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Protein

Alcohol dehydrogenase

Gene

Adh

Organism
Drosophila ambigua (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei138SubstrateBy similarity1
Active sitei151Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 33NADBy similarityAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase (EC:1.1.1.1)
Gene namesi
Name:Adh
OrganismiDrosophila ambigua (Fruit fly)
Taxonomic identifieri7216 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0012099. Damb\Adh.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000544531 – 254Alcohol dehydrogenaseAdd BLAST254

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliP25139.
SMRiP25139.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiView protein in InterPro
IPR002425. ADH_Drosophila-type.
IPR002424. ADH_insect.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
PfamiView protein in Pfam
PF00106. adh_short. 1 hit.
PRINTSiPR01168. ALCDHDRGNASE.
PR01167. INSADHFAMILY.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00061. ADH_SHORT. 1 hit.

Sequencei

Sequence statusi: Complete.

P25139-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLTNKNVIF VAGLGGIGLD TSRELVKRDL KNLVILDRID NPAAIAELKA
60 70 80 90 100
INPKVTVTFY PYDVTVPISE TTKLLKTIFA QLKTVDVLIN GAGILDDYQI
110 120 130 140 150
ERTIAVNYTG LVNTTTAILD FWDKRKGGPG GIICNIGSVT GFNAIYQVPV
160 170 180 190 200
YSGSKAAVVN FTSSLAKLAP ITGVTAYTVN PGITKTTLVH KFNSWLDVEP
210 220 230 240 250
NVAEKLLEHP TQTSQQCAEN FVKAIELNKN GAIWNLDLGT LEPITWTQHW

DSGI
Length:254
Mass (Da):27,618
Last modified:May 1, 1992 - v1
Checksum:i7DF055D723545B06
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54813 Genomic DNA. Translation: CAA38581.1.
PIRiS16453.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54813 Genomic DNA. Translation: CAA38581.1.
PIRiS16453.

3D structure databases

ProteinModelPortaliP25139.
SMRiP25139.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

FlyBaseiFBgn0012099. Damb\Adh.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiView protein in InterPro
IPR002425. ADH_Drosophila-type.
IPR002424. ADH_insect.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
PfamiView protein in Pfam
PF00106. adh_short. 1 hit.
PRINTSiPR01168. ALCDHDRGNASE.
PR01167. INSADHFAMILY.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00061. ADH_SHORT. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADH_DROAM
AccessioniPrimary (citable) accession number: P25139
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: March 15, 2017
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.