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P25118

- TNR1A_MOUSE

UniProt

P25118 - TNR1A_MOUSE

Protein

Tumor necrosis factor receptor superfamily member 1A

Gene

Tnfrsf1a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 146 (01 Oct 2014)
      Sequence version 1 (01 May 1992)
      Previous versions | rss
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    Functioni

    Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. tumor necrosis factor-activated receptor activity Source: MGI

    GO - Biological processi

    1. cell surface receptor signaling pathway Source: MGI
    2. cellular response to estradiol stimulus Source: Ensembl
    3. cellular response to mechanical stimulus Source: Ensembl
    4. cytokine-mediated signaling pathway Source: MGI
    5. defense response Source: MGI
    6. defense response to bacterium Source: MGI
    7. inflammatory response Source: MGI
    8. intrinsic apoptotic signaling pathway in response to DNA damage Source: MGI
    9. negative regulation of apoptotic process Source: Ensembl
    10. negative regulation of gene expression Source: Ensembl
    11. negative regulation of inflammatory response Source: Ensembl
    12. negative regulation of interleukin-6 production Source: Ensembl
    13. positive regulation of angiogenesis Source: Ensembl
    14. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
    15. positive regulation of inflammatory response Source: MGI
    16. positive regulation of protein import into nucleus, translocation Source: Ensembl
    17. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    18. positive regulation of tumor necrosis factor production Source: Ensembl
    19. positive regulation of tyrosine phosphorylation of Stat1 protein Source: Ensembl
    20. prostaglandin metabolic process Source: MGI
    21. protein heterooligomerization Source: Ensembl
    22. response to alkaloid Source: Ensembl
    23. response to amino acid Source: Ensembl
    24. response to ethanol Source: Ensembl
    25. response to hypoxia Source: Ensembl
    26. response to lipopolysaccharide Source: Ensembl
    27. tetrapyrrole metabolic process Source: Ensembl

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Apoptosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tumor necrosis factor receptor superfamily member 1A
    Alternative name(s):
    Tumor necrosis factor receptor 1
    Short name:
    TNF-R1
    Tumor necrosis factor receptor type I
    Short name:
    TNF-RI
    Short name:
    TNFR-I
    p55
    p60
    CD_antigen: CD120a
    Gene namesi
    Name:Tnfrsf1a
    Synonyms:Tnfr-1, Tnfr1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:1314884. Tnfrsf1a.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: Ensembl
    2. cell surface Source: BHF-UCL
    3. extracellular space Source: Ensembl
    4. Golgi membrane Source: UniProtKB
    5. integral component of membrane Source: UniProtKB-KW
    6. membrane raft Source: BHF-UCL
    7. nucleus Source: Ensembl
    8. plasma membrane Source: MGI
    9. receptor complex Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 454433Tumor necrosis factor receptor superfamily member 1APRO_0000034545Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi44 ↔ 58PROSITE-ProRule annotation
    Glycosylationi54 – 541N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi59 ↔ 72PROSITE-ProRule annotation
    Disulfide bondi62 ↔ 81PROSITE-ProRule annotation
    Disulfide bondi84 ↔ 99PROSITE-ProRule annotation
    Disulfide bondi102 ↔ 117PROSITE-ProRule annotation
    Disulfide bondi105 ↔ 125PROSITE-ProRule annotation
    Disulfide bondi127 ↔ 143PROSITE-ProRule annotation
    Disulfide bondi146 ↔ 158PROSITE-ProRule annotation
    Disulfide bondi149 ↔ 166PROSITE-ProRule annotation
    Glycosylationi151 – 1511N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi168 ↔ 179PROSITE-ProRule annotation
    Disulfide bondi182 ↔ 195PROSITE-ProRule annotation
    Disulfide bondi185 ↔ 191PROSITE-ProRule annotation
    Glycosylationi202 – 2021N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP25118.
    PRIDEiP25118.

    PTM databases

    PhosphoSiteiP25118.

    Expressioni

    Gene expression databases

    ArrayExpressiP25118.
    BgeeiP25118.
    GenevestigatoriP25118.

    Interactioni

    Subunit structurei

    Binding of TNF to the extracellular domain leads to homotrimerization. The aggregated death domains provide a novel molecular interface that interacts specifically with the death domain of TRADD. Various TRADD-interacting proteins such as TRAFS, RIPK1 and possibly FADD, are recruited to the complex by their association with TRADD. This complex activates at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4, BRE, FEM1B, GRB2, SQSTM1 and TRPC4AP. Interacts with DAB2IP By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Ern1Q9EQY02EBI-518014,EBI-5480799
    Ripk1Q608553EBI-518014,EBI-529119
    Slc39a7Q311253EBI-518014,EBI-644519

    Protein-protein interaction databases

    BioGridi204249. 13 interactions.
    DIPiDIP-34532N.
    IntActiP25118. 23 interactions.
    MINTiMINT-2631249.

