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P25100 (ADA1D_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 125. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alpha-1D adrenergic receptor
Alternative name(s):
Alpha-1A adrenergic receptor
Alpha-1D adrenoreceptor
Short name=Alpha-1D adrenoceptor
Alpha-adrenergic receptor 1a
Gene names
Name:ADRA1D
Synonyms:ADRA1A
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length572 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1D sub-subfamily.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMGlycoprotein
Lipoprotein
Palmitate
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA metabolic process

Traceable author statement PubMed 10969806. Source: ProtInc

G-protein coupled receptor signaling pathway

Traceable author statement Ref.1. Source: ProtInc

adenylate cyclase-modulating G-protein coupled receptor signaling pathway

Traceable author statement PubMed 10820200. Source: ProtInc

adrenergic receptor signaling pathway

Traceable author statement PubMed 10820200. Source: GOC

cell proliferation

Traceable author statement PubMed 10820200. Source: ProtInc

cell-cell signaling

Traceable author statement Ref.1. Source: ProtInc

multicellular organismal development

Traceable author statement PubMed 10820200. Source: ProtInc

negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure

Inferred from electronic annotation. Source: Ensembl

norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell proliferation

Traceable author statement PubMed 10860850. Source: ProtInc

   Cellular_componentintegral component of plasma membrane

Traceable author statement Ref.5. Source: ProtInc

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functionalpha1-adrenergic receptor activity

Traceable author statement PubMed 10820200. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 572572Alpha-1D adrenergic receptor
PRO_0000069073

Regions

Topological domain1 – 9595Extracellular By similarity
Transmembrane96 – 12126Helical; Name=1; By similarity
Topological domain122 – 13312Cytoplasmic By similarity
Transmembrane134 – 15926Helical; Name=2; By similarity
Topological domain160 – 16910Extracellular By similarity
Transmembrane170 – 19223Helical; Name=3; By similarity
Topological domain193 – 21321Cytoplasmic By similarity
Transmembrane214 – 23825Helical; Name=4; By similarity
Topological domain239 – 25113Extracellular By similarity
Transmembrane252 – 27524Helical; Name=5; By similarity
Topological domain276 – 34873Cytoplasmic By similarity
Transmembrane349 – 37325Helical; Name=6; By similarity
Topological domain374 – 3807Extracellular By similarity
Transmembrane381 – 40525Helical; Name=7; By similarity
Topological domain406 – 572167Cytoplasmic By similarity
Compositional bias422 – 4287Poly-Arg

Amino acid modifications

Lipidation4191S-palmitoyl cysteine Potential
Glycosylation651N-linked (GlcNAc...) Potential
Glycosylation821N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict1 – 8383MTFRD…GDVNG → MAAALRSVMMAGYLSEWRTP TYRSTEMVQRLRMEAVQHST S Ref.1
Sequence conflict311S → G in AAB31163. Ref.4
Sequence conflict489 – 57284KPPSA…RETDI → SHPAPSASGGCWGRSGDPRP SCAPKSPACRTRSPPGARSA QRQRAPSAQRWRLCP Ref.1
Sequence conflict5221R → P in AAB31163. Ref.4

Sequences

Sequence LengthMass (Da)Tools
P25100 [UniParc].

Last modified November 1, 1995. Version 2.
Checksum: EBEB134CF20A4988

FASTA57260,463
        10         20         30         40         50         60 
MTFRDLLSVS FEGPRPDSSA GGSSAGGGGG SAGGAAPSEG PAVGGVPGGA GGGGGVVGAG 

        70         80         90        100        110        120 
SGEDNRSSAG EPGSAGAGGD VNGTAAVGGL VVSAQGVGVG VFLAAFILMA VAGNLLVILS 

       130        140        150        160        170        180 
VACNRHLQTV TNYFIVNLAV ADLLLSATVL PFSATMEVLG FWAFGRAFCD VWAAVDVLCC 

       190        200        210        220        230        240 
TASILSLCTI SVDRYVGVRH SLKYPAIMTE RKAAAILALL WVVALVVSVG PLLGWKEPVP 

       250        260        270        280        290        300 
PDERFCGITE EAGYAVFSSV CSFYLPMAVI VVMYCRVYVV ARSTTRSLEA GVKRERGKAS 

       310        320        330        340        350        360 
EVVLRIHCRG AATGADGAHG MRSAKGHTFR SSLSVRLLKF SREKKAAKTL AIVVGVFVLC 

       370        380        390        400        410        420 
WFPFFFVLPL GSLFPQLKPS EGVFKVIFWL GYFNSCVNPL IYPCSSREFK RAFLRLLRCQ 

       430        440        450        460        470        480 
CRRRRRRRPL WRVYGHHWRA STSGLRQDCA PSSGDAPPGA PLALTALPDP DPEPPGTPEM 

       490        500        510        520        530        540 
QAPVASRRKP PSAFREWRLL GPFRRPTTQL RAKVSSLSHK IRAGGAQRAE AACAQRSEVE 

       550        560        570 
AVSLGVPHEV AEGATCQAYE LADYSNLRET DI 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and sequencing of a cDNA encoding a human alpha 1A adrenergic receptor."
Bruno J.F., Whittaker J., Song J., Berelowitz M.
Biochem. Biophys. Res. Commun. 179:1485-1490(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Hippocampus.
[2]"The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype."
Forray C., Bard J.A., Wetzel J.M., Chiu G., Shapiro E., Tang R., Lepor H., Hartig P.R., Weinshank R.L., Branchek T.A., Gluchowski C.
Mol. Pharmacol. 45:703-708(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Hippocampus.
[3]"Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues."
Schwinn D.A., Johnston G.I., Page S.O., Mosley M.J., Wilson K.H., Worman N.P., Campbell S., Fidock M.D., Furness L.M., Parry-Smith D.J., Peter B., Bailey D.S.
J. Pharmacol. Exp. Ther. 272:134-142(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c."
Weinberg D.H., Trivedi P., Tan C.P., Mitra S., Perkins-Barrow A., Borkowski D., Strader C.D., Bayne M.
Biochem. Biophys. Res. Commun. 201:1296-1304(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]"Cloning of the human alpha 1d-adrenergic receptor and inducible expression of three human subtypes in SK-N-MC cells."
Esbenshade T.A., Hirasawa A., Tsujimoto G., Tanaka T., Yano J., Minneman K.P., Murphy T.J.
Mol. Pharmacol. 47:977-985(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Placenta and Prostate.
[6]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M76446 mRNA. Translation: AAA35496.1.
U03864 mRNA. Translation: AAB60351.1.
L31772 mRNA. Translation: AAB59487.1.
S70782 mRNA. Translation: AAB31163.2.
D29952 Genomic DNA. Translation: BAA06222.1.
AL121675, AL357040 Genomic DNA. Translation: CAC00601.2.
CCDSCCDS13079.1.
PIRI39369.
JH0447.
RefSeqNP_000669.1. NM_000678.3.
UniGeneHs.557.

3D structure databases

ProteinModelPortalP25100.
SMRP25100. Positions 98-417.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid106656. 13 interactions.
IntActP25100. 1 interaction.
STRING9606.ENSP00000368766.

Chemistry

BindingDBP25100.
ChEMBLCHEMBL2095203.
DrugBankDB00346. Alfuzosin.
DB00217. Bethanidine.
DB00298. Dapiprazole.
DB04840. Debrisoquin.
DB00590. Doxazosin.
DB00226. Guanadrel Sulfate.
DB01170. Guanethidine.
DB01403. Methotrimeprazine.
DB00368. Norepinephrine.
DB00420. Promazine.
DB01608. Propericiazine.
DB00777. Propiomazine.
DB06144. Sertindole.
DB00706. Tamsulosin.
DB01162. Terazosin.
GuidetoPHARMACOLOGY24.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM1168243.

Proteomic databases

PaxDbP25100.
PRIDEP25100.

Protocols and materials databases

DNASU146.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000379453; ENSP00000368766; ENSG00000171873.
GeneID146.
KEGGhsa:146.
UCSCuc002wkr.2. human.

Organism-specific databases

CTD146.
GeneCardsGC20M004149.
HGNCHGNC:280. ADRA1D.
HPAHPA038789.
MIM104219. gene.
neXtProtNX_P25100.
PharmGKBPA24597.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG253615.
HOGENOMHOG000239244.
HOVERGENHBG106962.
InParanoidP25100.
KOK04137.
OMAGATCQAY.
OrthoDBEOG7H4DTB.
PhylomeDBP25100.
TreeFamTF331895.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressP25100.
BgeeP25100.
CleanExHS_ADRA1A.
HS_ADRA1D.
GenevestigatorP25100.

Family and domain databases

Gene3D1.20.1070.10. 2 hits.
InterProIPR002233. ADR_fam.
IPR000363. ADRA1D_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24248:SF14. PTHR24248:SF14. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR01103. ADRENERGICR.
PR00240. ADRENRGCA1DR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiAlpha-1D_adrenergic_receptor.
GenomeRNAi146.
NextBio577.
PROP25100.
SOURCESearch...

Entry information

Entry nameADA1D_HUMAN
AccessionPrimary (citable) accession number: P25100
Secondary accession number(s): Q9NPY0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries