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P25122

- KCNC1_RAT

UniProt

P25122 - KCNC1_RAT

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Protein

Potassium voltage-gated channel subfamily C member 1

Gene

Kcnc1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

GO - Molecular functioni

  1. delayed rectifier potassium channel activity Source: RefGenome

GO - Biological processi

  1. protein homooligomerization Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily C member 1
Alternative name(s):
NGK2
RAW2
Voltage-gated potassium channel subunit Kv3.1
Voltage-gated potassium channel subunit Kv4
Gene namesi
Name:Kcnc1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi2955. Kcnc1.

Subcellular locationi

GO - Cellular componenti

  1. voltage-gated potassium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 585585Potassium voltage-gated channel subfamily C member 1PRO_0000054053Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi220 – 2201N-linked (GlcNAc...)Sequence Analysis
Glycosylationi229 – 2291N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP25122.

PTM databases

PhosphoSiteiP25122.

Expressioni

Tissue specificityi

Brain.

Gene expression databases

GenevestigatoriP25122.

Interactioni

Subunit structurei

Heteromultimer with KCNG3, KCNG4 and KCNV2.By similarity

Protein-protein interaction databases

BioGridi247366. 1 interaction.
STRINGi10116.ENSRNOP00000015260.

Structurei

3D structure databases

ProteinModelPortaliP25122.
SMRiP25122. Positions 7-443.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 190190CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini268 – 2769CytoplasmicSequence Analysis
Topological domaini332 – 34413CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini437 – 585149CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei191 – 20919Helical; Name=Segment S1Sequence AnalysisAdd
BLAST
Transmembranei248 – 26720Helical; Name=Segment S2Sequence AnalysisAdd
BLAST
Transmembranei277 – 29519Helical; Name=Segment S3Sequence AnalysisAdd
BLAST
Transmembranei309 – 33123Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
BLAST
Transmembranei345 – 36622Helical; Name=Segment S5Sequence AnalysisAdd
BLAST
Transmembranei415 – 43622Helical; Name=Segment S6Sequence AnalysisAdd
BLAST

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi400 – 4056Selectivity filterBy similarity

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG280627.
HOGENOMiHOG000231012.
HOVERGENiHBG105862.
InParanoidiP25122.
KOiK04887.
PhylomeDBiP25122.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003974. K_chnl_volt-dep_Kv3.
IPR005403. K_chnl_volt-dep_Kv3.1.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01581. KV31CHANNEL.
PR01491. KVCHANNEL.
PR01498. SHAWCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P25122-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGQGDESERI VINVGGTRHQ TYRSTLRTLP GTRLAWLAEP DAHSHFDYDP
60 70 80 90 100
RADEFFFDRH PGVFAHILNY YRTGKLHCPA DVCGPLYEEE LAFWGIDETD
110 120 130 140 150
VEPCCWMTYR QHRDAEEALD SFGGAPLDNS ADDADADGPG DSGDGEDELE
160 170 180 190 200
MTKRLALSDS PDGRPGGFWR RWQPRIWALF EDPYSSRYAR YVAFASLFFI
210 220 230 240 250
LVSITTFCLE THERFNPIVN KTEIENVRNG TQVRYYREAE TEAFLTYIEG
260 270 280 290 300
VCVVWFTFEF LMRVVFCPNK VEFIKNSLNI IDFVAILPFY LEVGLSGLSS
310 320 330 340 350
KAAKDVLGFL RVVRFVRILR IFKLTRHFVG LRVLGHTLRA STNEFLLLII
360 370 380 390 400
FLALGVLIFA TMIYYAERIG AQPNDPSASE HTHFKNIPIG FWWAVVTMTT
410 420 430 440 450
LGYGDMYPQT WSGMLVGALC ALAGVLTIAM PVPVIVNNFG MYYSLAMAKQ
460 470 480 490 500
KLPKKKKKHI PRPPQLGSPN YCKSVVNSPH HSTQSDTCPL AQEEILEINR
510 520 530 540 550
ADSKLNGEVA KAALANEDCP HIDQALTPDE GLPFTRSGTR ERYGPCFLLS
560 570 580
TGEYACPPGG GMRKDLCKES PVIAKYMPTE AVRVT
Length:585
Mass (Da):65,857
Last modified:May 1, 1992 - v1
Checksum:iDD4E2D32848E2DCF
GO
Isoform 2 (identifier: P25122-2) [UniParc]FASTAAdd to Basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     502-511: DSKLNGEVAK → GRKPLRGMSI
     512-585: Missing.

Show »
Length:511
Mass (Da):57,928
Checksum:i50A939E8F7120F37
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei502 – 51110DSKLNGEVAK → GRKPLRGMSI in isoform 2. CuratedVSP_001016
Alternative sequencei512 – 58574Missing in isoform 2. CuratedVSP_001017Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M68880 mRNA. Translation: AAA41501.1.
X62840 mRNA. Translation: CAA44644.1.
PIRiA39395.
RefSeqiNP_036988.1. NM_012856.1. [P25122-1]
UniGeneiRn.33095.

Genome annotation databases

GeneIDi25327.
KEGGirno:25327.
UCSCiRGD:2955. rat. [P25122-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M68880 mRNA. Translation: AAA41501.1 .
X62840 mRNA. Translation: CAA44644.1 .
PIRi A39395.
RefSeqi NP_036988.1. NM_012856.1. [P25122-1 ]
UniGenei Rn.33095.

3D structure databases

ProteinModelPortali P25122.
SMRi P25122. Positions 7-443.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 247366. 1 interaction.
STRINGi 10116.ENSRNOP00000015260.

Chemistry

ChEMBLi CHEMBL2321617.
GuidetoPHARMACOLOGYi 548.

PTM databases

PhosphoSitei P25122.

Proteomic databases

PRIDEi P25122.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 25327.
KEGGi rno:25327.
UCSCi RGD:2955. rat. [P25122-1 ]

Organism-specific databases

CTDi 3746.
RGDi 2955. Kcnc1.

Phylogenomic databases

eggNOGi NOG280627.
HOGENOMi HOG000231012.
HOVERGENi HBG105862.
InParanoidi P25122.
KOi K04887.
PhylomeDBi P25122.

Miscellaneous databases

NextBioi 606189.
PROi P25122.

Gene expression databases

Genevestigatori P25122.

Family and domain databases

Gene3Di 1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003974. K_chnl_volt-dep_Kv3.
IPR005403. K_chnl_volt-dep_Kv3.1.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view ]
PANTHERi PTHR11537. PTHR11537. 1 hit.
Pfami PF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view ]
PRINTSi PR00169. KCHANNEL.
PR01581. KV31CHANNEL.
PR01491. KVCHANNEL.
PR01498. SHAWCHANNEL.
SMARTi SM00225. BTB. 1 hit.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Characterization of a Shaw-related potassium channel family in rat brain."
    Rettig J., Wunder F., Stocker M., Lichtinghagen R., Mastiaux F., Beckh S., Kues W., Pedarzani P., Schroeter K.H., Ruppersberg J.P., Veh R., Pongs O.
    EMBO J. 11:2473-2486(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiKCNC1_RAT
AccessioniPrimary (citable) accession number: P25122
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: October 1, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3