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P25153

- UBCD6_DROME

UniProt

P25153 - UBCD6_DROME

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Protein
Ubiquitin-conjugating enzyme E2-17 kDa
Gene
UbcD6, Dhr6, CG2013
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the covalent attachment of ubiquitin to other proteins. Required for postreplication repair of UV-damaged DNA.

Catalytic activityi

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei88 – 881Glycyl thioester intermediate By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. acid-amino acid ligase activity Source: InterPro
  3. p53 binding Source: BHF-UCL
  4. protein domain specific binding Source: BHF-UCL
  5. ubiquitin-protein transferase activity Source: BHF-UCL

GO - Biological processi

  1. DNA repair Source: FlyBase
  2. centrosome organization Source: FlyBase
  3. centrosome separation Source: FlyBase
  4. endocytic recycling Source: FlyBase
  5. mitochondrion degradation Source: FlyBase
  6. mitotic spindle organization Source: FlyBase
  7. negative regulation of DNA damage response, signal transduction by p53 class mediator Source: BHF-UCL
  8. negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: BHF-UCL
  9. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: BHF-UCL
  10. protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

DNA damage, DNA repair, Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_180708. Antigen processing: Ubiquitination & Proteasome degradation.
SignaLinkiP25153.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2-17 kDa (EC:6.3.2.19)
Alternative name(s):
Ubiquitin carrier protein
Ubiquitin-protein ligase
Gene namesi
Name:UbcD6
Synonyms:Dhr6
ORF Names:CG2013
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0004436. UbcD6.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: BHF-UCL
  2. nucleus Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 151151Ubiquitin-conjugating enzyme E2-17 kDa
PRO_0000082523Add
BLAST

Proteomic databases

PaxDbiP25153.

Expressioni

Gene expression databases

BgeeiP25153.

Interactioni

Protein-protein interaction databases

BioGridi65824. 1 interaction.
STRINGi7227.FBpp0078490.

Structurei

3D structure databases

ProteinModelPortaliP25153.
SMRiP25153. Positions 2-149.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5078.
GeneTreeiENSGT00730000110565.
InParanoidiP25153.
KOiK10573.
OMAiPVPDNVM.
OrthoDBiEOG7M0NTH.
PhylomeDBiP25153.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25153-1 [UniParc]FASTAAdd to Basket

« Hide

MSTPARRRLM RDFKRLQEDP PTGVSGAPTD NNIMIWNAVI FGPHDTPFED    50
GTFKLTIEFT EEYPNKPPTV RFVSKVFHPN VYADGGICLD ILQNRWSPTY 100
DVSAILTSIQ SLLSDPNPNS PANSTAAQLY KENRREYEKR VKACVEQSFI 150
D 151
Length:151
Mass (Da):17,152
Last modified:June 1, 2001 - v2
Checksum:iCC4B35992E4A9220
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti99 – 991T → R in AAA28308. 1 Publication
Sequence conflicti99 – 991T → R in AAA28309. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M63792 mRNA. Translation: AAA28308.1.
M64435, M63791 Genomic DNA. Translation: AAA28309.1.
AE014297 Genomic DNA. Translation: AAF52079.1.
BT003481 mRNA. Translation: AAO39484.1.
PIRiA39392.
RefSeqiNP_001246916.1. NM_001259987.2.
NP_524230.2. NM_079506.4.
UniGeneiDm.2229.

Genome annotation databases

EnsemblMetazoaiFBtr0078849; FBpp0078490; FBgn0004436.
FBtr0306106; FBpp0297243; FBgn0004436.
GeneIDi40610.
KEGGidme:Dmel_CG2013.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M63792 mRNA. Translation: AAA28308.1 .
M64435 , M63791 Genomic DNA. Translation: AAA28309.1 .
AE014297 Genomic DNA. Translation: AAF52079.1 .
BT003481 mRNA. Translation: AAO39484.1 .
PIRi A39392.
RefSeqi NP_001246916.1. NM_001259987.2.
NP_524230.2. NM_079506.4.
UniGenei Dm.2229.

3D structure databases

ProteinModelPortali P25153.
SMRi P25153. Positions 2-149.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 65824. 1 interaction.
STRINGi 7227.FBpp0078490.

Proteomic databases

PaxDbi P25153.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0078849 ; FBpp0078490 ; FBgn0004436 .
FBtr0306106 ; FBpp0297243 ; FBgn0004436 .
GeneIDi 40610.
KEGGi dme:Dmel_CG2013.

Organism-specific databases

CTDi 40610.
FlyBasei FBgn0004436. UbcD6.

Phylogenomic databases

eggNOGi COG5078.
GeneTreei ENSGT00730000110565.
InParanoidi P25153.
KOi K10573.
OMAi PVPDNVM.
OrthoDBi EOG7M0NTH.
PhylomeDBi P25153.

Enzyme and pathway databases

UniPathwayi UPA00143 .
Reactomei REACT_180708. Antigen processing: Ubiquitination & Proteasome degradation.
SignaLinki P25153.

Miscellaneous databases

GenomeRNAii 40610.
NextBioi 819645.
PROi P25153.

Gene expression databases

Bgeei P25153.

Family and domain databases

Gene3Di 3.10.110.10. 1 hit.
InterProi IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view ]
Pfami PF00179. UQ_con. 1 hit.
[Graphical view ]
SUPFAMi SSF54495. SSF54495. 1 hit.
PROSITEi PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Head.

Entry informationi

Entry nameiUBCD6_DROME
AccessioniPrimary (citable) accession number: P25153
Secondary accession number(s): Q9VN70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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