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Protein

ADP-ribosylation factor-like protein 1

Gene

Arl1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi23 – 30GTPBy similarity8
Nucleotide bindingi66 – 70GTPBy similarity5
Nucleotide bindingi125 – 128GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: FlyBase
  • GTP binding Source: FlyBase
  • protein domain specific binding Source: FlyBase

GO - Biological processi

  • dsRNA transport Source: FlyBase
  • endoplasmic reticulum membrane organization Source: FlyBase
  • Golgi organization Source: FlyBase
  • neurotransmitter secretion Source: FlyBase
  • protein localization to Golgi apparatus Source: FlyBase
  • protein localization to Golgi membrane Source: FlyBase
  • regulation of cell migration Source: FlyBase
  • regulation of ER to Golgi vesicle-mediated transport Source: FlyBase
  • regulation of protein exit from endoplasmic reticulum Source: FlyBase
  • salivary gland development Source: FlyBase
  • secretory granule organization Source: FlyBase
  • synaptic vesicle endocytosis Source: FlyBase
  • wing disc development Source: FlyBase

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-6811440 Retrograde transport at the Trans-Golgi-Network

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 1
Gene namesi
Name:Arl1
Synonyms:Arf72A, arl
ORF Names:CG6025
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0000115 Arl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedSequence analysis
ChainiPRO_00002074482 – 180ADP-ribosylation factor-like protein 1Add BLAST179

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineSequence analysis1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PaxDbiP25160
PRIDEiP25160

Expressioni

Gene expression databases

BgeeiFBgn0000115
GenevisibleiP25160 DM

Interactioni

GO - Molecular functioni

  • protein domain specific binding Source: FlyBase

Protein-protein interaction databases

BioGridi65056, 15 interactors
DIPiDIP-21617N
IntActiP25160, 2 interactors
STRINGi7227.FBpp0075272

Structurei

3D structure databases

ProteinModelPortaliP25160
SMRiP25160
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiKOG0072 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00910000144027
InParanoidiP25160
KOiK07942
OMAiWSKDQDV
OrthoDBiEOG091G0MRS
PhylomeDBiP25160

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR024156 Small_GTPase_ARF
IPR006689 Small_GTPase_ARF/SAR
PfamiView protein in Pfam
PF00025 Arf, 1 hit
PRINTSiPR00328 SAR1GTPBP
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51417 ARF, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25160-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGVLSYFRG LLGSREMRIL ILGLDGAGKT TILYRLQVGE VVTTIPTIGF
60 70 80 90 100
NVEQVTYKNL KFQVWDLGGQ TSIRPYWRCY YSNTDAIIYV VDSADRDRIG
110 120 130 140 150
ISKDELLYML REEELAGAIL VVLANKQDMD GCMTVAEVHH ALGLENLKNR
160 170 180
TFQIFKTSAT KGEGLDQAMD WLSNTLQSRK
Length:180
Mass (Da):20,247
Last modified:August 15, 2003 - v5
Checksum:iD9B1DE83D37201C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M61127 Genomic DNA Translation: AAA28365.1
AE014296 Genomic DNA Translation: AAF49556.2
BT001460 mRNA Translation: AAN71215.1
PIRiA40438
RefSeqiNP_524098.2, NM_079374.4
UniGeneiDm.23540

Genome annotation databases

EnsemblMetazoaiFBtr0075517; FBpp0075272; FBgn0000115
GeneIDi39745
KEGGidme:Dmel_CG6025

Similar proteinsi

Entry informationi

Entry nameiARL1_DROME
AccessioniPrimary (citable) accession number: P25160
Secondary accession number(s): Q9VUW7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: August 15, 2003
Last modified: May 23, 2018
This is version 156 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health