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Protein

Tumor necrosis factor receptor superfamily member 1B

Gene

Tnfrsf1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • aging Source: Ensembl
  • cell proliferation Source: MGI
  • cell surface receptor signaling pathway Source: MGI
  • cellular response to growth factor stimulus Source: Ensembl
  • cellular response to lipopolysaccharide Source: MGI
  • extrinsic apoptotic signaling pathway Source: MGI
  • immune response Source: GO_Central
  • inflammatory response Source: MGI
  • intrinsic apoptotic signaling pathway in response to DNA damage Source: MGI
  • multicellular organism development Source: GO_Central
  • negative regulation of inflammatory response Source: MGI
  • positive regulation of MAPK cascade Source: GO_Central
  • positive regulation of membrane protein ectodomain proteolysis Source: MGI
  • regulation of apoptotic process Source: GO_Central
  • regulation of cell proliferation Source: GO_Central
  • response to lipopolysaccharide Source: GO_Central
  • RNA destabilization Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-MMU-5668541. TNFR2 non-canonical NF-kB pathway.
R-MMU-5669034. TNFs bind their physiological receptors.
R-MMU-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 1B
Alternative name(s):
Tumor necrosis factor receptor 2
Short name:
TNF-R2
Tumor necrosis factor receptor type II
Short name:
TNF-RII
Short name:
TNFR-II
p75
p80 TNF-alpha receptor
CD_antigen: CD120b
Gene namesi
Name:Tnfrsf1b
Synonyms:Tnfr-2, Tnfr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1314883. Tnfrsf1b.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 258ExtracellularSequence analysisAdd BLAST236
Transmembranei259 – 288HelicalSequence analysisAdd BLAST30
Topological domaini289 – 474CytoplasmicSequence analysisAdd BLAST186

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • membrane Source: MGI
  • membrane raft Source: BHF-UCL
  • neuronal cell body Source: Ensembl
  • nucleus Source: Ensembl
  • perinuclear region of cytoplasm Source: Ensembl
  • varicosity Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Add BLAST22
ChainiPRO_000003455023 – 474Tumor necrosis factor receptor superfamily member 1BAdd BLAST452

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi30O-linked (GalNAc...)By similarity1
Disulfide bondi40 ↔ 54PROSITE-ProRule annotation
Disulfide bondi55 ↔ 68PROSITE-ProRule annotation
Disulfide bondi58 ↔ 76PROSITE-ProRule annotation
Glycosylationi69N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi79 ↔ 94PROSITE-ProRule annotation
Disulfide bondi97 ↔ 111PROSITE-ProRule annotation
Disulfide bondi101 ↔ 119PROSITE-ProRule annotation
Disulfide bondi121 ↔ 127PROSITE-ProRule annotation
Disulfide bondi136 ↔ 145PROSITE-ProRule annotation
Disulfide bondi139 ↔ 163PROSITE-ProRule annotation
Disulfide bondi166 ↔ 181PROSITE-ProRule annotation
Glycosylationi195N-linked (GlcNAc...)Sequence analysis1
Glycosylationi208O-linked (GalNAc...)By similarity1
Glycosylationi224O-linked (GalNAc...)By similarity1
Modified residuei331PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP25119.
PaxDbiP25119.
PeptideAtlasiP25119.
PRIDEiP25119.

PTM databases

PhosphoSitePlusiP25119.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028599.
ExpressionAtlasiP25119. baseline and differential.
GenevisibleiP25119. MM.

Interactioni

Subunit structurei

Binds to TRAF2. Interacts with BMX.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204250. 3 interactors.
DIPiDIP-60902N.
IntActiP25119. 3 interactors.
STRINGi10090.ENSMUSP00000030336.

Structurei

3D structure databases

ProteinModelPortaliP25119.
SMRiP25119.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati39 – 77TNFR-Cys 1Add BLAST39
Repeati78 – 119TNFR-Cys 2Add BLAST42
Repeati120 – 164TNFR-Cys 3Add BLAST45
Repeati165 – 203TNFR-Cys 4Add BLAST39

