Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Substance-P receptor

Gene

TACR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei197Antagonist CP 963451

GO - Molecular functioni

  • substance P receptor activity Source: GO_Central
  • tachykinin receptor activity Source: ProtInc

GO - Biological processi

  • cell surface receptor signaling pathway Source: GO_Central
  • chemical synaptic transmission Source: GO_Central
  • detection of abiotic stimulus Source: ProtInc
  • inflammatory response Source: ProtInc
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: ProtInc
  • positive regulation of smooth muscle contraction Source: GO_Central
  • regulation of uterine smooth muscle contraction Source: Ensembl
  • response to pain Source: Ensembl
  • tachykinin receptor signaling pathway Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000115353-MONOMER.
ReactomeiR-HSA-380095. Tachykinin receptors bind tachykinins.
R-HSA-416476. G alpha (q) signalling events.
R-HSA-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-HSA-8856828. Clathrin-mediated endocytosis.

Names & Taxonomyi

Protein namesi
Recommended name:
Substance-P receptor
Short name:
SPR
Alternative name(s):
NK-1 receptor
Short name:
NK-1R
Tachykinin receptor 1
Gene namesi
Name:TACR1
Synonyms:NK1R, TAC1R
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:11526. TACR1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 31ExtracellularSequence analysisAdd BLAST31
Transmembranei32 – 54Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini55 – 64CytoplasmicSequence analysis10
Transmembranei65 – 86Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini87 – 106ExtracellularSequence analysisAdd BLAST20
Transmembranei107 – 128Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini129 – 148CytoplasmicSequence analysisAdd BLAST20
Transmembranei149 – 169Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini170 – 194ExtracellularSequence analysisAdd BLAST25
Transmembranei195 – 219Helical; Name=5Sequence analysisAdd BLAST25
Topological domaini220 – 248CytoplasmicSequence analysisAdd BLAST29
Transmembranei249 – 270Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini271 – 283ExtracellularSequence analysisAdd BLAST13
Transmembranei284 – 308Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini309 – 407CytoplasmicSequence analysisAdd BLAST99

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6869.
OpenTargetsiENSG00000115353.
PharmGKBiPA36302.

Chemistry databases

ChEMBLiCHEMBL249.
DrugBankiDB00673. Aprepitant.
DB01221. Ketamine.
DB09048. Netupitant.
DB04894. Vapreotide.
GuidetoPHARMACOLOGYi360.

Polymorphism and mutation databases

BioMutaiTACR1.
DMDMi128359.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000698851 – 407Substance-P receptorAdd BLAST407

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi14N-linked (GlcNAc...)Sequence analysis1
Glycosylationi18N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi105 ↔ 180PROSITE-ProRule annotation1 Publication
Lipidationi322S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP25103.
PRIDEiP25103.

PTM databases

iPTMnetiP25103.
PhosphoSitePlusiP25103.

Expressioni

Gene expression databases

BgeeiENSG00000115353.
CleanExiHS_TACR1.
GenevisibleiP25103. HS.

Interactioni

Subunit structurei

Interacts with ARRB1.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
TAC1P203662EBI-6655287,EBI-6655360

Protein-protein interaction databases

BioGridi112732. 46 interactors.
IntActiP25103. 1 interactor.
STRINGi9606.ENSP00000303522.

Chemistry databases

BindingDBiP25103.

Structurei

Secondary structure

1407
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 8Combined sources5
Turni18 – 20Combined sources3
Turni24 – 26Combined sources3
Helixi29 – 59Combined sources31
Helixi66 – 83Combined sources18
Helixi85 – 95Combined sources11
Helixi102 – 135Combined sources34
Helixi144 – 162Combined sources19
Turni163 – 168Combined sources6
Beta strandi178 – 180Combined sources3
Turni189 – 192Combined sources4
Helixi193 – 204Combined sources12
Helixi206 – 221Combined sources16
Beta strandi229 – 234Combined sources6
Helixi238 – 273Combined sources36
Beta strandi279 – 281Combined sources3
Helixi284 – 308Combined sources25
Helixi310 – 320Combined sources11
Beta strandi321 – 323Combined sources3
Beta strandi335 – 340Combined sources6
Beta strandi342 – 344Combined sources3
Turni355 – 358Combined sources4
Beta strandi359 – 361Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KS9NMR-A1-364[»]
2KSANMR-A1-364[»]
2KSBNMR-A1-364[»]
ProteinModelPortaliP25103.
SMRiP25103.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP25103.

