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Protein

Potassium voltage-gated channel subfamily C member 1

Gene

Kcnc1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well (PubMed:10482766). Contributes to fire sustained trains of very brief action potentials at high frequency in pallidal neurons (PubMed:10482766).1 Publication

GO - Molecular functioni

  • delayed rectifier potassium channel activity Source: GO_Central
  • ion channel binding Source: UniProtKB

GO - Biological processi

  • brain development Source: RGD
  • cellular response to drug Source: RGD
  • cerebellum development Source: RGD
  • globus pallidus development Source: RGD
  • positive regulation of ion transmembrane transport Source: RGD
  • positive regulation of potassium ion transmembrane transport Source: RGD
  • potassium ion transmembrane transport Source: GO_Central
  • protein homooligomerization Source: InterPro
  • regulation of ion transmembrane transport Source: RGD
  • regulation of potassium ion transmembrane transport Source: RGD
  • response to amine Source: RGD
  • response to auditory stimulus Source: RGD
  • response to fibroblast growth factor Source: RGD
  • response to light intensity Source: RGD
  • response to nerve growth factor Source: RGD
  • response to potassium ion Source: RGD
  • response to toxic substance Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily C member 1
Alternative name(s):
NGK2
RAW2
Voltage-gated potassium channel subunit Kv3.1
Voltage-gated potassium channel subunit Kv4
Gene namesi
Name:Kcnc1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2955. Kcnc1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 190190CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei191 – 20919Helical; Name=Segment S1Sequence AnalysisAdd
BLAST
Transmembranei248 – 26720Helical; Name=Segment S2Sequence AnalysisAdd
BLAST
Topological domaini268 – 2769CytoplasmicSequence Analysis
Transmembranei277 – 29519Helical; Name=Segment S3Sequence AnalysisAdd
BLAST
Transmembranei309 – 33123Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
BLAST
Topological domaini332 – 34413CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei345 – 36622Helical; Name=Segment S5Sequence AnalysisAdd
BLAST
Transmembranei415 – 43622Helical; Name=Segment S6Sequence AnalysisAdd
BLAST
Topological domaini437 – 585149CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • cell surface Source: RGD
  • dendrite Source: RGD
  • integral component of membrane Source: GO_Central
  • membrane Source: RGD
  • neuronal cell body Source: RGD
  • neuronal cell body membrane Source: RGD
  • neuron projection membrane Source: RGD
  • voltage-gated potassium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 585585Potassium voltage-gated channel subfamily C member 1PRO_0000054053Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi220 – 2201N-linked (GlcNAc...)Sequence Analysis
Glycosylationi229 – 2291N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP25122.

PTM databases

PhosphoSiteiP25122.

Expressioni

Tissue specificityi

Expressed in globus pallidal neurons of the basal ganglia (at protein level) (PubMed:10482766). Brain (PubMed:1378392).1 Publication

Gene expression databases

GenevestigatoriP25122.

Interactioni

Subunit structurei

Heteromultimer with KCNG3, KCNG4 and KCNV2 (By similarity). Heteromultimer with KCNC2 (PubMed:10482766, PubMed:14679187). Interacts with KCNC2 (PubMed:10482766, PubMed:14679187).By similarity2 Publications

Protein-protein interaction databases

BioGridi247366. 1 interaction.
STRINGi10116.ENSRNOP00000015260.

Structurei

3D structure databases

ProteinModelPortaliP25122.
SMRiP25122. Positions 7-443.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi400 – 4056Selectivity filterBy similarity

