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P25122

- KCNC1_RAT

UniProt

P25122 - KCNC1_RAT

Protein

Potassium voltage-gated channel subfamily C member 1

Gene

Kcnc1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (01 May 1992)
      Previous versions | rss
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    Functioni

    This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

    GO - Molecular functioni

    1. delayed rectifier potassium channel activity Source: RefGenome

    GO - Biological processi

    1. protein homooligomerization Source: InterPro

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium voltage-gated channel subfamily C member 1
    Alternative name(s):
    NGK2
    RAW2
    Voltage-gated potassium channel subunit Kv3.1
    Voltage-gated potassium channel subunit Kv4
    Gene namesi
    Name:Kcnc1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi2955. Kcnc1.

    Subcellular locationi

    GO - Cellular componenti

    1. voltage-gated potassium channel complex Source: InterPro

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 585585Potassium voltage-gated channel subfamily C member 1PRO_0000054053Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi220 – 2201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi229 – 2291N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiP25122.

    PTM databases

    PhosphoSiteiP25122.

    Expressioni

    Tissue specificityi

    Brain.

    Gene expression databases

    GenevestigatoriP25122.

    Interactioni

    Subunit structurei

    Heteromultimer with KCNG3, KCNG4 and KCNV2.By similarity

    Protein-protein interaction databases

    BioGridi247366. 1 interaction.
    STRINGi10116.ENSRNOP00000015260.

    Structurei

    3D structure databases

    ProteinModelPortaliP25122.
    SMRiP25122. Positions 7-443.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 190190CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini268 – 2769CytoplasmicSequence Analysis
    Topological domaini332 – 34413CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini437 – 585149CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei191 – 20919Helical; Name=Segment S1Sequence AnalysisAdd
    BLAST
    Transmembranei248 – 26720Helical; Name=Segment S2Sequence AnalysisAdd
    BLAST
    Transmembranei277 – 29519Helical; Name=Segment S3Sequence AnalysisAdd
    BLAST
    Transmembranei309 – 33123Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
    BLAST
    Transmembranei345 – 36622Helical; Name=Segment S5Sequence AnalysisAdd
    BLAST
    Transmembranei415 – 43622Helical; Name=Segment S6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi400 – 4056Selectivity filterBy similarity

    Domaini

    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
    The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG280627.
    HOGENOMiHOG000231012.
    HOVERGENiHBG105862.
    InParanoidiP25122.
    KOiK04887.
    PhylomeDBiP25122.

    Family and domain databases

    Gene3Di1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003974. K_chnl_volt-dep_Kv3.
    IPR005403. K_chnl_volt-dep_Kv3.1.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view]
    PANTHERiPTHR11537. PTHR11537. 1 hit.
    PfamiPF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view]
    PRINTSiPR00169. KCHANNEL.
    PR01581. KV31CHANNEL.
    PR01491. KVCHANNEL.
    PR01498. SHAWCHANNEL.
    SMARTiSM00225. BTB. 1 hit.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P25122-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGQGDESERI VINVGGTRHQ TYRSTLRTLP GTRLAWLAEP DAHSHFDYDP    50
    RADEFFFDRH PGVFAHILNY YRTGKLHCPA DVCGPLYEEE LAFWGIDETD 100
    VEPCCWMTYR QHRDAEEALD SFGGAPLDNS ADDADADGPG DSGDGEDELE 150
    MTKRLALSDS PDGRPGGFWR RWQPRIWALF EDPYSSRYAR YVAFASLFFI 200
    LVSITTFCLE THERFNPIVN KTEIENVRNG TQVRYYREAE TEAFLTYIEG 250
    VCVVWFTFEF LMRVVFCPNK VEFIKNSLNI IDFVAILPFY LEVGLSGLSS 300
    KAAKDVLGFL RVVRFVRILR IFKLTRHFVG LRVLGHTLRA STNEFLLLII 350
    FLALGVLIFA TMIYYAERIG AQPNDPSASE HTHFKNIPIG FWWAVVTMTT 400
    LGYGDMYPQT WSGMLVGALC ALAGVLTIAM PVPVIVNNFG MYYSLAMAKQ 450
    KLPKKKKKHI PRPPQLGSPN YCKSVVNSPH HSTQSDTCPL AQEEILEINR 500
    ADSKLNGEVA KAALANEDCP HIDQALTPDE GLPFTRSGTR ERYGPCFLLS 550
    TGEYACPPGG GMRKDLCKES PVIAKYMPTE AVRVT 585
    Length:585
    Mass (Da):65,857
    Last modified:May 1, 1992 - v1
    Checksum:iDD4E2D32848E2DCF
    GO
    Isoform 2 (identifier: P25122-2) [UniParc]FASTAAdd to Basket

