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P25122 (KCNC1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium voltage-gated channel subfamily C member 1
Alternative name(s):
NGK2
RAW2
Voltage-gated potassium channel subunit Kv3.1
Voltage-gated potassium channel subunit Kv4
Gene names
Name:Kcnc1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length585 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

Subunit structure

Heteromultimer with KCNG3, KCNG4 and KCNV2 By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Brain.

Domain

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.

Sequence similarities

Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.1/KCNC1 sub-subfamily. [View classification]

Ontologies

Keywords
   Biological processIon transport
Potassium transport
Transport
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
Transmembrane helix
   LigandPotassium
   Molecular functionIon channel
Potassium channel
Voltage-gated channel
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotein homooligomerization

Inferred from electronic annotation. Source: InterPro

   Cellular_componentvoltage-gated potassium channel complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functiondelayed rectifier potassium channel activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P25122-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P25122-2)

Also known as: Short;

The sequence of this isoform differs from the canonical sequence as follows:
     502-511: DSKLNGEVAK → GRKPLRGMSI
     512-585: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 585585Potassium voltage-gated channel subfamily C member 1
PRO_0000054053

Regions

Topological domain1 – 190190Cytoplasmic Potential
Transmembrane191 – 20919Helical; Name=Segment S1; Potential
Transmembrane248 – 26720Helical; Name=Segment S2; Potential
Topological domain268 – 2769Cytoplasmic Potential
Transmembrane277 – 29519Helical; Name=Segment S3; Potential
Transmembrane309 – 33123Helical; Voltage-sensor; Name=Segment S4; Potential
Topological domain332 – 34413Cytoplasmic Potential
Transmembrane345 – 36622Helical; Name=Segment S5; Potential
Transmembrane415 – 43622Helical; Name=Segment S6; Potential
Topological domain437 – 585149Cytoplasmic Potential
Motif400 – 4056Selectivity filter By similarity

Amino acid modifications

Glycosylation2201N-linked (GlcNAc...) Potential
Glycosylation2291N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence502 – 51110DSKLNGEVAK → GRKPLRGMSI in isoform 2.
VSP_001016
Alternative sequence512 – 58574Missing in isoform 2.
VSP_001017

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 1, 1992. Version 1.
Checksum: DD4E2D32848E2DCF

FASTA58565,857
        10         20         30         40         50         60 
MGQGDESERI VINVGGTRHQ TYRSTLRTLP GTRLAWLAEP DAHSHFDYDP RADEFFFDRH 

        70         80         90        100        110        120 
PGVFAHILNY YRTGKLHCPA DVCGPLYEEE LAFWGIDETD VEPCCWMTYR QHRDAEEALD 

       130        140        150        160        170        180 
SFGGAPLDNS ADDADADGPG DSGDGEDELE MTKRLALSDS PDGRPGGFWR RWQPRIWALF 

       190        200        210        220        230        240 
EDPYSSRYAR YVAFASLFFI LVSITTFCLE THERFNPIVN KTEIENVRNG TQVRYYREAE 

       250        260        270        280        290        300 
TEAFLTYIEG VCVVWFTFEF LMRVVFCPNK VEFIKNSLNI IDFVAILPFY LEVGLSGLSS 

       310        320        330        340        350        360 
KAAKDVLGFL RVVRFVRILR IFKLTRHFVG LRVLGHTLRA STNEFLLLII FLALGVLIFA 

       370        380        390        400        410        420 
TMIYYAERIG AQPNDPSASE HTHFKNIPIG FWWAVVTMTT LGYGDMYPQT WSGMLVGALC 

       430        440        450        460        470        480 
ALAGVLTIAM PVPVIVNNFG MYYSLAMAKQ KLPKKKKKHI PRPPQLGSPN YCKSVVNSPH 

       490        500        510        520        530        540 
HSTQSDTCPL AQEEILEINR ADSKLNGEVA KAALANEDCP HIDQALTPDE GLPFTRSGTR 

       550        560        570        580 
ERYGPCFLLS TGEYACPPGG GMRKDLCKES PVIAKYMPTE AVRVT 

« Hide

Isoform 2 (Short) [UniParc].

Checksum: 50A939E8F7120F37
Show »

FASTA51157,928

References

[1]"Alternative splicing contributes to K+ channel diversity in the mammalian central nervous system."
Luneau C.J., Williams J.B., Marshall J., Levitan E.S., Oliva C., Smith J.S., Antanavage J., Folander K., Stein R.B., Swanson R., Kaczmarek L.K., Buhrow S.A.
Proc. Natl. Acad. Sci. U.S.A. 88:3932-3936(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Characterization of a Shaw-related potassium channel family in rat brain."
Rettig J., Wunder F., Stocker M., Lichtinghagen R., Mastiaux F., Beckh S., Kues W., Pedarzani P., Schroeter K.H., Ruppersberg J.P., Veh R., Pongs O.
EMBO J. 11:2473-2486(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M68880 mRNA. Translation: AAA41501.1.
X62840 mRNA. Translation: CAA44644.1.
PIRA39395.
RefSeqNP_036988.1. NM_012856.1.
UniGeneRn.33095.

3D structure databases

ProteinModelPortalP25122.
SMRP25122. Positions 7-443.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid247366. 1 interaction.
STRING10116.ENSRNOP00000015260.

Chemistry

ChEMBLCHEMBL2321617.
GuidetoPHARMACOLOGY548.

PTM databases

PhosphoSiteP25122.

Proteomic databases

PRIDEP25122.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID25327.
KEGGrno:25327.
UCSCRGD:2955. rat. [P25122-1]

Organism-specific databases

CTD3746.
RGD2955. Kcnc1.

Phylogenomic databases

eggNOGNOG280627.
HOGENOMHOG000231012.
HOVERGENHBG105862.
InParanoidP25122.
KOK04887.
PhylomeDBP25122.

Gene expression databases

GenevestigatorP25122.

Family and domain databases

Gene3D1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003974. K_chnl_volt-dep_Kv3.
IPR005403. K_chnl_volt-dep_Kv3.1.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERPTHR11537. PTHR11537. 1 hit.
PfamPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSPR00169. KCHANNEL.
PR01581. KV31CHANNEL.
PR01491. KVCHANNEL.
PR01498. SHAWCHANNEL.
SMARTSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMSSF54695. SSF54695. 1 hit.
ProtoNetSearch...

Other

NextBio606189.
PROP25122.

Entry information

Entry nameKCNC1_RAT
AccessionPrimary (citable) accession number: P25122
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: April 16, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families