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P25105

- PTAFR_HUMAN

UniProt

P25105 - PTAFR_HUMAN

Protein

Platelet-activating factor receptor

Gene

PTAFR

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 146 (01 Oct 2014)
      Sequence version 1 (01 May 1992)
      Previous versions | rss
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    Functioni

    Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system.4 Publications

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: ProtInc
    2. lipopolysaccharide binding Source: Ensembl
    3. lipopolysaccharide receptor activity Source: Ensembl
    4. phospholipid binding Source: UniProtKB
    5. platelet activating factor receptor activity Source: UniProtKB

    GO - Biological processi

    1. chemotaxis Source: ProtInc
    2. cytokine-mediated signaling pathway Source: Reactome
    3. cytokine production Source: Ensembl
    4. G-protein coupled receptor signaling pathway Source: UniProtKB
    5. immune response Source: ProtInc
    6. inflammatory response Source: ProtInc
    7. inositol trisphosphate biosynthetic process Source: Ensembl
    8. interferon-gamma-mediated signaling pathway Source: Reactome
    9. phosphatidylinositol-mediated signaling Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Chemotaxis

    Enzyme and pathway databases

    ReactomeiREACT_14828. Class A/1 (Rhodopsin-like receptors).
    REACT_18283. G alpha (q) signalling events.
    REACT_25078. Interferon gamma signaling.

    Protein family/group databases

    TCDBi9.A.14.13.3. the g-protein-coupled receptor (gpcr) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Platelet-activating factor receptor
    Short name:
    PAF-R
    Short name:
    PAFr
    Gene namesi
    Name:PTAFR
    Synonyms:PAFR
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:9582. PTAFR.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB
    2. integral component of plasma membrane Source: ProtInc
    3. membrane Source: UniProtKB
    4. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33933.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 342342Platelet-activating factor receptorPRO_0000070092Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi90 ↔ 173PROSITE-ProRule annotation
    Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP25105.

    PTM databases

    PhosphoSiteiP25105.

    Expressioni

    Tissue specificityi

    Expressed in the placenta, lung, left and right heart ventricles, heart atrium, leukocytes and differentiated HL-60 granulocytes.3 Publications

    Inductioni

    By CSF2/GM-CSF, IL5/interleukin-5 and n-butyrate.1 Publication

    Gene expression databases

    BgeeiP25105.
    CleanExiHS_PTAFR.
    GenevestigatoriP25105.

    Organism-specific databases

    HPAiHPA027543.

    Interactioni

    Subunit structurei

    Interacts with ARRB1.1 Publication

    Protein-protein interaction databases

    BioGridi111696. 12 interactions.
    IntActiP25105. 4 interactions.
    STRINGi9606.ENSP00000301974.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2B0Xmodel-A1-342[»]
    ProteinModelPortaliP25105.
    SMRiP25105. Positions 6-304.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1616ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini39 – 5416CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini75 – 9117ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini114 – 13320CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini156 – 18429ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini206 – 23328CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini255 – 27622ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini297 – 34246CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei17 – 3822Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei55 – 7420Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei92 – 11322Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei134 – 15522Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei185 – 20521Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei234 – 25421Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei277 – 29620Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG149133.
    HOGENOMiHOG000013041.
    HOVERGENiHBG101106.
    InParanoidiP25105.
    KOiK04279.
    OMAiFLCNLAG.
    OrthoDBiEOG7QVM3C.
    PhylomeDBiP25105.
    TreeFamiTF350009.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR002282. PAF_rcpt.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01153. PAFRECEPTOR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P25105-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPHDSSHMD SEFRYTLFPI VYSIIFVLGV IANGYVLWVF ARLYPCKKFN    50
    EIKIFMVNLT MADMLFLITL PLWIVYYQNQ GNWILPKFLC NVAGCLFFIN 100
    TYCSVAFLGV ITYNRFQAVT RPIKTAQANT RKRGISLSLV IWVAIVGAAS 150
    YFLILDSTNT VPDSAGSGNV TRCFEHYEKG SVPVLIIHIF IVFSFFLVFL 200
    IILFCNLVII RTLLMQPVQQ QRNAEVKRRA LWMVCTVLAV FIICFVPHHV 250
    VQLPWTLAEL GFQDSKFHQA INDAHQVTLC LLSTNCVLDP VIYCFLTKKF 300
    RKHLTEKFYS MRSSRKCSRA TTDTVTEVVV PFNQIPGNSL KN 342
    Length:342
    Mass (Da):39,203
    Last modified:May 1, 1992 - v1
    Checksum:i890073C9EBA79228
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti28 – 281L → P in AAA60108. 1 PublicationCurated
    Sequence conflicti66 – 661F → L in AAA60108. 1 PublicationCurated
    Sequence conflicti95 – 951C → R in AAA60108. 1 PublicationCurated
    Sequence conflicti227 – 2282KR → TG in AAA60214. (PubMed:1322356)Curated
    Sequence conflicti227 – 2282KR → TT in AAA60108. 1 PublicationCurated
    Sequence conflicti247 – 2471P → A in AAA60108. 1 PublicationCurated
    Sequence conflicti316 – 3161K → N in AAB24695. (PubMed:1281995)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti224 – 2241A → D.1 Publication
    Corresponds to variant rs5938 [ dbSNP | Ensembl ].
    VAR_011851
    Natural varianti338 – 3381N → S.1 Publication
    Corresponds to variant rs5939 [ dbSNP | Ensembl ].
    VAR_011852

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M80436 mRNA. Translation: AAA60001.1.
    D10202 mRNA. Translation: BAA01050.1.
    M76674 mRNA. Translation: AAA60002.1.
    M88177 Genomic DNA. Translation: AAA60214.1.
    S52624 mRNA. Translation: AAB24695.2.
    L07334 mRNA. Translation: AAA60108.1.
    S56396 Genomic DNA. Translation: AAB25755.1.
    AY275466 mRNA. Translation: AAP32298.1.
    BT009801 mRNA. Translation: AAP88803.1.
    AK290240 mRNA. Translation: BAF82929.1.
    CH471059 Genomic DNA. Translation: EAX07711.1.
    BC013816 mRNA. Translation: AAH13816.1.
    BC063000 mRNA. Translation: AAH63000.1.
    CCDSiCCDS318.1.
    PIRiA40191.
    RefSeqiNP_000943.1. NM_000952.4.
    NP_001158193.1. NM_001164721.1.
    NP_001158194.1. NM_001164722.2.
    NP_001158195.1. NM_001164723.2.
    UniGeneiHs.77542.

    Genome annotation databases

    EnsembliENST00000305392; ENSP00000301974; ENSG00000169403.
    ENST00000373857; ENSP00000362965; ENSG00000169403.
    ENST00000539896; ENSP00000442658; ENSG00000169403.
    GeneIDi5724.
    KEGGihsa:5724.
    UCSCiuc001bpl.3. human.

    Polymorphism databases

    DMDMi129557.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M80436 mRNA. Translation: AAA60001.1 .
    D10202 mRNA. Translation: BAA01050.1 .
    M76674 mRNA. Translation: AAA60002.1 .
    M88177 Genomic DNA. Translation: AAA60214.1 .
    S52624 mRNA. Translation: AAB24695.2 .
    L07334 mRNA. Translation: AAA60108.1 .
    S56396 Genomic DNA. Translation: AAB25755.1 .
    AY275466 mRNA. Translation: AAP32298.1 .
    BT009801 mRNA. Translation: AAP88803.1 .
    AK290240 mRNA. Translation: BAF82929.1 .
    CH471059 Genomic DNA. Translation: EAX07711.1 .
    BC013816 mRNA. Translation: AAH13816.1 .
    BC063000 mRNA. Translation: AAH63000.1 .
    CCDSi CCDS318.1.
    PIRi A40191.
    RefSeqi NP_000943.1. NM_000952.4.
    NP_001158193.1. NM_001164721.1.
    NP_001158194.1. NM_001164722.2.
    NP_001158195.1. NM_001164723.2.
    UniGenei Hs.77542.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2B0X model - A 1-342 [» ]
    ProteinModelPortali P25105.
    SMRi P25105. Positions 6-304.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111696. 12 interactions.
    IntActi P25105. 4 interactions.
    STRINGi 9606.ENSP00000301974.

    Chemistry

    BindingDBi P25105.
    ChEMBLi CHEMBL250.
    GuidetoPHARMACOLOGYi 334.

    Protein family/group databases

    TCDBi 9.A.14.13.3. the g-protein-coupled receptor (gpcr) family.
    GPCRDBi Search...

    PTM databases

    PhosphoSitei P25105.

    Polymorphism databases

    DMDMi 129557.

    Proteomic databases

    PRIDEi P25105.

