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Protein

Calcitonin receptor

Gene

CALCR

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. The receptor can also couple to an additional signaling pathway via a pertussis toxin-sensitive g protein in isolated osteoclasts and in LLC-PK1 cells.

GO - Molecular functioni

  • calcitonin binding Source: UniProtKB
  • calcitonin receptor activity Source: UniProtKB

GO - Biological processi

  • activation of phospholipase C activity Source: UniProtKB
  • cell surface receptor signaling pathway Source: InterPro
  • positive regulation of adenylate cyclase activity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Calcitonin receptor
Short name:
CT-R
Gene namesi
Name:CALCR
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 154125ExtracellularSequence analysisAdd
BLAST
Transmembranei155 – 17420Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini175 – 19723CytoplasmicSequence analysisAdd
BLAST
Transmembranei198 – 21720Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini218 – 23720ExtracellularSequence analysisAdd
BLAST
Transmembranei238 – 26023Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini261 – 27717CytoplasmicSequence analysisAdd
BLAST
Transmembranei278 – 29720Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini298 – 31316ExtracellularSequence analysisAdd
BLAST
Transmembranei314 – 33724Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini338 – 36023CytoplasmicSequence analysisAdd
BLAST
Transmembranei361 – 37818Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini379 – 39012ExtracellularSequence analysisAdd
BLAST
Transmembranei391 – 41222Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini413 – 49886CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence analysisAdd
BLAST
Chaini30 – 498469Calcitonin receptorPRO_0000012808Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi56 ↔ 82By similarity
Disulfide bondi73 ↔ 113By similarity
Glycosylationi74 – 741N-linked (GlcNAc...)Sequence analysis
Disulfide bondi96 ↔ 135By similarity
Glycosylationi126 – 1261N-linked (GlcNAc...)Sequence analysis
Glycosylationi131 – 1311N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP25117.

Interactioni

Subunit structurei

Interacts with GPRASP2.By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000016247.

Structurei

3D structure databases

ProteinModelPortaliP25117.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi213 – 2164Poly-Ile
Compositional biasi439 – 45416Poly-AlaAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
HOGENOMiHOG000230695.
HOVERGENiHBG102129.
InParanoidiP25117.
KOiK04576.

Family and domain databases

InterProiIPR003287. GCPR_2_calcitonin_rcpt_fam.
IPR017981. GPCR_2-like.
IPR001688. GPCR_2_calcitonin_rcpt.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00361. CALCITONINR.
PR01350. CTRFAMILY.
PR00249. GPCRSECRETIN.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: P25117-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRFTLTRWCL TLFIFLNRPL PVLPDSADGA HTPTLEPEPF LYILGKQRML
60 70 80 90 100
EAQHRCYDRM QKLPPYQGEG LYCNRTWDGW SCWDDTPAGV LAEQYCPDYF
110 120 130 140 150
PDFDAAEKVT KYCGEDGDWY RHPESNISWS NYTMCNAFTP DKLQNAYILY
160 170 180 190 200
YLAIVGHSLS ILTLLISLGI FMFLRYFNLL APFNALLYPT RSISCQRVTL
210 220 230 240 250
HKNMFLTYVL NSIIIIVHLV VIVPNGELVK RDPPICKVLH FFHQYMMSCN
260 270 280 290 300
YFWMLCEGVY LHTLIVVSVF AEGQRLWWYH VLGWGFPLIP TTAHAITRAV
310 320 330 340 350
LFNDNCWLSV DTNLLYIIHG PVMAALVVNF FFLLNILRVL VKKLKESQEA
360 370 380 390 400
ESHMYLKAVR ATLILVPLLG VQFVVLPWRP STPLLGKIYD YVVHSLIHFQ
410 420 430 440 450
GFFVAIIYCF CNHEVQGALK RQWNQYQAQR WAGRRSTRAA NAAAATAAAA
460 470 480 490
AALAETVEIP VYICHQEPRE EPAGEEPVVE VEGVEVIAME VLEQETSA
Length:498
Mass (Da):57,155
Last modified:October 1, 1996 - v2
Checksum:i618CE50EC4B5E7C3
GO
Isoform Short (identifier: P25117-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     176-191: Missing.

Show »
Length:482
Mass (Da):55,259
Checksum:i03F0CE0B3B6BFF5C
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei176 – 19116Missing in isoform Short. 1 PublicationVSP_001993Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74420 mRNA. Translation: AAA31023.1.
Z31356 Genomic DNA. Translation: CAA83233.1.
Z31356 Genomic DNA. Translation: CAA83232.1.
PIRiA39285.
I47130.
RefSeqiNP_999519.1. NM_214354.2. [P25117-2]
UniGeneiSsc.60684.

Genome annotation databases

GeneIDi397638.
KEGGissc:397638.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74420 mRNA. Translation: AAA31023.1.
Z31356 Genomic DNA. Translation: CAA83233.1.
Z31356 Genomic DNA. Translation: CAA83232.1.
PIRiA39285.
I47130.
RefSeqiNP_999519.1. NM_214354.2. [P25117-2]
UniGeneiSsc.60684.

3D structure databases

ProteinModelPortaliP25117.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000016247.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiP25117.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi397638.
KEGGissc:397638.

Organism-specific databases

CTDi799.

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
HOGENOMiHOG000230695.
HOVERGENiHBG102129.
InParanoidiP25117.
KOiK04576.

Family and domain databases

InterProiIPR003287. GCPR_2_calcitonin_rcpt_fam.
IPR017981. GPCR_2-like.
IPR001688. GPCR_2_calcitonin_rcpt.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00361. CALCITONINR.
PR01350. CTRFAMILY.
PR00249. GPCRSECRETIN.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
  2. "Isolation, characterization, and chromosomal localization of the porcine calcitonin receptor gene. Identification of two variants of the receptor generated by alternative splicing."
    Zolnierowicz S.S., Cron P., Solinas-Toldo S., Fries R., Lin H.Y., Hemmings B.A.
    J. Biol. Chem. 269:19530-19538(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS LONG AND SHORT).
    Tissue: Kidney.

Entry informationi

Entry nameiCALCR_PIG
AccessioniPrimary (citable) accession number: P25117
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: October 1, 1996
Last modified: December 9, 2015
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.