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Protein

D(1B) dopamine receptor

Gene

Drd5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

  • dopamine binding Source: GO_Central
  • dopamine neurotransmitter receptor activity Source: MGI
  • dopamine neurotransmitter receptor activity, coupled via Gs Source: RGD
  • drug binding Source: RGD
  • G-protein alpha-subunit binding Source: RGD

GO - Biological processi

  • adenylate cyclase-activating dopamine receptor signaling pathway Source: RGD
  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: MGI
  • dopamine receptor signaling pathway Source: RGD
  • negative regulation of cell migration Source: RGD
  • negative regulation of protein kinase activity Source: RGD
  • phospholipase C-activating dopamine receptor signaling pathway Source: GO_Central
  • positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway Source: InterPro
  • positive regulation of cAMP biosynthetic process Source: RGD
  • regulation of long-term neuronal synaptic plasticity Source: RGD
  • synaptic transmission, dopaminergic Source: RGD
  • visual learning Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
D(1B) dopamine receptor
Alternative name(s):
D(5) dopamine receptor
Dopamine D5 receptor
Gene namesi
Name:Drd5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2523. Drd5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38ExtracellularSequence analysisAdd BLAST38
Transmembranei39 – 64Helical; Name=1Sequence analysisAdd BLAST26
Topological domaini65 – 75CytoplasmicSequence analysisAdd BLAST11
Transmembranei76 – 102Helical; Name=2Sequence analysisAdd BLAST27
Topological domaini103 – 111ExtracellularSequence analysis9
Transmembranei112 – 134Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini135 – 153CytoplasmicSequence analysisAdd BLAST19
Transmembranei154 – 179Helical; Name=4Sequence analysisAdd BLAST26
Topological domaini180 – 215ExtracellularSequence analysisAdd BLAST36
Transmembranei216 – 240Helical; Name=5Sequence analysisAdd BLAST25
Topological domaini241 – 289CytoplasmicSequence analysisAdd BLAST49
Transmembranei290 – 317Helical; Name=6Sequence analysisAdd BLAST28
Topological domaini318 – 335ExtracellularSequence analysisAdd BLAST18
Transmembranei336 – 357Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini358 – 475CytoplasmicSequence analysisAdd BLAST118

GO - Cellular componenti

  • axon Source: RGD
  • brush border membrane Source: RGD
  • dendrite Source: RGD
  • dendritic spine Source: RGD
  • integral component of plasma membrane Source: InterPro
  • neuronal cell body Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2281.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000694081 – 475D(1B) dopamine receptorAdd BLAST475

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi7N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi111 ↔ 211PROSITE-ProRule annotation
Lipidationi370S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP25115.
PRIDEiP25115.

Expressioni

Tissue specificityi

Brain, in the lateral mammillary nuclei, the anterior pretectal nuclei, and several layers of the hippocampus.

Interactioni

GO - Molecular functioni

  • G-protein alpha-subunit binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007074.

Chemistry databases

BindingDBiP25115.

Structurei

3D structure databases

ProteinModelPortaliP25115.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP25115.
KOiK05840.
PhylomeDBiP25115.

Family and domain databases

InterProiIPR000497. Dopamine_D5_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00566. DOPAMINED1BR.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25115-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPPGRNRTA QPARLGLQRQ LAQVDAPAGS ATPLGPAQVV TAGLLTLLIV
60 70 80 90 100
WTLLGNVLVC AAIVRSRHLR AKMTNIFIVS LAVSDLFVAL LVMPWKAVAE
110 120 130 140 150
VAGYWPFGTF CDIWVAFDIM CSTASILNLC IISVDRYWAI SRPFRYERKM
160 170 180 190 200
TQRVALVMVG LAWTLSILIS FIPVQLNWHR DKAGSQGQEG LLSNGTPWEE
210 220 230 240 250
GWELEGRTEN CDSSLNRTYA ISSSLISFYI PVAIMIVTYT RIYRIAQVQI
260 270 280 290 300
RRISSLERAA EHAQSCRSRG AYEPDPSLRA SIKKETKVFK TLSMIMGVFV
310 320 330 340 350
CCWLPFFILN CMVPFCSSGD AEGPKTGFPC VSETTFDIFV WFGWANSSLN
360 370 380 390 400
PIIYAFNADF RKVFAQLLGC SHFCFRTPVQ TVNISNELIS YNQDTVFHKE
410 420 430 440 450
IATAYVHMIP NAVSSGDREV GEEEEEGPFD HMSQISPTTP DGDLAAESVW
460 470
ELDCEEEVSL GKISPLTPNC FDKTA
Length:475
Mass (Da):52,831
Last modified:May 1, 1992 - v1
Checksum:i4B0C004539540D82
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M69118 Genomic DNA. Translation: AAA41072.1.
PIRiA41271.
RefSeqiNP_036900.1. NM_012768.1.
UniGeneiRn.138110.

Genome annotation databases

GeneIDi25195.
KEGGirno:25195.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M69118 Genomic DNA. Translation: AAA41072.1.
PIRiA41271.
RefSeqiNP_036900.1. NM_012768.1.
UniGeneiRn.138110.

3D structure databases

ProteinModelPortaliP25115.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007074.

Chemistry databases

BindingDBiP25115.
ChEMBLiCHEMBL2281.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiP25115.
PRIDEiP25115.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25195.
KEGGirno:25195.

Organism-specific databases

CTDi1816.
RGDi2523. Drd5.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP25115.
KOiK05840.
PhylomeDBiP25115.

Miscellaneous databases

PROiP25115.

Family and domain databases

InterProiIPR000497. Dopamine_D5_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00566. DOPAMINED1BR.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDRD5_RAT
AccessioniPrimary (citable) accession number: P25115
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: October 5, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.