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P25180 (HN_SV41) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Hemagglutinin-neuraminidase

EC=3.2.1.18
Gene names
Name:HN
OrganismSimian virus 41 (SV41) [Complete proteome]
Taxonomic identifier11228 [NCBI]
Taxonomic lineageVirusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeParamyxovirinaeRubulavirus
Virus hostSimiiformes [TaxID: 314293]

Protein attributes

Sequence length568 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion By similarity.

Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins By similarity.

Catalytic activity

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

Subcellular location

Virion membrane; Single-pass type II membrane protein Potential. Host cell membrane; Single-pass type II membrane protein Potential.

Sequence similarities

Belongs to the paramyxoviruses hemagglutinin-neuraminidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 568568Hemagglutinin-neuraminidase
PRO_0000142645

Regions

Topological domain1 – 1818Intravirion Potential
Transmembrane19 – 3921Helical; Potential
Topological domain40 – 568529Virion surface Potential

Amino acid modifications

Glycosylation441N-linked (GlcNAc...); by host Potential
Glycosylation1111N-linked (GlcNAc...); by host Potential
Glycosylation2681N-linked (GlcNAc...); by host Potential
Glycosylation2801N-linked (GlcNAc...); by host Potential
Glycosylation3821N-linked (GlcNAc...); by host Potential
Glycosylation5131N-linked (GlcNAc...); by host Potential

Sequences

Sequence LengthMass (Da)Tools
P25180 [UniParc].

Last modified May 1, 1992. Version 1.
Checksum: 7C09738E2715F548

FASTA56861,733
        10         20         30         40         50         60 
MSGAEGNTNK RTFRAVFRTL IILITLTILA LSAAILYEVT HTSNGSESNN QVFDPTDTLN 

        70         80         90        100        110        120 
AITGNIKSMI ALLNQILYNA AIALPLKIDS TESVLLAAIK DLQFSNPASQ NCSSGGNLLN 

       130        140        150        160        170        180 
DALYINGINQ YLLSNSFAGT VGLGPLLNIP SFIPSATAPG GCTRIPSFSL TKTHWCYSHN 

       190        200        210        220        230        240 
VILAGCADSK ASNQYLAMGI VEQSSADFPF FRTMRTLYLS DGINRKSCSI VAIPGGCALY 

       250        260        270        280        290        300 
CYVATKTEQE DYAATTPSEL RLTFYYYNET LVERTLTIPN VTGNWATLNP AVGSGVYHLG 

       310        320        330        340        350        360 
YLAFPVYGGL IQNSAAWNSQ FGSYFLPQNP AVQCSGSAEQ QINTAKGSYV VNWFSGRLIQ 

       370        380        390        400        410        420 
SAVLVCPLSD QLTDQCRVVL FNNSETMMGA EGRLYTIGGD LYYYQRSSSW WTASLLYKIN 

       430        440        450        460        470        480 
TDFSQGLPPL IEAQWVPTYL VPRPGAQPCS AGNFCPANCI TGVYADVWPM NNPFPAGSSG 

       490        500        510        520        530        540 
VNPNYLFGGA FLWADVARVN PTFYMASATQ YKNTTGFPNS NQKAAYTSTT CFQNTGSKKI 

       550        560 
YCLFIIEMGS SLMGEFQIVP FLREVIIT 

« Hide

References

[1]"Antigenic and structural properties of a paramyxovirus simian virus 41 (SV41) reveal a close relationship with human parainfluenza type 2 virus."
Tsurudome M., Bando H., Nishio M., Iwamoto Y., Kawano M., Kondo K., Komada H., Ito Y.
Virology 179:738-748(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Toshiba/Chanock.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M62733 Genomic RNA. Translation: AAA47451.1.
X64275 Genomic RNA. Translation: CAA45568.1.
PIRHNNZ41. A36419.
RefSeqYP_138509.1. NC_006428.1.

3D structure databases

ProteinModelPortalP25180.
SMRP25180. Positions 119-568.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGH83. Glycoside Hydrolase Family 83.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3159463.

Family and domain databases

Gene3D2.120.10.10. 1 hit.
InterProIPR000665. Hemagglutn-neuramid.
IPR016285. Hemagglutn-neuramid_paramyxo.
IPR011040. Sialidases.
[Graphical view]
PfamPF00423. HN. 1 hit.
[Graphical view]
PIRSFPIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMSSF50939. SSF50939. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHN_SV41
AccessionPrimary (citable) accession number: P25180
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: April 16, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries