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Protein

D(1B) dopamine receptor

Gene

Drd5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

  1. dopamine neurotransmitter receptor activity Source: MGI
  2. dopamine neurotransmitter receptor activity, coupled via Gs Source: RGD
  3. drug binding Source: RGD
  4. G-protein alpha-subunit binding Source: RGD

GO - Biological processi

  1. adenylate cyclase-activating dopamine receptor signaling pathway Source: RGD
  2. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: MGI
  3. dopamine receptor signaling pathway Source: RGD
  4. negative regulation of cell migration Source: RGD
  5. negative regulation of protein kinase activity Source: RGD
  6. positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway Source: InterPro
  7. positive regulation of cAMP biosynthetic process Source: RGD
  8. regulation of long-term neuronal synaptic plasticity Source: RGD
  9. synaptic transmission, dopaminergic Source: RGD
  10. visual learning Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
D(1B) dopamine receptor
Alternative name(s):
D(5) dopamine receptor
Dopamine D5 receptor
Gene namesi
Name:Drd5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2523. Drd5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3838ExtracellularSequence AnalysisAdd
BLAST
Transmembranei39 – 6426Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini65 – 7511CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei76 – 10227Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini103 – 1119ExtracellularSequence Analysis
Transmembranei112 – 13423Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini135 – 15319CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei154 – 17926Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini180 – 21536ExtracellularSequence AnalysisAdd
BLAST
Transmembranei216 – 24025Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini241 – 28949CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei290 – 31728Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini318 – 33518ExtracellularSequence AnalysisAdd
BLAST
Transmembranei336 – 35722Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini358 – 475118CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. axon Source: RGD
  2. brush border membrane Source: RGD
  3. dendrite Source: RGD
  4. dendritic spine Source: RGD
  5. integral component of plasma membrane Source: InterPro
  6. neuronal cell body Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 475475D(1B) dopamine receptorPRO_0000069408Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi7 – 71N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi111 ↔ 211PROSITE-ProRule annotation
Lipidationi370 – 3701S-palmitoyl cysteineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PRIDEiP25115.

Expressioni

Tissue specificityi

Brain, in the lateral mammillary nuclei, the anterior pretectal nuclei, and several layers of the hippocampus.

Gene expression databases

GenevestigatoriP25115.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007074.

Structurei

3D structure databases

ProteinModelPortaliP25115.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG262978.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP25115.
KOiK05840.
PhylomeDBiP25115.

Family and domain databases

InterProiIPR000497. Dopamine_D5_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00566. DOPAMINED1BR.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25115-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPPGRNRTA QPARLGLQRQ LAQVDAPAGS ATPLGPAQVV TAGLLTLLIV
60 70 80 90 100
WTLLGNVLVC AAIVRSRHLR AKMTNIFIVS LAVSDLFVAL LVMPWKAVAE
110 120 130 140 150
VAGYWPFGTF CDIWVAFDIM CSTASILNLC IISVDRYWAI SRPFRYERKM
160 170 180 190 200
TQRVALVMVG LAWTLSILIS FIPVQLNWHR DKAGSQGQEG LLSNGTPWEE
210 220 230 240 250
GWELEGRTEN CDSSLNRTYA ISSSLISFYI PVAIMIVTYT RIYRIAQVQI
260 270 280 290 300
RRISSLERAA EHAQSCRSRG AYEPDPSLRA SIKKETKVFK TLSMIMGVFV
310 320 330 340 350
CCWLPFFILN CMVPFCSSGD AEGPKTGFPC VSETTFDIFV WFGWANSSLN
360 370 380 390 400
PIIYAFNADF RKVFAQLLGC SHFCFRTPVQ TVNISNELIS YNQDTVFHKE
410 420 430 440 450
IATAYVHMIP NAVSSGDREV GEEEEEGPFD HMSQISPTTP DGDLAAESVW
460 470
ELDCEEEVSL GKISPLTPNC FDKTA
Length:475
Mass (Da):52,831
Last modified:May 1, 1992 - v1
Checksum:i4B0C004539540D82
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M69118 Genomic DNA. Translation: AAA41072.1.
PIRiA41271.
RefSeqiNP_036900.1. NM_012768.1.
UniGeneiRn.138110.

Genome annotation databases

GeneIDi25195.
KEGGirno:25195.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M69118 Genomic DNA. Translation: AAA41072.1.
PIRiA41271.
RefSeqiNP_036900.1. NM_012768.1.
UniGeneiRn.138110.

3D structure databases

ProteinModelPortaliP25115.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007074.

Chemistry

BindingDBiP25115.
ChEMBLiCHEMBL2093868.
GuidetoPHARMACOLOGYi218.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PRIDEiP25115.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25195.
KEGGirno:25195.

Organism-specific databases

CTDi1816.
RGDi2523. Drd5.

Phylogenomic databases

eggNOGiNOG262978.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP25115.
KOiK05840.
PhylomeDBiP25115.

Miscellaneous databases

NextBioi605705.
PROiP25115.

Gene expression databases

GenevestigatoriP25115.

Family and domain databases

InterProiIPR000497. Dopamine_D5_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00566. DOPAMINED1BR.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning, molecular characterization, and chromosomal assignment of a gene encoding a second D1 dopamine receptor subtype: differential expression pattern in rat brain compared with the D1A receptor."
    Tiberi M., Jarvie K.R., Silvia C., Falardeau P., Gingrich J.A., Godinot N., Bertrand L., Yang-Feng T.L., Fremeau R.T. Jr., Caron M.G.
    Proc. Natl. Acad. Sci. U.S.A. 88:7491-7495(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiDRD5_RAT
AccessioniPrimary (citable) accession number: P25115
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: January 7, 2015
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.