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P25103 (NK1R_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 150. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Substance-P receptor

Short name=SPR
Alternative name(s):
NK-1 receptor
Short name=NK-1R
Tachykinin receptor 1
Gene names
Name:TACR1
Synonyms:NK1R, TAC1R
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length407 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.

Subunit structure

Interacts with ARRB1 By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
Lipoprotein
Palmitate
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processacute inflammatory response

Inferred from electronic annotation. Source: Ensembl

aggressive behavior

Inferred from electronic annotation. Source: Ensembl

angiotensin-mediated drinking behavior

Inferred from electronic annotation. Source: Ensembl

associative learning

Inferred from electronic annotation. Source: Ensembl

behavioral response to pain

Inferred from electronic annotation. Source: Ensembl

detection of abiotic stimulus

Traceable author statement PubMed 9537323. Source: ProtInc

eating behavior

Inferred from electronic annotation. Source: Ensembl

inflammatory response

Traceable author statement PubMed 10854844. Source: ProtInc

long-term memory

Inferred from electronic annotation. Source: Ensembl

operant conditioning

Inferred from electronic annotation. Source: Ensembl

phospholipase C-activating G-protein coupled receptor signaling pathway

Traceable author statement Ref.3. Source: ProtInc

positive regulation of action potential

Inferred from electronic annotation. Source: Ensembl

positive regulation of blood pressure

Inferred from electronic annotation. Source: Ensembl

positive regulation of cytosolic calcium ion concentration

Inferred from electronic annotation. Source: Ensembl

positive regulation of epithelial cell migration

Inferred from electronic annotation. Source: Ensembl

positive regulation of epithelial cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of hormone secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of leukocyte migration

Inferred from electronic annotation. Source: Ensembl

positive regulation of lymphocyte proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of ossification

Inferred from electronic annotation. Source: Ensembl

positive regulation of renal sodium excretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of saliva secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of stress fiber assembly

Inferred from electronic annotation. Source: Ensembl

positive regulation of synaptic transmission, GABAergic

Inferred from electronic annotation. Source: Ensembl

positive regulation of synaptic transmission, cholinergic

Inferred from electronic annotation. Source: Ensembl

positive regulation of uterine smooth muscle contraction

Inferred from electronic annotation. Source: Ensembl

positive regulation of vascular permeability

Inferred from electronic annotation. Source: Ensembl

positive regulation of vasoconstriction

Inferred from electronic annotation. Source: Ensembl

regulation of smooth muscle cell migration

Inferred from electronic annotation. Source: Ensembl

regulation of smooth muscle cell proliferation

Inferred from electronic annotation. Source: Ensembl

response to auditory stimulus

Inferred from electronic annotation. Source: Ensembl

response to estradiol

Inferred from electronic annotation. Source: Ensembl

response to ethanol

Inferred from electronic annotation. Source: Ensembl

response to heat

Inferred from electronic annotation. Source: Ensembl

response to morphine

Inferred from electronic annotation. Source: Ensembl

response to nicotine

Inferred from electronic annotation. Source: Ensembl

response to ozone

Inferred from electronic annotation. Source: Ensembl

response to progesterone

Inferred from electronic annotation. Source: Ensembl

smooth muscle contraction involved in micturition

Inferred from electronic annotation. Source: Ensembl

sperm ejaculation

Inferred from electronic annotation. Source: Ensembl

tachykinin receptor signaling pathway

Inferred from direct assay PubMed 17986524. Source: BHF-UCL

   Cellular_componentcell body

Inferred from electronic annotation. Source: Ensembl

cell surface

Inferred from electronic annotation. Source: Ensembl

cytoplasm

Inferred from electronic annotation. Source: Ensembl

dendrite

Inferred from electronic annotation. Source: Ensembl

integral component of plasma membrane

Traceable author statement Ref.3. Source: ProtInc

plasma membrane

Inferred from direct assay PubMed 17986524. Source: BHF-UCL

   Molecular_functionprotein binding

Inferred from physical interaction PubMed 23597562. Source: IntAct

substance P receptor activity

Inferred from electronic annotation. Source: Ensembl

tachykinin receptor activity

Traceable author statement PubMed 8985172. Source: ProtInc

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

TAC1P203662EBI-6655287,EBI-6655360

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P25103-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P25103-3)

The sequence of this isoform differs from the canonical sequence as follows:
     312-407: Missing.
Note: In contrast to Fong et al. data (PubMed:1310144), isoform 2 is not detected by PCR in any of 24 human tissues examined including the placenta (PubMed:11864635).

