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P25180

- HN_SV41

UniProt

P25180 - HN_SV41

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Protein
Hemagglutinin-neuraminidase
Gene
HN
Organism
Simian virus 41 (SV41)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion By similarity.
Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins By similarity.

Catalytic activityi

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

GO - Molecular functioni

  1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
  2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
  3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC

GO - Biological processi

  1. viral entry into host cell Source: UniProtKB-KW
  2. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hemagglutinin, Hydrolase

Keywords - Biological processi

Host-virus interaction, Viral attachment to host cell, Virus entry into host cell

Protein family/group databases

CAZyiGH83. Glycoside Hydrolase Family 83.

Names & Taxonomyi

Protein namesi
Recommended name:
Hemagglutinin-neuraminidase (EC:3.2.1.18)
Gene namesi
Name:HN
OrganismiSimian virus 41 (SV41)
Taxonomic identifieri11228 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeParamyxovirinaeRubulavirus
Virus hostiSimiiformes [TaxID: 314293]
ProteomesiUP000007231: Genome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1818Intravirion Reviewed prediction
Add
BLAST
Transmembranei19 – 3921Helical; Reviewed prediction
Add
BLAST
Topological domaini40 – 568529Virion surface Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. host cell plasma membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. viral envelope Source: UniProtKB-KW
  4. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 568568Hemagglutinin-neuraminidase
PRO_0000142645Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi44 – 441N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi111 – 1111N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi268 – 2681N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi280 – 2801N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi382 – 3821N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi513 – 5131N-linked (GlcNAc...); by host Reviewed prediction

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliP25180.
SMRiP25180. Positions 119-568.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR000665. Hemagglutn-neuramid.
IPR016285. Hemagglutn-neuramid_paramyxo.
IPR011040. Sialidases.
[Graphical view]
PfamiPF00423. HN. 1 hit.
[Graphical view]
PIRSFiPIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMiSSF50939. SSF50939. 1 hit.

Sequencei

Sequence statusi: Complete.

P25180-1 [UniParc]FASTAAdd to Basket

« Hide

MSGAEGNTNK RTFRAVFRTL IILITLTILA LSAAILYEVT HTSNGSESNN    50
QVFDPTDTLN AITGNIKSMI ALLNQILYNA AIALPLKIDS TESVLLAAIK 100
DLQFSNPASQ NCSSGGNLLN DALYINGINQ YLLSNSFAGT VGLGPLLNIP 150
SFIPSATAPG GCTRIPSFSL TKTHWCYSHN VILAGCADSK ASNQYLAMGI 200
VEQSSADFPF FRTMRTLYLS DGINRKSCSI VAIPGGCALY CYVATKTEQE 250
DYAATTPSEL RLTFYYYNET LVERTLTIPN VTGNWATLNP AVGSGVYHLG 300
YLAFPVYGGL IQNSAAWNSQ FGSYFLPQNP AVQCSGSAEQ QINTAKGSYV 350
VNWFSGRLIQ SAVLVCPLSD QLTDQCRVVL FNNSETMMGA EGRLYTIGGD 400
LYYYQRSSSW WTASLLYKIN TDFSQGLPPL IEAQWVPTYL VPRPGAQPCS 450
AGNFCPANCI TGVYADVWPM NNPFPAGSSG VNPNYLFGGA FLWADVARVN 500
PTFYMASATQ YKNTTGFPNS NQKAAYTSTT CFQNTGSKKI YCLFIIEMGS 550
SLMGEFQIVP FLREVIIT 568
Length:568
Mass (Da):61,733
Last modified:May 1, 1992 - v1
Checksum:i7C09738E2715F548
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M62733 Genomic RNA. Translation: AAA47451.1.
X64275 Genomic RNA. Translation: CAA45568.1.
PIRiA36419. HNNZ41.
RefSeqiYP_138509.1. NC_006428.1.

Genome annotation databases

GeneIDi3159463.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M62733 Genomic RNA. Translation: AAA47451.1 .
X64275 Genomic RNA. Translation: CAA45568.1 .
PIRi A36419. HNNZ41.
RefSeqi YP_138509.1. NC_006428.1.

3D structure databases

ProteinModelPortali P25180.
SMRi P25180. Positions 119-568.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH83. Glycoside Hydrolase Family 83.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3159463.

Family and domain databases

Gene3Di 2.120.10.10. 1 hit.
InterProi IPR000665. Hemagglutn-neuramid.
IPR016285. Hemagglutn-neuramid_paramyxo.
IPR011040. Sialidases.
[Graphical view ]
Pfami PF00423. HN. 1 hit.
[Graphical view ]
PIRSFi PIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMi SSF50939. SSF50939. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Antigenic and structural properties of a paramyxovirus simian virus 41 (SV41) reveal a close relationship with human parainfluenza type 2 virus."
    Tsurudome M., Bando H., Nishio M., Iwamoto Y., Kawano M., Kondo K., Komada H., Ito Y.
    Virology 179:738-748(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Toshiba/Chanock.

Entry informationi

Entry nameiHN_SV41
AccessioniPrimary (citable) accession number: P25180
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: April 16, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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