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Protein

Acetylcholine receptor subunit delta

Gene

Chrnd

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

GO - Molecular functioni

  • acetylcholine-activated cation-selective channel activity Source: RGD
  • acetylcholine binding Source: Ensembl
  • ligand-gated ion channel activity Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-629587. Highly sodium permeable acetylcholine nicotinic receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylcholine receptor subunit delta
Gene namesi
Name:Chrnd
Synonyms:Acrd
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi2352. Chrnd.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 245ExtracellularSequence analysisAdd BLAST224
Transmembranei246 – 270HelicalSequence analysisAdd BLAST25
Transmembranei278 – 296HelicalSequence analysisAdd BLAST19
Transmembranei312 – 333HelicalSequence analysisAdd BLAST22
Topological domaini334 – 471CytoplasmicSequence analysisAdd BLAST138
Transmembranei472 – 490HelicalSequence analysisAdd BLAST19

GO - Cellular componenti

  • acetylcholine-gated channel complex Source: RGD
  • cell junction Source: UniProtKB-KW
  • postsynaptic membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000000032422 – 517Acetylcholine receptor subunit deltaAdd BLAST496

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi97N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi151 ↔ 165By similarity
Glycosylationi164N-linked (GlcNAc...)Sequence analysis1
Glycosylationi190N-linked (GlcNAc...)Sequence analysis1
Modified residuei390Phosphotyrosine; by Tyr-kinasesBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP25110.
PRIDEiP25110.

PTM databases

iPTMnetiP25110.
PhosphoSitePlusiP25110.

Expressioni

Gene expression databases

BgeeiENSRNOG00000019527.
GenevisibleiP25110. RN.

Interactioni

Subunit structurei

Pentamer of two alpha chains, and one each of the beta, delta, and gamma (in immature muscle) or epsilon (in mature muscle) chains.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026504.

Structurei

Secondary structure

1517
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi276 – 297Combined sources22

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A11NMR-A276-298[»]
1CEKNMR-A276-298[»]
ProteinModelPortaliP25110.
SMRiP25110.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP25110.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
GeneTreeiENSGT00760000118930.
HOGENOMiHOG000006757.
HOVERGENiHBG003756.
InParanoidiP25110.
KOiK04816.
OMAiRLCLFLI.
OrthoDBiEOG091G0R20.
PhylomeDBiP25110.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25110-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGPVPTLGL LAALVVCGSW GLNEEQRLIQ HLFEEKGYNK ELRPVARKED
60 70 80 90 100
IVDVALSLTL SNLISLKEVE ETLTTNVWID HAWIDSRLQW NANEFGNITV
110 120 130 140 150
LRLPSDMVWL PEIVLENNND GSFQISYACN VLVSDSGHVT WLPPAIFRSS
160 170 180 190 200
CPISVTYFPF DWQNCSLKFS SLKYTAKEIR LSLKQEEEDN RSYPIEWIII
210 220 230 240 250
DPEGFTENGE WEIVHRAAKV NVDPSVPMDS TNHQDVTFYL IIRRKPLFYI
260 270 280 290 300
INILVPCVLI SFMINLVFYL PGDCGEKTSV AISVLLAQSV FLLLISKRLP
310 320 330 340 350
ATSMAIPLVG KFLLFGMVLV TMVVVICVIV LNIHFRTPST HVLSEGVKKF
360 370 380 390 400
FLETLPKLLH MSRPEEEDPG PRALIRRTSS LGYISKAEEY FSLKSRSDLM
410 420 430 440 450
FEKQSERHGL ARRLTTARKP PASSEQVQQE LFNEMKPAVD GANFIVNHMR
460 470 480 490 500
DQNSYNEEKD NWNQVARTVD RLCLFVVTPV MVVGTAWIFL QGVYNQPPPQ
510
PFPGDPFSYD EQDRRFI
Length:517
Mass (Da):58,884
Last modified:May 1, 1992 - v1
Checksum:i2E561B527788AE9B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74835 mRNA. Translation: CAA52829.1.
X66531 Genomic DNA. Translation: CAA47142.1.
PIRiS13875.
RefSeqiNP_062171.1. NM_019298.1.
UniGeneiRn.41469.

Genome annotation databases

EnsembliENSRNOT00000026504; ENSRNOP00000026504; ENSRNOG00000019527.
GeneIDi54240.
KEGGirno:54240.
UCSCiRGD:2352. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74835 mRNA. Translation: CAA52829.1.
X66531 Genomic DNA. Translation: CAA47142.1.
PIRiS13875.
RefSeqiNP_062171.1. NM_019298.1.
UniGeneiRn.41469.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A11NMR-A276-298[»]
1CEKNMR-A276-298[»]
ProteinModelPortaliP25110.
SMRiP25110.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026504.

PTM databases

iPTMnetiP25110.
PhosphoSitePlusiP25110.

Proteomic databases

PaxDbiP25110.
PRIDEiP25110.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000026504; ENSRNOP00000026504; ENSRNOG00000019527.
GeneIDi54240.
KEGGirno:54240.
UCSCiRGD:2352. rat.

Organism-specific databases

CTDi1144.
RGDi2352. Chrnd.

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
GeneTreeiENSGT00760000118930.
HOGENOMiHOG000006757.
HOVERGENiHBG003756.
InParanoidiP25110.
KOiK04816.
OMAiRLCLFLI.
OrthoDBiEOG091G0R20.
PhylomeDBiP25110.

Enzyme and pathway databases

ReactomeiR-RNO-629587. Highly sodium permeable acetylcholine nicotinic receptors.

Miscellaneous databases

EvolutionaryTraceiP25110.
PROiP25110.

Gene expression databases

BgeeiENSRNOG00000019527.
GenevisibleiP25110. RN.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACHD_RAT
AccessioniPrimary (citable) accession number: P25110
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: November 2, 2016
This is version 145 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.