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P25103

- NK1R_HUMAN

UniProt

P25103 - NK1R_HUMAN

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Protein

Substance-P receptor

Gene
TACR1, NK1R, TAC1R
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei197 – 1971Antagonist CP 96345

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. substance P receptor activity Source: Ensembl
  3. tachykinin receptor activity Source: ProtInc

GO - Biological processi

  1. acute inflammatory response Source: Ensembl
  2. aggressive behavior Source: Ensembl
  3. angiotensin-mediated drinking behavior Source: Ensembl
  4. associative learning Source: Ensembl
  5. behavioral response to pain Source: Ensembl
  6. detection of abiotic stimulus Source: ProtInc
  7. eating behavior Source: Ensembl
  8. inflammatory response Source: ProtInc
  9. long-term memory Source: Ensembl
  10. operant conditioning Source: Ensembl
  11. phospholipase C-activating G-protein coupled receptor signaling pathway Source: ProtInc
  12. positive regulation of action potential Source: Ensembl
  13. positive regulation of blood pressure Source: Ensembl
  14. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  15. positive regulation of epithelial cell migration Source: Ensembl
  16. positive regulation of epithelial cell proliferation Source: Ensembl
  17. positive regulation of hormone secretion Source: Ensembl
  18. positive regulation of leukocyte migration Source: Ensembl
  19. positive regulation of lymphocyte proliferation Source: Ensembl
  20. positive regulation of ossification Source: Ensembl
  21. positive regulation of renal sodium excretion Source: Ensembl
  22. positive regulation of saliva secretion Source: Ensembl
  23. positive regulation of stress fiber assembly Source: Ensembl
  24. positive regulation of synaptic transmission, cholinergic Source: Ensembl
  25. positive regulation of synaptic transmission, GABAergic Source: Ensembl
  26. positive regulation of uterine smooth muscle contraction Source: Ensembl
  27. positive regulation of vascular permeability Source: Ensembl
  28. positive regulation of vasoconstriction Source: Ensembl
  29. regulation of smooth muscle cell migration Source: Ensembl
  30. regulation of smooth muscle cell proliferation Source: Ensembl
  31. response to auditory stimulus Source: Ensembl
  32. response to estradiol Source: Ensembl
  33. response to ethanol Source: Ensembl
  34. response to heat Source: Ensembl
  35. response to morphine Source: Ensembl
  36. response to nicotine Source: Ensembl
  37. response to ozone Source: Ensembl
  38. response to progesterone Source: Ensembl
  39. smooth muscle contraction involved in micturition Source: Ensembl
  40. sperm ejaculation Source: Ensembl
  41. tachykinin receptor signaling pathway Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_16963. Tachykinin receptors bind tachykinins.
REACT_18283. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Substance-P receptor
Short name:
SPR
Alternative name(s):
NK-1 receptor
Short name:
NK-1R
Tachykinin receptor 1
Gene namesi
Name:TACR1
Synonyms:NK1R, TAC1R
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:11526. TACR1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3131Extracellular Reviewed predictionAdd
BLAST
Transmembranei32 – 5423Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini55 – 6410Cytoplasmic Reviewed prediction
Transmembranei65 – 8622Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini87 – 10620Extracellular Reviewed predictionAdd
BLAST
Transmembranei107 – 12822Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini129 – 14820Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei149 – 16921Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini170 – 19425Extracellular Reviewed predictionAdd
BLAST
Transmembranei195 – 21925Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini220 – 24829Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei249 – 27022Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini271 – 28313Extracellular Reviewed predictionAdd
BLAST
Transmembranei284 – 30825Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini309 – 40799Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cell body Source: Ensembl
  2. cell surface Source: Ensembl
  3. cytoplasm Source: Ensembl
  4. dendrite Source: Ensembl
  5. integral component of plasma membrane Source: ProtInc
  6. plasma membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36302.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 407407Substance-P receptorPRO_0000069885Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi14 – 141N-linked (GlcNAc...) Reviewed prediction
Glycosylationi18 – 181N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi105 ↔ 1801 Publication
Lipidationi322 – 3221S-palmitoyl cysteine Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP25103.
PRIDEiP25103.

PTM databases

PhosphoSiteiP25103.

Expressioni

Gene expression databases

ArrayExpressiP25103.
BgeeiP25103.
CleanExiHS_TACR1.
GenevestigatoriP25103.

Interactioni

Subunit structurei

Interacts with ARRB1 By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
TAC1P203662EBI-6655287,EBI-6655360

Protein-protein interaction databases

BioGridi112732. 2 interactions.
IntActiP25103. 1 interaction.
STRINGi9606.ENSP00000303522.

Structurei

Secondary structure

1
407
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 85
Turni18 – 203
Turni24 – 263
Helixi29 – 5931
Helixi66 – 8318
Helixi85 – 9511
Helixi102 – 13534
Helixi144 – 16219
Turni163 – 1686
Beta strandi178 – 1803
Turni189 – 1924
Helixi193 – 20412
Helixi206 – 22116
Beta strandi229 – 2346
Helixi238 – 27336
Beta strandi279 – 2813
Helixi284 – 30825
Helixi310 – 32011
Beta strandi321 – 3233
Beta strandi335 – 3406
Beta strandi342 – 3443
Turni355 – 3584
Beta strandi359 – 3613

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KS9NMR-A1-364[»]
2KSANMR-A1-364[»]
2KSBNMR-A1-364[»]
ProteinModelPortaliP25103.
SMRiP25103. Positions 2-364.

