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Protein

Alpha-1D adrenergic receptor

Gene

ADRA1D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.

GO - Molecular functioni

  • alpha1-adrenergic receptor activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171873-MONOMER.
ReactomeiR-HSA-390696. Adrenoceptors.
R-HSA-416476. G alpha (q) signalling events.
R-HSA-416482. G alpha (12/13) signalling events.
SIGNORiP25100.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1D adrenergic receptor
Alternative name(s):
Alpha-1A adrenergic receptor
Alpha-1D adrenoreceptor
Short name:
Alpha-1D adrenoceptor
Alpha-adrenergic receptor 1a
Gene namesi
Name:ADRA1D
Synonyms:ADRA1A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:280. ADRA1D.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 95ExtracellularBy similarityAdd BLAST95
Transmembranei96 – 121Helical; Name=1By similarityAdd BLAST26
Topological domaini122 – 133CytoplasmicBy similarityAdd BLAST12
Transmembranei134 – 159Helical; Name=2By similarityAdd BLAST26
Topological domaini160 – 169ExtracellularBy similarity10
Transmembranei170 – 192Helical; Name=3By similarityAdd BLAST23
Topological domaini193 – 213CytoplasmicBy similarityAdd BLAST21
Transmembranei214 – 238Helical; Name=4By similarityAdd BLAST25
Topological domaini239 – 251ExtracellularBy similarityAdd BLAST13
Transmembranei252 – 275Helical; Name=5By similarityAdd BLAST24
Topological domaini276 – 348CytoplasmicBy similarityAdd BLAST73
Transmembranei349 – 373Helical; Name=6By similarityAdd BLAST25
Topological domaini374 – 380ExtracellularBy similarity7
Transmembranei381 – 405Helical; Name=7By similarityAdd BLAST25
Topological domaini406 – 572CytoplasmicBy similarityAdd BLAST167

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi146.
OpenTargetsiENSG00000171873.
PharmGKBiPA24597.

Chemistry databases

ChEMBLiCHEMBL223.
DrugBankiDB00346. Alfuzosin.
DB00321. Amitriptyline.
DB00543. Amoxapine.
DB00182. Amphetamine.
DB01200. Bromocriptine.
DB00248. Cabergoline.
DB01136. Carvedilol.
DB00477. Chlorpromazine.
DB00575. Clonidine.
DB00298. Dapiprazole.
DB01151. Desipramine.
DB00590. Doxazosin.
DB01142. Doxepin.
DB04855. Dronedarone.
DB06262. Droxidopa.
DB00668. Epinephrine.
DB01049. Ergoloid mesylate.
DB00696. Ergotamine.
DB00800. Fenoldopam.
DB00458. Imipramine.
DB00598. Labetalol.
DB00934. Maprotiline.
DB01365. Mephentermine.
DB01403. Methotrimeprazine.
DB00723. Methoxamine.
DB06148. Mianserin.
DB00211. Midodrine.
DB00370. Mirtazapine.
DB00622. Nicardipine.
DB00368. Norepinephrine.
DB00540. Nortriptyline.
DB00935. Oxymetazoline.
DB01186. Pergolide.
DB00925. Phenoxybenzamine.
DB00388. Phenylephrine.
DB00457. Prazosin.
DB00420. Promazine.
DB00777. Propiomazine.
DB01224. Quetiapine.
DB06144. Sertindole.
DB06207. Silodosin.
DB00706. Tamsulosin.
DB01162. Terazosin.
DB06694. Xylometazoline.
GuidetoPHARMACOLOGYi24.

Polymorphism and mutation databases

BioMutaiADRA1D.
DMDMi1168243.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000690731 – 572Alpha-1D adrenergic receptorAdd BLAST572

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi65N-linked (GlcNAc...)Sequence analysis1
Glycosylationi82N-linked (GlcNAc...)Sequence analysis1
Lipidationi419S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP25100.
PRIDEiP25100.

PTM databases

iPTMnetiP25100.
PhosphoSitePlusiP25100.

Expressioni

Gene expression databases

BgeeiENSG00000171873.
CleanExiHS_ADRA1A.
HS_ADRA1D.
ExpressionAtlasiP25100. baseline and differential.
GenevisibleiP25100. HS.

Organism-specific databases

HPAiHPA038789.

Interactioni

Subunit structurei

Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA.1 Publication

Protein-protein interaction databases

BioGridi106656. 13 interactors.
IntActiP25100. 1 interactor.
STRINGi9606.ENSP00000368766.

Chemistry databases

BindingDBiP25100.

