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P25103

- NK1R_HUMAN

UniProt

P25103 - NK1R_HUMAN

Protein

Substance-P receptor

Gene

TACR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 152 (01 Oct 2014)
      Sequence version 1 (01 May 1992)
      Previous versions | rss
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    Functioni

    This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei197 – 1971Antagonist CP 96345

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. substance P receptor activity Source: Ensembl
    3. tachykinin receptor activity Source: ProtInc

    GO - Biological processi

    1. acute inflammatory response Source: Ensembl
    2. aggressive behavior Source: Ensembl
    3. angiotensin-mediated drinking behavior Source: Ensembl
    4. associative learning Source: Ensembl
    5. behavioral response to pain Source: Ensembl
    6. detection of abiotic stimulus Source: ProtInc
    7. eating behavior Source: Ensembl
    8. inflammatory response Source: ProtInc
    9. long-term memory Source: Ensembl
    10. operant conditioning Source: Ensembl
    11. phospholipase C-activating G-protein coupled receptor signaling pathway Source: ProtInc
    12. positive regulation of action potential Source: Ensembl
    13. positive regulation of blood pressure Source: Ensembl
    14. positive regulation of cytosolic calcium ion concentration Source: Ensembl
    15. positive regulation of epithelial cell migration Source: Ensembl
    16. positive regulation of epithelial cell proliferation Source: Ensembl
    17. positive regulation of hormone secretion Source: Ensembl
    18. positive regulation of leukocyte migration Source: Ensembl
    19. positive regulation of lymphocyte proliferation Source: Ensembl
    20. positive regulation of ossification Source: Ensembl
    21. positive regulation of renal sodium excretion Source: Ensembl
    22. positive regulation of saliva secretion Source: Ensembl
    23. positive regulation of stress fiber assembly Source: Ensembl
    24. positive regulation of synaptic transmission, cholinergic Source: Ensembl
    25. positive regulation of synaptic transmission, GABAergic Source: Ensembl
    26. positive regulation of uterine smooth muscle contraction Source: Ensembl
    27. positive regulation of vascular permeability Source: Ensembl
    28. positive regulation of vasoconstriction Source: Ensembl
    29. regulation of smooth muscle cell migration Source: Ensembl
    30. regulation of smooth muscle cell proliferation Source: Ensembl
    31. response to auditory stimulus Source: Ensembl
    32. response to estradiol Source: Ensembl
    33. response to ethanol Source: Ensembl
    34. response to heat Source: Ensembl
    35. response to morphine Source: Ensembl
    36. response to nicotine Source: Ensembl
    37. response to ozone Source: Ensembl
    38. response to progesterone Source: Ensembl
    39. smooth muscle contraction involved in micturition Source: Ensembl
    40. sperm ejaculation Source: Ensembl
    41. tachykinin receptor signaling pathway Source: BHF-UCL

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_16963. Tachykinin receptors bind tachykinins.
    REACT_18283. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Substance-P receptor
    Short name:
    SPR
    Alternative name(s):
    NK-1 receptor
    Short name:
    NK-1R
    Tachykinin receptor 1
    Gene namesi
    Name:TACR1
    Synonyms:NK1R, TAC1R
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:11526. TACR1.

    Subcellular locationi

    GO - Cellular componenti

    1. cell body Source: Ensembl
    2. cell surface Source: Ensembl
    3. cytoplasm Source: Ensembl
    4. dendrite Source: Ensembl
    5. integral component of plasma membrane Source: ProtInc
    6. plasma membrane Source: BHF-UCL

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36302.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 407407Substance-P receptorPRO_0000069885Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi14 – 141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi18 – 181N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi105 ↔ 1801 PublicationPROSITE-ProRule annotation
    Lipidationi322 – 3221S-palmitoyl cysteineSequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiP25103.
    PRIDEiP25103.

    PTM databases

    PhosphoSiteiP25103.

    Expressioni

    Gene expression databases

    ArrayExpressiP25103.
    BgeeiP25103.
    CleanExiHS_TACR1.
    GenevestigatoriP25103.

    Interactioni

    Subunit structurei

    Interacts with ARRB1.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    TAC1P203662EBI-6655287,EBI-6655360

    Protein-protein interaction databases

    BioGridi112732. 2 interactions.
    IntActiP25103. 1 interaction.
    STRINGi9606.ENSP00000303522.

    Structurei

    Secondary structure

    1
    407
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi4 – 85
    Turni18 – 203
    Turni24 – 263
    Helixi29 – 5931
    Helixi66 – 8318
    Helixi85 – 9511
    Helixi102 – 13534
    Helixi144 – 16219
    Turni163 – 1686
    Beta strandi178 – 1803
    Turni189 – 1924
    Helixi193 – 20412
    Helixi206 – 22116
    Beta strandi229 – 2346
    Helixi238 – 27336
    Beta strandi279 – 2813
    Helixi284 – 30825
    Helixi310 – 32011
    Beta strandi321 – 3233
    Beta strandi335 – 3406
    Beta strandi342 – 3443
    Turni355 – 3584
    Beta strandi359 – 3613

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2KS9NMR-A1-364[»]
    2KSANMR-A1-364[»]
    2KSBNMR-A1-364[»]
    ProteinModelPortaliP25103.
    SMRiP25103. Positions 2-364.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP25103.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3131ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini55 – 6410CytoplasmicSequence Analysis
    Topological domaini87 – 10620ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini129 – 14820CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini170 – 19425ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini220 – 24829CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini271 – 28313ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini309 – 40799CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei32 – 5423Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei65 – 8622Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei107 – 12822Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei149 – 16921Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei195 – 21925Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei249 – 27022Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei284 – 30825Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG331485.
    HOGENOMiHOG000013018.
    HOVERGENiHBG103412.
    InParanoidiP25103.
    KOiK04222.
    OMAiMIIVVCT.
    OrthoDBiEOG7N37FW.
    PhylomeDBiP25103.
    TreeFamiTF315303.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001681. Neurokn_rcpt.
    IPR000046. NK1_rcpt.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01024. NEUROKININ1R.
    PR00244. NEUROKININR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P25103-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDNVLPVDSD LSPNISTNTS EPNQFVQPAW QIVLWAAAYT VIVVTSVVGN    50
    VVVMWIILAH KRMRTVTNYF LVNLAFAEAS MAAFNTVVNF TYAVHNEWYY 100
    GLFYCKFHNF FPIAAVFASI YSMTAVAFDR YMAIIHPLQP RLSATATKVV 150
    ICVIWVLALL LAFPQGYYST TETMPSRVVC MIEWPEHPNK IYEKVYHICV 200
    TVLIYFLPLL VIGYAYTVVG ITLWASEIPG DSSDRYHEQV SAKRKVVKMM 250
    IVVVCTFAIC WLPFHIFFLL PYINPDLYLK KFIQQVYLAI MWLAMSSTMY 300
    NPIIYCCLND RFRLGFKHAF RCCPFISAGD YEGLEMKSTR YLQTQGSVYK 350
    VSRLETTIST VVGAHEEEPE DGPKATPSSL DLTSNCSSRS DSKTMTESFS 400
    FSSNVLS 407
    Length:407
    Mass (Da):46,251
    Last modified:May 1, 1992 - v1
    Checksum:i2AFFD3F61B1A3041
    GO
    Isoform 2 (identifier: P25103-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         312-407: Missing.

    Note: In contrast to Fong et al. data (PubMed:1310144), isoform 2 is not detected by PCR in any of 24 human tissues examined including the placenta (PubMed:11864635).2 Publications

    Show »
    Length:311
    Mass (Da):35,713
    Checksum:i23EC28E364E3E23D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti116 – 1161V → C in AAA59936. (PubMed:1657150)Curated
    Sequence conflicti218 – 2181V → I in AAA59936. (PubMed:1657150)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti192 – 1921Y → H Display properties similar to those of the wild-type receptor. 1 Publication
    VAR_026826

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei312 – 40796Missing in isoform 2. 1 PublicationVSP_053824Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S62045 mRNA. Translation: AAB20168.2.
    M74290 mRNA. Translation: AAA60601.1.
    M81797 mRNA. Translation: AAA59933.1.
    M76675 mRNA. Translation: AAA59936.1.
    X65177
    , X65178, X65179, X65180, X65181 Genomic DNA. Translation: CAA46292.1.
    M84425 mRNA. Translation: AAA36641.1.
    M84426 mRNA. Translation: AAA36644.1.
    AY462098 mRNA. Translation: AAR23925.1.
    AK289765 mRNA. Translation: BAF82454.1.
    CH471053 Genomic DNA. Translation: EAW99596.1.
    BC074911 mRNA. Translation: AAH74911.1.
    BC074912 mRNA. Translation: AAH74912.1.
    AC007400 Genomic DNA. No translation available.
    CCDSiCCDS1958.1. [P25103-1]
    CCDS46345.1. [P25103-3]
    PIRiA41134. JQ1274.
    RefSeqiNP_001049.1. NM_001058.3. [P25103-1]
    NP_056542.1. NM_015727.2. [P25103-3]
    UniGeneiHs.633301.

    Genome annotation databases

    EnsembliENST00000305249; ENSP00000303522; ENSG00000115353. [P25103-1]
    ENST00000409848; ENSP00000386448; ENSG00000115353. [P25103-3]
    GeneIDi6869.
    KEGGihsa:6869.
    UCSCiuc002sng.2. human. [P25103-1]

    Polymorphism databases

    DMDMi128359.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Tachykinin entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S62045 mRNA. Translation: AAB20168.2 .
    M74290 mRNA. Translation: AAA60601.1 .
    M81797 mRNA. Translation: AAA59933.1 .
    M76675 mRNA. Translation: AAA59936.1 .
    X65177
    , X65178 , X65179 , X65180 , X65181 Genomic DNA. Translation: CAA46292.1 .
    M84425 mRNA. Translation: AAA36641.1 .
    M84426 mRNA. Translation: AAA36644.1 .
    AY462098 mRNA. Translation: AAR23925.1 .
    AK289765 mRNA. Translation: BAF82454.1 .
    CH471053 Genomic DNA. Translation: EAW99596.1 .
    BC074911 mRNA. Translation: AAH74911.1 .
    BC074912 mRNA. Translation: AAH74912.1 .
    AC007400 Genomic DNA. No translation available.
    CCDSi CCDS1958.1. [P25103-1 ]
    CCDS46345.1. [P25103-3 ]
    PIRi A41134. JQ1274.
    RefSeqi NP_001049.1. NM_001058.3. [P25103-1 ]
    NP_056542.1. NM_015727.2. [P25103-3 ]
    UniGenei Hs.633301.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2KS9 NMR - A 1-364 [» ]
    2KSA NMR - A 1-364 [» ]
    2KSB NMR - A 1-364 [» ]
    ProteinModelPortali P25103.
    SMRi P25103. Positions 2-364.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112732. 2 interactions.
    IntActi P25103. 1 interaction.
    STRINGi 9606.ENSP00000303522.

    Chemistry

    BindingDBi P25103.
    ChEMBLi CHEMBL249.
    DrugBanki DB00673. Aprepitant.
    DB01221. Ketamine.
    DB04894. Vapreotide.
    GuidetoPHARMACOLOGYi 360.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P25103.

    Polymorphism databases

    DMDMi 128359.

    Proteomic databases

    PaxDbi P25103.
    PRIDEi P25103.

    Protocols and materials databases

    DNASUi 6869.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000305249 ; ENSP00000303522 ; ENSG00000115353 . [P25103-1 ]
    ENST00000409848 ; ENSP00000386448 ; ENSG00000115353 . [P25103-3 ]
    GeneIDi 6869.
    KEGGi hsa:6869.
    UCSCi uc002sng.2. human. [P25103-1 ]

    Organism-specific databases

    CTDi 6869.
    GeneCardsi GC02M075187.
    H-InvDB HIX0161946.
    HGNCi HGNC:11526. TACR1.
    MIMi 162323. gene.
    neXtProti NX_P25103.
    PharmGKBi PA36302.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG331485.
    HOGENOMi HOG000013018.
    HOVERGENi HBG103412.
    InParanoidi P25103.
    KOi K04222.
    OMAi MIIVVCT.
    OrthoDBi EOG7N37FW.
    PhylomeDBi P25103.
    TreeFami TF315303.

    Enzyme and pathway databases

    Reactomei REACT_16963. Tachykinin receptors bind tachykinins.
    REACT_18283. G alpha (q) signalling events.

    Miscellaneous databases

    EvolutionaryTracei P25103.
    GeneWikii Tachykinin_receptor_1.
    GenomeRNAii 6869.
    NextBioi 26811.
    PROi P25103.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P25103.
    Bgeei P25103.
    CleanExi HS_TACR1.
    Genevestigatori P25103.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001681. Neurokn_rcpt.
    IPR000046. NK1_rcpt.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01024. NEUROKININ1R.
    PR00244. NEUROKININR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning, structural characterization and functional expression of the human substance P receptor."
      Takeda Y., Chou K.B., Takeda J., Sachais B.S., Krause J.E.
      Biochem. Biophys. Res. Commun. 179:1232-1240(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Isolation and characterisation of the human lung NK-1 receptor cDNA."
      Hopkins B., Powell S.J., Danks P., Briggs I., Graham A.
      Biochem. Biophys. Res. Commun. 180:1110-1117(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Lung.
    3. "Human substance P receptor (NK-1): organization of the gene, chromosome localization, and functional expression of cDNA clones."
      Gerard N.P., Garraway L.A., Eddy R.L. Jr., Shows T.B., Iijima H., Paquet J.L., Gerard C.
      Biochemistry 30:10640-10646(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    4. "The primary structure and gene organization of human substance P and neuromedin K receptors."
      Takahashi K., Tanaka A., Hara M., Nakanishi S.
      Eur. J. Biochem. 204:1025-1033(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
      Tissue: Placenta.
    5. "Differential activation of intracellular effector by two isoforms of human neurokinin-1 receptor."
      Fong T.M., Anderson S.A., Yu H., Huang R.-R.C., Strader C.D.
      Mol. Pharmacol. 41:24-30(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    6. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Kopatz S.A., Aronstam R.S., Sharma S.V.
      Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    8. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    11. "The human tachykinin NK1 (short form) and tachykinin NK4 receptor: a reappraisal."
      Page N.M., Bell N.J.
      Eur. J. Pharmacol. 437:27-30(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: LACK OF DETECTION OF ISOFORM 2.
    12. "Amino-aromatic interaction between histidine 197 of the neurokinin-1 receptor and CP 96345."
      Fong T.M., Cascieri M.A., Yu H., Bansai A., Swain C., Strader C.D.
      Nature 362:350-353(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: BINDING TO ANTAGONIST CP 96345.
    13. "NMR evidence of GM1-induced conformational change of Substance P using isotropic bicelles."
      Gayen A., Goswami S.K., Mukhopadhyay C.
      Biochim. Biophys. Acta 1808:127-139(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 1-364, DISULFIDE BOND.
    14. "Identification of single-nucleotide polymorphisms of the human neurokinin 1 receptor gene and pharmacological characterization of a Y192H variant."
      Randolph G.P., Simon J.S., Arreaza M.G., Qiu P., Lachowicz J.E., Duffy R.A.
      Pharmacogenomics J. 4:394-402(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT HIS-192, CHARACTERIZATION OF VARIANT HIS-192.

    Entry informationi

    Entry nameiNK1R_HUMAN
    AccessioniPrimary (citable) accession number: P25103
    Secondary accession number(s): A8K150
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: May 1, 1992
    Last modified: October 1, 2014
    This is version 152 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3