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 407407Substance-P receptor
PRO_0000069885

Regions

Topological domain1 – 3131Extracellular Potential
Transmembrane32 – 5423Helical; Name=1; Potential
Topological domain55 – 6410Cytoplasmic Potential
Transmembrane65 – 8622Helical; Name=2; Potential
Topological domain87 – 10620Extracellular Potential
Transmembrane107 – 12822Helical; Name=3; Potential
Topological domain129 – 14820Cytoplasmic Potential
Transmembrane149 – 16921Helical; Name=4; Potential
Topological domain170 – 19425Extracellular Potential
Transmembrane195 – 21925Helical; Name=5; Potential
Topological domain220 – 24829Cytoplasmic Potential
Transmembrane249 – 27022Helical; Name=6; Potential
Topological domain271 – 28313Extracellular Potential
Transmembrane284 – 30825Helical; Name=7; Potential
Topological domain309 – 40799Cytoplasmic Potential

Sites

Binding site1971Antagonist CP 96345

Amino acid modifications

Lipidation3221S-palmitoyl cysteine Potential
Glycosylation141N-linked (GlcNAc...) Potential
Glycosylation181N-linked (GlcNAc...) Potential
Disulfide bond105 ↔ 180 Ref.13

Natural variations

Alternative sequence312 – 40796Missing in isoform 2.
VSP_053824
Natural variant1921Y → H Display properties similar to those of the wild-type receptor. Ref.14
VAR_026826

Experimental info

Sequence conflict1161V → C in AAA59936. Ref.3
Sequence conflict2181V → I in AAA59936. Ref.3

Secondary structure

........................................... 407
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 1, 1992. Version 1.
Checksum: 2AFFD3F61B1A3041

FASTA40746,251
        10         20         30         40         50         60 
MDNVLPVDSD LSPNISTNTS EPNQFVQPAW QIVLWAAAYT VIVVTSVVGN VVVMWIILAH 

        70         80         90        100        110        120 
KRMRTVTNYF LVNLAFAEAS MAAFNTVVNF TYAVHNEWYY GLFYCKFHNF FPIAAVFASI 

       130        140        150        160        170        180 
YSMTAVAFDR YMAIIHPLQP RLSATATKVV ICVIWVLALL LAFPQGYYST TETMPSRVVC 

       190        200        210        220        230        240 
MIEWPEHPNK IYEKVYHICV TVLIYFLPLL VIGYAYTVVG ITLWASEIPG DSSDRYHEQV 

       250        260        270        280        290        300 
SAKRKVVKMM IVVVCTFAIC WLPFHIFFLL PYINPDLYLK KFIQQVYLAI MWLAMSSTMY 

       310        320        330        340        350        360 
NPIIYCCLND RFRLGFKHAF RCCPFISAGD YEGLEMKSTR YLQTQGSVYK VSRLETTIST 

       370        380        390        400 
VVGAHEEEPE DGPKATPSSL DLTSNCSSRS DSKTMTESFS FSSNVLS 

« Hide

Isoform 2 [UniParc].

Checksum: 23EC28E364E3E23D
Show »

