P25100 (ADA1D_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alpha-1D adrenergic receptor

Alternative name(s):
Alpha-1A adrenergic receptor
Alpha-1D adrenoreceptor
Short name=Alpha-1D adrenoceptor
Alpha-adrenergic receptor 1a

Gene names

Name:	ADRA1D
Synonyms:	ADRA1A

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	572 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1D sub-subfamily.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA metabolic process Traceable author statement PubMed 10969806. Source: ProtInc adenylate cyclase-modulating G-protein coupled receptor signaling pathway Traceable author statement PubMed 10820200. Source: ProtInc cell proliferation Traceable author statement PubMed 10820200. Source: ProtInc cell-cell signaling Traceable author statement Ref.1. Source: ProtInc multicellular organismal development Traceable author statement PubMed 10820200. Source: ProtInc negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure Inferred from electronic annotation. Source: Compara norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure Inferred from electronic annotation. Source: Compara positive regulation of cell proliferation Traceable author statement PubMed 10860850. Source: ProtInc
Cellular_component	integral to plasma membrane Traceable author statement Ref.5. Source: ProtInc
Molecular_function	alpha1-adrenergic receptor activity Traceable author statement PubMed 10820200. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 572	572	Alpha-1D adrenergic receptor		PRO_0000069073
Regions
	Topological domain	1 – 95	95	Extracellular By similarity
	Transmembrane	96 – 121	26	Helical; Name=1; By similarity
	Topological domain	122 – 133	12	Cytoplasmic By similarity
	Transmembrane	134 – 159	26	Helical; Name=2; By similarity
	Topological domain	160 – 169	10	Extracellular By similarity
	Transmembrane	170 – 192	23	Helical; Name=3; By similarity
	Topological domain	193 – 213	21	Cytoplasmic By similarity
	Transmembrane	214 – 238	25	Helical; Name=4; By similarity
	Topological domain	239 – 251	13	Extracellular By similarity
	Transmembrane	252 – 275	24	Helical; Name=5; By similarity
	Topological domain	276 – 348	73	Cytoplasmic By similarity
	Transmembrane	349 – 373	25	Helical; Name=6; By similarity
	Topological domain	374 – 380	7	Extracellular By similarity
	Transmembrane	381 – 405	25	Helical; Name=7; By similarity
	Topological domain	406 – 572	167	Cytoplasmic By similarity
	Compositional bias	422 – 428	7	Poly-Arg
Amino acid modifications
	Lipidation	419	1	S-palmitoyl cysteine Potential
	Glycosylation	65	1	N-linked (GlcNAc...) Potential
	Glycosylation	82	1	N-linked (GlcNAc...) Potential
Experimental info
	Sequence conflict	1 – 83	83	MTFRD…GDVNG → MAAALRSVMMAGYLSEWRTP TYRSTEMVQRLRMEAVQHST S Ref.1
	Sequence conflict	31	1	S → G in AAB31163. Ref.4
	Sequence conflict	489 – 572	84	KPPSA…RETDI → SHPAPSASGGCWGRSGDPRP SCAPKSPACRTRSPPGARSA QRQRAPSAQRWRLCP Ref.1
	Sequence conflict	522	1	R → P in AAB31163. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	P25100 [UniParc]. Last modified November 1, 1995. Version 2. Checksum: EBEB134CF20A4988	FASTA	572	60,463
	10 20 30 40 50 60 MTFRDLLSVS FEGPRPDSSA GGSSAGGGGG SAGGAAPSEG PAVGGVPGGA GGGGGVVGAG 70 80 90 100 110 120 SGEDNRSSAG EPGSAGAGGD VNGTAAVGGL VVSAQGVGVG VFLAAFILMA VAGNLLVILS 130 140 150 160 170 180 VACNRHLQTV TNYFIVNLAV ADLLLSATVL PFSATMEVLG FWAFGRAFCD VWAAVDVLCC 190 200 210 220 230 240 TASILSLCTI SVDRYVGVRH SLKYPAIMTE RKAAAILALL WVVALVVSVG PLLGWKEPVP 250 260 270 280 290 300 PDERFCGITE EAGYAVFSSV CSFYLPMAVI VVMYCRVYVV ARSTTRSLEA GVKRERGKAS 310 320 330 340 350 360 EVVLRIHCRG AATGADGAHG MRSAKGHTFR SSLSVRLLKF SREKKAAKTL AIVVGVFVLC 370 380 390 400 410 420 WFPFFFVLPL GSLFPQLKPS EGVFKVIFWL GYFNSCVNPL IYPCSSREFK RAFLRLLRCQ 430 440 450 460 470 480 CRRRRRRRPL WRVYGHHWRA STSGLRQDCA PSSGDAPPGA PLALTALPDP DPEPPGTPEM 490 500 510 520 530 540 QAPVASRRKP PSAFREWRLL GPFRRPTTQL RAKVSSLSHK IRAGGAQRAE AACAQRSEVE 550 560 570 AVSLGVPHEV AEGATCQAYE LADYSNLRET DI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and sequencing of a cDNA encoding a human alpha 1A adrenergic receptor." Bruno J.F., Whittaker J., Song J., Berelowitz M. Biochem. Biophys. Res. Commun. 179:1485-1490(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Hippocampus.
[2]	"The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype." Forray C., Bard J.A., Wetzel J.M., Chiu G., Shapiro E., Tang R., Lepor H., Hartig P.R., Weinshank R.L., Branchek T.A., Gluchowski C. Mol. Pharmacol. 45:703-708(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Hippocampus.
[3]	"Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues." Schwinn D.A., Johnston G.I., Page S.O., Mosley M.J., Wilson K.H., Worman N.P., Campbell S., Fidock M.D., Furness L.M., Parry-Smith D.J., Peter B., Bailey D.S. J. Pharmacol. Exp. Ther. 272:134-142(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c." Weinberg D.H., Trivedi P., Tan C.P., Mitra S., Perkins-Barrow A., Borkowski D., Strader C.D., Bayne M. Biochem. Biophys. Res. Commun. 201:1296-1304(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]	"Cloning of the human alpha 1d-adrenergic receptor and inducible expression of three human subtypes in SK-N-MC cells." Esbenshade T.A., Hirasawa A., Tsujimoto G., Tanaka T., Yano J., Minneman K.P., Murphy T.J. Mol. Pharmacol. 47:977-985(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Placenta and Prostate.
[6]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M76446 mRNA. Translation: AAA35496.1. U03864 mRNA. Translation: AAB60351.1. L31772 mRNA. Translation: AAB59487.1. S70782 mRNA. Translation: AAB31163.2. D29952 Genomic DNA. Translation: BAA06222.1. AL121675, AL357040 Genomic DNA. Translation: CAC00601.2.
IPI	IPI00012725.
PIR	I39369. JH0447.
RefSeq	NP_000669.1. NM_000678.3.
UniGene	Hs.557.
3D structure databases
ProteinModelPortal	P25100.
ModBase	Search...
Protein-protein interaction databases
IntAct	P25100. 1 interaction.
STRING	9606.ENSP00000368766.
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	1168243.
Proteomic databases
PaxDb	P25100.
PRIDE	P25100.
Protocols and materials databases
DNASU	146.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000379453; ENSP00000368766; ENSG00000171873.
GeneID	146.
KEGG	hsa:146.
UCSC	uc002wkr.2. human.
Organism-specific databases
CTD	146.
GeneCards	GC20M004149.
HGNC	HGNC:280. ADRA1D.
HPA	HPA038789.
MIM	104219. gene.
neXtProt	NX_P25100.
PharmGKB	PA24597.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG253615.
HOGENOM	HOG000239244.
HOVERGEN	HBG106962.
InParanoid	P25100.
KO	K04137.
OMA	TCQAYEL.
OrthoDB	EOG480HWT.
PhylomeDB	P25100.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	P25100.
Bgee	P25100.
CleanEx	HS_ADRA1A. HS_ADRA1D.
Genevestigator	P25100.
GermOnline	ENSG00000171873. Homo sapiens.
Family and domain databases
InterPro	IPR000363. Adren_rcpt_A1A. IPR002233. Adrnrgc_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR01103. ADRENERGICR. PR00240. ADRENRGCA1DR. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P25100.
ChEMBL	CHEMBL223.
DrugBank	DB00346. Alfuzosin. DB00217. Bethanidine. DB00298. Dapiprazole. DB04840. Debrisoquin. DB00590. Doxazosin. DB00226. Guanadrel Sulfate. DB01170. Guanethidine. DB01403. Methotrimeprazine. DB00368. Norepinephrine. DB00420. Promazine. DB01608. Propericiazine. DB00777. Propiomazine. DB06144. Sertindole. DB00706. Tamsulosin. DB01162. Terazosin.
GenomeRNAi	146.
NextBio	577.
SOURCE	Search...

Entry information

Entry name

ADA1D_HUMAN

Accession

Primary (citable) accession number: P25100
Secondary accession number(s): Q9NPY0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1992
Last sequence update:	November 1, 1995
Last modified:	May 1, 2013
This is version 115 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.