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P25101 (EDNRA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 150. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Endothelin-1 receptor
Alternative name(s):
Endothelin A receptor
Short name=ET-A
Short name=ETA-R
Short name=hET-AR
Gene names
Name:EDNRA
Synonyms:ETA, ETRA
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length427 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.

Subunit structure

Interacts with HDAC7 and KAT5. Ref.17

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Isoform 1, isoform 3 and isoform 4 are expressed in a variety of tissues, with highest levels in the aorta and cerebellum, followed by lung, atrium and cerebral cortex, lower levels in the placenta, kidney, adrenal gland, duodenum, colon, ventricle and liver but no expression in umbilical vein endothelial cells. Within the placenta, isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in the villi and stem villi vessels. Ref.8 Ref.16

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRA sub-subfamily.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway

Non-traceable author statement Ref.8. Source: UniProtKB

Rho protein signal transduction

Inferred from electronic annotation. Source: Ensembl

activation of adenylate cyclase activity

Traceable author statement PubMed 8702836. Source: ProtInc

activation of phospholipase C activity

Traceable author statement PubMed 8702836. Source: ProtInc

aging

Inferred from electronic annotation. Source: Ensembl

artery smooth muscle contraction

Inferred from mutant phenotype PubMed 8982507. Source: BHF-UCL

cell proliferation

Non-traceable author statement Ref.16. Source: UniProtKB

cellular response to mechanical stimulus

Inferred from electronic annotation. Source: Ensembl

enteric nervous system development

Inferred from electronic annotation. Source: InterPro

fibroblast proliferation

Inferred from electronic annotation. Source: Ensembl

glomerular filtration

Inferred from electronic annotation. Source: Ensembl

glucose transport

Inferred from sequence or structural similarity. Source: UniProtKB

head development

Inferred from electronic annotation. Source: Ensembl

heart development

Inferred from electronic annotation. Source: Ensembl

histamine secretion

Inferred from electronic annotation. Source: Ensembl

in utero embryonic development

Inferred from electronic annotation. Source: Ensembl

maternal process involved in parturition

Inferred from electronic annotation. Source: Ensembl

metabolic process

Traceable author statement PubMed 8702836. Source: GOC

negative regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of cAMP biosynthetic process

Inferred from electronic annotation. Source: Ensembl

neural crest cell development

Inferred from electronic annotation. Source: Ensembl

patterning of blood vessels

Inferred from electronic annotation. Source: Ensembl

penile erection

Inferred from electronic annotation. Source: Ensembl

positive regulation of ERK1 and ERK2 cascade

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of cytosolic calcium ion concentration

Traceable author statement PubMed 1849646. Source: ProtInc

positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of inflammatory response

Inferred from electronic annotation. Source: Ensembl

positive regulation of kidney development

Inferred from electronic annotation. Source: Ensembl

positive regulation of neutrophil chemotaxis

Inferred from electronic annotation. Source: Ensembl

positive regulation of odontogenesis

Inferred from electronic annotation. Source: Ensembl

positive regulation of protein phosphorylation

Inferred from electronic annotation. Source: Ensembl

positive regulation of release of sequestered calcium ion into cytosol

Inferred from electronic annotation. Source: Ensembl

protein kinase C-activating G-protein coupled receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

regulation of blood pressure

Inferred from electronic annotation. Source: InterPro

regulation of epithelial cell proliferation

Inferred from electronic annotation. Source: Ensembl

respiratory gaseous exchange

Inferred from sequence or structural similarity. Source: UniProtKB

response to hypoxia

Inferred from electronic annotation. Source: Ensembl

response to lipopolysaccharide

Inferred from electronic annotation. Source: Ensembl

response to morphine

Inferred from electronic annotation. Source: Ensembl

sensory perception of pain

Inferred from electronic annotation. Source: Ensembl

signal transduction

Traceable author statement Ref.6. Source: ProtInc

smooth muscle cell proliferation

Inferred from electronic annotation. Source: Ensembl

smooth muscle contraction

Non-traceable author statement Ref.16. Source: UniProtKB

vasoconstriction

Inferred from mutant phenotype PubMed 8982507. Source: BHF-UCL

   Cellular_componentT-tubule

Inferred from electronic annotation. Source: Ensembl

integral component of plasma membrane

Traceable author statement Ref.6. Source: ProtInc

nuclear membrane

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functionendothelin receptor activity

