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Protein

Alcohol dehydrogenase 1

Gene

ADH1

Organism
Petunia hybrida (Petunia)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This protein is responsible for the conversion of alcohols to aldehydes in plants and is important for NAD metabolism during anaerobic respiration.1 Publication

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.1 Publication

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi49Zinc 1; catalyticBy similarity1
Metal bindingi51Zinc 1By similarity1
Binding sitei51NADBy similarity1
Binding sitei51SubstrateBy similarity1
Metal bindingi71Zinc 1; catalyticBy similarity1
Binding sitei71SubstrateBy similarity1
Metal bindingi101Zinc 2By similarity1
Metal bindingi104Zinc 2By similarity1
Metal bindingi107Zinc 2By similarity1
Metal bindingi115Zinc 2By similarity1
Metal bindingi179Zinc 1; catalyticBy similarity1
Binding sitei228NADBy similarity1
Binding sitei233NADBy similarity1
Binding sitei275NAD; via carbonyl oxygenBy similarity1
Binding sitei298NAD; via carbonyl oxygenBy similarity1
Binding sitei325NAD; via amide nitrogenBy similarity1
Binding sitei375NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi204 – 209NADBy similarity6
Nucleotide bindingi298 – 300NADBy similarity3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 11 Publication (EC:1.1.1.11 Publication)
Gene namesi
Name:ADH1
OrganismiPetunia hybrida (Petunia)
Taxonomic identifieri4102 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaePetunioideaePetunia

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607111 – 382Alcohol dehydrogenase 1Add BLAST382

Proteomic databases

PRIDEiP25141.

Interactioni

Subunit structurei

Homodimer.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP25141.
SMRiP25141.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.

Sequencei

Sequence statusi: Complete.

P25141-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSNTAGQVI RCKAAVAWEA GKPLVIEEVE VAPPQKMEVR LKILFTSLCH
60 70 80 90 100
TDVYFWEAKG QTPLFPRIFG HEAGGIVESV GEGVTDLKPG DHVLPVFTGE
110 120 130 140 150
CQQCRHCKSE ESNMCDLLRI NTDRGVMIHD GQTRFSKDGK PIYHFVGTST
160 170 180 190 200
FSEYTVCHSG CVTKIDPQAP LDKVCVLSCG ISTGLGATLN VAKPTKGSTV
210 220 230 240 250
AIFGLGAVGL AAAEGARIAG ASRIIGVDLN PSRFNDAKKF GVTEFVNPKD
260 270 280 290 300
HGDKPVQQVI AEMTDGGVDR SVECTGNVNA MISAFECVHD GWGVAVLVGV
310 320 330 340 350
PNKDDAFKTH PMNLLNERTL KGTFFGNYKP KSDIPSVVDK YMKKELELEK
360 370 380
FITHQVPFSE INKAFDYMLK GESIRCMITM EH
Length:382
Mass (Da):41,574
Last modified:May 1, 1992 - v1
Checksum:i43DFFE215650EDE0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54106 Genomic DNA. Translation: CAA38039.1.
PIRiS16596. DEPJA1.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiADH1_PETHY
AccessioniPrimary (citable) accession number: P25141
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: May 10, 2017
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families