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P25101

- EDNRA_HUMAN

UniProt

P25101 - EDNRA_HUMAN

Protein

Endothelin-1 receptor

Gene

EDNRA

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 152 (01 Oct 2014)
      Sequence version 1 (01 May 1992)
      Previous versions | rss
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    Functioni

    Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.

    GO - Molecular functioni

    1. endothelin receptor activity Source: UniProtKB
    2. phosphatidylinositol phospholipase C activity Source: ProtInc
    3. protein binding Source: IntAct

    GO - Biological processi

    1. activation of adenylate cyclase activity Source: ProtInc
    2. activation of phospholipase C activity Source: ProtInc
    3. aging Source: Ensembl
    4. artery smooth muscle contraction Source: BHF-UCL
    5. cell proliferation Source: UniProtKB
    6. cellular response to mechanical stimulus Source: Ensembl
    7. enteric nervous system development Source: InterPro
    8. fibroblast proliferation Source: Ensembl
    9. glomerular filtration Source: Ensembl
    10. glucose transport Source: UniProtKB
    11. G-protein coupled receptor signaling pathway Source: UniProtKB
    12. head development Source: Ensembl
    13. heart development Source: Ensembl
    14. histamine secretion Source: Ensembl
    15. in utero embryonic development Source: Ensembl
    16. maternal process involved in parturition Source: Ensembl
    17. metabolic process Source: GOC
    18. negative regulation of apoptotic process Source: Ensembl
    19. negative regulation of cAMP biosynthetic process Source: Ensembl
    20. neural crest cell development Source: Ensembl
    21. patterning of blood vessels Source: Ensembl
    22. penile erection Source: Ensembl
    23. positive regulation of cell proliferation Source: Ensembl
    24. positive regulation of cytosolic calcium ion concentration Source: ProtInc
    25. positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: Ensembl
    26. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
    27. positive regulation of inflammatory response Source: Ensembl
    28. positive regulation of kidney development Source: Ensembl
    29. positive regulation of neutrophil chemotaxis Source: Ensembl
    30. positive regulation of odontogenesis Source: Ensembl
    31. positive regulation of protein phosphorylation Source: Ensembl
    32. positive regulation of release of sequestered calcium ion into cytosol Source: Ensembl
    33. protein kinase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
    34. regulation of blood pressure Source: InterPro
    35. regulation of epithelial cell proliferation Source: Ensembl
    36. respiratory gaseous exchange Source: UniProtKB
    37. response to hypoxia Source: Ensembl
    38. response to lipopolysaccharide Source: Ensembl
    39. response to morphine Source: Ensembl
    40. Rho protein signal transduction Source: Ensembl
    41. sensory perception of pain Source: Ensembl
    42. signal transduction Source: ProtInc
    43. smooth muscle cell proliferation Source: Ensembl
    44. smooth muscle contraction Source: UniProtKB
    45. vasoconstriction Source: BHF-UCL

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_14819. Peptide ligand-binding receptors.
    REACT_18283. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endothelin-1 receptor
    Alternative name(s):
    Endothelin A receptor
    Short name:
    ET-A
    Short name:
    ETA-R
    Short name:
    hET-AR
    Gene namesi
    Name:EDNRA
    Synonyms:ETA, ETRA
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:3179. EDNRA.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. nuclear membrane Source: Ensembl
    3. plasma membrane Source: Reactome
    4. T-tubule Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27617.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 427407Endothelin-1 receptorPRO_0000012721Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi29 – 291N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi62 – 621N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi158 ↔ 239PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiP25101.
    PaxDbiP25101.
    PRIDEiP25101.

    PTM databases

    PhosphoSiteiP25101.

    Expressioni

    Tissue specificityi

    Isoform 1, isoform 3 and isoform 4 are expressed in a variety of tissues, with highest levels in the aorta and cerebellum, followed by lung, atrium and cerebral cortex, lower levels in the placenta, kidney, adrenal gland, duodenum, colon, ventricle and liver but no expression in umbilical vein endothelial cells. Within the placenta, isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in the villi and stem villi vessels.2 Publications

    Gene expression databases

    BgeeiP25101.
    CleanExiHS_EDNRA.
    GenevestigatoriP25101.

