Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P25100

- ADA1D_HUMAN

UniProt

P25100 - ADA1D_HUMAN

Protein

Alpha-1D adrenergic receptor

Gene

ADRA1D

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 2 (01 Nov 1995)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.

    GO - Molecular functioni

    1. alpha1-adrenergic receptor activity Source: ProtInc

    GO - Biological processi

    1. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: ProtInc
    2. adrenergic receptor signaling pathway Source: GOC
    3. cell-cell signaling Source: ProtInc
    4. cell proliferation Source: ProtInc
    5. DNA metabolic process Source: ProtInc
    6. G-protein coupled receptor signaling pathway Source: ProtInc
    7. multicellular organismal development Source: ProtInc
    8. negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure Source: Ensembl
    9. norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure Source: Ensembl
    10. positive regulation of cell proliferation Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_16927. Adrenoceptors.
    REACT_18283. G alpha (q) signalling events.
    REACT_18407. G alpha (12/13) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-1D adrenergic receptor
    Alternative name(s):
    Alpha-1A adrenergic receptor
    Alpha-1D adrenoreceptor
    Short name:
    Alpha-1D adrenoceptor
    Alpha-adrenergic receptor 1a
    Gene namesi
    Name:ADRA1D
    Synonyms:ADRA1A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:280. ADRA1D.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24597.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 572572Alpha-1D adrenergic receptorPRO_0000069073Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi65 – 651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi82 – 821N-linked (GlcNAc...)Sequence Analysis
    Lipidationi419 – 4191S-palmitoyl cysteineSequence Analysis

    Keywords - PTMi

    Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiP25100.
    PRIDEiP25100.

    Expressioni

    Gene expression databases

    ArrayExpressiP25100.
    BgeeiP25100.
    CleanExiHS_ADRA1A.
    HS_ADRA1D.
    GenevestigatoriP25100.

    Organism-specific databases

    HPAiHPA038789.

    Interactioni

    Protein-protein interaction databases

    BioGridi106656. 13 interactions.
    IntActiP25100. 1 interaction.
    STRINGi9606.ENSP00000368766.

    Structurei

    3D structure databases

    ProteinModelPortaliP25100.
    SMRiP25100. Positions 98-417.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 9595ExtracellularBy similarityAdd
    BLAST
    Topological domaini122 – 13312CytoplasmicBy similarityAdd
    BLAST
    Topological domaini160 – 16910ExtracellularBy similarity
    Topological domaini193 – 21321CytoplasmicBy similarityAdd
    BLAST
    Topological domaini239 – 25113ExtracellularBy similarityAdd
    BLAST
    Topological domaini276 – 34873CytoplasmicBy similarityAdd
    BLAST
    Topological domaini374 – 3807ExtracellularBy similarity
    Topological domaini406 – 572167CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei96 – 12126Helical; Name=1By similarityAdd
    BLAST
    Transmembranei134 – 15926Helical; Name=2By similarityAdd
    BLAST
    Transmembranei170 – 19223Helical; Name=3By similarityAdd
    BLAST
    Transmembranei214 – 23825Helical; Name=4By similarityAdd
    BLAST
    Transmembranei252 – 27524Helical; Name=5By similarityAdd
    BLAST
    Transmembranei349 – 37325Helical; Name=6By similarityAdd
    BLAST
    Transmembranei381 – 40525Helical; Name=7By similarityAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi422 – 4287Poly-Arg

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1D sub-subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG253615.
    HOGENOMiHOG000239244.
    HOVERGENiHBG106962.
    InParanoidiP25100.
    KOiK04137.
    OMAiGATCQAY.
    OrthoDBiEOG7H4DTB.
    PhylomeDBiP25100.
    TreeFamiTF331895.

    Family and domain databases

    Gene3Di1.20.1070.10. 2 hits.
    InterProiIPR002233. ADR_fam.
    IPR000363. ADRA1D_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24248:SF14. PTHR24248:SF14. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR01103. ADRENERGICR.
    PR00240. ADRENRGCA1DR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P25100-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTFRDLLSVS FEGPRPDSSA GGSSAGGGGG SAGGAAPSEG PAVGGVPGGA    50
    GGGGGVVGAG SGEDNRSSAG EPGSAGAGGD VNGTAAVGGL VVSAQGVGVG 100
    VFLAAFILMA VAGNLLVILS VACNRHLQTV TNYFIVNLAV ADLLLSATVL 150
    PFSATMEVLG FWAFGRAFCD VWAAVDVLCC TASILSLCTI SVDRYVGVRH 200
    SLKYPAIMTE RKAAAILALL WVVALVVSVG PLLGWKEPVP PDERFCGITE 250
    EAGYAVFSSV CSFYLPMAVI VVMYCRVYVV ARSTTRSLEA GVKRERGKAS 300
    EVVLRIHCRG AATGADGAHG MRSAKGHTFR SSLSVRLLKF SREKKAAKTL 350
    AIVVGVFVLC WFPFFFVLPL GSLFPQLKPS EGVFKVIFWL GYFNSCVNPL 400
    IYPCSSREFK RAFLRLLRCQ CRRRRRRRPL WRVYGHHWRA STSGLRQDCA 450
    PSSGDAPPGA PLALTALPDP DPEPPGTPEM QAPVASRRKP PSAFREWRLL 500
    GPFRRPTTQL RAKVSSLSHK IRAGGAQRAE AACAQRSEVE AVSLGVPHEV 550
    AEGATCQAYE LADYSNLRET DI 572
    Length:572
    Mass (Da):60,463
    Last modified:November 1, 1995 - v2
    Checksum:iEBEB134CF20A4988
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1 – 8383MTFRD…GDVNG → MAAALRSVMMAGYLSEWRTP TYRSTEMVQRLRMEAVQHST S(PubMed:1656955)CuratedAdd
    BLAST
    Sequence conflicti31 – 311S → G in AAB31163. (PubMed:8024574)Curated
    Sequence conflicti489 – 57284KPPSA…RETDI → SHPAPSASGGCWGRSGDPRP SCAPKSPACRTRSPPGARSA QRQRAPSAQRWRLCP(PubMed:1656955)CuratedAdd
    BLAST
    Sequence conflicti522 – 5221R → P in AAB31163. (PubMed:8024574)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M76446 mRNA. Translation: AAA35496.1.
    U03864 mRNA. Translation: AAB60351.1.
    L31772 mRNA. Translation: AAB59487.1.
    S70782 mRNA. Translation: AAB31163.2.
    D29952 Genomic DNA. Translation: BAA06222.1.
    AL121675, AL357040 Genomic DNA. Translation: CAC00601.2.
    CCDSiCCDS13079.1.
    PIRiI39369.
    JH0447.
    RefSeqiNP_000669.1. NM_000678.3.
    UniGeneiHs.557.

    Genome annotation databases

    EnsembliENST00000379453; ENSP00000368766; ENSG00000171873.
    GeneIDi146.
    KEGGihsa:146.
    UCSCiuc002wkr.2. human.

    Polymorphism databases

    DMDMi1168243.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M76446 mRNA. Translation: AAA35496.1 .
    U03864 mRNA. Translation: AAB60351.1 .
    L31772 mRNA. Translation: AAB59487.1 .
    S70782 mRNA. Translation: AAB31163.2 .
    D29952 Genomic DNA. Translation: BAA06222.1 .
    AL121675 , AL357040 Genomic DNA. Translation: CAC00601.2 .
    CCDSi CCDS13079.1.
    PIRi I39369.
    JH0447.
    RefSeqi NP_000669.1. NM_000678.3.
    UniGenei Hs.557.

    3D structure databases

    ProteinModelPortali P25100.
    SMRi P25100. Positions 98-417.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106656. 13 interactions.
    IntActi P25100. 1 interaction.
    STRINGi 9606.ENSP00000368766.

    Chemistry

    BindingDBi P25100.
    ChEMBLi CHEMBL2095203.
    DrugBanki DB00346. Alfuzosin.
    DB00217. Bethanidine.
    DB00298. Dapiprazole.
    DB04840. Debrisoquin.
    DB00590. Doxazosin.
    DB00226. Guanadrel Sulfate.
    DB01170. Guanethidine.
    DB01403. Methotrimeprazine.
    DB00368. Norepinephrine.
    DB00420. Promazine.
    DB01608. Propericiazine.
    DB00777. Propiomazine.
    DB06144. Sertindole.
    DB00706. Tamsulosin.
    DB01162. Terazosin.
    GuidetoPHARMACOLOGYi 24.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 1168243.

    Proteomic databases

    PaxDbi P25100.
    PRIDEi P25100.

    Protocols and materials databases

    DNASUi 146.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000379453 ; ENSP00000368766 ; ENSG00000171873 .
    GeneIDi 146.
    KEGGi hsa:146.
    UCSCi uc002wkr.2. human.

    Organism-specific databases

    CTDi 146.
    GeneCardsi GC20M004149.
    HGNCi HGNC:280. ADRA1D.
    HPAi HPA038789.
    MIMi 104219. gene.
    neXtProti NX_P25100.
    PharmGKBi PA24597.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG253615.
    HOGENOMi HOG000239244.
    HOVERGENi HBG106962.
    InParanoidi P25100.
    KOi K04137.
    OMAi GATCQAY.
    OrthoDBi EOG7H4DTB.
    PhylomeDBi P25100.
    TreeFami TF331895.

    Enzyme and pathway databases

    Reactomei REACT_16927. Adrenoceptors.
    REACT_18283. G alpha (q) signalling events.
    REACT_18407. G alpha (12/13) signalling events.

    Miscellaneous databases

    GeneWikii Alpha-1D_adrenergic_receptor.
    GenomeRNAii 146.
    NextBioi 577.
    PROi P25100.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P25100.
    Bgeei P25100.
    CleanExi HS_ADRA1A.
    HS_ADRA1D.
    Genevestigatori P25100.

    Family and domain databases

    Gene3Di 1.20.1070.10. 2 hits.
    InterProi IPR002233. ADR_fam.
    IPR000363. ADRA1D_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24248:SF14. PTHR24248:SF14. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01103. ADRENERGICR.
    PR00240. ADRENRGCA1DR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and sequencing of a cDNA encoding a human alpha 1A adrenergic receptor."
      Bruno J.F., Whittaker J., Song J., Berelowitz M.
      Biochem. Biophys. Res. Commun. 179:1485-1490(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Hippocampus.
    2. "The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype."
      Forray C., Bard J.A., Wetzel J.M., Chiu G., Shapiro E., Tang R., Lepor H., Hartig P.R., Weinshank R.L., Branchek T.A., Gluchowski C.
      Mol. Pharmacol. 45:703-708(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Hippocampus.
    3. "Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues."
      Schwinn D.A., Johnston G.I., Page S.O., Mosley M.J., Wilson K.H., Worman N.P., Campbell S., Fidock M.D., Furness L.M., Parry-Smith D.J., Peter B., Bailey D.S.
      J. Pharmacol. Exp. Ther. 272:134-142(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c."
      Weinberg D.H., Trivedi P., Tan C.P., Mitra S., Perkins-Barrow A., Borkowski D., Strader C.D., Bayne M.
      Biochem. Biophys. Res. Commun. 201:1296-1304(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    5. "Cloning of the human alpha 1d-adrenergic receptor and inducible expression of three human subtypes in SK-N-MC cells."
      Esbenshade T.A., Hirasawa A., Tsujimoto G., Tanaka T., Yano J., Minneman K.P., Murphy T.J.
      Mol. Pharmacol. 47:977-985(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Placenta and Prostate.
    6. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiADA1D_HUMAN
    AccessioniPrimary (citable) accession number: P25100
    Secondary accession number(s): Q9NPY0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 127 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3