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Protein

Type-1 angiotensin II receptor

Gene

AGTR1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-BTA-375276. Peptide ligand-binding receptors.
R-BTA-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Type-1 angiotensin II receptor
Alternative name(s):
Angiotensin II type-1 receptor
Short name:
AT1
Gene namesi
Name:AGTR1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 1

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727ExtracellularSequence analysisAdd
BLAST
Transmembranei28 – 5225Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini53 – 6412CytoplasmicSequence analysisAdd
BLAST
Transmembranei65 – 8723Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini88 – 10215ExtracellularSequence analysisAdd
BLAST
Transmembranei103 – 12422Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini125 – 14218CytoplasmicSequence analysisAdd
BLAST
Transmembranei143 – 16220Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini163 – 19230ExtracellularSequence analysisAdd
BLAST
Transmembranei193 – 21422Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini215 – 24026CytoplasmicSequence analysisAdd
BLAST
Transmembranei241 – 26222Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini263 – 27513ExtracellularSequence analysisAdd
BLAST
Transmembranei276 – 29621Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini297 – 35963CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL3374.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359Type-1 angiotensin II receptorPRO_0000069150Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence analysis
Disulfide bondi101 ↔ 180PROSITE-ProRule annotation
Glycosylationi176 – 1761N-linked (GlcNAc...)Sequence analysis
Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence analysis
Lipidationi355 – 3551S-palmitoyl cysteineSequence analysis

Post-translational modificationi

C-terminal Ser or Thr residues may be phosphorylated.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP25104.
PRIDEiP25104.

Expressioni

Tissue specificityi

Adrenal medulla, cortex and kidney.

Gene expression databases

BgeeiENSBTAG00000045633.

Interactioni

Subunit structurei

Interacts with MAS1 (By similarity). Interacts with ARRB1 (By similarity). Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000055053.

Chemistry

BindingDBiP25104.

Structurei

3D structure databases

ProteinModelPortaliP25104.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119055.
HOGENOMiHOG000234122.
HOVERGENiHBG104998.
InParanoidiP25104.
KOiK04166.
OMAiCIVIWLL.
OrthoDBiEOG091G0C1Y.
TreeFamiTF330024.

Family and domain databases

InterProiIPR000190. ATII_AT1_rcpt.
IPR000248. ATII_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00241. ANGIOTENSINR.
PR00635. ANGIOTENSN1R.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25104-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILNSSTEDG IKRIQDDCPK AGRHNYIFIM IPTLYSIIFV VGIFGNSLVV
60 70 80 90 100
IVIYFYMKLK TVASVFLLNL ALADLCFLLT LPLWAVYTAM EYRWPFGNYL
110 120 130 140 150
CKIASASVSF NLYASVFLLT CLSIDRYLAI VHPMKSRLRR TMLVAKVTCI
160 170 180 190 200
IIWLLAGLAS LPTIIHRNVF FIENTNITVC AFHYESQNST LPVGLGLTKN
210 220 230 240 250
ILGFLFPFLI ILTSYTLIWK TLKKAYEIQK NKPRKDDIFK IILAIVLFFF
260 270 280 290 300
FSWVPHQIFT FMDVLIQLGL IRDCKIEDIV DTAMPITICL AYFNNCLNPL
310 320 330 340 350
FYGFLGKKFK KYFLQLLKYI PPKAKSHSNL STKMSTLSYR PSENGNSSTK

KPAPCIEVE
Length:359
Mass (Da):41,088
Last modified:May 1, 1992 - v1
Checksum:iB426BFFF6B61DFEA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62294 mRNA. Translation: CAA44182.1.
RefSeqiNP_776658.1. NM_174233.2.
UniGeneiBt.4539.

Genome annotation databases

EnsembliENSBTAT00000063575; ENSBTAP00000055053; ENSBTAG00000045633.
GeneIDi281607.
KEGGibta:281607.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62294 mRNA. Translation: CAA44182.1.
RefSeqiNP_776658.1. NM_174233.2.
UniGeneiBt.4539.

3D structure databases

ProteinModelPortaliP25104.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000055053.

Chemistry

BindingDBiP25104.
ChEMBLiCHEMBL3374.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiP25104.
PRIDEiP25104.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000063575; ENSBTAP00000055053; ENSBTAG00000045633.
GeneIDi281607.
KEGGibta:281607.

Organism-specific databases

CTDi185.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119055.
HOGENOMiHOG000234122.
HOVERGENiHBG104998.
InParanoidiP25104.
KOiK04166.
OMAiCIVIWLL.
OrthoDBiEOG091G0C1Y.
TreeFamiTF330024.

Enzyme and pathway databases

ReactomeiR-BTA-375276. Peptide ligand-binding receptors.
R-BTA-416476. G alpha (q) signalling events.

Miscellaneous databases

PROiP25104.

Gene expression databases

BgeeiENSBTAG00000045633.

Family and domain databases

InterProiIPR000190. ATII_AT1_rcpt.
IPR000248. ATII_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00241. ANGIOTENSINR.
PR00635. ANGIOTENSN1R.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAGTR1_BOVIN
AccessioniPrimary (citable) accession number: P25104
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: September 7, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.