Non-traceable author statement Ref.8Ref.16. Source: UniProtKB

phosphatidylinositol phospholipase C activity

Traceable author statement PubMed 8702836. Source: ProtInc

protein binding

Inferred from physical interaction PubMed 23597562. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

EDN1P053052EBI-6624559,EBI-715181

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P25101-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P25101-2)

Also known as: Delta-3;

The sequence of this isoform differs from the canonical sequence as follows:
     141-161: LLAGRWPFDHNDFGVFLCKLF → VQSSCLLESCSGNWDSFGNCH
     162-427: Missing.
Isoform 3 (identifier: P25101-3)

Also known as: Delta-4;

The sequence of this isoform differs from the canonical sequence as follows:
     183-187: RYRAV → SSTKM
     188-427: Missing.
Isoform 4 (identifier: P25101-4)

Also known as: Delta-3,4;

The sequence of this isoform differs from the canonical sequence as follows:
     141-249: Missing.
Isoform 5 (identifier: P25101-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-225: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 427407Endothelin-1 receptor
PRO_0000012721

Regions

Topological domain21 – 8060Extracellular Potential
Transmembrane81 – 10222Helical; Name=1; Potential
Topological domain103 – 11210Cytoplasmic Potential
Transmembrane113 – 13220Helical; Name=2; Potential
Topological domain133 – 15927Extracellular Potential
Transmembrane160 – 18122Helical; Name=3; Potential
Topological domain182 – 20524Cytoplasmic Potential
Transmembrane206 – 22924Helical; Name=4; Potential
Topological domain230 – 25627Extracellular Potential
Transmembrane257 – 27822Helical; Name=5; Potential
Topological domain279 – 30628Cytoplasmic Potential
Transmembrane307 – 32822Helical; Name=6; Potential
Topological domain329 – 34719Extracellular Potential
Transmembrane348 – 37225Helical; Name=7; Potential
Topological domain373 – 42755Cytoplasmic Potential

Amino acid modifications

Glycosylation291N-linked (GlcNAc...) Potential
Glycosylation621N-linked (GlcNAc...) Potential
Disulfide bond158 ↔ 239 By similarity

Natural variations

Alternative sequence1 – 225225Missing in isoform 5.
VSP_045578
Alternative sequence141 – 249109Missing in isoform 4.
VSP_011061
Alternative sequence141 – 16121LLAGR…LCKLF → VQSSCLLESCSGNWDSFGNC H in isoform 2.
VSP_011059
Alternative sequence162 – 427266Missing in isoform 2.
VSP_011060
Alternative sequence183 – 1875RYRAV → SSTKM in isoform 3.
VSP_011062
Alternative sequence188 – 427240Missing in isoform 3.
VSP_011063
Natural variant1361I → L in a breast cancer sample; somatic mutation. Ref.18
VAR_035758

Experimental info

Sequence conflict1101C → Y in AAB23644. Ref.7
Sequence conflict1151P → H in AAH22511. Ref.14
Sequence conflict2071V → A in AAA58447. Ref.5
Sequence conflict2321R → K in BAH14302. Ref.11
Sequence conflict2341E → G in AAA58447. Ref.5
Sequence conflict2801C → G in AAA58447. Ref.5
Sequence conflict3001Q → H in BAG65268. Ref.11
Sequence conflict3221L → V in AAH22511. Ref.14
Sequence conflict3451S → G in BAG65268. Ref.11
Sequence conflict4091N → D in AAH22511. Ref.14

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 1, 1992. Version 1.
Checksum: 207272D4A231404F

FASTA42748,722
        10         20         30         40         50         60 
METLCLRASF WLALVGCVIS DNPERYSTNL SNHVDDFTTF RGTELSFLVT THQPTNLVLP 

        70         80         90        100        110        120 
SNGSMHNYCP QQTKITSAFK YINTVISCTI FIVGMVGNAT LLRIIYQNKC MRNGPNALIA 

       130        140        150        160        170        180 
SLALGDLIYV VIDLPINVFK LLAGRWPFDH NDFGVFLCKL FPFLQKSSVG ITVLNLCALS 

       190        200        210        220        230        240 
VDRYRAVASW SRVQGIGIPL VTAIEIVSIW ILSFILAIPE AIGFVMVPFE YRGEQHKTCM 

       250        260        270        280        290        300 
LNATSKFMEF YQDVKDWWLF GFYFCMPLVC TAIFYTLMTC EMLNRRNGSL RIALSEHLKQ 

       310        320        330        340        350        360 
RREVAKTVFC LVVIFALCWF PLHLSRILKK TVYNEMDKNR CELLSFLLLM DYIGINLATM 

       370        380        390        400        410        420 
NSCINPIALY FVSKKFKNCF QSCLCCCCYQ SKSLMTSVPM NGTSIQWKNH DQNNHNTDRS 


SHKDSMN 

« Hide

Isoform 2 (Delta-3) [UniParc].

Checksum: B6227E27C1B05915
Show »

FASTA16117,820
Isoform 3 (Delta-4) [UniParc].

Checksum: 60E5564BDE6D7A96
Show »

FASTA18720,763
Isoform 4 (Delta-3,4) [UniParc].

Checksum: 0423FAA16DB6A9BF
Show »

FASTA31836,489
Isoform 5 [UniParc].

Checksum: 01C9764279D905CD
Show »

FASTA20223,803

References

« Hide 'large scale' references
[1]"Cloning and characterization of cDNA encoding human A-type endothelin receptor."
Adachi M., Yang Y.Y., Furuichi Y., Miyamoto C.
Biochem. Biophys. Res. Commun. 180:1265-1272(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1).
Tissue: Placenta.
[2]"Cloning and chromosomal localization of a human endothelin ETA receptor."
Cyr C., Huebner K., Druck T., Kris R.
Biochem. Biophys. Res. Commun. 181:184-190(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1).
Tissue: Placenta.
[3]"Cloning and expression of human endothelin-1 receptor cDNA."
Hosoda K., Nakao K., Arai H., Suga S., Ogawa Y., Mukoyama M., Shirakami G., Saito Y., Nakanishi S., Imura H.
FEBS Lett. 287:23-26(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1).
[4]"Molecular cloning of human endothelin receptors and their expression in vascular endothelial cells and smooth muscle cells."
Arai H., Nakao K., Hosoda K., Ogawa Y., Nakagawa O., Komatsu Y., Imura H.
Jpn. Circ. J. 56:1303-1307(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1).
[5]"Molecular characterization and regulation of the human endothelin receptors."
Elshourbagy N.A., Korman D.R., Wu H.L., Sylvester D.R., Lee J.A., Nuthalaganti P., Bergsma D.J., Kumar C.S., Nambi P.
J. Biol. Chem. 268:3873-3879(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[6]"Organization, structure, chromosomal assignment, and expression of the gene encoding the human endothelin-A receptor."
Hosoda K., Nakao K., Tamura N., Arai H., Ogawa Y., Suga S., Nakanishi S., Imura H.
J. Biol. Chem. 267:18797-18804(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
[7]"Cloning and expression of a human endothelin receptor: subtype A."
Hayzer D.J., Rose P.M., Lynch J.S., Webb M.L., Kienzle B.K., Liu E.C., Bogosian E.A., Brinson E., Runge M.S.
Am. J. Med. Sci. 304:231-238(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
Tissue: Placenta.
[8]"Alternative RNA splicing of the human endothelin-A receptor generates multiple transcripts."
Miyamoto Y., Yoshimasa T., Arai H., Takaya K., Ogawa Y., Itoh H., Nakao K.
Biochem. J. 313:795-801(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3 AND 4), TISSUE SPECIFICITY.
Tissue: Lung.
[9]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Warren C.N., Aronstam R.S., Sharma S.V.
Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Placenta.
[10]NIEHS SNPs program
Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[11]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5).
Tissue: Cerebellum, Testis and Trachea.
[12]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[13]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[14]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[15]"Molecular characterization of the 5'-flanking region of human genomic ETA gene."
Yang H., Tabuchi H., Furuichi Y., Miyamoto C.
Biochem. Biophys. Res. Commun. 190:332-339(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-140 (ISOFORMS 1/2/3/4).
[16]"Endothelin-1 and ETA receptor expression in vascular smooth muscle cells from human placenta: a new ETA receptor messenger ribonucleic acid is generated by alternative splicing of exon 3."
Bourgeois C., Robert B., Rebourcet R., Mondon F., Mignot T.-M., Duc-Goiran P., Ferre F.
J. Clin. Endocrinol. Metab. 82:3116-3123(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 52-427 (ISOFORM 2), TISSUE SPECIFICITY.
Tissue: Placenta.
[17]"Tip60 and HDAC7 interact with the endothelin receptor a and may be involved in downstream signaling."
Lee H.-J., Chun M., Kandror K.V.
J. Biol. Chem. 276:16597-16600(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH HDAC7 AND KAT5.
[18]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-136.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S63938 mRNA. Translation: AAB20278.1.
S67127 mRNA. Translation: AAB20407.1.
X61950 mRNA. Translation: CAA43953.1.
D90348 mRNA. Translation: BAA14359.1.
S57498 mRNA. Translation: AAB25530.2.
L06622 mRNA. Translation: AAA58447.1.
D11151 Genomic DNA. Translation: BAA01920.1.
S45956 mRNA. Translation: AAB23644.1.
S81539 mRNA. Translation: AAB36325.1.
S81542 mRNA. Translation: AAB36326.1.
S81545 mRNA. Translation: AAB36327.1.
AY275462 mRNA. Translation: AAP32294.1.
AY422989 Genomic DNA. Translation: AAQ87880.1.
AK304451 mRNA. Translation: BAG65268.1.
AK312812 mRNA. Translation: BAG35670.1.
AK315931 mRNA. Translation: BAH14302.1.
AC093908 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX05019.1.
CH471056 Genomic DNA. Translation: EAX05021.1.
BC022511 mRNA. Translation: AAH22511.1.
S55772 Genomic DNA. Translation: AAB25212.1.
AF014826 mRNA. Translation: AAB94859.1.
CCDSCCDS3769.1. [P25101-1]
CCDS54810.1. [P25101-4]
CCDS58927.1. [P25101-5]
PIRA44158.
RefSeqNP_001159527.1. NM_001166055.1. [P25101-4]
NP_001243212.1. NM_001256283.1. [P25101-5]
NP_001948.1. NM_001957.3. [P25101-1]
UniGeneHs.183713.

