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Protein

Substance-P receptor

Gene

TACR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei197Antagonist CP 963451

GO - Molecular functioni

  • substance P receptor activity Source: UniProtKB
  • tachykinin receptor activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-380095. Tachykinin receptors bind tachykinins.
R-HSA-416476. G alpha (q) signalling events.
R-HSA-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-HSA-8856828. Clathrin-mediated endocytosis.

Names & Taxonomyi

Protein namesi
Recommended name:
Substance-P receptor
Short name:
SPR
Alternative name(s):
NK-1 receptor
Short name:
NK-1R
Tachykinin receptor 1
Gene namesi
Name:TACR1
Synonyms:NK1R, TAC1R
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000115353.10.
HGNCiHGNC:11526. TACR1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 31ExtracellularIEP:Add BLAST31
Transmembranei32 – 54Helical; Name=1IEP:Add BLAST23
Topological domaini55 – 64CytoplasmicIEP:10
Transmembranei65 – 86Helical; Name=2IEP:Add BLAST22
Topological domaini87 – 106ExtracellularIEP:Add BLAST20
Transmembranei107 – 128Helical; Name=3IEP:Add BLAST22
Topological domaini129 – 148CytoplasmicIEP:Add BLAST20
Transmembranei149 – 169Helical; Name=4IEP:Add BLAST21
Topological domaini170 – 194ExtracellularIEP:Add BLAST25
Transmembranei195 – 219Helical; Name=5IEP:Add BLAST25
Topological domaini220 – 248CytoplasmicIEP:Add BLAST29
Transmembranei249 – 270Helical; Name=6IEP:Add BLAST22
Topological domaini271 – 283ExtracellularIEP:Add BLAST13
Transmembranei284 – 308Helical; Name=7IEP:Add BLAST25
Topological domaini309 – 407CytoplasmicIEP:Add BLAST99

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6869.
OpenTargetsiENSG00000115353.
PharmGKBiPA36302.

Chemistry databases

ChEMBLiCHEMBL249.
DrugBankiDB00673. Aprepitant.
DB05072. AV608.
DB05421. CP-122721.
DB05418. GW 597599.
DB01221. Ketamine.
DB09048. Netupitant.
DB05466. R673.
DB05790. SR 140333.
DB04894. Vapreotide.
GuidetoPHARMACOLOGYi360.

Polymorphism and mutation databases

BioMutaiTACR1.
DMDMi128359.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000698851 – 407Substance-P receptorAdd BLAST407

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi14N-linked (GlcNAc...) asparagineIEP:1
Glycosylationi18N-linked (GlcNAc...) asparagineIEP:1
Disulfide bondi105 ↔ 180IEP:1 Publication
Lipidationi322S-palmitoyl cysteineIEP:1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP25103.
PRIDEiP25103.

PTM databases

iPTMnetiP25103.
PhosphoSitePlusiP25103.

Expressioni

Gene expression databases

BgeeiENSG00000115353.
CleanExiHS_TACR1.
GenevisibleiP25103. HS.

Organism-specific databases

HPAiHPA074573.

Interactioni

Subunit structurei

Interacts with ARRB1.HMP:

Binary interactionsi

WithEntry#Exp.IntActNotes
TAC1P203662EBI-6655287,EBI-6655360

Protein-protein interaction databases

BioGridi112732. 52 interactors.
IntActiP25103. 1 interactor.
STRINGi9606.ENSP00000303522.

Chemistry databases

BindingDBiP25103.

Structurei

Secondary structure

1407
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 8ND:5
Turni18 – 20ND:3
Turni24 – 26ND:3
Helixi29 – 59ND:31
Helixi66 – 83ND:18
Helixi85 – 95ND:11
Helixi102 – 135ND:34
Helixi144 – 162ND:19
Turni163 – 168ND:6
Beta strandi178 – 180ND:3
Turni189 – 192ND:4
Helixi193 – 204ND:12
Helixi206 – 221ND:16
Beta strandi229 – 234ND:6
Helixi238 – 273ND:36
Beta strandi279 – 281ND:3
Helixi284 – 308ND:25
Helixi310 – 320ND:11
Beta strandi321 – 323ND:3
Beta strandi335 – 340ND:6
Beta strandi342 – 344ND:3
Turni355 – 358ND:4
Beta strandi359 – 361ND:3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KS9NMR-A1-364[»]
2KSANMR-A1-364[»]
2KSBNMR-A1-364[»]
ProteinModelPortaliP25103.
SMRiP25103.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP25103.

