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P25170

- TRPG_PHACH

UniProt

P25170 - TRPG_PHACH

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Protein
Multifunctional tryptophan biosynthesis protein
Gene
TRPC
Organism
Phanerochaete chrysosporium (White-rot fungus) (Sporotrichum pruinosum)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.UniRule annotation

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.UniRule annotation
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O.UniRule annotation
Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei91 – 911For GATase activity By similarity
Active sitei181 – 1811For GATase activity By similarity
Active sitei183 – 1831For GATase activity By similarity

GO - Molecular functioni

  1. anthranilate synthase activity Source: UniProtKB-EC
  2. indole-3-glycerol-phosphate synthase activity Source: UniProtKB-EC
  3. phosphoribosylanthranilate isomerase activity Source: UniProtKB-EC
  4. transferase activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. glutamine metabolic process Source: UniProtKB-KW
  2. tryptophan biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Isomerase, Lyase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00035; UER00040.
UPA00035; UER00042.
UPA00035; UER00043.

Names & Taxonomyi

Protein namesi
Recommended name:
Multifunctional tryptophan biosynthesis protein
Including the following 3 domains:
Anthranilate synthase component 2 (EC:4.1.3.27)
Short name:
AS
Alternative name(s):
Anthranilate synthase, glutamine amidotransferase component
Indole-3-glycerol phosphate synthase (EC:4.1.1.48)
Short name:
IGPS
N-(5'-phosphoribosyl)anthranilate isomerase (EC:5.3.1.24)
Short name:
PRAI
Gene namesi
Name:TRPC
OrganismiPhanerochaete chrysosporium (White-rot fungus) (Sporotrichum pruinosum)
Taxonomic identifieri5306 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesCorticialesCorticiaceaePhanerochaete

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 788788Multifunctional tryptophan biosynthesis proteinUniRule annotation
PRO_0000056863Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5306.JGI27842.

Structurei

3D structure databases

ProteinModelPortaliP25170.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 207196Glutamine amidotransferase type-1
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni238 – 503266Indole-3-glycerol phosphate synthaseUniRule annotation
Add
BLAST
Regioni520 – 788269N-(5'-phosphoribosyl)anthranilate isomeraseUniRule annotation
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

eggNOGiCOG0134.

Family and domain databases

Gene3Di3.20.20.70. 3 hits.
3.40.50.880. 1 hit.
HAMAPiMF_00134_B. IGPS_B.
MF_00135. PRAI.
InterProiIPR013785. Aldolase_TIM.
IPR016302. Anthranilate_synth_II.
IPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
IPR006221. TrpG/PapA_dom.
[Graphical view]
PfamiPF00117. GATase. 1 hit.
PF00218. IGPS. 1 hit.
PF00697. PRAI. 1 hit.
[Graphical view]
PIRSFiPIRSF001382. TrpG-trpC-trpF. 1 hit.
SUPFAMiSSF51366. SSF51366. 3 hits.
SSF52317. SSF52317. 1 hit.
TIGRFAMsiTIGR00566. trpG_papA. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
PS00614. IGPS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25170-1 [UniParc]FASTAAdd to Basket

« Hide

MSLPPHLCVP IDILMIDNFD SFTWNLYQSL CLLGADVTVI RNDAIPRSAI    50
PQLRIKRLIV SPGPGHPQTD SGISREAIKY FAGKVPIMGV CMGLECVVDV 100
FGGQIAYAGE IMHGKVSGIR HDARGCFKDL PQGIQSTRYH SLSAGVKTLP 150
DELAVTAVTE HERVIMGIRH RKYTVEAVQY HPESILSESG DDLLRHFMKL 200
KGGTWEENPE FRVLDPSLPA FEIGSQPAAS TSAKIPTILE KICAQRQKDV 250
DQAKATPGTT PEDLKTLLSM KLSPPQISFP DRLKAAEVKP ALMAEVKRAS 300
PSKGPIAMNG NAAQQALTYA LAGASVISVL TEPTWFKGSL LDMRLARQAI 350
DNLPHRPAIL RKDFIIDEYQ IDEARLHGAD TVLLIVATLT EKRLEELYAY 400
SQSLGMEPLV EVNNAKEMEI ALKLGAKVIG VNNRNLHDFN VDMGTTSRLA 450
EMVRERDVIL CALSGIKDAQ DVNTYVEQGV GAVLVGESLM RAPDTRAFIR 500
QLLSIPESEA KGKGKETTPL SRSCGIRTEE EALAAAEAGA DMLGLMFVPK 550
SKRYVSLEKA QQIAAAIHSR RLSKPVLTSG KTLENEPWFT AQQPPSRSFV 600
WRFAARPLLV GVFQNQPLSV YLTPCVPQLD LVQLHGSEPA ELAKHYPVPV 650
IRVFHVSADG RGLADLARPG LHQFALLDAV LPGSASALSG GTGTTVDWAL 700
ARDAVRSGEV RVARSAQGDG PVLSLNSSEA LYPMPVILAG GPQPENVSEA 750
VDTVAPWAVD VSGGVELEDG SGKDLEKVRA FVKAAKKL 788
Length:788
Mass (Da):85,345
Last modified:May 1, 1992 - v1
Checksum:i20108D088803D787
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X56047 Genomic DNA. Translation: CAA39518.1.
PIRiS15239.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X56047 Genomic DNA. Translation: CAA39518.1 .
PIRi S15239.

3D structure databases

ProteinModelPortali P25170.
ModBasei Search...

Protein-protein interaction databases

STRINGi 5306.JGI27842.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG0134.

Enzyme and pathway databases

UniPathwayi UPA00035 ; UER00040 .
UPA00035 ; UER00042 .
UPA00035 ; UER00043 .

Family and domain databases

Gene3Di 3.20.20.70. 3 hits.
3.40.50.880. 1 hit.
HAMAPi MF_00134_B. IGPS_B.
MF_00135. PRAI.
InterProi IPR013785. Aldolase_TIM.
IPR016302. Anthranilate_synth_II.
IPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
IPR006221. TrpG/PapA_dom.
[Graphical view ]
Pfami PF00117. GATase. 1 hit.
PF00218. IGPS. 1 hit.
PF00697. PRAI. 1 hit.
[Graphical view ]
PIRSFi PIRSF001382. TrpG-trpC-trpF. 1 hit.
SUPFAMi SSF51366. SSF51366. 3 hits.
SSF52317. SSF52317. 1 hit.
TIGRFAMsi TIGR00566. trpG_papA. 1 hit.
PROSITEi PS51273. GATASE_TYPE_1. 1 hit.
PS00614. IGPS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The trpC gene of Phanerochaete chrysosporium is unique in containing an intron but nevertheless maintains the order of functional domains seen in other fungi."
    Schrank A., Tempelaars C., Sims P.F.G., Oliver S.G., Broda P.
    Mol. Microbiol. 5:467-476(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 34541 / NBRC 31249 / ME-446 / PRL 2750.

Entry informationi

Entry nameiTRPG_PHACH
AccessioniPrimary (citable) accession number: P25170
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: June 11, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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