Sequence similaritiesi

Contains 4 TNFR-Cys repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ06. Eukaryota.
ENOG410YPQW. LUCA.
GeneTreeiENSGT00760000119204.
HOGENOMiHOG000132845.
HOVERGENiHBG054237.
InParanoidiP25119.
KOiK05141.
OMAiNCVIMTQ.
OrthoDBiEOG091G03XW.
PhylomeDBiP25119.
TreeFamiTF331157.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020411. TNFR_1B.
[Graphical view]
PfamiPF00020. TNFR_c6. 2 hits.
[Graphical view]
PRINTSiPR01919. TNFACTORR1B.
SMARTiSM00208. TNFR. 4 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25119-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPAALWVAL VFELQLWATG HTVPAQVVLT PYKPEPGYEC QISQEYYDRK
60 70 80 90 100
AQMCCAKCPP GQYVKHFCNK TSDTVCADCE ASMYTQVWNQ FRTCLSCSSS
110 120 130 140 150
CTTDQVEIRA CTKQQNRVCA CEAGRYCALK THSGSCRQCM RLSKCGPGFG
160 170 180 190 200
VASSRAPNGN VLCKACAPGT FSDTTSSTDV CRPHRICSIL AIPGNASTDA
210 220 230 240 250
VCAPESPTLS AIPRTLYVSQ PEPTRSQPLD QEPGPSQTPS ILTSLGSTPI
260 270 280 290 300
IEQSTKGGIS LPIGLIVGVT SLGLLMLGLV NCIILVQRKK KPSCLQRDAK
310 320 330 340 350
VPHVPDEKSQ DAVGLEQQHL LTTAPSSSSS SLESSASAGD RRAPPGGHPQ
360 370 380 390 400
ARVMAEAQGF QEARASSRIS DSSHGSHGTH VNVTCIVNVC SSSDHSSQCS
410 420 430 440 450
SQASATVGDP DAKPSASPKD EQVPFSQEEC PSQSPCETTE TLQSHEKPLP
460 470
LGVPDMGMKP SQAGWFDQIA VKVA
Length:474
Mass (Da):50,320
Last modified:May 1, 1992 - v1
Checksum:i462EAE398C4D6563
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti78D → DSDTVCAD (PubMed:9740674).Curated1
Sequence conflicti102T → S in CAA74969 (PubMed:9740674).Curated1
Sequence conflicti108I → T in CAA74969 (PubMed:9740674).Curated1
Sequence conflicti283I → F in CAA74969 (PubMed:9740674).Curated1
Sequence conflicti331S → SS in CAA74969 (PubMed:9740674).Curated1
Sequence conflicti360F → S in CAA74969 (PubMed:9740674).Curated1
Sequence conflicti436C → Y in CAA74969 (PubMed:9740674).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60469 mRNA. Translation: AAA39752.1.
M59378 mRNA. Translation: AAA40463.1.
Y14619
, Y14620, Y14621, Y14622, Y14679, Y14623 Genomic DNA. Translation: CAA74969.1.
U39488 Genomic DNA. Translation: AAA85021.1.
X87128 Genomic DNA. Translation: CAA60618.1.
CCDSiCCDS18914.1.
PIRiB38634.
RefSeqiNP_035740.2. NM_011610.3.
UniGeneiMm.235328.

Genome annotation databases

EnsembliENSMUST00000030336; ENSMUSP00000030336; ENSMUSG00000028599.
GeneIDi21938.
KEGGimmu:21938.
UCSCiuc008vrt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60469 mRNA. Translation: AAA39752.1.
M59378 mRNA. Translation: AAA40463.1.
Y14619
, Y14620, Y14621, Y14622, Y14679, Y14623 Genomic DNA. Translation: CAA74969.1.
U39488 Genomic DNA. Translation: AAA85021.1.
X87128 Genomic DNA. Translation: CAA60618.1.
CCDSiCCDS18914.1.
PIRiB38634.
RefSeqiNP_035740.2. NM_011610.3.
UniGeneiMm.235328.

3D structure databases

ProteinModelPortaliP25119.
SMRiP25119.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204250. 3 interactors.
DIPiDIP-60902N.
IntActiP25119. 3 interactors.
STRINGi10090.ENSMUSP00000030336.

PTM databases

PhosphoSitePlusiP25119.

Proteomic databases

EPDiP25119.
PaxDbiP25119.
PeptideAtlasiP25119.
PRIDEiP25119.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030336; ENSMUSP00000030336; ENSMUSG00000028599.
GeneIDi21938.
KEGGimmu:21938.
UCSCiuc008vrt.1. mouse.

Organism-specific databases

CTDi7133.
MGIiMGI:1314883. Tnfrsf1b.

Phylogenomic databases

eggNOGiENOG410IJ06. Eukaryota.
ENOG410YPQW. LUCA.
GeneTreeiENSGT00760000119204.
HOGENOMiHOG000132845.
HOVERGENiHBG054237.
InParanoidiP25119.
KOiK05141.
OMAiNCVIMTQ.
OrthoDBiEOG091G03XW.
PhylomeDBiP25119.
TreeFamiTF331157.

Enzyme and pathway databases

ReactomeiR-MMU-5668541. TNFR2 non-canonical NF-kB pathway.
R-MMU-5669034. TNFs bind their physiological receptors.
R-MMU-6798695. Neutrophil degranulation.

Miscellaneous databases

ChiTaRSiTnfrsf1b. mouse.
PROiP25119.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028599.
ExpressionAtlasiP25119. baseline and differential.
GenevisibleiP25119. MM.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020411. TNFR_1B.
[Graphical view]
PfamiPF00020. TNFR_c6. 2 hits.
[Graphical view]
PRINTSiPR01919. TNFACTORR1B.
SMARTiSM00208. TNFR. 4 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTNR1B_MOUSE
AccessioniPrimary (citable) accession number: P25119
Secondary accession number(s): O88734, P97893
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: November 30, 2016
This is version 150 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.