Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tumor necrosis factor receptor superfamily member 1A

Gene

Tnfrsf1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (By similarity).By similarity

GO - Molecular functioni

  • tumor necrosis factor-activated receptor activity Source: MGI
  • tumor necrosis factor binding Source: GO_Central

GO - Biological processi

  • cell surface receptor signaling pathway Source: MGI
  • cellular response to mechanical stimulus Source: Ensembl
  • cytokine-mediated signaling pathway Source: MGI
  • defense response Source: MGI
  • defense response to bacterium Source: MGI
  • establishment of protein localization to plasma membrane Source: MGI
  • extrinsic apoptotic signaling pathway via death domain receptors Source: GO_Central
  • immune response Source: GO_Central
  • inflammatory response Source: MGI
  • intrinsic apoptotic signaling pathway in response to DNA damage Source: MGI
  • multicellular organism development Source: GO_Central
  • negative regulation of inflammatory response Source: MGI
  • positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
  • positive regulation of inflammatory response Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • positive regulation of tyrosine phosphorylation of Stat1 protein Source: MGI
  • prostaglandin metabolic process Source: MGI
  • regulation of apoptotic process Source: GO_Central
  • regulation of cell proliferation Source: GO_Central
  • regulation of establishment of endothelial barrier Source: MGI
  • response to lipopolysaccharide Source: GO_Central
  • tumor necrosis factor-mediated signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

ReactomeiR-MMU-5357786. TNFR1-induced proapoptotic signaling.
R-MMU-5357905. Regulation of TNFR1 signaling.
R-MMU-5357956. TNFR1-induced NFkappaB signaling pathway.
R-MMU-5626978. TNFR1-mediated ceramide production.
R-MMU-5669034. TNFs bind their physiological receptors.
R-MMU-75893. TNF signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 1A
Alternative name(s):
Tumor necrosis factor receptor 1
Short name:
TNF-R1
Tumor necrosis factor receptor type I
Short name:
TNF-RI
Short name:
TNFR-I
p55
p60
CD_antigen: CD120a
Gene namesi
Name:Tnfrsf1a
Synonyms:Tnfr-1, Tnfr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1314884. Tnfrsf1a.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 212ExtracellularSequence analysisAdd BLAST191
Transmembranei213 – 235HelicalSequence analysisAdd BLAST23
Topological domaini236 – 454CytoplasmicSequence analysisAdd BLAST219

GO - Cellular componenti

  • cell surface Source: BHF-UCL
  • extracellular space Source: MGI
  • Golgi membrane Source: UniProtKB
  • integral component of plasma membrane Source: GO_Central
  • membrane raft Source: BHF-UCL
  • mitochondrion Source: GO_Central
  • plasma membrane Source: MGI
  • receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000003454522 – 454Tumor necrosis factor receptor superfamily member 1AAdd BLAST433

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi44 ↔ 58PROSITE-ProRule annotation
Glycosylationi54N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi59 ↔ 72PROSITE-ProRule annotation
Disulfide bondi62 ↔ 81PROSITE-ProRule annotation
Disulfide bondi84 ↔ 99PROSITE-ProRule annotation
Disulfide bondi102 ↔ 117PROSITE-ProRule annotation
Disulfide bondi105 ↔ 125PROSITE-ProRule annotation
Disulfide bondi127 ↔ 143PROSITE-ProRule annotation
Disulfide bondi146 ↔ 158PROSITE-ProRule annotation
Disulfide bondi149 ↔ 166PROSITE-ProRule annotation
Glycosylationi151N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi168 ↔ 179PROSITE-ProRule annotation
Disulfide bondi182 ↔ 195PROSITE-ProRule annotation
Disulfide bondi185 ↔ 191PROSITE-ProRule annotation
Glycosylationi202N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP25118.
PeptideAtlasiP25118.
PRIDEiP25118.

