Reviewed, UniProtKB/Swiss-Prot P25106 (CXCR7_HUMAN)

Names and origin

Protein names

Recommended name:
    C-X-C chemokine receptor type 7
      Short name=CXC-R7
      Short name=CXCR-7
Alternative name(s):
    G-protein coupled receptor RDC1 homolog
      Short name=RDC-1
    Chemokine orphan receptor 1
    G-protein coupled receptor 159

Gene names

Name:	CXCR7
Synonyms:	CMKOR1, GPR159, RDC1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Receptor for CXCL12/SDF1. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates. Ref.7 Ref.8
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in monocytes, basophils, and B-cells. Lower expression in CD4+ T-lymphocytes and natural killer cells. Ref.8 Ref.9
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.
Caution	Was originally (Ref.1) thought to be the receptor for VIP.

Ontologies

Keywords
Biological process	Host-virus interaction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Biological process	G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW interspecies interaction between organisms Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Non-traceable author statement. Source: UniProtKB plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
GRB2	P62993	1	EBI-1965291,EBI-401755

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 362	362	C-X-C chemokine receptor type 7		PRO_0000070101
Regions
	Topological domain	1 – 40	40	Extracellular Potential
	Transmembrane	41 – 61	21	1 Potential
	Topological domain	62 – 81	20	Cytoplasmic Potential
	Transmembrane	82 – 102	21	2 Potential
	Topological domain	103 – 118	16	Extracellular Potential
	Transmembrane	119 – 139	21	3 Potential
	Topological domain	140 – 162	23	Cytoplasmic Potential
	Transmembrane	163 – 183	21	4 Potential
	Topological domain	184 – 213	30	Extracellular Potential
	Transmembrane	214 – 234	21	5 Potential
	Topological domain	235 – 252	18	Cytoplasmic Potential
	Transmembrane	253 – 273	21	6 Potential
	Topological domain	274 – 296	23	Extracellular Potential
	Transmembrane	297 – 319	23	7 Potential
	Topological domain	320 – 362	43	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	13	1	N-linked (GlcNAc...) Potential
	Glycosylation	22	1	N-linked (GlcNAc...) Potential
	Glycosylation	39	1	N-linked (GlcNAc...) Potential
	Disulfide bond	117 ↔ 196		By similarity
Natural variations
	Natural variant	219	1	L → W: dbSNP rs10183641.		VAR_027477
Experimental info
	Sequence conflict	9	1	S → A in AAA62370. Ref.1
	Sequence conflict	130	1	G → S Ref.1
	Sequence conflict	130	1	G → S Ref.2
	Sequence conflict	130	1	G → S Ref.3
	Sequence conflict	131	1	S → G Ref.1
	Sequence conflict	228	1	I → V in AAH36661. Ref.6
	Sequence conflict	360 – 361	2	ST → NA in AAA62370. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P25106-1 [UniParc]. Last modified October 3, 2006. Version 3. Checksum: A863EC1AFB5B158B	FASTA	362	41,493
	10 20 30 40 50 60 MDLHLFDYSE PGNFSDISWP CNSSDCIVVD TVMCPNMPNK SVLLYTLSFI YIFIFVIGMI 70 80 90 100 110 120 ANSVVVWVNI QAKTTGYDTH CYILNLAIAD LWVVLTIPVW VVSLVQHNQW PMGELTCKVT 130 140 150 160 170 180 HLIFSINLFG SIFFLTCMSV DRYLSITYFT NTPSSRKKMV RRVVCILVWL LAFCVSLPDT 190 200 210 220 230 240 YYLKTVTSAS NNETYCRSFY PEHSIKEWLI GMELVSVVLG FAVPFSIIAV FYFLLARAIS 250 260 270 280 290 300 ASSDQEKHSS RKIIFSYVVV FLVCWLPYHV AVLLDIFSIL HYIPFTCRLE HALFTALHVT 310 320 330 340 350 360 QCLSLVHCCV NPVLYSFINR NYRYELMKAF IFKYSAKTGL TKLIDASRVS ETEYSALEQS TK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and expression of the human vasoactive intestinal peptide receptor." Sreedharan S.P., Robichon A., Peterson K.E., Goetzl E.J. Proc. Natl. Acad. Sci. U.S.A. 88:4986-4990(1991) [PubMed: 1675791] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]	"Coding and 3'-noncoding sequence of human RDC1, an orphan G protein-coupled receptor." Oates E.L., Roos B.A., Howard G.A. Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Human RDC1 gene." Bi A., Yu L., Zhang Q., Tu Q., Xing Y., Zheng L. Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"Isolation of cDNA coding for Homo sapiens chemokine orphan receptor 1 (CMKOR1)." Martin A.L., Kaighin V.A., Aronstam R.S. Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[7]	"RDC1 may not be VIP receptor." Nagata S., Ishihara T., Robberecht P., Libert F., Parmentier M., Christophe J., Vassart G. Trends Pharmacol. Sci. 13:102-103(1992) [PubMed: 1315461] [Abstract] Cited for: DOUBTS ON THE ORIGINAL FUNCTION.
[8]	"The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes." Balabanian K., Lagane B., Infantino S., Chow K.Y., Harriague J., Moepps B., Arenzana-Seisdedos F., Thelen M., Bachelerie F. J. Biol. Chem. 280:35760-35766(2005) [PubMed: 16107333] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY.
[9]	"Expression and regulation of the orphan receptor RDC1 and its putative ligand in human dendritic and B cells." Infantino S., Moepps B., Thelen M. J. Immunol. 176:2197-2207(2006) [PubMed: 16455976] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Wikipedia

CXC chemokine receptors entry

Cross-references

Sequence databases
EMBLGenBankDDBJ	M64749 mRNA. Translation: AAA62370.1. U73141 Genomic DNA. Translation: AAB18130.1. U67784 mRNA. Translation: AAB16913.1. AF030297 mRNA. Translation: AAB94130.1. DQ822477 mRNA. Translation: ABH01258.1. AC079611 Genomic DNA. Translation: AAX93086.1. BC036661 mRNA. Translation: AAH36661.1.
IPI	IPI00012733.
PIR	A39714.
RefSeq	NP_064707.1.
UniGene	Hs.471751
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P25106. 1 interaction.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P25106.
Proteomic databases
PeptideAtlas	P25106.
PRIDE	P25106.
Genome annotation databases
Ensembl	ENSG00000144476. Homo sapiens. [Contig view]
GeneID	57007.
KEGG	hsa:57007.
Organism-specific databases
GeneCards	GC02P237143.
H-InvDB	HIX0023982.
HGNC	HGNC:23692. CXCR7.
MIM	610376. gene.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	P25106.
OMA	P25106. INRNYRY.
Enzyme and pathway databases
Reactome	REACT_14797. Signaling by GPCR.
Gene expression databases
ArrayExpress	P25106.
Bgee	P25106.
CleanEx	HS_CXCR7.
GermOnline	ENSG00000144476. Homo sapiens.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. IPR001416. RDC1_rcpt. [Graphical view]
PANTHER	PTHR19264:SF259. RDC1_rcpt. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00646. RDC1ORPHANR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	62747.
SOURCE	Search...

Entry information

Entry name

CXCR7_HUMAN

Accession

Primary (citable) accession number: P25106
Secondary accession number(s): Q53RV4 , Q8NE10, Q92938, Q92986

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1992
Last sequence update:	October 3, 2006
Last modified:	June 16, 2009
This is version 91 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)