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Protein

ADP-ribosylation factor-like protein 1

Gene

Arl1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi23 – 30GTPBy similarity8
Nucleotide bindingi66 – 70GTPBy similarity5
Nucleotide bindingi125 – 128GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: FlyBase
  • GTP binding Source: FlyBase
  • protein domain specific binding Source: FlyBase

GO - Biological processi

  • dsRNA transport Source: FlyBase
  • endoplasmic reticulum membrane organization Source: FlyBase
  • endosomal transport Source: FlyBase
  • Golgi organization Source: FlyBase
  • neurotransmitter secretion Source: FlyBase
  • protein localization to Golgi apparatus Source: FlyBase
  • protein targeting to Golgi Source: FlyBase
  • regulation of cell migration Source: FlyBase
  • regulation of ER to Golgi vesicle-mediated transport Source: FlyBase
  • regulation of protein exit from endoplasmic reticulum Source: FlyBase
  • salivary gland development Source: FlyBase
  • secretory granule organization Source: FlyBase
  • small GTPase mediated signal transduction Source: InterPro
  • synaptic vesicle endocytosis Source: FlyBase
  • wing disc development Source: FlyBase
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-6811440. Retrograde transport at the Trans-Golgi-Network.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 1
Gene namesi
Name:Arl1
Synonyms:Arf72A, arl
ORF Names:CG6025
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0000115. Arl1.

Subcellular locationi

GO - Cellular componenti

  • Golgi apparatus Source: FlyBase
  • presynapse Source: GOC
  • trans-Golgi network Source: FlyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedSequence analysis
ChainiPRO_00002074482 – 180ADP-ribosylation factor-like protein 1Add BLAST179

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineSequence analysis1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PaxDbiP25160.
PRIDEiP25160.

Expressioni

Gene expression databases

BgeeiFBgn0000115.
GenevisibleiP25160. DM.

Interactioni

GO - Molecular functioni

  • protein domain specific binding Source: FlyBase

Protein-protein interaction databases

BioGridi65056. 7 interactors.
DIPiDIP-21617N.
IntActiP25160. 2 interactors.
MINTiMINT-780830.
STRINGi7227.FBpp0075272.

Structurei

3D structure databases

ProteinModelPortaliP25160.
SMRiP25160.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiKOG0072. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00830000128269.
InParanoidiP25160.
KOiK07942.
OMAiDMEGCMS.
OrthoDBiEOG091G0MRS.
PhylomeDBiP25160.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25160-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGVLSYFRG LLGSREMRIL ILGLDGAGKT TILYRLQVGE VVTTIPTIGF
60 70 80 90 100
NVEQVTYKNL KFQVWDLGGQ TSIRPYWRCY YSNTDAIIYV VDSADRDRIG
110 120 130 140 150
ISKDELLYML REEELAGAIL VVLANKQDMD GCMTVAEVHH ALGLENLKNR
160 170 180
TFQIFKTSAT KGEGLDQAMD WLSNTLQSRK
Length:180
Mass (Da):20,247
Last modified:August 15, 2003 - v5
Checksum:iD9B1DE83D37201C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M61127 Genomic DNA. Translation: AAA28365.1.
AE014296 Genomic DNA. Translation: AAF49556.2.
BT001460 mRNA. Translation: AAN71215.1.
PIRiA40438.
RefSeqiNP_524098.2. NM_079374.4.
UniGeneiDm.23540.

Genome annotation databases

EnsemblMetazoaiFBtr0075517; FBpp0075272; FBgn0000115.
GeneIDi39745.
KEGGidme:Dmel_CG6025.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M61127 Genomic DNA. Translation: AAA28365.1.
AE014296 Genomic DNA. Translation: AAF49556.2.
BT001460 mRNA. Translation: AAN71215.1.
PIRiA40438.
RefSeqiNP_524098.2. NM_079374.4.
UniGeneiDm.23540.

3D structure databases

ProteinModelPortaliP25160.
SMRiP25160.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi65056. 7 interactors.
DIPiDIP-21617N.
IntActiP25160. 2 interactors.
MINTiMINT-780830.
STRINGi7227.FBpp0075272.

Proteomic databases

PaxDbiP25160.
PRIDEiP25160.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0075517; FBpp0075272; FBgn0000115.
GeneIDi39745.
KEGGidme:Dmel_CG6025.

Organism-specific databases

CTDi400.
FlyBaseiFBgn0000115. Arl1.

Phylogenomic databases

eggNOGiKOG0072. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00830000128269.
InParanoidiP25160.
KOiK07942.
OMAiDMEGCMS.
OrthoDBiEOG091G0MRS.
PhylomeDBiP25160.

Enzyme and pathway databases

ReactomeiR-DME-6811440. Retrograde transport at the Trans-Golgi-Network.

Miscellaneous databases

GenomeRNAii39745.
PROiP25160.

Gene expression databases

BgeeiFBgn0000115.
GenevisibleiP25160. DM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARL1_DROME
AccessioniPrimary (citable) accession number: P25160
Secondary accession number(s): Q9VUW7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: August 15, 2003
Last modified: November 2, 2016
This is version 145 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.