PTM databases

iPTMnetiP25118.
PhosphoSitePlusiP25118.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030341.
ExpressionAtlasiP25118. baseline and differential.
GenevisibleiP25118. MM.

Interactioni

Subunit structurei

Binding of TNF to the extracellular domain leads to homotrimerization. The aggregated death domains provide a novel molecular interface that interacts specifically with the death domain of TRADD. Various TRADD-interacting proteins such as TRAFS, RIPK1 and possibly FADD, are recruited to the complex by their association with TRADD. This complex activates at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4, BRE, FEM1B, GRB2, SQSTM1 and TRPC4AP. Interacts with DAB2IP (By similarity). Interacts directly with NOL3 (via CARD domain); inhibits TNF-signaling pathway.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Ern1Q9EQY02EBI-518014,EBI-5480799
Ripk1Q608553EBI-518014,EBI-529119
Slc39a7Q311253EBI-518014,EBI-644519

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204249. 13 interactors.
DIPiDIP-34532N.
IntActiP25118. 23 interactors.
MINTiMINT-2631249.
STRINGi10090.ENSMUSP00000032491.

Structurei

3D structure databases

ProteinModelPortaliP25118.
SMRiP25118.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati43 – 82TNFR-Cys 1Add BLAST40
Repeati83 – 125TNFR-Cys 2Add BLAST43
Repeati126 – 166TNFR-Cys 3Add BLAST41
Repeati167 – 196TNFR-Cys 4Add BLAST30
Domaini356 – 441DeathPROSITE-ProRule annotationAdd BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni339 – 349N-SMase activation domain (NSD)Add BLAST11

Domaini

Both the cytoplasmic membrane-proximal region and the C-terminal region containing the death domain are involved in the interaction with TRPC4AP.

Sequence similaritiesi

Contains 1 death domain.PROSITE-ProRule annotation
Contains 4 TNFR-Cys repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXBX. Eukaryota.
ENOG4111YG2. LUCA.
GeneTreeiENSGT00530000064001.
HOGENOMiHOG000133001.
HOVERGENiHBG058842.
InParanoidiP25118.
KOiK03158.
OMAiCLREAHY.
OrthoDBiEOG091G07LE.
PhylomeDBiP25118.
TreeFamiTF333916.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020419. TNFR_1A.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF00020. TNFR_c6. 3 hits.
[Graphical view]
PRINTSiPR01918. TNFACTORR1A.
SMARTiSM00005. DEATH. 1 hit.
SM00208. TNFR. 4 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 3 hits.
PS50050. TNFR_NGFR_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25118-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLPTVPGLL LSLVLLALLM GIHPSGVTGL VPSLGDREKR DSLCPQGKYV
60 70 80 90 100
HSKNNSICCT KCHKGTYLVS DCPSPGRDTV CRECEKGTFT ASQNYLRQCL
110 120 130 140 150
SCKTCRKEMS QVEISPCQAD KDTVCGCKEN QFQRYLSETH FQCVDCSPCF
160 170 180 190 200
NGTVTIPCKE TQNTVCNCHA GFFLRESECV PCSHCKKNEE CMKLCLPPPL
210 220 230 240 250
ANVTNPQDSG TAVLLPLVIL LGLCLLSFIF ISLMCRYPRW RPEVYSIICR
260 270 280 290 300
DPVPVKEEKA GKPLTPAPSP AFSPTSGFNP TLGFSTPGFS SPVSSTPISP
310 320 330 340 350
IFGPSNWHFM PPVSEVVPTQ GADPLLYESL CSVPAPTSVQ KWEDSAHPQR
360 370 380 390 400
PDNADLAILY AVVDGVPPAR WKEFMRFMGL SEHEIERLEM QNGRCLREAQ
410 420 430 440 450
YSMLEAWRRR TPRHEDTLEV VGLVLSKMNL AGCLENILEA LRNPAPSSTT

