Reviewed, UniProtKB/Swiss-Prot P25180 (HN_SV41)

Names and origin

Protein names

Recommended name:
    Hemagglutinin-neuraminidase
    EC=3.2.1.18

Gene names

Name:

HN

Organism

Simian virus 41 (SV41)

Taxonomic identifier

11228 [NCBI]

Taxonomic lineage

Viruses › ssRNA negative-strand viruses › Mononegavirales › Paramyxoviridae › Paramyxovirinae › Rubulavirus

Virus host

Simiiformes [TaxID: 314293]

Protein attributes

Sequence length	568 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion By similarity. Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins By similarity.
Catalytic activity	Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
Subcellular location	Virion membrane; Single-pass type II membrane protein Potential. Host cell membrane; Single-pass type II membrane protein Potential.
Sequence similarities	Belongs to the paramyxoviruses hemagglutinin-neuraminidase family.

Ontologies

Keywords
Cellular component	Cell membrane Envelope protein Membrane Virion
Domain	Signal-anchor Transmembrane
Molecular function	Hemagglutinin Hydrolase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	viral infectious cycle Inferred from electronic annotation. Source: InterPro
Cellular component	host cell plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW viral envelope Inferred from electronic annotation. Source: UniProtKB-KW virion membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	exo-alpha-sialidase activity Inferred from electronic annotation. Source: EC host cell surface receptor binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 568	568	Hemagglutinin-neuraminidase		PRO_0000142645
Regions
	Topological domain	1 – 18	18	Cytoplasmic Potential
	Transmembrane	19 – 39	21	Potential
	Topological domain	40 – 568	529	Extracellular Potential
Amino acid modifications
	Glycosylation	44	1	N-linked (GlcNAc...); by host Potential
	Glycosylation	111	1	N-linked (GlcNAc...); by host Potential
	Glycosylation	268	1	N-linked (GlcNAc...); by host Potential
	Glycosylation	280	1	N-linked (GlcNAc...); by host Potential
	Glycosylation	382	1	N-linked (GlcNAc...); by host Potential
	Glycosylation	513	1	N-linked (GlcNAc...); by host Potential

Sequences

	Sequence		Length	Mass (Da)
	P25180-1 [UniParc]. Last modified May 1, 1992. Version 1. Checksum: 7C09738E2715F548	FASTA	568	61,733
	10 20 30 40 50 60 MSGAEGNTNK RTFRAVFRTL IILITLTILA LSAAILYEVT HTSNGSESNN QVFDPTDTLN 70 80 90 100 110 120 AITGNIKSMI ALLNQILYNA AIALPLKIDS TESVLLAAIK DLQFSNPASQ NCSSGGNLLN 130 140 150 160 170 180 DALYINGINQ YLLSNSFAGT VGLGPLLNIP SFIPSATAPG GCTRIPSFSL TKTHWCYSHN 190 200 210 220 230 240 VILAGCADSK ASNQYLAMGI VEQSSADFPF FRTMRTLYLS DGINRKSCSI VAIPGGCALY 250 260 270 280 290 300 CYVATKTEQE DYAATTPSEL RLTFYYYNET LVERTLTIPN VTGNWATLNP AVGSGVYHLG 310 320 330 340 350 360 YLAFPVYGGL IQNSAAWNSQ FGSYFLPQNP AVQCSGSAEQ QINTAKGSYV VNWFSGRLIQ 370 380 390 400 410 420 SAVLVCPLSD QLTDQCRVVL FNNSETMMGA EGRLYTIGGD LYYYQRSSSW WTASLLYKIN 430 440 450 460 470 480 TDFSQGLPPL IEAQWVPTYL VPRPGAQPCS AGNFCPANCI TGVYADVWPM NNPFPAGSSG 490 500 510 520 530 540 VNPNYLFGGA FLWADVARVN PTFYMASATQ YKNTTGFPNS NQKAAYTSTT CFQNTGSKKI 550 560 YCLFIIEMGS SLMGEFQIVP FLREVIIT

References

[1]

"Antigenic and structural properties of a paramyxovirus simian virus 41 (SV41) reveal a close relationship with human parainfluenza type 2 virus." Tsurudome M., Bando H., Nishio M., Iwamoto Y., Kawano M., Kondo K., Komada H., Ito Y. Virology 179:738-748(1990) [PubMed: 2173260] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA]. Strain: Toshiba/Chanock.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M62733 Genomic RNA. Translation: AAA47451.1. X64275 Genomic RNA. Translation: CAA45568.1.
PIR	HNNZ41. A36419.
RefSeq	YP_138509.1.
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	GH83. Glycoside Hydrolase Family 83.
Genome annotation databases
GeneID	3159463.
Enzyme and pathway databases
BRENDA	3.2.1.18. 305323.
Family and domain databases
InterPro	IPR000665. Hemagglutn-neuramid_glycoprot. IPR016285. Hemagglutn-neuramid_paramyxo. [Graphical view]
Pfam	PF00423. HN. 1 hit. [Graphical view]
PIRSF	PIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HN_SV41

Accession

Primary (citable) accession number: P25180

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1992
Last sequence update:	May 1, 1992
Last modified:	June 16, 2009
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Virus (Virus annotation project)