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.IEP:

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4219. Eukaryota.
ENOG410XSC5. LUCA.
GeneTreeiENSGT00900000140861.
HOGENOMiHOG000013018.
HOVERGENiHBG103412.
InParanoidiP25103.
KOiK04222.
OMAiMIIVVCT.
OrthoDBiEOG091G0WYG.
PhylomeDBiP25103.
TreeFamiTF315303.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001681. Neurokn_rcpt.
IPR000046. NK1_rcpt.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR01024. NEUROKININ1R.
PR00244. NEUROKININR.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P25103-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDNVLPVDSD LSPNISTNTS EPNQFVQPAW QIVLWAAAYT VIVVTSVVGN
60 70 80 90 100
VVVMWIILAH KRMRTVTNYF LVNLAFAEAS MAAFNTVVNF TYAVHNEWYY
110 120 130 140 150
GLFYCKFHNF FPIAAVFASI YSMTAVAFDR YMAIIHPLQP RLSATATKVV
160 170 180 190 200
ICVIWVLALL LAFPQGYYST TETMPSRVVC MIEWPEHPNK IYEKVYHICV
210 220 230 240 250
TVLIYFLPLL VIGYAYTVVG ITLWASEIPG DSSDRYHEQV SAKRKVVKMM
260 270 280 290 300
IVVVCTFAIC WLPFHIFFLL PYINPDLYLK KFIQQVYLAI MWLAMSSTMY
310 320 330 340 350
NPIIYCCLND RFRLGFKHAF RCCPFISAGD YEGLEMKSTR YLQTQGSVYK
360 370 380 390 400
VSRLETTIST VVGAHEEEPE DGPKATPSSL DLTSNCSSRS DSKTMTESFS

FSSNVLS
Length:407
Mass (Da):46,251
Last modified:May 1, 1992 - v1
Checksum:i2AFFD3F61B1A3041
GO
Isoform 2 (identifier: P25103-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     312-407: Missing.

Note: In contrast to Fong et al. data (PubMed:1310144), isoform 2 is not detected by PCR in any of 24 human tissues examined including the placenta (PubMed:11864635).IKR:
Show »
Length:311
Mass (Da):35,713
Checksum:i23EC28E364E3E23D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti116V → C in AAA59936 (PubMed:1657150).IKR:1
Sequence conflicti218V → I in AAA59936 (PubMed:1657150).IKR:1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_026826192Y → H Display properties similar to those of the wild-type receptor. 1 PublicationCorresponds to variant dbSNP:rs200685841Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_053824312 – 407Missing in isoform 2. IBD:Add BLAST96

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S62045 mRNA. Translation: AAB20168.2.
M74290 mRNA. Translation: AAA60601.1.
M81797 mRNA. Translation: AAA59933.1.
M76675 mRNA. Translation: AAA59936.1.
X65177
, X65178, X65179, X65180, X65181 Genomic DNA. Translation: CAA46292.1.
M84425 mRNA. Translation: AAA36641.1.
M84426 mRNA. Translation: AAA36644.1.
AY462098 mRNA. Translation: AAR23925.1.
AK289765 mRNA. Translation: BAF82454.1.
CH471053 Genomic DNA. Translation: EAW99596.1.
BC074911 mRNA. Translation: AAH74911.1.
BC074912 mRNA. Translation: AAH74912.1.
AC007400 Genomic DNA. No translation available.
CCDSiCCDS1958.1. [P25103-1]
CCDS46345.1. [P25103-3]
PIRiA41134. JQ1274.
RefSeqiNP_001049.1. NM_001058.3. [P25103-1]
NP_056542.1. NM_015727.2. [P25103-3]
UniGeneiHs.633301.

Genome annotation databases

EnsembliENST00000305249; ENSP00000303522; ENSG00000115353. [P25103-1]
ENST00000409848; ENSP00000386448; ENSG00000115353. [P25103-3]
GeneIDi6869.
KEGGihsa:6869.
UCSCiuc002sng.3. human. [P25103-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNK1R_HUMAN
AccessioniPrimary (citable) accession number: P25103
Secondary accession number(s): A8K150
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: November 22, 2017
This is version 178 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families