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Protein

Acetylcholine receptor subunit delta

Gene

Chrnd

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-629587 Highly sodium permeable acetylcholine nicotinic receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylcholine receptor subunit delta
Gene namesi
Name:Chrnd
Synonyms:Acrd
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi2352 Chrnd

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 245ExtracellularSequence analysisAdd BLAST224
Transmembranei246 – 270HelicalSequence analysisAdd BLAST25
Transmembranei278 – 296HelicalSequence analysisAdd BLAST19
Transmembranei312 – 333HelicalSequence analysisAdd BLAST22
Topological domaini334 – 471CytoplasmicSequence analysisAdd BLAST138
Transmembranei472 – 490HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000000032422 – 517Acetylcholine receptor subunit deltaAdd BLAST496

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi97N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi151 ↔ 165By similarity
Glycosylationi164N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi190N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei390Phosphotyrosine; by Tyr-kinasesBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP25110
PRIDEiP25110

PTM databases

iPTMnetiP25110
PhosphoSitePlusiP25110

Expressioni

Gene expression databases

BgeeiENSRNOG00000019527
GenevisibleiP25110 RN

Interactioni

Subunit structurei

Pentamer of two alpha chains, and one each of the beta, delta, and gamma (in immature muscle) or epsilon (in mature muscle) chains. The muscle heteropentamer composed of alpha-1, beta-1, delta, epsilon subunits interacts with the alpha-conotoxin ImII (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026504

Structurei

Secondary structure

1517
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi275 – 297Combined sources23

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A11NMR-A276-298[»]
1CEKNMR-A276-298[»]
ProteinModelPortaliP25110
SMRiP25110
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP25110

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3645 Eukaryota
ENOG410XQGR LUCA
GeneTreeiENSGT00910000144023
HOGENOMiHOG000006757
HOVERGENiHBG003756
InParanoidiP25110
KOiK04816
OMAiVLISFMI
OrthoDBiEOG091G0R20
PhylomeDBiP25110

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00254 NICOTINICR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25110-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGPVPTLGL LAALVVCGSW GLNEEQRLIQ HLFEEKGYNK ELRPVARKED
60 70 80 90 100
IVDVALSLTL SNLISLKEVE ETLTTNVWID HAWIDSRLQW NANEFGNITV
110 120 130 140 150
LRLPSDMVWL PEIVLENNND GSFQISYACN VLVSDSGHVT WLPPAIFRSS
160 170 180 190 200
CPISVTYFPF DWQNCSLKFS SLKYTAKEIR LSLKQEEEDN RSYPIEWIII
210 220 230 240 250
DPEGFTENGE WEIVHRAAKV NVDPSVPMDS TNHQDVTFYL IIRRKPLFYI
260 270 280 290 300
INILVPCVLI SFMINLVFYL PGDCGEKTSV AISVLLAQSV FLLLISKRLP
310 320 330 340 350
ATSMAIPLVG KFLLFGMVLV TMVVVICVIV LNIHFRTPST HVLSEGVKKF
360 370 380 390 400
FLETLPKLLH MSRPEEEDPG PRALIRRTSS LGYISKAEEY FSLKSRSDLM
410 420 430 440 450
FEKQSERHGL ARRLTTARKP PASSEQVQQE LFNEMKPAVD GANFIVNHMR
460 470 480 490 500
DQNSYNEEKD NWNQVARTVD RLCLFVVTPV MVVGTAWIFL QGVYNQPPPQ
510
PFPGDPFSYD EQDRRFI
Length:517
Mass (Da):58,884
Last modified:May 1, 1992 - v1
Checksum:i2E561B527788AE9B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74835 mRNA Translation: CAA52829.1
X66531 Genomic DNA Translation: CAA47142.1
PIRiS13875
RefSeqiNP_062171.1, NM_019298.1
UniGeneiRn.41469

Genome annotation databases

EnsembliENSRNOT00000026504; ENSRNOP00000026504; ENSRNOG00000019527
GeneIDi54240
KEGGirno:54240
UCSCiRGD:2352 rat

Similar proteinsi

Entry informationi

Entry nameiACHD_RAT
AccessioniPrimary (citable) accession number: P25110
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: May 23, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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