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P25115

- DRD5_RAT

UniProt

P25115 - DRD5_RAT

Protein

D(1B) dopamine receptor

Gene

Drd5

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 May 1992)
      Previous versions | rss
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    Functioni

    Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.

    GO - Molecular functioni

    1. dopamine neurotransmitter receptor activity Source: MGI
    2. dopamine neurotransmitter receptor activity, coupled via Gs Source: RGD
    3. drug binding Source: RGD
    4. G-protein alpha-subunit binding Source: RGD
    5. protein binding Source: RGD

    GO - Biological processi

    1. adenylate cyclase-activating dopamine receptor signaling pathway Source: RGD
    2. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: MGI
    3. dopamine receptor signaling pathway Source: RGD
    4. negative regulation of cell migration Source: RGD
    5. negative regulation of protein kinase activity Source: RGD
    6. positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway Source: InterPro
    7. positive regulation of cAMP biosynthetic process Source: RGD
    8. regulation of long-term neuronal synaptic plasticity Source: RGD
    9. synaptic transmission, dopaminergic Source: RGD
    10. visual learning Source: RGD

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    D(1B) dopamine receptor
    Alternative name(s):
    D(5) dopamine receptor
    Dopamine D5 receptor
    Gene namesi
    Name:Drd5
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi2523. Drd5.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: RGD
    2. brush border membrane Source: RGD
    3. dendrite Source: RGD
    4. dendritic spine Source: RGD
    5. integral component of plasma membrane Source: InterPro
    6. neuronal cell body Source: RGD

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 475475D(1B) dopamine receptorPRO_0000069408Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi7 – 71N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi111 ↔ 211PROSITE-ProRule annotation
    Lipidationi370 – 3701S-palmitoyl cysteineBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PRIDEiP25115.

    Expressioni

    Tissue specificityi

    Brain, in the lateral mammillary nuclei, the anterior pretectal nuclei, and several layers of the hippocampus.

    Gene expression databases

    GenevestigatoriP25115.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000007074.

    Structurei

    3D structure databases

    ProteinModelPortaliP25115.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3838ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini65 – 7511CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini103 – 1119ExtracellularSequence Analysis
    Topological domaini135 – 15319CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini180 – 21536ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini241 – 28949CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini318 – 33518ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini358 – 475118CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei39 – 6426Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei76 – 10227Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei112 – 13423Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei154 – 17926Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei216 – 24025Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei290 – 31728Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei336 – 35722Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG262978.
    HOGENOMiHOG000239242.
    HOVERGENiHBG106962.
    InParanoidiP25115.
    KOiK05840.
    PhylomeDBiP25115.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000497. Dopamine_D5_rcpt.
    IPR000929. Dopamine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00566. DOPAMINED1BR.
    PR00242. DOPAMINER.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P25115-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLPPGRNRTA QPARLGLQRQ LAQVDAPAGS ATPLGPAQVV TAGLLTLLIV    50
    WTLLGNVLVC AAIVRSRHLR AKMTNIFIVS LAVSDLFVAL LVMPWKAVAE 100
    VAGYWPFGTF CDIWVAFDIM CSTASILNLC IISVDRYWAI SRPFRYERKM 150
    TQRVALVMVG LAWTLSILIS FIPVQLNWHR DKAGSQGQEG LLSNGTPWEE 200
    GWELEGRTEN CDSSLNRTYA ISSSLISFYI PVAIMIVTYT RIYRIAQVQI 250
    RRISSLERAA EHAQSCRSRG AYEPDPSLRA SIKKETKVFK TLSMIMGVFV 300
    CCWLPFFILN CMVPFCSSGD AEGPKTGFPC VSETTFDIFV WFGWANSSLN 350
    PIIYAFNADF RKVFAQLLGC SHFCFRTPVQ TVNISNELIS YNQDTVFHKE 400
    IATAYVHMIP NAVSSGDREV GEEEEEGPFD HMSQISPTTP DGDLAAESVW 450
    ELDCEEEVSL GKISPLTPNC FDKTA 475
    Length:475
    Mass (Da):52,831
    Last modified:May 1, 1992 - v1
    Checksum:i4B0C004539540D82
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M69118 Genomic DNA. Translation: AAA41072.1.
    PIRiA41271.
    RefSeqiNP_036900.1. NM_012768.1.
    UniGeneiRn.138110.

    Genome annotation databases

    GeneIDi25195.
    KEGGirno:25195.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M69118 Genomic DNA. Translation: AAA41072.1 .
    PIRi A41271.
    RefSeqi NP_036900.1. NM_012768.1.
    UniGenei Rn.138110.

    3D structure databases

    ProteinModelPortali P25115.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000007074.

    Chemistry

    BindingDBi P25115.
    ChEMBLi CHEMBL2281.
    GuidetoPHARMACOLOGYi 218.

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PRIDEi P25115.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 25195.
    KEGGi rno:25195.

    Organism-specific databases

    CTDi 1816.
    RGDi 2523. Drd5.

    Phylogenomic databases

    eggNOGi NOG262978.
    HOGENOMi HOG000239242.
    HOVERGENi HBG106962.
    InParanoidi P25115.
    KOi K05840.
    PhylomeDBi P25115.

    Miscellaneous databases

    NextBioi 605705.
    PROi P25115.

    Gene expression databases

    Genevestigatori P25115.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000497. Dopamine_D5_rcpt.
    IPR000929. Dopamine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00566. DOPAMINED1BR.
    PR00242. DOPAMINER.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, molecular characterization, and chromosomal assignment of a gene encoding a second D1 dopamine receptor subtype: differential expression pattern in rat brain compared with the D1A receptor."
      Tiberi M., Jarvie K.R., Silvia C., Falardeau P., Gingrich J.A., Godinot N., Bertrand L., Yang-Feng T.L., Fremeau R.T. Jr., Caron M.G.
      Proc. Natl. Acad. Sci. U.S.A. 88:7491-7495(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Sprague-Dawley.

    Entry informationi

    Entry nameiDRD5_RAT
    AccessioniPrimary (citable) accession number: P25115
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: May 1, 1992
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3