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Protein

Acetylcholine receptor subunit beta

Gene

Chrnb1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

GO - Molecular functioni

  • acetylcholine binding Source: Ensembl
  • acetylcholine-gated cation-selective channel activity Source: RGD
  • ligand-gated ion channel activity Source: RGD

GO - Biological processi

Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylcholine receptor subunit beta
Gene namesi
Name:Chrnb1
Synonyms:Acrb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi2349. Chrnb1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 244ExtracellularSequence analysisAdd BLAST221
Transmembranei245 – 269HelicalSequence analysisAdd BLAST25
Transmembranei277 – 295HelicalSequence analysisAdd BLAST19
Transmembranei311 – 332HelicalSequence analysisAdd BLAST22
Topological domaini333 – 469CytoplasmicSequence analysisAdd BLAST137
Transmembranei470 – 488HelicalSequence analysisAdd BLAST19

GO - Cellular componenti

  • acetylcholine-gated channel complex Source: RGD
  • cell junction Source: UniProtKB-KW
  • postsynaptic membrane Source: UniProtKB-SubCell

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23By similarityAdd BLAST23
ChainiPRO_000000031724 – 501Acetylcholine receptor subunit betaAdd BLAST478

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi151 ↔ 165By similarity
Glycosylationi164N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei390Phosphotyrosine; by Tyr-kinasesBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP25109.
PRIDEiP25109.

Expressioni

Gene expression databases

BgeeiENSRNOG00000014698.
GenevisibleiP25109. RN.

Interactioni

Subunit structurei

Pentamer of two alpha chains, and one each of the beta, delta, and gamma (in immature muscle) or epsilon (in mature muscle) chains. The muscle heteropentamer composed of alpha-1, beta-1, delta, epsilon subunits interacts with the alpha-conotoxin ImII.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019947.

Structurei

3D structure databases

ProteinModelPortaliP25109.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
GeneTreeiENSGT00760000118930.
HOGENOMiHOG000006757.
HOVERGENiHBG003756.
InParanoidiP25109.
KOiK04812.
OMAiFIDGPNR.
OrthoDBiEOG091G0R20.
PhylomeDBiP25109.
TreeFamiTF315605.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiView protein in InterPro
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiView protein in Pfam
PF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiView protein in PROSITE
PS00236. NEUROTR_ION_CHANNEL. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25109-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALGALLLIL GILGTPLAPG ARGSEAEGQL LKKLFSDYDS SVRPAQEVGD
60 70 80 90 100
RVGVSIGLTL AQLISLNEKD EEMSTKVYLD LEWTDYRLSW DPAEHDGIES
110 120 130 140 150
LRVTAESVWL PDVVLLNNND GNFDVALDIN VVVSFEGSVR WQPPGLYRSS
160 170 180 190 200
CSIQVTYFPF DWQNCTMVFS SYSYDSSEVS LKTGPDPDGQ ERQEIYIHEG
210 220 230 240 250
TFIENGQWEI IHKPSRLIHL PGDRRGGKEG HREEVIFYLI IRRKPLFYLV
260 270 280 290 300
NVIAPCILIT LLAIFVFYLP PDAGEKMGLS IFALLTLTVF LLLLADKVPE
310 320 330 340 350
TSLAVPIIIK YLMFTMILVT FSVILSVVVL NLHHRSPHTH QMPFWVRQIF
360 370 380 390 400
IHKLPPYLGL KRPKPERDQL PEPHHSFSPR SGWGRGTDEY FIRKPPCDFL
410 420 430 440 450
FPKLNRFQPE SPAPDLRRFI DGPPRAVGLP QELREVISSI SYMARQLQEQ
460 470 480 490 500
EDHDALKEDW QFVAMVVDRL FLWTFIVFTS VGTLVIFLDA TYHLPPPEPF

P
Length:501
Mass (Da):57,027
Last modified:May 1, 1992 - v1
Checksum:i2E7DD6AAD1D9364D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74833 mRNA. Translation: CAA52827.1.
PIRiS13873.
RefSeqiNP_036660.1. NM_012528.1.
UniGeneiRn.44611.

Genome annotation databases

EnsembliENSRNOT00000019947; ENSRNOP00000019947; ENSRNOG00000014698.
GeneIDi24261.
KEGGirno:24261.
UCSCiRGD:2349. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiACHB_RAT
AccessioniPrimary (citable) accession number: P25109
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: May 10, 2017
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families