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG280627.
HOGENOMiHOG000231012.
HOVERGENiHBG105862.
InParanoidiP25122.
KOiK04887.
PhylomeDBiP25122.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003974. K_chnl_volt-dep_Kv3.
IPR005403. K_chnl_volt-dep_Kv3.1.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01581. KV31CHANNEL.
PR01491. KVCHANNEL.
PR01498. SHAWCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P25122-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGQGDESERI VINVGGTRHQ TYRSTLRTLP GTRLAWLAEP DAHSHFDYDP
60 70 80 90 100
RADEFFFDRH PGVFAHILNY YRTGKLHCPA DVCGPLYEEE LAFWGIDETD
110 120 130 140 150
VEPCCWMTYR QHRDAEEALD SFGGAPLDNS ADDADADGPG DSGDGEDELE
160 170 180 190 200
MTKRLALSDS PDGRPGGFWR RWQPRIWALF EDPYSSRYAR YVAFASLFFI
210 220 230 240 250
LVSITTFCLE THERFNPIVN KTEIENVRNG TQVRYYREAE TEAFLTYIEG
260 270 280 290 300
VCVVWFTFEF LMRVVFCPNK VEFIKNSLNI IDFVAILPFY LEVGLSGLSS
310 320 330 340 350
KAAKDVLGFL RVVRFVRILR IFKLTRHFVG LRVLGHTLRA STNEFLLLII
360 370 380 390 400
FLALGVLIFA TMIYYAERIG AQPNDPSASE HTHFKNIPIG FWWAVVTMTT
410 420 430 440 450
LGYGDMYPQT WSGMLVGALC ALAGVLTIAM PVPVIVNNFG MYYSLAMAKQ
460 470 480 490 500
KLPKKKKKHI PRPPQLGSPN YCKSVVNSPH HSTQSDTCPL AQEEILEINR
510 520 530 540 550
ADSKLNGEVA KAALANEDCP HIDQALTPDE GLPFTRSGTR ERYGPCFLLS
560 570 580
TGEYACPPGG GMRKDLCKES PVIAKYMPTE AVRVT
Length:585
Mass (Da):65,857
Last modified:May 1, 1992 - v1
Checksum:iDD4E2D32848E2DCF
GO
Isoform 2 (identifier: P25122-2) [UniParc]FASTAAdd to basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     502-511: DSKLNGEVAK → GRKPLRGMSI
     512-585: Missing.

Show »
Length:511
Mass (Da):57,928
Checksum:i50A939E8F7120F37
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei502 – 51110DSKLNGEVAK → GRKPLRGMSI in isoform 2. CuratedVSP_001016
Alternative sequencei512 – 58574Missing in isoform 2. CuratedVSP_001017Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M68880 mRNA. Translation: AAA41501.1.
X62840 mRNA. Translation: CAA44644.1.
PIRiA39395.
RefSeqiNP_036988.1. NM_012856.1. [P25122-1]
UniGeneiRn.33095.

Genome annotation databases

GeneIDi25327.
KEGGirno:25327.
UCSCiRGD:2955. rat. [P25122-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M68880 mRNA. Translation: AAA41501.1.
X62840 mRNA. Translation: CAA44644.1.
PIRiA39395.
RefSeqiNP_036988.1. NM_012856.1. [P25122-1]
UniGeneiRn.33095.

3D structure databases

ProteinModelPortaliP25122.
SMRiP25122. Positions 7-443.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247366. 1 interaction.
STRINGi10116.ENSRNOP00000015260.

Chemistry

BindingDBiP25122.
ChEMBLiCHEMBL2321617.
GuidetoPHARMACOLOGYi548.

PTM databases

PhosphoSiteiP25122.

Proteomic databases

PRIDEiP25122.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25327.
KEGGirno:25327.
UCSCiRGD:2955. rat. [P25122-1]

Organism-specific databases

CTDi3746.
RGDi2955. Kcnc1.

Phylogenomic databases

eggNOGiNOG280627.
HOGENOMiHOG000231012.
HOVERGENiHBG105862.
InParanoidiP25122.
KOiK04887.
PhylomeDBiP25122.

Miscellaneous databases

NextBioi606189.
PROiP25122.

Gene expression databases

GenevestigatoriP25122.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003974. K_chnl_volt-dep_Kv3.
IPR005403. K_chnl_volt-dep_Kv3.1.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01581. KV31CHANNEL.
PR01491. KVCHANNEL.
PR01498. SHAWCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Characterization of a Shaw-related potassium channel family in rat brain."
    Rettig J., Wunder F., Stocker M., Lichtinghagen R., Mastiaux F., Beckh S., Kues W., Pedarzani P., Schroeter K.H., Ruppersberg J.P., Veh R., Pongs O.
    EMBO J. 11:2473-2486(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Kv3.1-Kv3.2 channels underlie a high-voltage-activating component of the delayed rectifier K+ current in projecting neurons from the globus pallidus."
    Hernandez-Pineda R., Chow A., Amarillo Y., Moreno H., Saganich M., Vega-Saenz de Miera E.C., Hernandez-Cruz A., Rudy B.
    J. Neurophysiol. 82:1512-1528(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, INTERACTION WITH KCNC2, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  4. "MinK, MiRP1, and MiRP2 diversify Kv3.1 and Kv3.2 potassium channel gating."
    Lewis A., McCrossan Z.A., Abbott G.W.
    J. Biol. Chem. 279:7884-7892(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, INTERACTION WITH KCNC2.

Entry informationi

Entry nameiKCNC1_RAT
AccessioniPrimary (citable) accession number: P25122
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: May 27, 2015
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.