    Also known as: Short

    The sequence of this isoform differs from the canonical sequence as follows:
         502-511: DSKLNGEVAK → GRKPLRGMSI
         512-585: Missing.

    Show »
    Length:511
    Mass (Da):57,928
    Checksum:i50A939E8F7120F37
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei502 – 51110DSKLNGEVAK → GRKPLRGMSI in isoform 2. CuratedVSP_001016
    Alternative sequencei512 – 58574Missing in isoform 2. CuratedVSP_001017Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M68880 mRNA. Translation: AAA41501.1.
    X62840 mRNA. Translation: CAA44644.1.
    PIRiA39395.
    RefSeqiNP_036988.1. NM_012856.1. [P25122-1]
    UniGeneiRn.33095.

    Genome annotation databases

    GeneIDi25327.
    KEGGirno:25327.
    UCSCiRGD:2955. rat. [P25122-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M68880 mRNA. Translation: AAA41501.1 .
    X62840 mRNA. Translation: CAA44644.1 .
    PIRi A39395.
    RefSeqi NP_036988.1. NM_012856.1. [P25122-1 ]
    UniGenei Rn.33095.

    3D structure databases

    ProteinModelPortali P25122.
    SMRi P25122. Positions 7-443.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 247366. 1 interaction.
    STRINGi 10116.ENSRNOP00000015260.

    Chemistry

    ChEMBLi CHEMBL2321617.
    GuidetoPHARMACOLOGYi 548.

    PTM databases

    PhosphoSitei P25122.

    Proteomic databases

    PRIDEi P25122.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 25327.
    KEGGi rno:25327.
    UCSCi RGD:2955. rat. [P25122-1 ]

    Organism-specific databases

    CTDi 3746.
    RGDi 2955. Kcnc1.

    Phylogenomic databases

    eggNOGi NOG280627.
    HOGENOMi HOG000231012.
    HOVERGENi HBG105862.
    InParanoidi P25122.
    KOi K04887.
    PhylomeDBi P25122.

    Miscellaneous databases

    NextBioi 606189.
    PROi P25122.

    Gene expression databases

    Genevestigatori P25122.

    Family and domain databases

    Gene3Di 1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003974. K_chnl_volt-dep_Kv3.
    IPR005403. K_chnl_volt-dep_Kv3.1.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view ]
    PANTHERi PTHR11537. PTHR11537. 1 hit.
    Pfami PF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view ]
    PRINTSi PR00169. KCHANNEL.
    PR01581. KV31CHANNEL.
    PR01491. KVCHANNEL.
    PR01498. SHAWCHANNEL.
    SMARTi SM00225. BTB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Characterization of a Shaw-related potassium channel family in rat brain."
      Rettig J., Wunder F., Stocker M., Lichtinghagen R., Mastiaux F., Beckh S., Kues W., Pedarzani P., Schroeter K.H., Ruppersberg J.P., Veh R., Pongs O.
      EMBO J. 11:2473-2486(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiKCNC1_RAT
    AccessioniPrimary (citable) accession number: P25122
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: May 1, 1992
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3