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P25180

- HN_SV41

UniProt

P25180 - HN_SV41

Protein

Hemagglutinin-neuraminidase

Gene

HN

Organism
Simian virus 41 (SV41)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 May 1992)
      Previous versions | rss
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    Functioni

    Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion By similarity.By similarity
    Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins.By similarity

    Catalytic activityi

    Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

    GO - Molecular functioni

    1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
    2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
    3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. viral entry into host cell Source: UniProtKB-KW
    2. virion attachment to host cell Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hemagglutinin, Hydrolase

    Keywords - Biological processi

    Host-virus interaction, Viral attachment to host cell, Virus entry into host cell

    Protein family/group databases

    CAZyiGH83. Glycoside Hydrolase Family 83.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hemagglutinin-neuraminidase (EC:3.2.1.18)
    Gene namesi
    Name:HN
    OrganismiSimian virus 41 (SV41)
    Taxonomic identifieri11228 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeParamyxovirinaeRubulavirus
    Virus hostiSimiiformes [TaxID: 314293]
    ProteomesiUP000007231: Genome

    Subcellular locationi

    GO - Cellular componenti

    1. host cell plasma membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. viral envelope Source: UniProtKB-KW
    4. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 568568Hemagglutinin-neuraminidasePRO_0000142645Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi44 – 441N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi111 – 1111N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi268 – 2681N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi280 – 2801N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi382 – 3821N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi513 – 5131N-linked (GlcNAc...); by hostSequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliP25180.
    SMRiP25180. Positions 119-568.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1818IntravirionSequence AnalysisAdd
    BLAST
    Topological domaini40 – 568529Virion surfaceSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei19 – 3921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di2.120.10.10. 1 hit.
    InterProiIPR000665. Hemagglutn-neuramid.
    IPR016285. Hemagglutn-neuramid_paramyxo.
    IPR011040. Sialidases.
    [Graphical view]
    PfamiPF00423. HN. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
    SUPFAMiSSF50939. SSF50939. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P25180-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGAEGNTNK RTFRAVFRTL IILITLTILA LSAAILYEVT HTSNGSESNN    50
    QVFDPTDTLN AITGNIKSMI ALLNQILYNA AIALPLKIDS TESVLLAAIK 100
    DLQFSNPASQ NCSSGGNLLN DALYINGINQ YLLSNSFAGT VGLGPLLNIP 150
    SFIPSATAPG GCTRIPSFSL TKTHWCYSHN VILAGCADSK ASNQYLAMGI 200
    VEQSSADFPF FRTMRTLYLS DGINRKSCSI VAIPGGCALY CYVATKTEQE 250
    DYAATTPSEL RLTFYYYNET LVERTLTIPN VTGNWATLNP AVGSGVYHLG 300
    YLAFPVYGGL IQNSAAWNSQ FGSYFLPQNP AVQCSGSAEQ QINTAKGSYV 350
    VNWFSGRLIQ SAVLVCPLSD QLTDQCRVVL FNNSETMMGA EGRLYTIGGD 400
    LYYYQRSSSW WTASLLYKIN TDFSQGLPPL IEAQWVPTYL VPRPGAQPCS 450
    AGNFCPANCI TGVYADVWPM NNPFPAGSSG VNPNYLFGGA FLWADVARVN 500
    PTFYMASATQ YKNTTGFPNS NQKAAYTSTT CFQNTGSKKI YCLFIIEMGS 550
    SLMGEFQIVP FLREVIIT 568
    Length:568
    Mass (Da):61,733
    Last modified:May 1, 1992 - v1
    Checksum:i7C09738E2715F548
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M62733 Genomic RNA. Translation: AAA47451.1.
    X64275 Genomic RNA. Translation: CAA45568.1.
    PIRiA36419. HNNZ41.
    RefSeqiYP_138509.1. NC_006428.1.

    Genome annotation databases

    GeneIDi3159463.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M62733 Genomic RNA. Translation: AAA47451.1 .
    X64275 Genomic RNA. Translation: CAA45568.1 .
    PIRi A36419. HNNZ41.
    RefSeqi YP_138509.1. NC_006428.1.

    3D structure databases

    ProteinModelPortali P25180.
    SMRi P25180. Positions 119-568.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH83. Glycoside Hydrolase Family 83.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3159463.

    Family and domain databases

    Gene3Di 2.120.10.10. 1 hit.
    InterProi IPR000665. Hemagglutn-neuramid.
    IPR016285. Hemagglutn-neuramid_paramyxo.
    IPR011040. Sialidases.
    [Graphical view ]
    Pfami PF00423. HN. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
    SUPFAMi SSF50939. SSF50939. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Antigenic and structural properties of a paramyxovirus simian virus 41 (SV41) reveal a close relationship with human parainfluenza type 2 virus."
      Tsurudome M., Bando H., Nishio M., Iwamoto Y., Kawano M., Kondo K., Komada H., Ito Y.
      Virology 179:738-748(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
      Strain: Toshiba/Chanock.

    Entry informationi

    Entry nameiHN_SV41
    AccessioniPrimary (citable) accession number: P25180
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: May 1, 1992
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3