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P25170

- TRPG_PHACH

UniProt

P25170 - TRPG_PHACH

Protein

Multifunctional tryptophan biosynthesis protein

Gene

TRPC

Organism
Phanerochaete chrysosporium (White-rot fungus) (Sporotrichum pruinosum)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 May 1992)
      Previous versions | rss
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    Functioni

    Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.

    Catalytic activityi

    N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.
    1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O.
    Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei91 – 911For GATase activityBy similarity
    Active sitei181 – 1811For GATase activityBy similarity
    Active sitei183 – 1831For GATase activityBy similarity

    GO - Molecular functioni

    1. anthranilate synthase activity Source: UniProtKB-EC
    2. indole-3-glycerol-phosphate synthase activity Source: UniProtKB-EC
    3. phosphoribosylanthranilate isomerase activity Source: UniProtKB-EC
    4. transferase activity Source: UniProtKB-KW

    GO - Biological processi

    1. glutamine metabolic process Source: UniProtKB-KW
    2. tryptophan biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Decarboxylase, Isomerase, Lyase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00035; UER00040.
    UPA00035; UER00042.
    UPA00035; UER00043.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Multifunctional tryptophan biosynthesis protein
    Including the following 3 domains:
    Anthranilate synthase component 2 (EC:4.1.3.27)
    Short name:
    AS
    Alternative name(s):
    Anthranilate synthase, glutamine amidotransferase component
    Indole-3-glycerol phosphate synthase (EC:4.1.1.48)
    Short name:
    IGPS
    N-(5'-phosphoribosyl)anthranilate isomerase (EC:5.3.1.24)
    Short name:
    PRAI
    Gene namesi
    Name:TRPC
    OrganismiPhanerochaete chrysosporium (White-rot fungus) (Sporotrichum pruinosum)
    Taxonomic identifieri5306 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesCorticialesCorticiaceaePhanerochaete

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 788788Multifunctional tryptophan biosynthesis proteinPRO_0000056863Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi5306.JGI27842.

    Structurei

    3D structure databases

    ProteinModelPortaliP25170.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini12 – 207196Glutamine amidotransferase type-1Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni238 – 503266Indole-3-glycerol phosphate synthaseAdd
    BLAST
    Regioni520 – 788269N-(5'-phosphoribosyl)anthranilate isomeraseAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Glutamine amidotransferase

    Phylogenomic databases

    eggNOGiCOG0134.

    Family and domain databases

    Gene3Di3.20.20.70. 3 hits.
    3.40.50.880. 1 hit.
    HAMAPiMF_00134_B. IGPS_B.
    MF_00135. PRAI.
    InterProiIPR013785. Aldolase_TIM.
    IPR016302. Anthranilate_synth_II.
    IPR029062. Class_I_gatase-like.
    IPR017926. GATASE.
    IPR013798. Indole-3-glycerol_P_synth.
    IPR001468. Indole-3-GlycerolPSynthase_CS.
    IPR001240. PRAI_dom.
    IPR011060. RibuloseP-bd_barrel.
    IPR006221. TrpG/PapA_dom.
    [Graphical view]
    PfamiPF00117. GATase. 1 hit.
    PF00218. IGPS. 1 hit.
    PF00697. PRAI. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001382. TrpG-trpC-trpF. 1 hit.
    SUPFAMiSSF51366. SSF51366. 3 hits.
    SSF52317. SSF52317. 1 hit.
    TIGRFAMsiTIGR00566. trpG_papA. 1 hit.
    PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
    PS00614. IGPS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P25170-1 [UniParc]FASTAAdd to Basket

