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Protein

D(1B) dopamine receptor

Gene

Drd5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

  • dopamine neurotransmitter receptor activity Source: MGI
  • dopamine neurotransmitter receptor activity, coupled via Gs Source: RGD
  • drug binding Source: RGD

GO - Biological processi

  • adenylate cyclase-activating dopamine receptor signaling pathway Source: RGD
  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: MGI
  • dopamine receptor signaling pathway Source: RGD
  • negative regulation of cell migration Source: RGD
  • negative regulation of protein kinase activity Source: RGD
  • phospholipase C-activating dopamine receptor signaling pathway Source: GO_Central
  • regulation of long-term neuronal synaptic plasticity Source: RGD
  • synaptic transmission, dopaminergic Source: RGD
  • visual learning Source: RGD

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
D(1B) dopamine receptor
Alternative name(s):
D(5) dopamine receptor
Dopamine D5 receptor
Gene namesi
Name:Drd5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi2523 Drd5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38ExtracellularSequence analysisAdd BLAST38
Transmembranei39 – 64Helical; Name=1Sequence analysisAdd BLAST26
Topological domaini65 – 75CytoplasmicSequence analysisAdd BLAST11
Transmembranei76 – 102Helical; Name=2Sequence analysisAdd BLAST27
Topological domaini103 – 111ExtracellularSequence analysis9
Transmembranei112 – 134Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini135 – 153CytoplasmicSequence analysisAdd BLAST19
Transmembranei154 – 179Helical; Name=4Sequence analysisAdd BLAST26
Topological domaini180 – 215ExtracellularSequence analysisAdd BLAST36
Transmembranei216 – 240Helical; Name=5Sequence analysisAdd BLAST25
Topological domaini241 – 289CytoplasmicSequence analysisAdd BLAST49
Transmembranei290 – 317Helical; Name=6Sequence analysisAdd BLAST28
Topological domaini318 – 335ExtracellularSequence analysisAdd BLAST18
Transmembranei336 – 357Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini358 – 475CytoplasmicSequence analysisAdd BLAST118

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2281

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000694081 – 475D(1B) dopamine receptorAdd BLAST475

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi7N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi111 ↔ 211PROSITE-ProRule annotation
Lipidationi370S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP25115
PRIDEiP25115

PTM databases

CarbonylDBiP25115

Expressioni

Tissue specificityi

Brain, in the lateral mammillary nuclei, the anterior pretectal nuclei, and several layers of the hippocampus.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007074

Chemistry databases

BindingDBiP25115

Structurei

3D structure databases

ProteinModelPortaliP25115
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
HOGENOMiHOG000239242
HOVERGENiHBG106962
InParanoidiP25115
KOiK05840
PhylomeDBiP25115

Family and domain databases

InterProiView protein in InterPro
IPR000497 Dopamine_D5_rcpt
IPR000929 Dopamine_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR43893:SF8 PTHR43893:SF8, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00566 DOPAMINED1BR
PR00242 DOPAMINER
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P25115-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPPGRNRTA QPARLGLQRQ LAQVDAPAGS ATPLGPAQVV TAGLLTLLIV
60 70 80 90 100
WTLLGNVLVC AAIVRSRHLR AKMTNIFIVS LAVSDLFVAL LVMPWKAVAE
110 120 130 140 150
VAGYWPFGTF CDIWVAFDIM CSTASILNLC IISVDRYWAI SRPFRYERKM
160 170 180 190 200
TQRVALVMVG LAWTLSILIS FIPVQLNWHR DKAGSQGQEG LLSNGTPWEE
210 220 230 240 250
GWELEGRTEN CDSSLNRTYA ISSSLISFYI PVAIMIVTYT RIYRIAQVQI
260 270 280 290 300
RRISSLERAA EHAQSCRSRG AYEPDPSLRA SIKKETKVFK TLSMIMGVFV
310 320 330 340 350
CCWLPFFILN CMVPFCSSGD AEGPKTGFPC VSETTFDIFV WFGWANSSLN
360 370 380 390 400
PIIYAFNADF RKVFAQLLGC SHFCFRTPVQ TVNISNELIS YNQDTVFHKE
410 420 430 440 450
IATAYVHMIP NAVSSGDREV GEEEEEGPFD HMSQISPTTP DGDLAAESVW
460 470
ELDCEEEVSL GKISPLTPNC FDKTA
Length:475
Mass (Da):52,831
Last modified:May 1, 1992 - v1
Checksum:i4B0C004539540D82
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M69118 Genomic DNA Translation: AAA41072.1
PIRiA41271
RefSeqiNP_036900.1, NM_012768.1
UniGeneiRn.138110

Genome annotation databases

GeneIDi25195
KEGGirno:25195

Entry informationi

Entry nameiDRD5_RAT
AccessioniPrimary (citable) accession number: P25115
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: May 23, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

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