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P25101

- EDNRA_HUMAN

UniProt

P25101 - EDNRA_HUMAN

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Protein

Endothelin-1 receptor

Gene

EDNRA

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.

GO - Molecular functioni

  1. endothelin receptor activity Source: UniProtKB
  2. phosphatidylinositol phospholipase C activity Source: ProtInc

GO - Biological processi

  1. activation of adenylate cyclase activity Source: ProtInc
  2. activation of phospholipase C activity Source: ProtInc
  3. aging Source: Ensembl
  4. artery smooth muscle contraction Source: BHF-UCL
  5. cell proliferation Source: UniProtKB
  6. cellular response to mechanical stimulus Source: Ensembl
  7. endothelin receptor signaling pathway Source: GOC
  8. enteric nervous system development Source: InterPro
  9. fibroblast proliferation Source: Ensembl
  10. glomerular filtration Source: Ensembl
  11. glucose transport Source: UniProtKB
  12. G-protein coupled receptor signaling pathway Source: UniProtKB
  13. head development Source: Ensembl
  14. heart development Source: Ensembl
  15. histamine secretion Source: Ensembl
  16. in utero embryonic development Source: Ensembl
  17. maternal process involved in parturition Source: Ensembl
  18. metabolic process Source: GOC
  19. negative regulation of apoptotic process Source: Ensembl
  20. negative regulation of cAMP biosynthetic process Source: Ensembl
  21. neural crest cell development Source: Ensembl
  22. patterning of blood vessels Source: Ensembl
  23. penile erection Source: Ensembl
  24. positive regulation of cell proliferation Source: Ensembl
  25. positive regulation of cytosolic calcium ion concentration Source: ProtInc
  26. positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: Ensembl
  27. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  28. positive regulation of inflammatory response Source: Ensembl
  29. positive regulation of kidney development Source: Ensembl
  30. positive regulation of neutrophil chemotaxis Source: Ensembl
  31. positive regulation of odontogenesis Source: Ensembl
  32. positive regulation of protein phosphorylation Source: Ensembl
  33. positive regulation of release of sequestered calcium ion into cytosol Source: Ensembl
  34. protein kinase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
  35. regulation of blood pressure Source: InterPro
  36. regulation of epithelial cell proliferation Source: Ensembl
  37. respiratory gaseous exchange Source: UniProtKB
  38. response to hypoxia Source: Ensembl
  39. response to lipopolysaccharide Source: Ensembl
  40. response to morphine Source: Ensembl
  41. Rho protein signal transduction Source: Ensembl
  42. sensory perception of pain Source: Ensembl
  43. signal transduction Source: ProtInc
  44. smooth muscle cell proliferation Source: Ensembl
  45. smooth muscle contraction Source: UniProtKB
  46. vasoconstriction Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin-1 receptor
Alternative name(s):
Endothelin A receptor
Short name:
ET-A
Short name:
ETA-R
Short name:
hET-AR
Gene namesi
Name:EDNRA
Synonyms:ETA, ETRA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:3179. EDNRA.

Subcellular locationi

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. nuclear membrane Source: Ensembl
  3. plasma membrane Source: Reactome
  4. T-tubule Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27617.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 427407Endothelin-1 receptorPRO_0000012721Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi29 – 291N-linked (GlcNAc...)Sequence Analysis
Glycosylationi62 – 621N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi158 ↔ 239PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP25101.
PaxDbiP25101.
PRIDEiP25101.

PTM databases

PhosphoSiteiP25101.

Expressioni

Tissue specificityi

Isoform 1, isoform 3 and isoform 4 are expressed in a variety of tissues, with highest levels in the aorta and cerebellum, followed by lung, atrium and cerebral cortex, lower levels in the placenta, kidney, adrenal gland, duodenum, colon, ventricle and liver but no expression in umbilical vein endothelial cells. Within the placenta, isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in the villi and stem villi vessels.2 Publications

Gene expression databases

BgeeiP25101.
CleanExiHS_EDNRA.
GenevestigatoriP25101.

Organism-specific databases

HPAiCAB018957.
HPA013774.
HPA014087.

Interactioni

Subunit structurei

Interacts with HDAC7 and KAT5.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
EDN1P053052EBI-6624559,EBI-715181

Protein-protein interaction databases

BioGridi108231. 23 interactions.
DIPiDIP-48718N.
IntActiP25101. 1 interaction.
STRINGi9606.ENSP00000315011.

Structurei

3D structure databases

ProteinModelPortaliP25101.
SMRiP25101. Positions 80-381.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 8060ExtracellularSequence AnalysisAdd
BLAST
Topological domaini103 – 11210CytoplasmicSequence Analysis
Topological domaini133 – 15927ExtracellularSequence AnalysisAdd
BLAST
Topological domaini182 – 20524CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini230 – 25627ExtracellularSequence AnalysisAdd
BLAST
Topological domaini279 – 30628CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini329 – 34719ExtracellularSequence AnalysisAdd
BLAST
Topological domaini373 – 42755CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei81 – 10222Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei113 – 13220Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei160 – 18122Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei206 – 22924Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei257 – 27822Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei307 – 32822Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei348 – 37225Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRA sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG278704.
GeneTreeiENSGT00760000119177.
HOVERGENiHBG051443.
InParanoidiP25101.
KOiK04197.
OMAiSIQWKNQ.
OrthoDBiEOG7HHWS4.
PhylomeDBiP25101.
TreeFamiTF331292.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000499. Endthln_rcpt.
IPR002175. ETA_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00570. ENDOTHELINAR.
PR00366. ENDOTHELINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P25101-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
METLCLRASF WLALVGCVIS DNPERYSTNL SNHVDDFTTF RGTELSFLVT
60 70 80 90 100
THQPTNLVLP SNGSMHNYCP QQTKITSAFK YINTVISCTI FIVGMVGNAT
110 120 130 140 150
LLRIIYQNKC MRNGPNALIA SLALGDLIYV VIDLPINVFK LLAGRWPFDH
160 170 180 190 200
NDFGVFLCKL FPFLQKSSVG ITVLNLCALS VDRYRAVASW SRVQGIGIPL
210 220 230 240 250
VTAIEIVSIW ILSFILAIPE AIGFVMVPFE YRGEQHKTCM LNATSKFMEF
260 270 280 290 300
YQDVKDWWLF GFYFCMPLVC TAIFYTLMTC EMLNRRNGSL RIALSEHLKQ
310 320 330 340 350
RREVAKTVFC LVVIFALCWF PLHLSRILKK TVYNEMDKNR CELLSFLLLM
360 370 380 390 400
DYIGINLATM NSCINPIALY FVSKKFKNCF QSCLCCCCYQ SKSLMTSVPM
410 420
NGTSIQWKNH DQNNHNTDRS SHKDSMN
Length:427
Mass (Da):48,722
Last modified:May 1, 1992 - v1
Checksum:i207272D4A231404F
GO
Isoform 2 (identifier: P25101-2) [UniParc]FASTAAdd to Basket

Also known as: Delta-3

The sequence of this isoform differs from the canonical sequence as follows:
     141-161: LLAGRWPFDHNDFGVFLCKLF → VQSSCLLESCSGNWDSFGNCH
     162-427: Missing.

Show »
Length:161
Mass (Da):17,820
Checksum:iB6227E27C1B05915
GO
Isoform 3 (identifier: P25101-3) [UniParc]FASTAAdd to Basket

Also known as: Delta-4

The sequence of this isoform differs from the canonical sequence as follows:
     183-187: RYRAV → SSTKM
     188-427: Missing.

Show »
Length:187
Mass (Da):20,763
Checksum:i60E5564BDE6D7A96
GO
Isoform 4 (identifier: P25101-4) [UniParc]FASTAAdd to Basket

Also known as: Delta-3,4

The sequence of this isoform differs from the canonical sequence as follows:
     141-249: Missing.

Show »
Length:318
Mass (Da):36,489
Checksum:i0423FAA16DB6A9BF
GO
Isoform 5 (identifier: P25101-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-225: Missing.

Note: No experimental confirmation available.

Show »
Length:202
Mass (Da):23,803
Checksum:i01C9764279D905CD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti110 – 1101C → Y in AAB23644. (PubMed:1415318)Curated
Sequence conflicti115 – 1151P → H in AAH22511. (PubMed:15489334)Curated
Sequence conflicti207 – 2071V → A in AAA58447. (PubMed:8440682)Curated
Sequence conflicti232 – 2321R → K in BAH14302. (PubMed:14702039)Curated
Sequence conflicti234 – 2341E → G in AAA58447. (PubMed:8440682)Curated
Sequence conflicti280 – 2801C → G in AAA58447. (PubMed:8440682)Curated
Sequence conflicti300 – 3001Q → H in BAG65268. (PubMed:14702039)Curated
Sequence conflicti322 – 3221L → V in AAH22511. (PubMed:15489334)Curated
Sequence conflicti345 – 3451S → G in BAG65268. (PubMed:14702039)Curated
Sequence conflicti409 – 4091N → D in AAH22511. (PubMed:15489334)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti136 – 1361I → L in a breast cancer sample; somatic mutation. 1 Publication
VAR_035758

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 225225Missing in isoform 5. 1 PublicationVSP_045578Add
BLAST
Alternative sequencei141 – 249109Missing in isoform 4. 1 PublicationVSP_011061Add
BLAST
Alternative sequencei141 – 16121LLAGR…LCKLF → VQSSCLLESCSGNWDSFGNC H in isoform 2. 1 PublicationVSP_011059Add
BLAST
Alternative sequencei162 – 427266Missing in isoform 2. 1 PublicationVSP_011060Add
BLAST
Alternative sequencei183 – 1875RYRAV → SSTKM in isoform 3. 1 PublicationVSP_011062
Alternative sequencei188 – 427240Missing in isoform 3. 1 PublicationVSP_011063Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S63938 mRNA. Translation: AAB20278.1.
S67127 mRNA. Translation: AAB20407.1.
X61950 mRNA. Translation: CAA43953.1.
D90348 mRNA. Translation: BAA14359.1.
S57498 mRNA. Translation: AAB25530.2.
L06622 mRNA. Translation: AAA58447.1.
D11151 Genomic DNA. Translation: BAA01920.1.
S45956 mRNA. Translation: AAB23644.1.
S81539 mRNA. Translation: AAB36325.1.
S81542 mRNA. Translation: AAB36326.1.
S81545 mRNA. Translation: AAB36327.1.
AY275462 mRNA. Translation: AAP32294.1.
AY422989 Genomic DNA. Translation: AAQ87880.1.
AK304451 mRNA. Translation: BAG65268.1.
AK312812 mRNA. Translation: BAG35670.1.
AK315931 mRNA. Translation: BAH14302.1.
AC093908 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX05019.1.
CH471056 Genomic DNA. Translation: EAX05021.1.
BC022511 mRNA. Translation: AAH22511.1.
S55772 Genomic DNA. Translation: AAB25212.1.
AF014826 mRNA. Translation: AAB94859.1.
CCDSiCCDS3769.1. [P25101-1]
CCDS54810.1. [P25101-4]
CCDS58927.1. [P25101-5]
PIRiA44158.
RefSeqiNP_001159527.1. NM_001166055.1. [P25101-4]
NP_001243212.1. NM_001256283.1. [P25101-5]
NP_001948.1. NM_001957.3. [P25101-1]
UniGeneiHs.183713.

Genome annotation databases

EnsembliENST00000324300; ENSP00000315011; ENSG00000151617. [P25101-1]
ENST00000358556; ENSP00000351359; ENSG00000151617. [P25101-4]
ENST00000506066; ENSP00000425281; ENSG00000151617. [P25101-4]
ENST00000510697; ENSP00000427259; ENSG00000151617. [P25101-3]
ENST00000511804; ENSP00000425354; ENSG00000151617. [P25101-5]
GeneIDi1909.
KEGGihsa:1909.
UCSCiuc003iky.3. human. [P25101-1]
uc010ipe.1. human. [P25101-2]
uc010ipg.2. human. [P25101-4]

Polymorphism databases

DMDMi119606.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S63938 mRNA. Translation: AAB20278.1 .
S67127 mRNA. Translation: AAB20407.1 .
X61950 mRNA. Translation: CAA43953.1 .
D90348 mRNA. Translation: BAA14359.1 .
S57498 mRNA. Translation: AAB25530.2 .
L06622 mRNA. Translation: AAA58447.1 .
D11151 Genomic DNA. Translation: BAA01920.1 .
S45956 mRNA. Translation: AAB23644.1 .
S81539 mRNA. Translation: AAB36325.1 .
S81542 mRNA. Translation: AAB36326.1 .
S81545 mRNA. Translation: AAB36327.1 .
AY275462 mRNA. Translation: AAP32294.1 .
AY422989 Genomic DNA. Translation: AAQ87880.1 .
AK304451 mRNA. Translation: BAG65268.1 .
AK312812 mRNA. Translation: BAG35670.1 .
AK315931 mRNA. Translation: BAH14302.1 .
AC093908 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX05019.1 .
CH471056 Genomic DNA. Translation: EAX05021.1 .
BC022511 mRNA. Translation: AAH22511.1 .
S55772 Genomic DNA. Translation: AAB25212.1 .
AF014826 mRNA. Translation: AAB94859.1 .
CCDSi CCDS3769.1. [P25101-1 ]
CCDS54810.1. [P25101-4 ]
CCDS58927.1. [P25101-5 ]
PIRi A44158.
RefSeqi NP_001159527.1. NM_001166055.1. [P25101-4 ]
NP_001243212.1. NM_001256283.1. [P25101-5 ]
NP_001948.1. NM_001957.3. [P25101-1 ]
UniGenei Hs.183713.

3D structure databases

ProteinModelPortali P25101.
SMRi P25101. Positions 80-381.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108231. 23 interactions.
DIPi DIP-48718N.
IntActi P25101. 1 interaction.
STRINGi 9606.ENSP00000315011.

Chemistry

BindingDBi P25101.
ChEMBLi CHEMBL2096678.
DrugBanki DB00945. Acetylsalicylic acid.
DB00559. Bosentan.
DB08932. MACITENTAN.
DB06268. Sitaxentan.
GuidetoPHARMACOLOGYi 219.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P25101.

Polymorphism databases

DMDMi 119606.

Proteomic databases

MaxQBi P25101.
PaxDbi P25101.
PRIDEi P25101.

Protocols and materials databases

DNASUi 1909.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000324300 ; ENSP00000315011 ; ENSG00000151617 . [P25101-1 ]
ENST00000358556 ; ENSP00000351359 ; ENSG00000151617 . [P25101-4 ]
ENST00000506066 ; ENSP00000425281 ; ENSG00000151617 . [P25101-4 ]
ENST00000510697 ; ENSP00000427259 ; ENSG00000151617 . [P25101-3 ]
ENST00000511804 ; ENSP00000425354 ; ENSG00000151617 . [P25101-5 ]
GeneIDi 1909.
KEGGi hsa:1909.
UCSCi uc003iky.3. human. [P25101-1 ]
uc010ipe.1. human. [P25101-2 ]
uc010ipg.2. human. [P25101-4 ]

Organism-specific databases

CTDi 1909.
GeneCardsi GC04P148401.
HGNCi HGNC:3179. EDNRA.
HPAi CAB018957.
HPA013774.
HPA014087.
MIMi 131243. gene.
neXtProti NX_P25101.
PharmGKBi PA27617.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG278704.
GeneTreei ENSGT00760000119177.
HOVERGENi HBG051443.
InParanoidi P25101.
KOi K04197.
OMAi SIQWKNQ.
OrthoDBi EOG7HHWS4.
PhylomeDBi P25101.
TreeFami TF331292.

Enzyme and pathway databases

Reactomei REACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.