    Organism-specific databases

    HPAiCAB018957.
    HPA013774.
    HPA014087.

    Interactioni

    Subunit structurei

    Interacts with HDAC7 and KAT5.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    EDN1P053052EBI-6624559,EBI-715181

    Protein-protein interaction databases

    BioGridi108231. 11 interactions.
    DIPiDIP-48718N.
    IntActiP25101. 1 interaction.
    STRINGi9606.ENSP00000315011.

    Structurei

    3D structure databases

    ProteinModelPortaliP25101.
    SMRiP25101. Positions 80-381.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini21 – 8060ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini103 – 11210CytoplasmicSequence Analysis
    Topological domaini133 – 15927ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini182 – 20524CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini230 – 25627ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini279 – 30628CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini329 – 34719ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini373 – 42755CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei81 – 10222Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei113 – 13220Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei160 – 18122Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei206 – 22924Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei257 – 27822Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei307 – 32822Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei348 – 37225Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRA sub-subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG278704.
    HOVERGENiHBG051443.
    InParanoidiP25101.
    KOiK04197.
    OMAiSIQWKNQ.
    OrthoDBiEOG7HHWS4.
    PhylomeDBiP25101.
    TreeFamiTF331292.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000499. Endthln_rcpt.
    IPR002175. ETA_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00570. ENDOTHELINAR.
    PR00366. ENDOTHELINR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P25101-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    METLCLRASF WLALVGCVIS DNPERYSTNL SNHVDDFTTF RGTELSFLVT    50
    THQPTNLVLP SNGSMHNYCP QQTKITSAFK YINTVISCTI FIVGMVGNAT 100
    LLRIIYQNKC MRNGPNALIA SLALGDLIYV VIDLPINVFK LLAGRWPFDH 150
    NDFGVFLCKL FPFLQKSSVG ITVLNLCALS VDRYRAVASW SRVQGIGIPL 200
    VTAIEIVSIW ILSFILAIPE AIGFVMVPFE YRGEQHKTCM LNATSKFMEF 250
    YQDVKDWWLF GFYFCMPLVC TAIFYTLMTC EMLNRRNGSL RIALSEHLKQ 300
    RREVAKTVFC LVVIFALCWF PLHLSRILKK TVYNEMDKNR CELLSFLLLM 350
    DYIGINLATM NSCINPIALY FVSKKFKNCF QSCLCCCCYQ SKSLMTSVPM 400
    NGTSIQWKNH DQNNHNTDRS SHKDSMN 427
    Length:427
    Mass (Da):48,722
    Last modified:May 1, 1992 - v1
    Checksum:i207272D4A231404F
    GO
    Isoform 2 (identifier: P25101-2) [UniParc]FASTAAdd to Basket

    Also known as: Delta-3

    The sequence of this isoform differs from the canonical sequence as follows:
         141-161: LLAGRWPFDHNDFGVFLCKLF → VQSSCLLESCSGNWDSFGNCH
         162-427: Missing.

    Show »
    Length:161
    Mass (Da):17,820
    Checksum:iB6227E27C1B05915
    GO
    Isoform 3 (identifier: P25101-3) [UniParc]FASTAAdd to Basket

    Also known as: Delta-4

    The sequence of this isoform differs from the canonical sequence as follows:
         183-187: RYRAV → SSTKM
         188-427: Missing.

    Show »
    Length:187
    Mass (Da):20,763
    Checksum:i60E5564BDE6D7A96
    GO
    Isoform 4 (identifier: P25101-4) [UniParc]FASTAAdd to Basket

    Also known as: Delta-3,4

    The sequence of this isoform differs from the canonical sequence as follows:
         141-249: Missing.

    Show »
    Length:318
    Mass (Da):36,489
    Checksum:i0423FAA16DB6A9BF
    GO
    Isoform 5 (identifier: P25101-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-225: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:202
    Mass (Da):23,803
    Checksum:i01C9764279D905CD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti110 – 1101C → Y in AAB23644. (PubMed:1415318)Curated
    Sequence conflicti115 – 1151P → H in AAH22511. (PubMed:15489334)Curated
    Sequence conflicti207 – 2071V → A in AAA58447. (PubMed:8440682)Curated
    Sequence conflicti232 – 2321R → K in BAH14302. (PubMed:14702039)Curated
    Sequence conflicti234 – 2341E → G in AAA58447. (PubMed:8440682)Curated
    Sequence conflicti280 – 2801C → G in AAA58447. (PubMed:8440682)Curated
    Sequence conflicti300 – 3001Q → H in BAG65268. (PubMed:14702039)Curated
    Sequence conflicti322 – 3221L → V in AAH22511. (PubMed:15489334)Curated
    Sequence conflicti345 – 3451S → G in BAG65268. (PubMed:14702039)Curated
    Sequence conflicti409 – 4091N → D in AAH22511. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti136 – 1361I → L in a breast cancer sample; somatic mutation. 1 Publication
    VAR_035758

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 225225Missing in isoform 5. 1 PublicationVSP_045578Add
    BLAST
    Alternative sequencei141 – 249109Missing in isoform 4. 1 PublicationVSP_011061Add
    BLAST
    Alternative sequencei141 – 16121LLAGR…LCKLF → VQSSCLLESCSGNWDSFGNC H in isoform 2. 1 PublicationVSP_011059Add
    BLAST
    Alternative sequencei162 – 427266Missing in isoform 2. 1 PublicationVSP_011060Add
    BLAST
    Alternative sequencei183 – 1875RYRAV → SSTKM in isoform 3. 1 PublicationVSP_011062
    Alternative sequencei188 – 427240Missing in isoform 3. 1 PublicationVSP_011063Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S63938 mRNA. Translation: AAB20278.1.
    S67127 mRNA. Translation: AAB20407.1.
    X61950 mRNA. Translation: CAA43953.1.
    D90348 mRNA. Translation: BAA14359.1.
    S57498 mRNA. Translation: AAB25530.2.
    L06622 mRNA. Translation: AAA58447.1.
    D11151 Genomic DNA. Translation: BAA01920.1.
    S45956 mRNA. Translation: AAB23644.1.
    S81539 mRNA. Translation: AAB36325.1.
    S81542 mRNA. Translation: AAB36326.1.
    S81545 mRNA. Translation: AAB36327.1.
    AY275462 mRNA. Translation: AAP32294.1.
    AY422989 Genomic DNA. Translation: AAQ87880.1.
    AK304451 mRNA. Translation: BAG65268.1.
    AK312812 mRNA. Translation: BAG35670.1.
    AK315931 mRNA. Translation: BAH14302.1.
    AC093908 Genomic DNA. No translation available.
    CH471056 Genomic DNA. Translation: EAX05019.1.
    CH471056 Genomic DNA. Translation: EAX05021.1.
    BC022511 mRNA. Translation: AAH22511.1.
    S55772 Genomic DNA. Translation: AAB25212.1.
    AF014826 mRNA. Translation: AAB94859.1.
    CCDSiCCDS3769.1. [P25101-1]
    CCDS54810.1. [P25101-4]
    CCDS58927.1. [P25101-5]
    PIRiA44158.
    RefSeqiNP_001159527.1. NM_001166055.1. [P25101-4]
    NP_001243212.1. NM_001256283.1. [P25101-5]
    NP_001948.1. NM_001957.3. [P25101-1]
    UniGeneiHs.183713.

    Genome annotation databases

    EnsembliENST00000324300; ENSP00000315011; ENSG00000151617. [P25101-1]
    ENST00000358556; ENSP00000351359; ENSG00000151617. [P25101-4]
    ENST00000506066; ENSP00000425281; ENSG00000151617. [P25101-4]
    ENST00000510697; ENSP00000427259; ENSG00000151617. [P25101-3]
    ENST00000511804; ENSP00000425354; ENSG00000151617. [P25101-5]
    GeneIDi1909.
    KEGGihsa:1909.
    UCSCiuc003iky.3. human. [P25101-1]
    uc010ipe.1. human. [P25101-2]
    uc010ipg.2. human. [P25101-4]

    Polymorphism databases

    DMDMi119606.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S63938 mRNA. Translation: AAB20278.1 .
    S67127 mRNA. Translation: AAB20407.1 .
    X61950 mRNA. Translation: CAA43953.1 .
    D90348 mRNA. Translation: BAA14359.1 .
    S57498 mRNA. Translation: AAB25530.2 .
    L06622 mRNA. Translation: AAA58447.1 .
    D11151 Genomic DNA. Translation: BAA01920.1 .
    S45956 mRNA. Translation: AAB23644.1 .
    S81539 mRNA. Translation: AAB36325.1 .
    S81542 mRNA. Translation: AAB36326.1 .
    S81545 mRNA. Translation: AAB36327.1 .
    AY275462 mRNA. Translation: AAP32294.1 .
    AY422989 Genomic DNA. Translation: AAQ87880.1 .
    AK304451 mRNA. Translation: BAG65268.1 .
    AK312812 mRNA. Translation: BAG35670.1 .
    AK315931 mRNA. Translation: BAH14302.1 .
    AC093908 Genomic DNA. No translation available.
    CH471056 Genomic DNA. Translation: EAX05019.1 .
    CH471056 Genomic DNA. Translation: EAX05021.1 .
    BC022511 mRNA. Translation: AAH22511.1 .
    S55772 Genomic DNA. Translation: AAB25212.1 .
    AF014826 mRNA. Translation: AAB94859.1 .
    CCDSi CCDS3769.1. [P25101-1 ]
    CCDS54810.1. [P25101-4 ]
    CCDS58927.1. [P25101-5 ]
    PIRi A44158.
    RefSeqi NP_001159527.1. NM_001166055.1. [P25101-4 ]
    NP_001243212.1. NM_001256283.1. [P25101-5 ]
    NP_001948.1. NM_001957.3. [P25101-1 ]
    UniGenei Hs.183713.

    3D structure databases

    ProteinModelPortali P25101.
    SMRi P25101. Positions 80-381.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108231. 11 interactions.
    DIPi DIP-48718N.
    IntActi P25101. 1 interaction.
    STRINGi 9606.ENSP00000315011.

    Chemistry

    BindingDBi P25101.
    ChEMBLi CHEMBL2096678.
    DrugBanki DB00559. Bosentan.
    GuidetoPHARMACOLOGYi 219.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P25101.

    Polymorphism databases

    DMDMi 119606.

    Proteomic databases

    MaxQBi P25101.
    PaxDbi P25101.
    PRIDEi P25101.

    Protocols and materials databases

    DNASUi 1909.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000324300 ; ENSP00000315011 ; ENSG00000151617 . [P25101-1 ]
    ENST00000358556 ; ENSP00000351359 ; ENSG00000151617 . [P25101-4 ]
    ENST00000506066 ; ENSP00000425281 ; ENSG00000151617 . [P25101-4 ]
    ENST00000510697 ; ENSP00000427259 ; ENSG00000151617 . [P25101-3 ]
    ENST00000511804 ; ENSP00000425354 ; ENSG00000151617 . [P25101-5 ]
    GeneIDi 1909.
    KEGGi hsa:1909.
    UCSCi uc003iky.3. human. [P25101-1 ]
    uc010ipe.1. human. [P25101-2 ]
    uc010ipg.2. human. [P25101-4 ]

    Organism-specific databases

    CTDi 1909.
    GeneCardsi GC04P148401.
    HGNCi HGNC:3179. EDNRA.
    HPAi CAB018957.
    HPA013774.
    HPA014087.
    MIMi 131243. gene.
    neXtProti NX_P25101.
    PharmGKBi PA27617.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG278704.
    HOVERGENi HBG051443.
    InParanoidi P25101.
    KOi K04197.
    OMAi SIQWKNQ.
    OrthoDBi EOG7HHWS4.
    PhylomeDBi P25101.
    TreeFami TF331292.

    Enzyme and pathway databases

    Reactomei REACT_14819. Peptide ligand-binding receptors.
    REACT_18283. G alpha (q) signalling events.

    Miscellaneous databases

    GeneWikii Endothelin_receptor_type_A.
    GenomeRNAii 1909.
    NextBioi 35477375.
    PROi P25101.
    SOURCEi Search...

    Gene expression databases

    Bgeei P25101.
    CleanExi HS_EDNRA.
    Genevestigatori P25101.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000499. Endthln_rcpt.
    IPR002175. ETA_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00570. ENDOTHELINAR.
    PR00366. ENDOTHELINR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of cDNA encoding human A-type endothelin receptor."
      Adachi M., Yang Y.Y., Furuichi Y., Miyamoto C.
      Biochem. Biophys. Res. Commun. 180:1265-1272(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1).
      Tissue: Placenta.
    2. "Cloning and chromosomal localization of a human endothelin ETA receptor."
      Cyr C., Huebner K., Druck T., Kris R.
      Biochem. Biophys. Res. Commun. 181:184-190(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1).
      Tissue: Placenta.
    3. Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1).
    4. "Molecular cloning of human endothelin receptors and their expression in vascular endothelial cells and smooth muscle cells."
      Arai H., Nakao K., Hosoda K., Ogawa Y., Nakagawa O., Komatsu Y., Imura H.
      Jpn. Circ. J. 56:1303-1307(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1).
    5. "Molecular characterization and regulation of the human endothelin receptors."
      Elshourbagy N.A., Korman D.R., Wu H.L., Sylvester D.R., Lee J.A., Nuthalaganti P., Bergsma D.J., Kumar C.S., Nambi P.
      J. Biol. Chem. 268:3873-3879(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    6. "Organization, structure, chromosomal assignment, and expression of the gene encoding the human endothelin-A receptor."
      Hosoda K., Nakao K., Tamura N., Arai H., Ogawa Y., Suga S., Nakanishi S., Imura H.
      J. Biol. Chem. 267:18797-18804(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
    7. "Cloning and expression of a human endothelin receptor: subtype A."
      Hayzer D.J., Rose P.M., Lynch J.S., Webb M.L., Kienzle B.K., Liu E.C., Bogosian E.A., Brinson E., Runge M.S.
      Am. J. Med. Sci. 304:231-238(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
      Tissue: Placenta.
    8. "Alternative RNA splicing of the human endothelin-A receptor generates multiple transcripts."
      Miyamoto Y., Yoshimasa T., Arai H., Takaya K., Ogawa Y., Itoh H., Nakao K.
      Biochem. J. 313:795-801(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3 AND 4), TISSUE SPECIFICITY.
      Tissue: Lung.
    9. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Warren C.N., Aronstam R.S., Sharma S.V.
      Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Placenta.
    10. NIEHS SNPs program
      Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    11. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5).
      Tissue: Cerebellum, Testis and Trachea.
    12. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    13. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    14. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    15. "Molecular characterization of the 5'-flanking region of human genomic ETA gene."
      Yang H., Tabuchi H., Furuichi Y., Miyamoto C.
      Biochem. Biophys. Res. Commun. 190:332-339(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-140 (ISOFORMS 1/2/3/4).
    16. "Endothelin-1 and ETA receptor expression in vascular smooth muscle cells from human placenta: a new ETA receptor messenger ribonucleic acid is generated by alternative splicing of exon 3."
      Bourgeois C., Robert B., Rebourcet R., Mondon F., Mignot T.-M., Duc-Goiran P., Ferre F.
      J. Clin. Endocrinol. Metab. 82:3116-3123(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 52-427 (ISOFORM 2), TISSUE SPECIFICITY.
      Tissue: Placenta.
    17. "Tip60 and HDAC7 interact with the endothelin receptor a and may be involved in downstream signaling."
      Lee H.-J., Chun M., Kandror K.V.
      J. Biol. Chem. 276:16597-16600(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HDAC7 AND KAT5.
    18. Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-136.

    Entry informationi

    Entry nameiEDNRA_HUMAN
    AccessioniPrimary (citable) accession number: P25101
    Secondary accession number(s): B2R723
    , B4E2V6, B7Z9G6, D3DP03, E7ER36, O43441, Q16432, Q16433, Q8TBH2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: May 1, 1992
    Last modified: October 1, 2014
    This is version 152 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3