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P25115 (DRD5_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D(1B) dopamine receptor
Alternative name(s):
D(5) dopamine receptor
Dopamine D5 receptor
Gene names
Name:Drd5
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length475 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Brain, in the lateral mammillary nuclei, the anterior pretectal nuclei, and several layers of the hippocampus.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
Lipoprotein
Palmitate
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processadenylate cyclase-activating dopamine receptor signaling pathway

Inferred from mutant phenotype PubMed 15328036. Source: RGD

negative regulation of cell migration

Inferred from mutant phenotype PubMed 12688394. Source: RGD

negative regulation of protein kinase activity

Inferred from mutant phenotype PubMed 12688394. Source: RGD

positive regulation of cAMP biosynthetic process

Inferred from mutant phenotype PubMed 12688394. Source: RGD

regulation of long-term neuronal synaptic plasticity

Inferred from mutant phenotype PubMed 16855100. Source: RGD

synaptic transmission, dopaminergic

Inferred from mutant phenotype PubMed 16855100. Source: RGD

visual learning

Inferred from mutant phenotype PubMed 16855100PubMed 17142305. Source: RGD

   Cellular_componentaxon

Inferred from direct assay PubMed 16175554. Source: RGD

brush border membrane

Inferred from direct assay PubMed 12623966. Source: RGD

dendritic spine

Inferred from direct assay PubMed 21749912. Source: RGD

integral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

neuronal cell body

Inferred from direct assay PubMed 21749912. Source: RGD

   Molecular_functiondopamine neurotransmitter receptor activity, coupled via Gs

Inferred from mutant phenotype PubMed 16855100. Source: RGD

drug binding

Inferred from direct assay PubMed 16855100. Source: RGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 475475D(1B) dopamine receptor
PRO_0000069408

Regions

Topological domain1 – 3838Extracellular Potential
Transmembrane39 – 6426Helical; Name=1; Potential
Topological domain65 – 7511Cytoplasmic Potential
Transmembrane76 – 10227Helical; Name=2; Potential
Topological domain103 – 1119Extracellular Potential
Transmembrane112 – 13423Helical; Name=3; Potential
Topological domain135 – 15319Cytoplasmic Potential
Transmembrane154 – 17926Helical; Name=4; Potential
Topological domain180 – 21536Extracellular Potential
Transmembrane216 – 24025Helical; Name=5; Potential
Topological domain241 – 28949Cytoplasmic Potential
Transmembrane290 – 31728Helical; Name=6; Potential
Topological domain318 – 33518Extracellular Potential
Transmembrane336 – 35722Helical; Name=7; Potential
Topological domain358 – 475118Cytoplasmic Potential

Amino acid modifications

Lipidation3701S-palmitoyl cysteine By similarity
Glycosylation71N-linked (GlcNAc...) Potential
Disulfide bond111 ↔ 211 By similarity

Sequences

Sequence LengthMass (Da)Tools
P25115 [UniParc].

Last modified May 1, 1992. Version 1.
Checksum: 4B0C004539540D82

FASTA47552,831
        10         20         30         40         50         60 
MLPPGRNRTA QPARLGLQRQ LAQVDAPAGS ATPLGPAQVV TAGLLTLLIV WTLLGNVLVC 

        70         80         90        100        110        120 
AAIVRSRHLR AKMTNIFIVS LAVSDLFVAL LVMPWKAVAE VAGYWPFGTF CDIWVAFDIM 

       130        140        150        160        170        180 
CSTASILNLC IISVDRYWAI SRPFRYERKM TQRVALVMVG LAWTLSILIS FIPVQLNWHR 

       190        200        210        220        230        240 
DKAGSQGQEG LLSNGTPWEE GWELEGRTEN CDSSLNRTYA ISSSLISFYI PVAIMIVTYT 

       250        260        270        280        290        300 
RIYRIAQVQI RRISSLERAA EHAQSCRSRG AYEPDPSLRA SIKKETKVFK TLSMIMGVFV 

       310        320        330        340        350        360 
CCWLPFFILN CMVPFCSSGD AEGPKTGFPC VSETTFDIFV WFGWANSSLN PIIYAFNADF 

       370        380        390        400        410        420 
RKVFAQLLGC SHFCFRTPVQ TVNISNELIS YNQDTVFHKE IATAYVHMIP NAVSSGDREV 

       430        440        450        460        470 
GEEEEEGPFD HMSQISPTTP DGDLAAESVW ELDCEEEVSL GKISPLTPNC FDKTA

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References

[1]"Cloning, molecular characterization, and chromosomal assignment of a gene encoding a second D1 dopamine receptor subtype: differential expression pattern in rat brain compared with the D1A receptor."
Tiberi M., Jarvie K.R., Silvia C., Falardeau P., Gingrich J.A., Godinot N., Bertrand L., Yang-Feng T.L., Fremeau R.T. Jr., Caron M.G.
Proc. Natl. Acad. Sci. U.S.A. 88:7491-7495(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Sprague-Dawley.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M69118 Genomic DNA. Translation: AAA41072.1.
IPIIPI00215188.
PIRA41271.
RefSeqNP_036900.1. NM_012768.1.
UniGeneRn.138110.

3D structure databases

ProteinModelPortalP25115.
ModBaseSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000007074.

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PRIDEP25115.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID25195.
KEGGrno:25195.

Organism-specific databases

CTD1816.
RGD2523. Drd5.

Phylogenomic databases

eggNOGNOG262978.
HOGENOMHOG000239242.
HOVERGENHBG106962.
InParanoidP25115.
KOK05840.
OrthoDBEOG4PVNZH.

Gene expression databases

GenevestigatorP25115.
GermOnlineENSRNOG00000005338. Rattus norvegicus.

Family and domain databases

InterProIPR000497. Dopa_1B_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00566. DOPAMINED1BR.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

BindingDBP25115.
ChEMBLCHEMBL2281.
NextBio605705.

Entry information

Entry nameDRD5_RAT
AccessionPrimary (citable) accession number: P25115
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: April 3, 2013
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

SIMILARITY comments

Index of protein domains and families

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