Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Internalin B

Gene

inlB

Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the entry of Listeria monocytogenes into cells.

Names & Taxonomyi

Protein namesi
Recommended name:
Internalin B
Gene namesi
Name:inlB
Ordered Locus Names:lmo0434
OrganismiListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Taxonomic identifieri169963 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
Proteomesi
  • UP000000817 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000002151431 – 630Internalin BAdd BLAST600

Proteomic databases

PaxDbiP25147.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
C1QBPQ9MZE03EBI-1379295,EBI-6375765From a different organism.
METP085814EBI-1379295,EBI-1039152From a different organism.

Protein-protein interaction databases

IntActiP25147. 2 interactors.
STRINGi169963.lmo0434.

Structurei

Secondary structure

1630
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi44 – 47Combined sources4
Helixi51 – 60Combined sources10
Beta strandi68 – 70Combined sources3
Helixi72 – 76Combined sources5
Beta strandi80 – 82Combined sources3
Helixi94 – 96Combined sources3
Beta strandi102 – 104Combined sources3
Helixi114 – 116Combined sources3
Beta strandi124 – 126Combined sources3
Helixi136 – 138Combined sources3
Beta strandi146 – 148Combined sources3
Helixi158 – 162Combined sources5
Beta strandi168 – 170Combined sources3
Helixi180 – 184Combined sources5
Beta strandi189 – 192Combined sources4
Helixi202 – 204Combined sources3
Beta strandi212 – 214Combined sources3
Helixi224 – 226Combined sources3
Beta strandi233 – 243Combined sources11
Beta strandi251 – 256Combined sources6
Beta strandi262 – 264Combined sources3
Beta strandi270 – 273Combined sources4
Beta strandi277 – 279Combined sources3
Beta strandi282 – 286Combined sources5
Beta strandi288 – 290Combined sources3
Beta strandi292 – 304Combined sources13
Beta strandi307 – 320Combined sources14
Beta strandi322 – 329Combined sources8
Beta strandi332 – 339Combined sources8
Beta strandi355 – 366Combined sources12
Turni372 – 374Combined sources3
Beta strandi382 – 390Combined sources9
Turni406 – 409Combined sources4
Beta strandi411 – 417Combined sources7
Helixi420 – 422Combined sources3
Beta strandi423 – 427Combined sources5
Turni429 – 432Combined sources4
Beta strandi448 – 451Combined sources4
Beta strandi456 – 458Combined sources3
Turni459 – 461Combined sources3
Beta strandi478 – 483Combined sources6
Beta strandi489 – 497Combined sources9
Beta strandi503 – 505Combined sources3
Helixi506 – 509Combined sources4
Beta strandi514 – 516Combined sources3
Beta strandi526 – 532Combined sources7
Beta strandi535 – 541Combined sources7
Turni542 – 544Combined sources3
Beta strandi545 – 550Combined sources6
Helixi551 – 553Combined sources3
Beta strandi555 – 563Combined sources9
Turni565 – 569Combined sources5
Beta strandi570 – 577Combined sources8
Helixi580 – 582Combined sources3
Beta strandi583 – 586Combined sources4
Helixi587 – 589Combined sources3
Beta strandi595 – 603Combined sources9
Beta strandi606 – 612Combined sources7
Beta strandi614 – 622Combined sources9
Helixi623 – 625Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D0BX-ray1.86A36-248[»]
1H6TX-ray1.60A36-321[»]
1M9SX-ray2.65A36-630[»]
1OTMX-ray1.93A36-248[»]
1OTNX-ray1.97A36-248[»]
1OTOX-ray1.96A36-248[»]
2UZXX-ray2.80A/C36-321[»]
2UZYX-ray4.00A/C36-321[»]
2WQUX-ray2.60A/B/C/D/E/F36-321[»]
2WQVX-ray2.80A/B36-321[»]
2WQWX-ray2.24A/B36-321[»]
2WQXX-ray2.03A/B36-321[»]
2Y5PX-ray1.30A/B/C/D322-392[»]
2Y5QX-ray3.20A36-392[»]
4AW4X-ray1.93A/B/C36-321[»]
4CILX-ray1.50A93-321[»]
ProteinModelPortaliP25147.
SMRiP25147.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP25147.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 76LRRNTAdd BLAST46
Repeati77 – 98LRR 1Add BLAST22
Repeati99 – 120LRR 2Add BLAST22
Repeati121 – 142LRR 3Add BLAST22
Repeati143 – 164LRR 4Add BLAST22
Repeati165 – 186LRR 5Add BLAST22
Repeati187 – 208LRR 6Add BLAST22
Repeati209 – 230LRR 7Add BLAST22
Domaini241 – 330LRRCTAdd BLAST90
Domaini393 – 467GW 1PROSITE-ProRule annotationAdd BLAST75
Repeati399 – 4652-1Add BLAST67
Domaini472 – 550GW 2PROSITE-ProRule annotationAdd BLAST79
Domaini553 – 630GW 3PROSITE-ProRule annotationAdd BLAST78
Repeati559 – 6302-2Add BLAST72

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni399 – 6302 X approximate repeatsAdd BLAST232

Sequence similaritiesi

Contains 3 GW domains.PROSITE-ProRule annotation
Contains 7 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiENOG4108NJY. Bacteria.
COG4886. LUCA.
COG5632. LUCA.
KOiK13731.
OMAiKYCLISG.
PhylomeDBiP25147.

Family and domain databases

Gene3Di2.60.40.1220. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR014755. Cu-Rt/internalin_Ig-like.
IPR014756. Ig_E-set.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR013378. Listeria/Bacterioides_rpt.
IPR012569. LRR-contain_adjacent_dom.
IPR025987. SH3-like_dom.
[Graphical view]
PfamiPF09479. Flg_new. 1 hit.
PF12799. LRR_4. 3 hits.
PF08191. LRR_adjacent. 1 hit.
PF13457. SH3_8. 3 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 5 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
SSF81296. SSF81296. 1 hit.
TIGRFAMsiTIGR02543. List_Bact_rpt. 1 hit.
PROSITEiPS51780. GW. 3 hits.
PS51450. LRR. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25147-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEKHNPRRK YCLISGLAII FSLWIIIGNG AKVQAETITV PTPIKQIFSD
60 70 80 90 100
DAFAETIKDN LKKKSVTDAV TQNELNSIDQ IIANNSDIKS VQGIQYLPNV
110 120 130 140 150
TKLFLNGNKL TDIKPLANLK NLGWLFLDEN KVKDLSSLKD LKKLKSLSLE
160 170 180 190 200
HNGISDINGL VHLPQLESLY LGNNKITDIT VLSRLTKLDT LSLEDNQISD
210 220 230 240 250
IVPLAGLTKL QNLYLSKNHI SDLRALAGLK NLDVLELFSQ ECLNKPINHQ
260 270 280 290 300
SNLVVPNTVK NTDGSLVTPE IISDDGDYEK PNVKWHLPEF TNEVSFIFYQ
310 320 330 340 350
PVTIGKAKAR FHGRVTQPLK EVYTVSYDVD GTVIKTKVEA GTRITAPKPP
360 370 380 390 400
TKQGYVFKGW YTEKNGGHEW NFNTDYMSGN DFTLYAVFKA ETTEKAVNLT
410 420 430 440 450
RYVKYIRGNA GIYKLPREDN SLKQGTLASH RCKALTVDRE ARNGGKLWYR
460 470 480 490 500
LKNIGWTKAE NLSLDRYDKM EYDKGVTAYA RVRNASGNSV WTKPYNTAGA
510 520 530 540 550
KHVNKLSVYQ GKNMRILREA KTPITTWYQF SIGGKVIGWV DTRALNTFYK
560 570 580 590 600
QSMEKPTRLT RYVSANKAGE SYYKVPVADN PVKRGTLAKY KNQKLIVDCQ
610 620 630
ATIEGQLWYR IRTSSTFIGW TKAANLRAQK
Length:630
Mass (Da):71,147
Last modified:December 5, 2001 - v2
Checksum:iCA05F31BEFE9748C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti41P → S in AAA25290 (PubMed:1905979).Curated1
Sequence conflicti49S → P in AAA25290 (PubMed:1905979).Curated1
Sequence conflicti117A → T in AAA25290 (PubMed:1905979).Curated1
Sequence conflicti132V → I in AAA25290 (PubMed:1905979).Curated1
Sequence conflicti396A → T in AAA25290 (PubMed:1905979).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M67471 Genomic DNA. Translation: AAA25290.1.
AJ012346 Genomic DNA. Translation: CAC20629.1.
AL591975 Genomic DNA. Translation: CAC98513.1.
PIRiAC1129.
C39930.
RefSeqiNP_463963.1. NC_003210.1.
WP_010989463.1. NC_003210.1.

Genome annotation databases

EnsemblBacteriaiCAC98513; CAC98513; CAC98513.
GeneIDi986892.
KEGGilmo:lmo0434.
PATRICi20309923. VBILisMon69206_0447.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M67471 Genomic DNA. Translation: AAA25290.1.
AJ012346 Genomic DNA. Translation: CAC20629.1.
AL591975 Genomic DNA. Translation: CAC98513.1.
PIRiAC1129.
C39930.
RefSeqiNP_463963.1. NC_003210.1.
WP_010989463.1. NC_003210.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D0BX-ray1.86A36-248[»]
1H6TX-ray1.60A36-321[»]
1M9SX-ray2.65A36-630[»]
1OTMX-ray1.93A36-248[»]
1OTNX-ray1.97A36-248[»]
1OTOX-ray1.96A36-248[»]
2UZXX-ray2.80A/C36-321[»]
2UZYX-ray4.00A/C36-321[»]
2WQUX-ray2.60A/B/C/D/E/F36-321[»]
2WQVX-ray2.80A/B36-321[»]
2WQWX-ray2.24A/B36-321[»]
2WQXX-ray2.03A/B36-321[»]
2Y5PX-ray1.30A/B/C/D322-392[»]
2Y5QX-ray3.20A36-392[»]
4AW4X-ray1.93A/B/C36-321[»]
4CILX-ray1.50A93-321[»]
ProteinModelPortaliP25147.
SMRiP25147.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP25147. 2 interactors.
STRINGi169963.lmo0434.

Proteomic databases

PaxDbiP25147.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC98513; CAC98513; CAC98513.
GeneIDi986892.
KEGGilmo:lmo0434.
PATRICi20309923. VBILisMon69206_0447.

Phylogenomic databases

eggNOGiENOG4108NJY. Bacteria.
COG4886. LUCA.
COG5632. LUCA.
KOiK13731.
OMAiKYCLISG.
PhylomeDBiP25147.

Miscellaneous databases

EvolutionaryTraceiP25147.

Family and domain databases

Gene3Di2.60.40.1220. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR014755. Cu-Rt/internalin_Ig-like.
IPR014756. Ig_E-set.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR013378. Listeria/Bacterioides_rpt.
IPR012569. LRR-contain_adjacent_dom.
IPR025987. SH3-like_dom.
[Graphical view]
PfamiPF09479. Flg_new. 1 hit.
PF12799. LRR_4. 3 hits.
PF08191. LRR_adjacent. 1 hit.
PF13457. SH3_8. 3 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 5 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
SSF81296. SSF81296. 1 hit.
TIGRFAMsiTIGR02543. List_Bact_rpt. 1 hit.
PROSITEiPS51780. GW. 3 hits.
PS51450. LRR. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiINLB_LISMO
AccessioniPrimary (citable) accession number: P25147
Secondary accession number(s): Q9EXG1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: December 5, 2001
Last modified: November 2, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.