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Protein

Type-1 angiotensin II receptor

Gene

AGTR1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-BTA-375276 Peptide ligand-binding receptors
R-BTA-416476 G alpha (q) signalling events
R-BTA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-BTA-8856828 Clathrin-mediated endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Type-1 angiotensin II receptor
Alternative name(s):
Angiotensin II type-1 receptor
Short name:
AT1
Gene namesi
Name:AGTR1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 1

Organism-specific databases

VGNCiVGNC:25745 AGTR1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
Transmembranei28 – 52Helical; Name=1Sequence analysisAdd BLAST25
Topological domaini53 – 64CytoplasmicSequence analysisAdd BLAST12
Transmembranei65 – 87Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini88 – 102ExtracellularSequence analysisAdd BLAST15
Transmembranei103 – 124Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini125 – 142CytoplasmicSequence analysisAdd BLAST18
Transmembranei143 – 162Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini163 – 192ExtracellularSequence analysisAdd BLAST30
Transmembranei193 – 214Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini215 – 240CytoplasmicSequence analysisAdd BLAST26
Transmembranei241 – 262Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini263 – 275ExtracellularSequence analysisAdd BLAST13
Transmembranei276 – 296Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini297 – 359CytoplasmicSequence analysisAdd BLAST63

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3374

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000691501 – 359Type-1 angiotensin II receptorAdd BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi101 ↔ 180PROSITE-ProRule annotation
Glycosylationi176N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi355S-palmitoyl cysteineSequence analysis1

Post-translational modificationi

C-terminal Ser or Thr residues may be phosphorylated.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP25104
PRIDEiP25104

Expressioni

Tissue specificityi

Adrenal medulla, cortex and kidney.

Gene expression databases

BgeeiENSBTAG00000045633

Interactioni

Subunit structurei

Interacts with MAS1 (By similarity). Interacts with ARRB1 (By similarity). Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000055053

Chemistry databases

BindingDBiP25104

Structurei

3D structure databases

ProteinModelPortaliP25104
SMRiP25104
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000119055
HOGENOMiHOG000234122
HOVERGENiHBG104998
InParanoidiP25104
KOiK04166
OMAiYTLIWKT
OrthoDBiEOG091G0C1Y
TreeFamiTF330024

Family and domain databases

CDDicd15192 7tmA_AT1R, 1 hit
InterProiView protein in InterPro
IPR000190 ATII_AT1_rcpt
IPR000248 ATII_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00241 ANGIOTENSINR
PR00635 ANGIOTENSN1R
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P25104-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILNSSTEDG IKRIQDDCPK AGRHNYIFIM IPTLYSIIFV VGIFGNSLVV
60 70 80 90 100
IVIYFYMKLK TVASVFLLNL ALADLCFLLT LPLWAVYTAM EYRWPFGNYL
110 120 130 140 150
CKIASASVSF NLYASVFLLT CLSIDRYLAI VHPMKSRLRR TMLVAKVTCI
160 170 180 190 200
IIWLLAGLAS LPTIIHRNVF FIENTNITVC AFHYESQNST LPVGLGLTKN
210 220 230 240 250
ILGFLFPFLI ILTSYTLIWK TLKKAYEIQK NKPRKDDIFK IILAIVLFFF
260 270 280 290 300
FSWVPHQIFT FMDVLIQLGL IRDCKIEDIV DTAMPITICL AYFNNCLNPL
310 320 330 340 350
FYGFLGKKFK KYFLQLLKYI PPKAKSHSNL STKMSTLSYR PSENGNSSTK

KPAPCIEVE
Length:359
Mass (Da):41,088
Last modified:May 1, 1992 - v1
Checksum:iB426BFFF6B61DFEA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62294 mRNA Translation: CAA44182.1
RefSeqiNP_776658.1, NM_174233.2
UniGeneiBt.4539

Genome annotation databases

EnsembliENSBTAT00000063575; ENSBTAP00000055053; ENSBTAG00000045633
GeneIDi281607
KEGGibta:281607

Similar proteinsi

Entry informationi

Entry nameiAGTR1_BOVIN
AccessioniPrimary (citable) accession number: P25104
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: March 28, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health