RLPR
Length:454
Mass (Da):50,130
Last modified:May 1, 1992 - v1
Checksum:i0710C2E8C3C2B6D9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti394R → G in AAA40465 (PubMed:8381516).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60468 mRNA. Translation: AAA39751.1.
M59377 mRNA. Translation: AAA40464.1.
X59238 mRNA. Translation: CAA41922.1.
X57796 mRNA. Translation: CAA40936.1.
L26349 mRNA. Translation: AAA59361.1.
M76656, M88067, M76655 Genomic DNA. Translation: AAA40465.1.
BC004599 mRNA. Translation: AAH04599.1.
BC052675 mRNA. Translation: AAH52675.1.
CCDSiCCDS20550.1.
PIRiA38634. GQMST1.
RefSeqiNP_035739.2. NM_011609.4.
UniGeneiMm.1258.
Mm.474976.

Genome annotation databases

EnsembliENSMUST00000032491; ENSMUSP00000032491; ENSMUSG00000030341.
GeneIDi21937.
KEGGimmu:21937.
UCSCiuc009dul.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60468 mRNA. Translation: AAA39751.1.
M59377 mRNA. Translation: AAA40464.1.
X59238 mRNA. Translation: CAA41922.1.
X57796 mRNA. Translation: CAA40936.1.
L26349 mRNA. Translation: AAA59361.1.
M76656, M88067, M76655 Genomic DNA. Translation: AAA40465.1.
BC004599 mRNA. Translation: AAH04599.1.
BC052675 mRNA. Translation: AAH52675.1.
CCDSiCCDS20550.1.
PIRiA38634. GQMST1.
RefSeqiNP_035739.2. NM_011609.4.
UniGeneiMm.1258.
Mm.474976.

3D structure databases

ProteinModelPortaliP25118.
SMRiP25118.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204249. 13 interactors.
DIPiDIP-34532N.
IntActiP25118. 23 interactors.
MINTiMINT-2631249.
STRINGi10090.ENSMUSP00000032491.

PTM databases

iPTMnetiP25118.
PhosphoSitePlusiP25118.

Proteomic databases

PaxDbiP25118.
PeptideAtlasiP25118.
PRIDEiP25118.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032491; ENSMUSP00000032491; ENSMUSG00000030341.
GeneIDi21937.
KEGGimmu:21937.
UCSCiuc009dul.2. mouse.

Organism-specific databases

CTDi7132.
MGIiMGI:1314884. Tnfrsf1a.

Phylogenomic databases

eggNOGiENOG410IXBX. Eukaryota.
ENOG4111YG2. LUCA.
GeneTreeiENSGT00530000064001.
HOGENOMiHOG000133001.
HOVERGENiHBG058842.
InParanoidiP25118.
KOiK03158.
OMAiCLREAHY.
OrthoDBiEOG091G07LE.
PhylomeDBiP25118.
TreeFamiTF333916.

Enzyme and pathway databases

ReactomeiR-MMU-5357786. TNFR1-induced proapoptotic signaling.
R-MMU-5357905. Regulation of TNFR1 signaling.
R-MMU-5357956. TNFR1-induced NFkappaB signaling pathway.
R-MMU-5626978. TNFR1-mediated ceramide production.
R-MMU-5669034. TNFs bind their physiological receptors.
R-MMU-75893. TNF signaling.

Miscellaneous databases

PROiP25118.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030341.
ExpressionAtlasiP25118. baseline and differential.
GenevisibleiP25118. MM.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020419. TNFR_1A.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF00020. TNFR_c6. 3 hits.
[Graphical view]
PRINTSiPR01918. TNFACTORR1A.
SMARTiSM00005. DEATH. 1 hit.
SM00208. TNFR. 4 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 3 hits.
PS50050. TNFR_NGFR_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTNR1A_MOUSE
AccessioniPrimary (citable) accession number: P25118
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: November 2, 2016
This is version 166 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.