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P25102 (HRH2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histamine H2 receptor
Short name=H2R
Short name=HH2R
Alternative name(s):
Gastric receptor I
Gene names
Name:Hrh2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length358 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The H2 subclass of histamine receptors mediates gastric acid secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 358358Histamine H2 receptor
PRO_0000069688

Regions

Topological domain1 – 2222Extracellular Potential
Transmembrane23 – 4422Helical; Name=1; Potential
Topological domain45 – 5713Cytoplasmic Potential
Transmembrane58 – 8124Helical; Name=2; Potential
Topological domain82 – 9211Extracellular Potential
Transmembrane93 – 11422Helical; Name=3; Potential
Topological domain115 – 13420Cytoplasmic Potential
Transmembrane135 – 15925Helical; Name=4; Potential
Topological domain160 – 17920Extracellular Potential
Transmembrane180 – 20324Helical; Name=5; Potential
Topological domain204 – 23330Cytoplasmic Potential
Transmembrane234 – 25724Helical; Name=6; Potential
Topological domain258 – 2669Extracellular Potential
Transmembrane267 – 28822Helical; Name=7; Potential
Topological domain289 – 35870Cytoplasmic Potential

Sites

Site981Essential for histamine binding By similarity
Site1851Essential for tiotidine binding and implicated in histamine binding By similarity
Site1891Implicated in histamine binding By similarity

Amino acid modifications

Lipidation3041S-palmitoyl cysteine By similarity
Glycosylation41N-linked (GlcNAc...) Potential
Disulfide bond91 ↔ 173 By similarity

Sequences

Sequence LengthMass (Da)Tools
P25102 [UniParc].

Last modified May 1, 1992. Version 1.
Checksum: 4889F69B7B5D5DDC

FASTA35840,253
        10         20         30         40         50         60 
MEPNGTVHSC CLDSMALKVT ISVVLTTLIL ITIAGNVVVC LAVSLNRRLR SLTNCFIVSL 

        70         80         90        100        110        120 
AATDLLLGLL VLPFSAIYQL SFTWSFGHVF CNIYTSLDVM LCTASILNLF MISLDRYCAV 

       130        140        150        160        170        180 
TDPLRYPVLV TPVRVAISLV FIWVISITLS FLSIHLGWNS RNGTRGGNDT FKCKVQVNEV 

       190        200        210        220        230        240 
YGLVDGLVTF YLPLLIMCVT YYRIFKIARE QAKRINHISS WKAATIREHK ATVTLAAVMG 

       250        260        270        280        290        300 
AFIICWFPYF TAFVYRGLRG DDAINEAVEG IVLWLGYANS ALNPILYAAL NRDFRTAYQQ 

       310        320        330        340        350 
LFHCKFASHN SHKTSLRLNN SLLPRSQSRE GRWQEEKPLK LQVWSGTELT HPQGNPIR

« Hide

References

[1]"Cloning and tissue expression of a rat histamine H2-receptor gene."
Ruat M., Traiffort E., Arrang J.-M., Leurs R., Schwartz J.-C.
Biochem. Biophys. Res. Commun. 179:1470-1478(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		S57565 Genomic DNA. Translation: AAB19935.1.
IPIIPI00215163.
PIRJQ1278.
RefSeqNP_037097.3. NM_012965.3.
UniGeneRn.138113.

3D structure databases

ProteinModelPortalP25102.
ModBaseSearch...

Protein-protein interaction databases

IntActP25102. 2 interactions.
STRING10116.ENSRNOP00000024580.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP25102.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID25461.
KEGGrno:25461.

Organism-specific databases

CTD3274.
RGD2831. Hrh2.

Phylogenomic databases

eggNOGNOG283797.
HOGENOMHOG000239242.
HOVERGENHBG106962.
InParanoidP25102.
KOK04150.
OrthoDBEOG418BP4.

Gene expression databases

ArrayExpressP25102.
GenevestigatorP25102.
GermOnlineENSRNOG00000018260. Rattus norvegicus.

Family and domain databases

InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000503. Histamine_H2_rcpt.
[Graphical view]
PANTHERPTHR24249:SF29. PTHR24249:SF29. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00531. HISTAMINEH2R.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

BindingDBP25102.
ChEMBLCHEMBL4654.
NextBio606739.

Entry information

Entry nameHRH2_RAT
AccessionPrimary (citable) accession number: P25102
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: May 1, 2013
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

SIMILARITY comments

Index of protein domains and families

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