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Protein

Calcitonin receptor

Gene

CALCR

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. The receptor can also couple to an additional signaling pathway via a pertussis toxin-sensitive g protein in isolated osteoclasts and in LLC-PK1 cells.

GO - Molecular functioni

  • calcitonin binding Source: UniProtKB
  • calcitonin receptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Calcitonin receptor
Short name:
CT-R
Gene namesi
Name:CALCR
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 154ExtracellularSequence analysisAdd BLAST125
Transmembranei155 – 174Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini175 – 197CytoplasmicSequence analysisAdd BLAST23
Transmembranei198 – 217Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini218 – 237ExtracellularSequence analysisAdd BLAST20
Transmembranei238 – 260Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini261 – 277CytoplasmicSequence analysisAdd BLAST17
Transmembranei278 – 297Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini298 – 313ExtracellularSequence analysisAdd BLAST16
Transmembranei314 – 337Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini338 – 360CytoplasmicSequence analysisAdd BLAST23
Transmembranei361 – 378Helical; Name=6Sequence analysisAdd BLAST18
Topological domaini379 – 390ExtracellularSequence analysisAdd BLAST12
Transmembranei391 – 412Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini413 – 498CytoplasmicSequence analysisAdd BLAST86

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000001280830 – 498Calcitonin receptorAdd BLAST469

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi56 ↔ 82By similarity
Disulfide bondi73 ↔ 113By similarity
Glycosylationi74N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi96 ↔ 135By similarity
Glycosylationi126N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi131N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP25117
PRIDEiP25117

Interactioni

Subunit structurei

Interacts with GPRASP2.By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000016247

Structurei

3D structure databases

ProteinModelPortaliP25117
SMRiP25117
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi213 – 216Poly-Ile4
Compositional biasi439 – 454Poly-AlaAdd BLAST16

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4564 Eukaryota
ENOG410XRS2 LUCA
GeneTreeiENSGT00900000140884
HOGENOMiHOG000230695
HOVERGENiHBG102129
InParanoidiP25117
KOiK04576

Family and domain databases

CDDicd15274 7tmB1_calcitonin_R, 1 hit
Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR003287 GCPR_2_calcitonin_rcpt_fam
IPR017981 GPCR_2-like
IPR001688 GPCR_2_calcitonin_rcpt
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
PANTHERiPTHR12011:SF84 PTHR12011:SF84, 1 hit
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF02793 HRM, 1 hit
PRINTSiPR00361 CALCITONINR
PR01350 CTRFAMILY
PR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00008 HormR, 1 hit
SUPFAMiSSF111418 SSF111418, 1 hit
PROSITEiView protein in PROSITE
PS00649 G_PROTEIN_RECEP_F2_1, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: P25117-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRFTLTRWCL TLFIFLNRPL PVLPDSADGA HTPTLEPEPF LYILGKQRML
60 70 80 90 100
EAQHRCYDRM QKLPPYQGEG LYCNRTWDGW SCWDDTPAGV LAEQYCPDYF
110 120 130 140 150
PDFDAAEKVT KYCGEDGDWY RHPESNISWS NYTMCNAFTP DKLQNAYILY
160 170 180 190 200
YLAIVGHSLS ILTLLISLGI FMFLRYFNLL APFNALLYPT RSISCQRVTL
210 220 230 240 250
HKNMFLTYVL NSIIIIVHLV VIVPNGELVK RDPPICKVLH FFHQYMMSCN
260 270 280 290 300
YFWMLCEGVY LHTLIVVSVF AEGQRLWWYH VLGWGFPLIP TTAHAITRAV
310 320 330 340 350
LFNDNCWLSV DTNLLYIIHG PVMAALVVNF FFLLNILRVL VKKLKESQEA
360 370 380 390 400
ESHMYLKAVR ATLILVPLLG VQFVVLPWRP STPLLGKIYD YVVHSLIHFQ
410 420 430 440 450
GFFVAIIYCF CNHEVQGALK RQWNQYQAQR WAGRRSTRAA NAAAATAAAA
460 470 480 490
AALAETVEIP VYICHQEPRE EPAGEEPVVE VEGVEVIAME VLEQETSA
Length:498
Mass (Da):57,155
Last modified:October 1, 1996 - v2
Checksum:i618CE50EC4B5E7C3
GO
Isoform Short (identifier: P25117-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     176-191: Missing.

Show »
Length:482
Mass (Da):55,259
Checksum:i03F0CE0B3B6BFF5C
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001993176 – 191Missing in isoform Short. 1 PublicationAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74420 mRNA Translation: AAA31023.1
Z31356 Genomic DNA Translation: CAA83233.1
Z31356 Genomic DNA Translation: CAA83232.1
PIRiA39285
I47130
RefSeqiNP_999519.1, NM_214354.2 [P25117-2]
UniGeneiSsc.60684

Genome annotation databases

EnsembliENSSSCT00000016693; ENSSSCP00000016247; ENSSSCG00000015320 [P25117-2]
ENSSSCT00000064940; ENSSSCP00000057815; ENSSSCG00000015320 [P25117-2]
GeneIDi397638
KEGGissc:397638

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCALCR_PIG
AccessioniPrimary (citable) accession number: P25117
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: October 1, 1996
Last modified: April 25, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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