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    MSLPPHLCVP IDILMIDNFD SFTWNLYQSL CLLGADVTVI RNDAIPRSAI    50
    PQLRIKRLIV SPGPGHPQTD SGISREAIKY FAGKVPIMGV CMGLECVVDV 100
    FGGQIAYAGE IMHGKVSGIR HDARGCFKDL PQGIQSTRYH SLSAGVKTLP 150
    DELAVTAVTE HERVIMGIRH RKYTVEAVQY HPESILSESG DDLLRHFMKL 200
    KGGTWEENPE FRVLDPSLPA FEIGSQPAAS TSAKIPTILE KICAQRQKDV 250
    DQAKATPGTT PEDLKTLLSM KLSPPQISFP DRLKAAEVKP ALMAEVKRAS 300
    PSKGPIAMNG NAAQQALTYA LAGASVISVL TEPTWFKGSL LDMRLARQAI 350
    DNLPHRPAIL RKDFIIDEYQ IDEARLHGAD TVLLIVATLT EKRLEELYAY 400
    SQSLGMEPLV EVNNAKEMEI ALKLGAKVIG VNNRNLHDFN VDMGTTSRLA 450
    EMVRERDVIL CALSGIKDAQ DVNTYVEQGV GAVLVGESLM RAPDTRAFIR 500
    QLLSIPESEA KGKGKETTPL SRSCGIRTEE EALAAAEAGA DMLGLMFVPK 550
    SKRYVSLEKA QQIAAAIHSR RLSKPVLTSG KTLENEPWFT AQQPPSRSFV 600
    WRFAARPLLV GVFQNQPLSV YLTPCVPQLD LVQLHGSEPA ELAKHYPVPV 650
    IRVFHVSADG RGLADLARPG LHQFALLDAV LPGSASALSG GTGTTVDWAL 700
    ARDAVRSGEV RVARSAQGDG PVLSLNSSEA LYPMPVILAG GPQPENVSEA 750
    VDTVAPWAVD VSGGVELEDG SGKDLEKVRA FVKAAKKL 788
    Length:788
    Mass (Da):85,345
    Last modified:May 1, 1992 - v1
    Checksum:i20108D088803D787
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X56047 Genomic DNA. Translation: CAA39518.1.
    PIRiS15239.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X56047 Genomic DNA. Translation: CAA39518.1 .
    PIRi S15239.

    3D structure databases

    ProteinModelPortali P25170.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5306.JGI27842.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG0134.

    Enzyme and pathway databases

    UniPathwayi UPA00035 ; UER00040 .
    UPA00035 ; UER00042 .
    UPA00035 ; UER00043 .

    Family and domain databases

    Gene3Di 3.20.20.70. 3 hits.
    3.40.50.880. 1 hit.
    HAMAPi MF_00134_B. IGPS_B.
    MF_00135. PRAI.
    InterProi IPR013785. Aldolase_TIM.
    IPR016302. Anthranilate_synth_II.
    IPR029062. Class_I_gatase-like.
    IPR017926. GATASE.
    IPR013798. Indole-3-glycerol_P_synth.
    IPR001468. Indole-3-GlycerolPSynthase_CS.
    IPR001240. PRAI_dom.
    IPR011060. RibuloseP-bd_barrel.
    IPR006221. TrpG/PapA_dom.
    [Graphical view ]
    Pfami PF00117. GATase. 1 hit.
    PF00218. IGPS. 1 hit.
    PF00697. PRAI. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001382. TrpG-trpC-trpF. 1 hit.
    SUPFAMi SSF51366. SSF51366. 3 hits.
    SSF52317. SSF52317. 1 hit.
    TIGRFAMsi TIGR00566. trpG_papA. 1 hit.
    PROSITEi PS51273. GATASE_TYPE_1. 1 hit.
    PS00614. IGPS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The trpC gene of Phanerochaete chrysosporium is unique in containing an intron but nevertheless maintains the order of functional domains seen in other fungi."
      Schrank A., Tempelaars C., Sims P.F.G., Oliver S.G., Broda P.
      Mol. Microbiol. 5:467-476(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 34541 / NBRC 31249 / ME-446 / PRL 2750.

    Entry informationi

    Entry nameiTRPG_PHACH
    AccessioniPrimary (citable) accession number: P25170
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: May 1, 1992
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Multifunctional enzyme

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3