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Protein

Catabolite control protein A

Gene

ccpA

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Global transcriptional regulator of carbon catabolite repression (CCR) and carbon catabolite activation (CCA), which ensures optimal energy usage under diverse conditions. Interacts with either P-Ser-HPr or P-Ser-Crh, leading to the formation of a complex that binds to DNA at the catabolite-response elements (cre). Binding to DNA allows activation or repression of many different genes and operons.5 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi6 – 25H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciBSUB:BSU29740-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Catabolite control protein A
Alternative name(s):
Glucose-resistance amylase regulator
Gene namesi
Name:ccpA
Synonyms:alsA, amyR, graR
Ordered Locus Names:BSU29740
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001079251 – 334Catabolite control protein AAdd BLAST334

Proteomic databases

PaxDbiP25144.
PRIDEiP25144.

Expressioni

Gene expression databases

CollecTFiEXPREG_000009c0.

Interactioni

Subunit structurei

Homodimer. Interacts with P-Ser-HPr and P-Ser-Crh.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
codYP397793EBI-5247535,EBI-7827914
ptsHP088773EBI-5247535,EBI-1034482
rpoAP204295EBI-5247535,EBI-5247865

Protein-protein interaction databases

IntActiP25144. 222 interactors.
MINTiMINT-8363378.
STRINGi224308.Bsubs1_010100016226.

Structurei

Secondary structure

1334
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 13Combined sources8
Helixi17 – 25Combined sources9
Helixi32 – 45Combined sources14
Helixi51 – 58Combined sources8
Beta strandi63 – 69Combined sources7
Helixi74 – 89Combined sources16
Beta strandi93 – 98Combined sources6
Helixi103 – 115Combined sources13
Beta strandi119 – 123Combined sources5
Helixi130 – 138Combined sources9
Beta strandi139 – 141Combined sources3
Beta strandi143 – 147Combined sources5
Beta strandi157 – 159Combined sources3
Helixi162 – 175Combined sources14
Beta strandi179 – 186Combined sources8
Beta strandi188 – 190Combined sources3
Helixi191 – 194Combined sources4
Helixi197 – 207Combined sources11
Helixi214 – 216Combined sources3
Beta strandi217 – 219Combined sources3
Helixi224 – 234Combined sources11
Beta strandi237 – 239Combined sources3
Beta strandi242 – 248Combined sources7
Helixi249 – 261Combined sources13
Turni266 – 269Combined sources4
Beta strandi271 – 276Combined sources6
Helixi279 – 281Combined sources3
Beta strandi283 – 286Combined sources4
Beta strandi289 – 292Combined sources4
Helixi295 – 310Combined sources16
Beta strandi318 – 321Combined sources4
Beta strandi325 – 327Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZVVX-ray2.98A/B/G5-333[»]
2FEPX-ray2.45A58-334[»]
3OQMX-ray2.96A/C3-334[»]
3OQNX-ray3.30A/C3-334[»]
3OQOX-ray2.97A/C3-333[»]
ProteinModelPortaliP25144.
SMRiP25144.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP25144.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 58HTH lacI-typePROSITE-ProRule annotationAdd BLAST58

Sequence similaritiesi

Contains 1 HTH lacI-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105ETE. Bacteria.
COG1609. LUCA.
HOGENOMiHOG000220180.
InParanoidiP25144.
KOiK02529.
OMAiCSEYPES.
PhylomeDBiP25144.