Miscellaneous databases

EvolutionaryTraceiP25103.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG331485.
HOGENOMiHOG000013018.
HOVERGENiHBG103412.
InParanoidiP25103.
KOiK04222.
OMAiMIIVVCT.
OrthoDBiEOG7N37FW.
PhylomeDBiP25103.
TreeFamiTF315303.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001681. Neurokn_rcpt.
IPR000046. NK1_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01024. NEUROKININ1R.
PR00244. NEUROKININR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P25103-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDNVLPVDSD LSPNISTNTS EPNQFVQPAW QIVLWAAAYT VIVVTSVVGN    50
VVVMWIILAH KRMRTVTNYF LVNLAFAEAS MAAFNTVVNF TYAVHNEWYY 100
GLFYCKFHNF FPIAAVFASI YSMTAVAFDR YMAIIHPLQP RLSATATKVV 150
ICVIWVLALL LAFPQGYYST TETMPSRVVC MIEWPEHPNK IYEKVYHICV 200
TVLIYFLPLL VIGYAYTVVG ITLWASEIPG DSSDRYHEQV SAKRKVVKMM 250
IVVVCTFAIC WLPFHIFFLL PYINPDLYLK KFIQQVYLAI MWLAMSSTMY 300
NPIIYCCLND RFRLGFKHAF RCCPFISAGD YEGLEMKSTR YLQTQGSVYK 350
VSRLETTIST VVGAHEEEPE DGPKATPSSL DLTSNCSSRS DSKTMTESFS 400
FSSNVLS 407
Length:407
Mass (Da):46,251
Last modified:May 1, 1992 - v1
Checksum:i2AFFD3F61B1A3041
GO
Isoform 2 (identifier: P25103-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     312-407: Missing.

Note: In contrast to Fong et al. data (PubMed:1310144), isoform 2 is not detected by PCR in any of 24 human tissues examined including the placenta (PubMed:11864635).

Show »
Length:311
Mass (Da):35,713
Checksum:i23EC28E364E3E23D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti192 – 1921Y → H Display properties similar to those of the wild-type receptor. 1 Publication
VAR_026826

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei312 – 40796Missing in isoform 2. VSP_053824Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti116 – 1161V → C in AAA59936. 1 Publication
Sequence conflicti218 – 2181V → I in AAA59936. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S62045 mRNA. Translation: AAB20168.2.
M74290 mRNA. Translation: AAA60601.1.
M81797 mRNA. Translation: AAA59933.1.
M76675 mRNA. Translation: AAA59936.1.
X65177
, X65178, X65179, X65180, X65181 Genomic DNA. Translation: CAA46292.1.
M84425 mRNA. Translation: AAA36641.1.
M84426 mRNA. Translation: AAA36644.1.
AY462098 mRNA. Translation: AAR23925.1.
AK289765 mRNA. Translation: BAF82454.1.
CH471053 Genomic DNA. Translation: EAW99596.1.
BC074911 mRNA. Translation: AAH74911.1.
BC074912 mRNA. Translation: AAH74912.1.
AC007400 Genomic DNA. No translation available.
CCDSiCCDS1958.1. [P25103-1]
CCDS46345.1. [P25103-3]
PIRiA41134. JQ1274.
RefSeqiNP_001049.1. NM_001058.3. [P25103-1]
NP_056542.1. NM_015727.2. [P25103-3]
UniGeneiHs.633301.

Genome annotation databases

EnsembliENST00000305249; ENSP00000303522; ENSG00000115353.
ENST00000409848; ENSP00000386448; ENSG00000115353.
GeneIDi6869.
KEGGihsa:6869.
UCSCiuc002sng.2. human. [P25103-1]

Polymorphism databases

DMDMi128359.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Tachykinin entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S62045 mRNA. Translation: AAB20168.2 .
M74290 mRNA. Translation: AAA60601.1 .
M81797 mRNA. Translation: AAA59933.1 .
M76675 mRNA. Translation: AAA59936.1 .
X65177
, X65178 , X65179 , X65180 , X65181 Genomic DNA. Translation: CAA46292.1 .
M84425 mRNA. Translation: AAA36641.1 .
M84426 mRNA. Translation: AAA36644.1 .
AY462098 mRNA. Translation: AAR23925.1 .
AK289765 mRNA. Translation: BAF82454.1 .
CH471053 Genomic DNA. Translation: EAW99596.1 .
BC074911 mRNA. Translation: AAH74911.1 .
BC074912 mRNA. Translation: AAH74912.1 .
AC007400 Genomic DNA. No translation available.
CCDSi CCDS1958.1. [P25103-1 ]
CCDS46345.1. [P25103-3 ]
PIRi A41134. JQ1274.
RefSeqi NP_001049.1. NM_001058.3. [P25103-1 ]
NP_056542.1. NM_015727.2. [P25103-3 ]
UniGenei Hs.633301.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2KS9 NMR - A 1-364 [» ]
2KSA NMR - A 1-364 [» ]
2KSB NMR - A 1-364 [» ]
ProteinModelPortali P25103.
SMRi P25103. Positions 2-364.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112732. 2 interactions.
IntActi P25103. 1 interaction.
STRINGi 9606.ENSP00000303522.

Chemistry

BindingDBi P25103.
ChEMBLi CHEMBL249.
DrugBanki DB00673. Aprepitant.
DB01221. Ketamine.
DB04894. Vapreotide.
GuidetoPHARMACOLOGYi 360.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P25103.

Polymorphism databases

DMDMi 128359.

Proteomic databases

PaxDbi P25103.
PRIDEi P25103.

Protocols and materials databases

DNASUi 6869.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000305249 ; ENSP00000303522 ; ENSG00000115353 .
ENST00000409848 ; ENSP00000386448 ; ENSG00000115353 .
GeneIDi 6869.
KEGGi hsa:6869.
UCSCi uc002sng.2. human. [P25103-1 ]

Organism-specific databases

CTDi 6869.
GeneCardsi GC02M075187.
H-InvDB HIX0161946.
HGNCi HGNC:11526. TACR1.
MIMi 162323. gene.
neXtProti NX_P25103.
PharmGKBi PA36302.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG331485.
HOGENOMi HOG000013018.
HOVERGENi HBG103412.
InParanoidi P25103.
KOi K04222.
OMAi MIIVVCT.
OrthoDBi EOG7N37FW.
PhylomeDBi P25103.
TreeFami TF315303.

Enzyme and pathway databases

Reactomei REACT_16963. Tachykinin receptors bind tachykinins.
REACT_18283. G alpha (q) signalling events.

Miscellaneous databases

EvolutionaryTracei P25103.
GeneWikii Tachykinin_receptor_1.
GenomeRNAii 6869.
NextBioi 26811.
PROi P25103.
SOURCEi Search...

Gene expression databases

ArrayExpressi P25103.
Bgeei P25103.
CleanExi HS_TACR1.
Genevestigatori P25103.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001681. Neurokn_rcpt.
IPR000046. NK1_rcpt.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01024. NEUROKININ1R.
PR00244. NEUROKININR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning, structural characterization and functional expression of the human substance P receptor."
    Takeda Y., Chou K.B., Takeda J., Sachais B.S., Krause J.E.
    Biochem. Biophys. Res. Commun. 179:1232-1240(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Isolation and characterisation of the human lung NK-1 receptor cDNA."
    Hopkins B., Powell S.J., Danks P., Briggs I., Graham A.
    Biochem. Biophys. Res. Commun. 180:1110-1117(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Lung.
  3. "Human substance P receptor (NK-1): organization of the gene, chromosome localization, and functional expression of cDNA clones."
    Gerard N.P., Garraway L.A., Eddy R.L. Jr., Shows T.B., Iijima H., Paquet J.L., Gerard C.
    Biochemistry 30:10640-10646(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. "The primary structure and gene organization of human substance P and neuromedin K receptors."
    Takahashi K., Tanaka A., Hara M., Nakanishi S.
    Eur. J. Biochem. 204:1025-1033(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
    Tissue: Placenta.
  5. "Differential activation of intracellular effector by two isoforms of human neurokinin-1 receptor."
    Fong T.M., Anderson S.A., Yu H., Huang R.-R.C., Strader C.D.
    Mol. Pharmacol. 41:24-30(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  6. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Kopatz S.A., Aronstam R.S., Sharma S.V.
    Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  8. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  11. "The human tachykinin NK1 (short form) and tachykinin NK4 receptor: a reappraisal."
    Page N.M., Bell N.J.
    Eur. J. Pharmacol. 437:27-30(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: LACK OF DETECTION OF ISOFORM 2.
  12. "Amino-aromatic interaction between histidine 197 of the neurokinin-1 receptor and CP 96345."
    Fong T.M., Cascieri M.A., Yu H., Bansai A., Swain C., Strader C.D.
    Nature 362:350-353(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: BINDING TO ANTAGONIST CP 96345.
  13. "NMR evidence of GM1-induced conformational change of Substance P using isotropic bicelles."
    Gayen A., Goswami S.K., Mukhopadhyay C.
    Biochim. Biophys. Acta 1808:127-139(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 1-364, DISULFIDE BOND.
  14. "Identification of single-nucleotide polymorphisms of the human neurokinin 1 receptor gene and pharmacological characterization of a Y192H variant."
    Randolph G.P., Simon J.S., Arreaza M.G., Qiu P., Lachowicz J.E., Duffy R.A.
    Pharmacogenomics J. 4:394-402(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT HIS-192, CHARACTERIZATION OF VARIANT HIS-192.

Entry informationi

Entry nameiNK1R_HUMAN
AccessioniPrimary (citable) accession number: P25103
Secondary accession number(s): A8K150
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: September 3, 2014
This is version 151 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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