FASTA31135,713

References

« Hide 'large scale' references
[1]"Molecular cloning, structural characterization and functional expression of the human substance P receptor."
Takeda Y., Chou K.B., Takeda J., Sachais B.S., Krause J.E.
Biochem. Biophys. Res. Commun. 179:1232-1240(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"Isolation and characterisation of the human lung NK-1 receptor cDNA."
Hopkins B., Powell S.J., Danks P., Briggs I., Graham A.
Biochem. Biophys. Res. Commun. 180:1110-1117(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Lung.
[3]"Human substance P receptor (NK-1): organization of the gene, chromosome localization, and functional expression of cDNA clones."
Gerard N.P., Garraway L.A., Eddy R.L. Jr., Shows T.B., Iijima H., Paquet J.L., Gerard C.
Biochemistry 30:10640-10646(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[4]"The primary structure and gene organization of human substance P and neuromedin K receptors."
Takahashi K., Tanaka A., Hara M., Nakanishi S.
Eur. J. Biochem. 204:1025-1033(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
Tissue: Placenta.
[5]"Differential activation of intracellular effector by two isoforms of human neurokinin-1 receptor."
Fong T.M., Anderson S.A., Yu H., Huang R.-R.C., Strader C.D.
Mol. Pharmacol. 41:24-30(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
[6]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Kopatz S.A., Aronstam R.S., Sharma S.V.
Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[7]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[8]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[10]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[11]"The human tachykinin NK1 (short form) and tachykinin NK4 receptor: a reappraisal."
Page N.M., Bell N.J.
Eur. J. Pharmacol. 437:27-30(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: LACK OF DETECTION OF ISOFORM 2.
[12]"Amino-aromatic interaction between histidine 197 of the neurokinin-1 receptor and CP 96345."
Fong T.M., Cascieri M.A., Yu H., Bansai A., Swain C., Strader C.D.
Nature 362:350-353(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: BINDING TO ANTAGONIST CP 96345.
[13]"NMR evidence of GM1-induced conformational change of Substance P using isotropic bicelles."
Gayen A., Goswami S.K., Mukhopadhyay C.
Biochim. Biophys. Acta 1808:127-139(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF 1-364, DISULFIDE BOND.
[14]"Identification of single-nucleotide polymorphisms of the human neurokinin 1 receptor gene and pharmacological characterization of a Y192H variant."
Randolph G.P., Simon J.S., Arreaza M.G., Qiu P., Lachowicz J.E., Duffy R.A.
Pharmacogenomics J. 4:394-402(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT HIS-192, CHARACTERIZATION OF VARIANT HIS-192.
+Additional computationally mapped references.

Web resources

Wikipedia

Tachykinin entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S62045 mRNA. Translation: AAB20168.2.
M74290 mRNA. Translation: AAA60601.1.
M81797 mRNA. Translation: AAA59933.1.
M76675 mRNA. Translation: AAA59936.1.
X65177 expand/collapse EMBL AC list , X65178, X65179, X65180, X65181 Genomic DNA. Translation: CAA46292.1.
M84425 mRNA. Translation: AAA36641.1.
M84426 mRNA. Translation: AAA36644.1.
AY462098 mRNA. Translation: AAR23925.1.
AK289765 mRNA. Translation: BAF82454.1.
CH471053 Genomic DNA. Translation: EAW99596.1.
BC074911 mRNA. Translation: AAH74911.1.
BC074912 mRNA. Translation: AAH74912.1.
AC007400 Genomic DNA. No translation available.
CCDSCCDS1958.1.
PIRJQ1274. A41134.
RefSeqNP_001049.1. NM_001058.3. [P25103-1]
NP_056542.1. NM_015727.2. [P25103-3]
UniGeneHs.633301.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2KS9NMR-A1-364[»]
2KSANMR-A1-364[»]
2KSBNMR-A1-364[»]
ProteinModelPortalP25103.
SMRP25103. Positions 2-364.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112732. 2 interactions.
IntActP25103. 1 interaction.
STRING9606.ENSP00000303522.

Chemistry

BindingDBP25103.
ChEMBLCHEMBL249.
DrugBankDB00673. Aprepitant.
DB01221. Ketamine.
DB04894. Vapreotide.
GuidetoPHARMACOLOGY360.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP25103.

Polymorphism databases

DMDM128359.

Proteomic databases

PaxDbP25103.
PRIDEP25103.

Protocols and materials databases

DNASU6869.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000305249; ENSP00000303522; ENSG00000115353.
ENST00000409848; ENSP00000386448; ENSG00000115353.
GeneID6869.
KEGGhsa:6869.
UCSCuc002sng.2. human. [P25103-1]

Organism-specific databases

CTD6869.
GeneCardsGC02M075187.
H-InvDBHIX0161946.
HGNCHGNC:11526. TACR1.
MIM162323. gene.
neXtProtNX_P25103.
PharmGKBPA36302.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG331485.
HOGENOMHOG000013018.
HOVERGENHBG103412.
InParanoidP25103.
KOK04222.
OMAMIIVVCT.
OrthoDBEOG7N37FW.
PhylomeDBP25103.
TreeFamTF315303.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressP25103.
BgeeP25103.
CleanExHS_TACR1.
GenevestigatorP25103.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001681. Neurokn_rcpt.
IPR000046. NK1_rcpt.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01024. NEUROKININ1R.
PR00244. NEUROKININR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP25103.
GeneWikiTachykinin_receptor_1.
GenomeRNAi6869.
NextBio26811.
PROP25103.
SOURCESearch...

Entry information

Entry nameNK1R_HUMAN
AccessionPrimary (citable) accession number: P25103
Secondary accession number(s): A8K150
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: July 9, 2014
This is version 150 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries