P25122 (KCNC1_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Potassium voltage-gated channel subfamily C member 1

Alternative name(s):
NGK2
RAW2
Voltage-gated potassium channel subunit Kv3.1
Voltage-gated potassium channel subunit Kv4

Gene names

Name:

Kcnc1

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	585 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
Subunit structure	Heteromultimer with KCNG3, KCNG4 and KCNV2 By similarity.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Brain.
Domain	The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
Sequence similarities	Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.1/KCNC1 sub-subfamily. [View classification]

Ontologies

Keywords
Biological process	Ion transport Potassium transport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
Ligand	Potassium
Molecular function	Ion channel Potassium channel Voltage-gated channel
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein homooligomerization Inferred from electronic annotation. Source: InterPro
Cellular_component	voltage-gated potassium channel complex Inferred from electronic annotation. Source: InterPro
Molecular_function	delayed rectifier potassium channel activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P25122-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P25122-2)

Also known as: Short;

The sequence of this isoform differs from the canonical sequence as follows:
     502-511: DSKLNGEVAK → GRKPLRGMSI
     512-585: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 585	585	Potassium voltage-gated channel subfamily C member 1		PRO_0000054053
Regions
	Topological domain	1 – 190	190	Cytoplasmic Potential
	Transmembrane	191 – 209	19	Helical; Name=Segment S1; Potential
	Transmembrane	248 – 267	20	Helical; Name=Segment S2; Potential
	Topological domain	268 – 276	9	Cytoplasmic Potential
	Transmembrane	277 – 295	19	Helical; Name=Segment S3; Potential
	Transmembrane	309 – 331	23	Helical; Voltage-sensor; Name=Segment S4; Potential
	Topological domain	332 – 344	13	Cytoplasmic Potential
	Transmembrane	345 – 366	22	Helical; Name=Segment S5; Potential
	Transmembrane	415 – 436	22	Helical; Name=Segment S6; Potential
	Topological domain	437 – 585	149	Cytoplasmic Potential
	Motif	400 – 405	6	Selectivity filter By similarity
Amino acid modifications
	Glycosylation	220	1	N-linked (GlcNAc...) Potential
	Glycosylation	229	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	502 – 511	10	DSKLNGEVAK → GRKPLRGMSI in isoform 2.		VSP_001016
	Alternative sequence	512 – 585	74	Missing in isoform 2.		VSP_001017

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 1, 1992. Version 1. Checksum: DD4E2D32848E2DCF	FASTA	585	65,857
	10 20 30 40 50 60 MGQGDESERI VINVGGTRHQ TYRSTLRTLP GTRLAWLAEP DAHSHFDYDP RADEFFFDRH 70 80 90 100 110 120 PGVFAHILNY YRTGKLHCPA DVCGPLYEEE LAFWGIDETD VEPCCWMTYR QHRDAEEALD 130 140 150 160 170 180 SFGGAPLDNS ADDADADGPG DSGDGEDELE MTKRLALSDS PDGRPGGFWR RWQPRIWALF 190 200 210 220 230 240 EDPYSSRYAR YVAFASLFFI LVSITTFCLE THERFNPIVN KTEIENVRNG TQVRYYREAE 250 260 270 280 290 300 TEAFLTYIEG VCVVWFTFEF LMRVVFCPNK VEFIKNSLNI IDFVAILPFY LEVGLSGLSS 310 320 330 340 350 360 KAAKDVLGFL RVVRFVRILR IFKLTRHFVG LRVLGHTLRA STNEFLLLII FLALGVLIFA 370 380 390 400 410 420 TMIYYAERIG AQPNDPSASE HTHFKNIPIG FWWAVVTMTT LGYGDMYPQT WSGMLVGALC 430 440 450 460 470 480 ALAGVLTIAM PVPVIVNNFG MYYSLAMAKQ KLPKKKKKHI PRPPQLGSPN YCKSVVNSPH 490 500 510 520 530 540 HSTQSDTCPL AQEEILEINR ADSKLNGEVA KAALANEDCP HIDQALTPDE GLPFTRSGTR 550 560 570 580 ERYGPCFLLS TGEYACPPGG GMRKDLCKES PVIAKYMPTE AVRVT
	Isoform 2 (Short) [UniParc]. Checksum: 50A939E8F7120F37	FASTA	511	57,928
	10 20 30 40 50 60 MGQGDESERI VINVGGTRHQ TYRSTLRTLP GTRLAWLAEP DAHSHFDYDP RADEFFFDRH 70 80 90 100 110 120 PGVFAHILNY YRTGKLHCPA DVCGPLYEEE LAFWGIDETD VEPCCWMTYR QHRDAEEALD 130 140 150 160 170 180 SFGGAPLDNS ADDADADGPG DSGDGEDELE MTKRLALSDS PDGRPGGFWR RWQPRIWALF 190 200 210 220 230 240 EDPYSSRYAR YVAFASLFFI LVSITTFCLE THERFNPIVN KTEIENVRNG TQVRYYREAE 250 260 270 280 290 300 TEAFLTYIEG VCVVWFTFEF LMRVVFCPNK VEFIKNSLNI IDFVAILPFY LEVGLSGLSS 310 320 330 340 350 360 KAAKDVLGFL RVVRFVRILR IFKLTRHFVG LRVLGHTLRA STNEFLLLII FLALGVLIFA 370 380 390 400 410 420 TMIYYAERIG AQPNDPSASE HTHFKNIPIG FWWAVVTMTT LGYGDMYPQT WSGMLVGALC 430 440 450 460 470 480 ALAGVLTIAM PVPVIVNNFG MYYSLAMAKQ KLPKKKKKHI PRPPQLGSPN YCKSVVNSPH 490 500 510 HSTQSDTCPL AQEEILEINR AGRKPLRGMS I

References

[1]	"Alternative splicing contributes to K+ channel diversity in the mammalian central nervous system." Luneau C.J., Williams J.B., Marshall J., Levitan E.S., Oliva C., Smith J.S., Antanavage J., Folander K., Stein R.B., Swanson R., Kaczmarek L.K., Buhrow S.A. Proc. Natl. Acad. Sci. U.S.A. 88:3932-3936(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Characterization of a Shaw-related potassium channel family in rat brain." Rettig J., Wunder F., Stocker M., Lichtinghagen R., Mastiaux F., Beckh S., Kues W., Pedarzani P., Schroeter K.H., Ruppersberg J.P., Veh R., Pongs O. EMBO J. 11:2473-2486(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M68880 mRNA. Translation: AAA41501.1. X62840 mRNA. Translation: CAA44644.1.
IPI	IPI00215209. IPI00231972.
PIR	A39395.
RefSeq	NP_036988.1. NM_012856.1.
UniGene	Rn.33095.
3D structure databases
ProteinModelPortal	P25122.
SMR	P25122. Positions 7-443.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000015260.
PTM databases
PhosphoSite	P25122.
Proteomic databases
PRIDE	P25122.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	25327.
KEGG	rno:25327.
UCSC	RGD:2955. rat.
Organism-specific databases
CTD	3746.
RGD	2955. Kcnc1.
Phylogenomic databases
eggNOG	NOG280627.
HOGENOM	HOG000231012.
HOVERGEN	HBG105862.
InParanoid	P25122.
KO	K04887.
OrthoDB	EOG4CRKZX.
Gene expression databases
Genevestigator	P25122.
GermOnline	ENSRNOG00000011380. Rattus norvegicus.
Family and domain databases
Gene3D	3.30.710.10. 1 hit.
InterPro	IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR005821. Ion_trans_dom. IPR003091. K_chnl. IPR003968. K_chnl_volt-dep_Kv. IPR003974. K_chnl_volt-dep_Kv3. IPR005403. K_chnl_volt-dep_Kv3.1. IPR003131. T1-type_BTB. [Graphical view]
PANTHER	PTHR11537. PTHR11537. 1 hit.
Pfam	PF00520. Ion_trans. 1 hit. PF02214. K_tetra. 1 hit. [Graphical view]
PRINTS	PR00169. KCHANNEL. PR01581. KV31CHANNEL. PR01491. KVCHANNEL. PR01498. SHAWCHANNEL.
SMART	SM00225. BTB. 1 hit. [Graphical view]
SUPFAM	SSF54695. BTB/POZ_fold. 1 hit.
ProtoNet	Search...
Other
NextBio	606189.

Entry information

Entry name

KCNC1_RAT

Accession

Primary (citable) accession number: P25122

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1992
Last sequence update:	May 1, 1992
Last modified:	May 1, 2013
This is version 107 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program