3D structure databases

ProteinModelPortalP25101.
SMRP25101. Positions 80-381.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid108231. 11 interactions.
DIPDIP-48718N.
IntActP25101. 1 interaction.
STRING9606.ENSP00000315011.

Chemistry

BindingDBP25101.
ChEMBLCHEMBL2096678.
DrugBankDB00559. Bosentan.
GuidetoPHARMACOLOGY219.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP25101.

Polymorphism databases

DMDM119606.

Proteomic databases

MaxQBP25101.
PaxDbP25101.
PRIDEP25101.

Protocols and materials databases

DNASU1909.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000324300; ENSP00000315011; ENSG00000151617. [P25101-1]
ENST00000339690; ENSP00000341556; ENSG00000151617. [P25101-2]
ENST00000358556; ENSP00000351359; ENSG00000151617. [P25101-4]
ENST00000506066; ENSP00000425281; ENSG00000151617. [P25101-4]
ENST00000510697; ENSP00000427259; ENSG00000151617. [P25101-3]
ENST00000511804; ENSP00000425354; ENSG00000151617. [P25101-5]
GeneID1909.
KEGGhsa:1909.
UCSCuc003iky.3. human. [P25101-1]
uc010ipe.1. human. [P25101-2]
uc010ipg.2. human. [P25101-4]

Organism-specific databases

CTD1909.
GeneCardsGC04P148401.
HGNCHGNC:3179. EDNRA.
HPACAB018957.
HPA013774.
HPA014087.
MIM131243. gene.
neXtProtNX_P25101.
PharmGKBPA27617.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG278704.
HOVERGENHBG051443.
InParanoidP25101.
KOK04197.
OMASIQWKNQ.
OrthoDBEOG7HHWS4.
PhylomeDBP25101.
TreeFamTF331292.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeP25101.
CleanExHS_EDNRA.
GenevestigatorP25101.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000499. Endthln_rcpt.
IPR002175. ETA_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00570. ENDOTHELINAR.
PR00366. ENDOTHELINR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiEndothelin_receptor_type_A.
GenomeRNAi1909.
NextBio35477375.
PROP25101.
SOURCESearch...

Entry information

Entry nameEDNRA_HUMAN
AccessionPrimary (citable) accession number: P25101
Secondary accession number(s): B2R723 expand/collapse secondary AC list , B4E2V6, B7Z9G6, D3DP03, E7ER36, O43441, Q16432, Q16433, Q8TBH2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: July 9, 2014
This is version 150 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries