O-23.

Sequences

	Sequence		Length	Mass (Da)
	P25183 [UniParc]. Last modified May 1, 1992. Version 1. Checksum: DCF77FCCEBAB6639	FASTA	424	45,071
	10 20 30 40 50 60 MKGKKTLKRT IAAEESNGTS DVKKTKALPI VTHPSHGTVG GQVLTLGQGD VGQLGLGEDI 70 80 90 100 110 120 MERKKPALVT LTEDIVQAAA GGMHTVCLGA SGSIYTFGCN DEGALGRDTS EEGSEMQPGK 130 140 150 160 170 180 VELAEKVVQV SAGDSHTAAL TEDGRVFVFG SFRDNNGVIG LLEPMKKSMV PVQVQINTPV 190 200 210 220 230 240 IKIASGNDHL VLLTVDGDLY TSGCGEQGQL GRVPERFTNR GGRKGLERLL VPQCIHLKAK 250 260 270 280 290 300 GSGRVHFQDV FCGAYFTFAV SQEGHVYGFG LSNYHQLGTK NTQACYAPQN LTSFKNSTKS 310 320 330 340 350 360 WIGFSGGQHH TVCVDSEGKA YSLGRAEYGR LGLGENAEEQ SEPTPIPDLP KINSVASGAS 370 380 390 400 410 420 VSYAVSTDGC VFAWGMGTNL QLGTGEEEDV WSPEQMTGKH LEDREVLSVS SGGQHTVLLV RKRS

References

[1]	"Cloning of Xenopus RCC1 cDNA, a homolog of the human RCC1 gene: complementation of tsBN2 mutation and identification of the product." Nishitani H., Kobayashi H., Ohtsubo M., Nishimoto T. J. Biochem. 107:228-235(1990) [PubMed: 2361953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D00679 mRNA. Translation: BAA00586.1. D00646 mRNA. Translation: BAA00542.1.
PIR	I51559.
RefSeq	NP_001081229.1. NM_001087760.1.
UniGene	Xl.29555.
3D structure databases
ProteinModelPortal	P25183.
SMR	P25183. Positions 31-423.
ModBase	Search...
Proteomic databases
PRIDE	P25183.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	397722.
KEGG	xla:397722.
Organism-specific databases
CTD	397722.
Xenbase	XB-GENE-6252622. rcc1.
Phylogenomic databases
HOVERGEN	HBG017712.
Family and domain databases
InterPro	IPR000408. Reg_chr_condens. IPR009091. Reg_csome_cond/b-lactamase_inh. [Graphical view]
Gene3D	G3DSA:2.130.10.30. Reg_csome_cond/b-lactamase_inh. 1 hit.
KO	K11493.
Pfam	PF00415. RCC1. 7 hits. [Graphical view]
PRINTS	PR00633. RCCNDNSATION.
SUPFAM	SSF50985. RCC1/BLIP-II. 1 hit.
PROSITE	PS00625. RCC1_1. 1 hit. PS00626. RCC1_2. 5 hits. PS50012. RCC1_3. 7 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RCC1_XENLA

Accession

Primary (citable) accession number: P25183

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1992
Last sequence update:	May 1, 1992
Last modified:	November 16, 2011
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program