    Structurei

    3D structure databases

    ProteinModelPortaliP25118.
    SMRiP25118. Positions 41-197, 357-441.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 212191ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini236 – 454219CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei213 – 23523HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati43 – 8240TNFR-Cys 1Add
    BLAST
    Repeati83 – 12543TNFR-Cys 2Add
    BLAST
    Repeati126 – 16641TNFR-Cys 3Add
    BLAST
    Repeati167 – 19630TNFR-Cys 4Add
    BLAST
    Domaini356 – 44186DeathPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni339 – 34911N-SMase activation domain (NSD)Add
    BLAST

    Domaini

    Both the cytoplasmic membrane-proximal region and the C-terminal region containing the death domain are involved in the interaction with TRPC4AP.

    Sequence similaritiesi

    Contains 1 death domain.PROSITE-ProRule annotation
    Contains 4 TNFR-Cys repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG39168.
    HOGENOMiHOG000133001.
    HOVERGENiHBG058842.
    InParanoidiP25118.
    KOiK03158.
    OMAiCLREAHY.
    PhylomeDBiP25118.
    TreeFamiTF333916.

    Family and domain databases

    Gene3Di1.10.533.10. 1 hit.
    InterProiIPR011029. DEATH-like_dom.
    IPR000488. Death_domain.
    IPR001368. TNFR/NGFR_Cys_rich_reg.
    IPR020419. TNFR_1A.
    [Graphical view]
    PfamiPF00531. Death. 1 hit.
    PF00020. TNFR_c6. 3 hits.
    [Graphical view]
    PRINTSiPR01918. TNFACTORR1A.
    SMARTiSM00005. DEATH. 1 hit.
    SM00208. TNFR. 4 hits.
    [Graphical view]
    SUPFAMiSSF47986. SSF47986. 1 hit.
    PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
    PS00652. TNFR_NGFR_1. 3 hits.
    PS50050. TNFR_NGFR_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P25118-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGLPTVPGLL LSLVLLALLM GIHPSGVTGL VPSLGDREKR DSLCPQGKYV    50
    HSKNNSICCT KCHKGTYLVS DCPSPGRDTV CRECEKGTFT ASQNYLRQCL 100
    SCKTCRKEMS QVEISPCQAD KDTVCGCKEN QFQRYLSETH FQCVDCSPCF 150
    NGTVTIPCKE TQNTVCNCHA GFFLRESECV PCSHCKKNEE CMKLCLPPPL 200
    ANVTNPQDSG TAVLLPLVIL LGLCLLSFIF ISLMCRYPRW RPEVYSIICR 250
    DPVPVKEEKA GKPLTPAPSP AFSPTSGFNP TLGFSTPGFS SPVSSTPISP 300
    IFGPSNWHFM PPVSEVVPTQ GADPLLYESL CSVPAPTSVQ KWEDSAHPQR 350
    PDNADLAILY AVVDGVPPAR WKEFMRFMGL SEHEIERLEM QNGRCLREAQ 400
    YSMLEAWRRR TPRHEDTLEV VGLVLSKMNL AGCLENILEA LRNPAPSSTT 450
    RLPR 454
    Length:454
    Mass (Da):50,130
    Last modified:May 1, 1992 - v1
    Checksum:i0710C2E8C3C2B6D9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti394 – 3941R → G in AAA40465. (PubMed:8381516)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M60468 mRNA. Translation: AAA39751.1.
    M59377 mRNA. Translation: AAA40464.1.
    X59238 mRNA. Translation: CAA41922.1.
    X57796 mRNA. Translation: CAA40936.1.
    L26349 mRNA. Translation: AAA59361.1.
    M76656, M88067, M76655 Genomic DNA. Translation: AAA40465.1.
    BC004599 mRNA. Translation: AAH04599.1.
    BC052675 mRNA. Translation: AAH52675.1.
    CCDSiCCDS20550.1.
    PIRiA38634. GQMST1.
    RefSeqiNP_035739.2. NM_011609.4.
    UniGeneiMm.1258.
    Mm.474976.