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4219. Eukaryota.
ENOG410XSC5. LUCA.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000013018.
HOVERGENiHBG103412.
InParanoidiP25103.
KOiK04222.
OMAiMIIVVCT.
OrthoDBiEOG091G0WYG.
PhylomeDBiP25103.
TreeFamiTF315303.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001681. Neurokn_rcpt.
IPR000046. NK1_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01024. NEUROKININ1R.
PR00244. NEUROKININR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P25103-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDNVLPVDSD LSPNISTNTS EPNQFVQPAW QIVLWAAAYT VIVVTSVVGN
60 70 80 90 100
VVVMWIILAH KRMRTVTNYF LVNLAFAEAS MAAFNTVVNF TYAVHNEWYY
110 120 130 140 150
GLFYCKFHNF FPIAAVFASI YSMTAVAFDR YMAIIHPLQP RLSATATKVV
160 170 180 190 200
ICVIWVLALL LAFPQGYYST TETMPSRVVC MIEWPEHPNK IYEKVYHICV
210 220 230 240 250
TVLIYFLPLL VIGYAYTVVG ITLWASEIPG DSSDRYHEQV SAKRKVVKMM
260 270 280 290 300
IVVVCTFAIC WLPFHIFFLL PYINPDLYLK KFIQQVYLAI MWLAMSSTMY
310 320 330 340 350
NPIIYCCLND RFRLGFKHAF RCCPFISAGD YEGLEMKSTR YLQTQGSVYK
360 370 380 390 400
VSRLETTIST VVGAHEEEPE DGPKATPSSL DLTSNCSSRS DSKTMTESFS

FSSNVLS
Length:407
Mass (Da):46,251
Last modified:May 1, 1992 - v1
Checksum:i2AFFD3F61B1A3041
GO
Isoform 2 (identifier: P25103-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     312-407: Missing.

Note: In contrast to Fong et al. data (PubMed:1310144), isoform 2 is not detected by PCR in any of 24 human tissues examined including the placenta (PubMed:11864635).2 Publications
Show »
Length:311
Mass (Da):35,713
Checksum:i23EC28E364E3E23D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti116V → C in AAA59936 (PubMed:1657150).Curated1
Sequence conflicti218V → I in AAA59936 (PubMed:1657150).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_026826192Y → H Display properties similar to those of the wild-type receptor. 1 PublicationCorresponds to variant rs200685841dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_053824312 – 407Missing in isoform 2. 1 PublicationAdd BLAST96

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S62045 mRNA. Translation: AAB20168.2.
M74290 mRNA. Translation: AAA60601.1.
M81797 mRNA. Translation: AAA59933.1.
M76675 mRNA. Translation: AAA59936.1.
X65177
, X65178, X65179, X65180, X65181 Genomic DNA. Translation: CAA46292.1.
M84425 mRNA. Translation: AAA36641.1.
M84426 mRNA. Translation: AAA36644.1.
AY462098 mRNA. Translation: AAR23925.1.
AK289765 mRNA. Translation: BAF82454.1.
CH471053 Genomic DNA. Translation: EAW99596.1.
BC074911 mRNA. Translation: AAH74911.1.
BC074912 mRNA. Translation: AAH74912.1.
AC007400 Genomic DNA. No translation available.
CCDSiCCDS1958.1. [P25103-1]
CCDS46345.1. [P25103-3]
PIRiA41134. JQ1274.
RefSeqiNP_001049.1. NM_001058.3. [P25103-1]
NP_056542.1. NM_015727.2. [P25103-3]
UniGeneiHs.633301.

Genome annotation databases

EnsembliENST00000305249; ENSP00000303522; ENSG00000115353. [P25103-1]
ENST00000409848; ENSP00000386448; ENSG00000115353. [P25103-3]
GeneIDi6869.
KEGGihsa:6869.
UCSCiuc002sng.3. human. [P25103-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Tachykinin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S62045 mRNA. Translation: AAB20168.2.
M74290 mRNA. Translation: AAA60601.1.
M81797 mRNA. Translation: AAA59933.1.
M76675 mRNA. Translation: AAA59936.1.
X65177
, X65178, X65179, X65180, X65181 Genomic DNA. Translation: CAA46292.1.
M84425 mRNA. Translation: AAA36641.1.
M84426 mRNA. Translation: AAA36644.1.
AY462098 mRNA. Translation: AAR23925.1.
AK289765 mRNA. Translation: BAF82454.1.
CH471053 Genomic DNA. Translation: EAW99596.1.
BC074911 mRNA. Translation: AAH74911.1.
BC074912 mRNA. Translation: AAH74912.1.
AC007400 Genomic DNA. No translation available.
CCDSiCCDS1958.1. [P25103-1]
CCDS46345.1. [P25103-3]
PIRiA41134. JQ1274.
RefSeqiNP_001049.1. NM_001058.3. [P25103-1]
NP_056542.1. NM_015727.2. [P25103-3]
UniGeneiHs.633301.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KS9NMR-A1-364[»]
2KSANMR-A1-364[»]
2KSBNMR-A1-364[»]
ProteinModelPortaliP25103.
SMRiP25103.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112732. 46 interactors.
IntActiP25103. 1 interactor.
STRINGi9606.ENSP00000303522.

Chemistry databases

BindingDBiP25103.
ChEMBLiCHEMBL249.
DrugBankiDB00673. Aprepitant.
DB01221. Ketamine.
DB09048. Netupitant.
DB04894. Vapreotide.
GuidetoPHARMACOLOGYi360.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP25103.
PhosphoSitePlusiP25103.

Polymorphism and mutation databases

BioMutaiTACR1.
DMDMi128359.

Proteomic databases

PaxDbiP25103.
PRIDEiP25103.

Protocols and materials databases

DNASUi6869.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305249; ENSP00000303522; ENSG00000115353. [P25103-1]
ENST00000409848; ENSP00000386448; ENSG00000115353. [P25103-3]
GeneIDi6869.
KEGGihsa:6869.
UCSCiuc002sng.3. human. [P25103-1]

Organism-specific databases

CTDi6869.
DisGeNETi6869.
GeneCardsiTACR1.
H-InvDBHIX0161946.
HGNCiHGNC:11526. TACR1.
MIMi162323. gene.
neXtProtiNX_P25103.
OpenTargetsiENSG00000115353.
PharmGKBiPA36302.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4219. Eukaryota.
ENOG410XSC5. LUCA.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000013018.
HOVERGENiHBG103412.
InParanoidiP25103.
KOiK04222.
OMAiMIIVVCT.
OrthoDBiEOG091G0WYG.
PhylomeDBiP25103.
TreeFamiTF315303.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000115353-MONOMER.
ReactomeiR-HSA-380095. Tachykinin receptors bind tachykinins.
R-HSA-416476. G alpha (q) signalling events.
R-HSA-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-HSA-8856828. Clathrin-mediated endocytosis.

Miscellaneous databases

ChiTaRSiTACR1. human.
EvolutionaryTraceiP25103.
GeneWikiiTachykinin_receptor_1.
GenomeRNAii6869.
PROiP25103.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000115353.
CleanExiHS_TACR1.
GenevisibleiP25103. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001681. Neurokn_rcpt.
IPR000046. NK1_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01024. NEUROKININ1R.
PR00244. NEUROKININR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNK1R_HUMAN
AccessioniPrimary (citable) accession number: P25103
Secondary accession number(s): A8K150
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: November 2, 2016
This is version 171 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.