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Protein

Histamine H2 receptor

Gene

Hrh2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

The H2 subclass of histamine receptors mediates gastric acid secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei98 – 981Essential for histamine bindingBy similarity
Sitei185 – 1851Essential for tiotidine binding and implicated in histamine bindingBy similarity
Sitei189 – 1891Implicated in histamine bindingBy similarity

GO - Molecular functioni

  • heterocyclic compound binding Source: RGD
  • histamine receptor activity Source: RGD

GO - Biological processi

  • cellular response to histamine Source: RGD
  • gastric acid secretion Source: InterPro
  • negative regulation of arachidonic acid secretion Source: RGD
  • positive regulation of vasoconstriction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Histamine H2 receptor
Short name:
H2R
Short name:
HH2R
Alternative name(s):
Gastric receptor I
Gene namesi
Name:Hrh2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2831. Hrh2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2222ExtracellularSequence analysisAdd
BLAST
Transmembranei23 – 4422Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini45 – 5713CytoplasmicSequence analysisAdd
BLAST
Transmembranei58 – 8124Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini82 – 9211ExtracellularSequence analysisAdd
BLAST
Transmembranei93 – 11422Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini115 – 13420CytoplasmicSequence analysisAdd
BLAST
Transmembranei135 – 15925Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini160 – 17920ExtracellularSequence analysisAdd
BLAST
Transmembranei180 – 20324Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini204 – 23330CytoplasmicSequence analysisAdd
BLAST
Transmembranei234 – 25724Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini258 – 2669ExtracellularSequence analysis
Transmembranei267 – 28822Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini289 – 35870CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: RGD
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL4654.
GuidetoPHARMACOLOGYi263.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 358358Histamine H2 receptorPRO_0000069688Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence analysis
Disulfide bondi91 ↔ 173PROSITE-ProRule annotation
Lipidationi304 – 3041S-palmitoyl cysteineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP25102.

PTM databases

PhosphoSiteiP25102.

Interactioni

Protein-protein interaction databases

IntActiP25102. 2 interactions.
STRINGi10116.ENSRNOP00000024580.

Chemistry

BindingDBiP25102.

Structurei

3D structure databases

ProteinModelPortaliP25102.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP25102.
KOiK04150.
PhylomeDBiP25102.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000503. Histamine_H2_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00531. HISTAMINEH2R.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25102-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPNGTVHSC CLDSMALKVT ISVVLTTLIL ITIAGNVVVC LAVSLNRRLR
60 70 80 90 100
SLTNCFIVSL AATDLLLGLL VLPFSAIYQL SFTWSFGHVF CNIYTSLDVM
110 120 130 140 150
LCTASILNLF MISLDRYCAV TDPLRYPVLV TPVRVAISLV FIWVISITLS
160 170 180 190 200
FLSIHLGWNS RNGTRGGNDT FKCKVQVNEV YGLVDGLVTF YLPLLIMCVT
210 220 230 240 250
YYRIFKIARE QAKRINHISS WKAATIREHK ATVTLAAVMG AFIICWFPYF
260 270 280 290 300
TAFVYRGLRG DDAINEAVEG IVLWLGYANS ALNPILYAAL NRDFRTAYQQ
310 320 330 340 350
LFHCKFASHN SHKTSLRLNN SLLPRSQSRE GRWQEEKPLK LQVWSGTELT

HPQGNPIR
Length:358
Mass (Da):40,253
Last modified:May 1, 1992 - v1
Checksum:i4889F69B7B5D5DDC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S57565 Genomic DNA. Translation: AAB19935.1.
PIRiJQ1278.
RefSeqiNP_037097.3. NM_012965.3.
UniGeneiRn.138113.

Genome annotation databases

GeneIDi25461.
KEGGirno:25461.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S57565 Genomic DNA. Translation: AAB19935.1.
PIRiJQ1278.
RefSeqiNP_037097.3. NM_012965.3.
UniGeneiRn.138113.

3D structure databases

ProteinModelPortaliP25102.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP25102. 2 interactions.
STRINGi10116.ENSRNOP00000024580.

Chemistry

BindingDBiP25102.
ChEMBLiCHEMBL4654.
GuidetoPHARMACOLOGYi263.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP25102.

Proteomic databases

PaxDbiP25102.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25461.
KEGGirno:25461.

Organism-specific databases

CTDi3274.
RGDi2831. Hrh2.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP25102.
KOiK04150.
PhylomeDBiP25102.

Miscellaneous databases

PROiP25102.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000503. Histamine_H2_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00531. HISTAMINEH2R.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and tissue expression of a rat histamine H2-receptor gene."
    Ruat M., Traiffort E., Arrang J.-M., Leurs R., Schwartz J.-C.
    Biochem. Biophys. Res. Commun. 179:1470-1478(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiHRH2_RAT
AccessioniPrimary (citable) accession number: P25102
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: June 8, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.