    Genome annotation databases

    EnsembliENSMUST00000032491; ENSMUSP00000032491; ENSMUSG00000030341.
    GeneIDi21937.
    KEGGimmu:21937.
    UCSCiuc009dul.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M60468 mRNA. Translation: AAA39751.1 .
    M59377 mRNA. Translation: AAA40464.1 .
    X59238 mRNA. Translation: CAA41922.1 .
    X57796 mRNA. Translation: CAA40936.1 .
    L26349 mRNA. Translation: AAA59361.1 .
    M76656 , M88067 , M76655 Genomic DNA. Translation: AAA40465.1 .
    BC004599 mRNA. Translation: AAH04599.1 .
    BC052675 mRNA. Translation: AAH52675.1 .
    CCDSi CCDS20550.1.
    PIRi A38634. GQMST1.
    RefSeqi NP_035739.2. NM_011609.4.
    UniGenei Mm.1258.
    Mm.474976.

    3D structure databases

    ProteinModelPortali P25118.
    SMRi P25118. Positions 41-197, 357-441.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204249. 13 interactions.
    DIPi DIP-34532N.
    IntActi P25118. 23 interactions.
    MINTi MINT-2631249.

    PTM databases

    PhosphoSitei P25118.

    Proteomic databases

    PaxDbi P25118.
    PRIDEi P25118.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000032491 ; ENSMUSP00000032491 ; ENSMUSG00000030341 .
    GeneIDi 21937.
    KEGGi mmu:21937.
    UCSCi uc009dul.2. mouse.

    Organism-specific databases

    CTDi 7132.
    MGIi MGI:1314884. Tnfrsf1a.

    Phylogenomic databases

    eggNOGi NOG39168.
    HOGENOMi HOG000133001.
    HOVERGENi HBG058842.
    InParanoidi P25118.
    KOi K03158.
    OMAi CLREAHY.
    PhylomeDBi P25118.
    TreeFami TF333916.

    Miscellaneous databases

    NextBioi 301546.
    PROi P25118.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P25118.
    Bgeei P25118.
    Genevestigatori P25118.

    Family and domain databases

    Gene3Di 1.10.533.10. 1 hit.
    InterProi IPR011029. DEATH-like_dom.
    IPR000488. Death_domain.
    IPR001368. TNFR/NGFR_Cys_rich_reg.
    IPR020419. TNFR_1A.
    [Graphical view ]
    Pfami PF00531. Death. 1 hit.
    PF00020. TNFR_c6. 3 hits.
    [Graphical view ]
    PRINTSi PR01918. TNFACTORR1A.
    SMARTi SM00005. DEATH. 1 hit.
    SM00208. TNFR. 4 hits.
    [Graphical view ]
    SUPFAMi SSF47986. SSF47986. 1 hit.
    PROSITEi PS50017. DEATH_DOMAIN. 1 hit.
    PS00652. TNFR_NGFR_1. 3 hits.
    PS50050. TNFR_NGFR_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of cDNAs for two distinct murine tumor necrosis factor receptors demonstrate one receptor is species specific."
      Lewis M., Tartaglia L.A., Lee A., Bennett G.L., Rice G.C., Wong G.H., Chen E.Y., Goeddel D.V.
      Proc. Natl. Acad. Sci. U.S.A. 88:2830-2834(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Molecular cloning and expression of the type 1 and type 2 murine receptors for tumor necrosis factor."
      Goodwin R.G., Anderson D., Jerzy R., Davis T., Brannan C.I., Copeland N.G., Jenkins N.A., Smith C.A.
      Mol. Cell. Biol. 11:3020-3026(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Cloning, expression and cross-linking analysis of the murine p55 tumor necrosis factor receptor."
      Barrett K., Taylor-Fishwick D.A., Cope A.P., Kissonerghis A.M., Gray P.W., Feldmann M., Foxwell B.M.J.
      Eur. J. Immunol. 21:1649-1656(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Molecular cloning and expression of the mouse Tnf receptor type b."
      Rothe J.G., Brockhaus M., Gentz R., Lesslauer W.
      Immunogenetics 34:338-340(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Spleen.
    5. "Nucleotide sequence of the TNF type I receptor from a mouse endothelioma cell line."
      Bebo B.F., Linthicum D.S.
      Immunogenetics 39:450-451(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    6. "Genomic organization and promoter function of the murine tumor necrosis factor receptor beta gene."
      Rothe J., Bluethmann H., Gentz R., Lesslauer W., Steinmetz M.
      Mol. Immunol. 30:165-175(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C3H/He.
      Tissue: Mesenchymal cell.

    Entry informationi

    Entry nameiTNR1A_MOUSE
    AccessioniPrimary (citable) accession number: P25118
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: May 1, 1992
    Last modified: October 1, 2014
    This is version 146 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3