Miscellaneous databases

GeneWikii Endothelin_receptor_type_A.
GenomeRNAii 1909.
NextBioi 35477375.
PROi P25101.
SOURCEi Search...

Gene expression databases

Bgeei P25101.
CleanExi HS_EDNRA.
Genevestigatori P25101.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000499. Endthln_rcpt.
IPR002175. ETA_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00570. ENDOTHELINAR.
PR00366. ENDOTHELINR.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of cDNA encoding human A-type endothelin receptor."
    Adachi M., Yang Y.Y., Furuichi Y., Miyamoto C.
    Biochem. Biophys. Res. Commun. 180:1265-1272(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1).
    Tissue: Placenta.
  2. "Cloning and chromosomal localization of a human endothelin ETA receptor."
    Cyr C., Huebner K., Druck T., Kris R.
    Biochem. Biophys. Res. Commun. 181:184-190(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1).
    Tissue: Placenta.
  3. Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1).
  4. "Molecular cloning of human endothelin receptors and their expression in vascular endothelial cells and smooth muscle cells."
    Arai H., Nakao K., Hosoda K., Ogawa Y., Nakagawa O., Komatsu Y., Imura H.
    Jpn. Circ. J. 56:1303-1307(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1).
  5. "Molecular characterization and regulation of the human endothelin receptors."
    Elshourbagy N.A., Korman D.R., Wu H.L., Sylvester D.R., Lee J.A., Nuthalaganti P., Bergsma D.J., Kumar C.S., Nambi P.
    J. Biol. Chem. 268:3873-3879(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  6. "Organization, structure, chromosomal assignment, and expression of the gene encoding the human endothelin-A receptor."
    Hosoda K., Nakao K., Tamura N., Arai H., Ogawa Y., Suga S., Nakanishi S., Imura H.
    J. Biol. Chem. 267:18797-18804(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
  7. "Cloning and expression of a human endothelin receptor: subtype A."
    Hayzer D.J., Rose P.M., Lynch J.S., Webb M.L., Kienzle B.K., Liu E.C., Bogosian E.A., Brinson E., Runge M.S.
    Am. J. Med. Sci. 304:231-238(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
    Tissue: Placenta.
  8. "Alternative RNA splicing of the human endothelin-A receptor generates multiple transcripts."
    Miyamoto Y., Yoshimasa T., Arai H., Takaya K., Ogawa Y., Itoh H., Nakao K.
    Biochem. J. 313:795-801(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3 AND 4), TISSUE SPECIFICITY.
    Tissue: Lung.
  9. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Warren C.N., Aronstam R.S., Sharma S.V.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.
  10. NIEHS SNPs program
    Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  11. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5).
    Tissue: Cerebellum, Testis and Trachea.
  12. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  13. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  14. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  15. "Molecular characterization of the 5'-flanking region of human genomic ETA gene."
    Yang H., Tabuchi H., Furuichi Y., Miyamoto C.
    Biochem. Biophys. Res. Commun. 190:332-339(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-140 (ISOFORMS 1/2/3/4).
  16. "Endothelin-1 and ETA receptor expression in vascular smooth muscle cells from human placenta: a new ETA receptor messenger ribonucleic acid is generated by alternative splicing of exon 3."
    Bourgeois C., Robert B., Rebourcet R., Mondon F., Mignot T.-M., Duc-Goiran P., Ferre F.
    J. Clin. Endocrinol. Metab. 82:3116-3123(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 52-427 (ISOFORM 2), TISSUE SPECIFICITY.
    Tissue: Placenta.
  17. "Tip60 and HDAC7 interact with the endothelin receptor a and may be involved in downstream signaling."
    Lee H.-J., Chun M., Kandror K.V.
    J. Biol. Chem. 276:16597-16600(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HDAC7 AND KAT5.
  18. Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-136.

Entry informationi

Entry nameiEDNRA_HUMAN
AccessioniPrimary (citable) accession number: P25101
Secondary accession number(s): B2R723
, B4E2V6, B7Z9G6, D3DP03, E7ER36, O43441, Q16432, Q16433, Q8TBH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: October 29, 2014
This is version 153 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3