    Protocols and materials databases

    DNASUi 5724.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000305392 ; ENSP00000301974 ; ENSG00000169403 .
    ENST00000373857 ; ENSP00000362965 ; ENSG00000169403 .
    ENST00000539896 ; ENSP00000442658 ; ENSG00000169403 .
    GeneIDi 5724.
    KEGGi hsa:5724.
    UCSCi uc001bpl.3. human.

    Organism-specific databases

    CTDi 5724.
    GeneCardsi GC01M028473.
    HGNCi HGNC:9582. PTAFR.
    HPAi HPA027543.
    MIMi 173393. gene.
    neXtProti NX_P25105.
    PharmGKBi PA33933.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG149133.
    HOGENOMi HOG000013041.
    HOVERGENi HBG101106.
    InParanoidi P25105.
    KOi K04279.
    OMAi FLCNLAG.
    OrthoDBi EOG7QVM3C.
    PhylomeDBi P25105.
    TreeFami TF350009.

    Enzyme and pathway databases

    Reactomei REACT_14828. Class A/1 (Rhodopsin-like receptors).
    REACT_18283. G alpha (q) signalling events.
    REACT_25078. Interferon gamma signaling.

    Miscellaneous databases

    GeneWikii Platelet-activating_factor_receptor.
    GenomeRNAii 5724.
    NextBioi 22248.
    PROi P25105.
    SOURCEi Search...

    Gene expression databases

    Bgeei P25105.
    CleanExi HS_PTAFR.
    Genevestigatori P25105.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR002282. PAF_rcpt.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01153. PAFRECEPTOR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of a human cDNA that encodes a functional receptor for platelet activating factor."
      Ye R.D., Prossnitz E.R., Zou A., Cochrane C.G.
      Biochem. Biophys. Res. Commun. 180:105-111(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Tissue: Granulocyte.
    2. "Molecular cloning and expression of platelet-activating factor receptor from human leukocytes."
      Nakamura M., Honda Z., Izumi T., Sakanaka C., Mutoh H., Minami M., Bito H., Seyama Y., Matsumoto T., Noma M., Shimizu T.
      J. Biol. Chem. 266:20400-20405(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, INDUCTION.
      Tissue: Leukocyte.
    3. "The human leukocyte platelet-activating factor receptor. cDNA cloning, cell surface expression, and construction of a novel epitope-bearing analog."
      Kunz D., Gerard N.P., Gerard C.
      J. Biol. Chem. 267:9101-9106(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.
      Tissue: Leukocyte.
    4. "The human platelet-activating factor receptor gene (PTAFR) contains no introns and maps to chromosome 1."
      Seyfried C.E., Schweickart V.L., Godiska R., Gray P.W.
      Genomics 13:832-834(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Fetal liver.
    5. "Molecular cloning and characterization of the platelet-activating factor receptor gene expressed in the human heart."
      Sugimoto T., Tsuchimochi H., McGregor C.G.A., Mutoh H., Shimizu T., Kurachi Y.
      Biochem. Biophys. Res. Commun. 189:617-624(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Tissue: Heart ventricle.
    6. "Nucleotide sequence of platelet-activating-factor receptor derived from HeLa cell genomic DNA and Rhesus monkey genomic DNA."
      Behal R.H., Debuysere M.S., Olson M.S.
      Submitted (DEC-1992) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Cervix carcinoma.
    7. "Cloning of a human platelet-activating factor receptor gene: evidence for an intron in the 5'-untranslated region."
      Chase P.B., Halonen M., Regan J.W.
      Am. J. Respir. Cell Mol. Biol. 8:240-244(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    8. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Warren C.N., Aronstam R.S., Sharma S.V.
      Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    9. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    10. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Umbilical cord blood.
    11. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    12. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Lymph.
    13. "Platelet-activating factor-induced clathrin-mediated endocytosis requires beta-arrestin-1 recruitment and activation of the p38 MAPK signalosome at the plasma membrane for actin bundle formation."
      McLaughlin N.J., Banerjee A., Kelher M.R., Gamboni-Robertson F., Hamiel C., Sheppard F.R., Moore E.E., Silliman C.C.
      J. Immunol. 176:7039-7050(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ARRB1.
    14. Cited for: VARIANTS ASP-224 AND SER-338.

    Entry informationi

    Entry nameiPTAFR_HUMAN
    AccessioniPrimary (citable) accession number: P25105
    Secondary accession number(s): A3KMC8, A8K2H5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: May 1, 1992
    Last modified: October 1, 2014
    This is version 146 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3