Family and domain databases

CDDicd01392. HTH_LacI. 1 hit.
Gene3Di1.10.260.40. 1 hit.
InterProiIPR006377. CcpA.
IPR000843. HTH_LacI.
IPR010982. Lambda_DNA-bd_dom.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00356. LacI. 1 hit.
[Graphical view]
PRINTSiPR00036. HTHLACI.
SMARTiSM00354. HTH_LACI. 1 hit.
[Graphical view]
SUPFAMiSSF47413. SSF47413. 1 hit.
SSF53822. SSF53822. 1 hit.
TIGRFAMsiTIGR01481. ccpA. 1 hit.
PROSITEiPS00356. HTH_LACI_1. 1 hit.
PS50932. HTH_LACI_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25144-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNITIYDVA REANVSMATV SRVVNGNPNV KPTTRKKVLE AIERLGYRPN
60 70 80 90 100
AVARGLASKK TTTVGVIIPD ISSIFYSELA RGIEDIATMY KYNIILSNSD
110 120 130 140 150
QNMEKELHLL NTMLGKQVDG IVFMGGNITD EHVAEFKRSP VPIVLAASVE
160 170 180 190 200
EQEETPSVAI DYEQAIYDAV KLLVDKGHTD IAFVSGPMAE PINRSKKLQG
210 220 230 240 250
YKRALEEANL PFNEQFVAEG DYTYDSGLEA LQHLMSLDKK PTAILSATDE
260 270 280 290 300
MALGIIHAAQ DQGLSIPEDL DIIGFDNTRL SLMVRPQLST VVQPTYDIGA
310 320 330
VAMRLLTKLM NKEPVEEHIV ELPHRIELRK STKS
Length:334
Mass (Da):36,940
Last modified:May 1, 1992 - v1
Checksum:i62AD6CA7294E1FAA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M85182 Genomic DNA. Translation: AAA22501.1.
AF008220 Genomic DNA. Translation: AAC00299.1.
AL009126 Genomic DNA. Translation: CAB14952.1.
PIRiS15318.
RefSeqiNP_390852.1. NC_000964.3.
WP_003229285.1. NZ_JNCM01000036.1.

Genome annotation databases

EnsemblBacteriaiCAB14952; CAB14952; BSU29740.
GeneIDi935942.
KEGGibsu:BSU29740.
PATRICi18977856. VBIBacSub10457_3116.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M85182 Genomic DNA. Translation: AAA22501.1.
AF008220 Genomic DNA. Translation: AAC00299.1.
AL009126 Genomic DNA. Translation: CAB14952.1.
PIRiS15318.
RefSeqiNP_390852.1. NC_000964.3.
WP_003229285.1. NZ_JNCM01000036.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZVVX-ray2.98A/B/G5-333[»]
2FEPX-ray2.45A58-334[»]
3OQMX-ray2.96A/C3-334[»]
3OQNX-ray3.30A/C3-334[»]
3OQOX-ray2.97A/C3-333[»]
ProteinModelPortaliP25144.
SMRiP25144.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP25144. 222 interactors.
MINTiMINT-8363378.
STRINGi224308.Bsubs1_010100016226.

Proteomic databases

PaxDbiP25144.
PRIDEiP25144.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB14952; CAB14952; BSU29740.
GeneIDi935942.
KEGGibsu:BSU29740.
PATRICi18977856. VBIBacSub10457_3116.

Phylogenomic databases

eggNOGiENOG4105ETE. Bacteria.
COG1609. LUCA.
HOGENOMiHOG000220180.
InParanoidiP25144.
KOiK02529.
OMAiCSEYPES.
PhylomeDBiP25144.

Enzyme and pathway databases

BioCyciBSUB:BSU29740-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP25144.
PROiP25144.

Gene expression databases

CollecTFiEXPREG_000009c0.

Family and domain databases

CDDicd01392. HTH_LacI. 1 hit.
Gene3Di1.10.260.40. 1 hit.
InterProiIPR006377. CcpA.
IPR000843. HTH_LacI.
IPR010982. Lambda_DNA-bd_dom.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00356. LacI. 1 hit.
[Graphical view]
PRINTSiPR00036. HTHLACI.
SMARTiSM00354. HTH_LACI. 1 hit.
[Graphical view]
SUPFAMiSSF47413. SSF47413. 1 hit.
SSF53822. SSF53822. 1 hit.
TIGRFAMsiTIGR01481. ccpA. 1 hit.
PROSITEiPS00356. HTH_LACI_1. 1 hit.
PS50932. HTH_LACI_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCPA_BACSU
AccessioniPrimary (citable) accession number: P25144
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: November 2, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.