Structurei

3D structure databases

ProteinModelPortaliP25100.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi422 – 428Poly-Arg7

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1D sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118795.
HOGENOMiHOG000239244.
HOVERGENiHBG106962.
InParanoidiP25100.
KOiK04137.
OMAiGATCQAY.
OrthoDBiEOG091G06VI.
PhylomeDBiP25100.
TreeFamiTF331895.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR000363. ADRA1D_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24248:SF14. PTHR24248:SF14. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00240. ADRENRGCA1DR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25100-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTFRDLLSVS FEGPRPDSSA GGSSAGGGGG SAGGAAPSEG PAVGGVPGGA
60 70 80 90 100
GGGGGVVGAG SGEDNRSSAG EPGSAGAGGD VNGTAAVGGL VVSAQGVGVG
110 120 130 140 150
VFLAAFILMA VAGNLLVILS VACNRHLQTV TNYFIVNLAV ADLLLSATVL
160 170 180 190 200
PFSATMEVLG FWAFGRAFCD VWAAVDVLCC TASILSLCTI SVDRYVGVRH
210 220 230 240 250
SLKYPAIMTE RKAAAILALL WVVALVVSVG PLLGWKEPVP PDERFCGITE
260 270 280 290 300
EAGYAVFSSV CSFYLPMAVI VVMYCRVYVV ARSTTRSLEA GVKRERGKAS
310 320 330 340 350
EVVLRIHCRG AATGADGAHG MRSAKGHTFR SSLSVRLLKF SREKKAAKTL
360 370 380 390 400
AIVVGVFVLC WFPFFFVLPL GSLFPQLKPS EGVFKVIFWL GYFNSCVNPL
410 420 430 440 450
IYPCSSREFK RAFLRLLRCQ CRRRRRRRPL WRVYGHHWRA STSGLRQDCA
460 470 480 490 500
PSSGDAPPGA PLALTALPDP DPEPPGTPEM QAPVASRRKP PSAFREWRLL
510 520 530 540 550
GPFRRPTTQL RAKVSSLSHK IRAGGAQRAE AACAQRSEVE AVSLGVPHEV
560 570
AEGATCQAYE LADYSNLRET DI
Length:572
Mass (Da):60,463
Last modified:November 1, 1995 - v2
Checksum:iEBEB134CF20A4988
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1 – 83MTFRD…GDVNG → MAAALRSVMMAGYLSEWRTP TYRSTEMVQRLRMEAVQHST S (PubMed:1656955).CuratedAdd BLAST83
Sequence conflicti31S → G in AAB31163 (PubMed:8024574).Curated1
Sequence conflicti489 – 572KPPSA…RETDI → SHPAPSASGGCWGRSGDPRP SCAPKSPACRTRSPPGARSA QRQRAPSAQRWRLCP (PubMed:1656955).CuratedAdd BLAST84
Sequence conflicti522R → P in AAB31163 (PubMed:8024574).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M76446 mRNA. Translation: AAA35496.1.
U03864 mRNA. Translation: AAB60351.1.
L31772 mRNA. Translation: AAB59487.1.
S70782 mRNA. Translation: AAB31163.2.
D29952 Genomic DNA. Translation: BAA06222.1.
AL121675, AL357040 Genomic DNA. Translation: CAC00601.2.
CCDSiCCDS13079.1.
PIRiI39369.
JH0447.
RefSeqiNP_000669.1. NM_000678.3.
UniGeneiHs.557.

Genome annotation databases

EnsembliENST00000379453; ENSP00000368766; ENSG00000171873.
GeneIDi146.
KEGGihsa:146.
UCSCiuc002wkr.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M76446 mRNA. Translation: AAA35496.1.
U03864 mRNA. Translation: AAB60351.1.
L31772 mRNA. Translation: AAB59487.1.
S70782 mRNA. Translation: AAB31163.2.
D29952 Genomic DNA. Translation: BAA06222.1.
AL121675, AL357040 Genomic DNA. Translation: CAC00601.2.
CCDSiCCDS13079.1.
PIRiI39369.
JH0447.
RefSeqiNP_000669.1. NM_000678.3.
UniGeneiHs.557.

3D structure databases

ProteinModelPortaliP25100.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106656. 13 interactors.
IntActiP25100. 1 interactor.
STRINGi9606.ENSP00000368766.

Chemistry databases

BindingDBiP25100.
ChEMBLiCHEMBL223.
DrugBankiDB00346. Alfuzosin.
DB00321. Amitriptyline.
DB00543. Amoxapine.
DB00182. Amphetamine.
DB01200. Bromocriptine.
DB00248. Cabergoline.
DB01136. Carvedilol.
DB00477. Chlorpromazine.
DB00575. Clonidine.
DB00298. Dapiprazole.
DB01151. Desipramine.
DB00590. Doxazosin.
DB01142. Doxepin.
DB04855. Dronedarone.
DB06262. Droxidopa.
DB00668. Epinephrine.
DB01049. Ergoloid mesylate.
DB00696. Ergotamine.
DB00800. Fenoldopam.
DB00458. Imipramine.
DB00598. Labetalol.
DB00934. Maprotiline.
DB01365. Mephentermine.
DB01403. Methotrimeprazine.
DB00723. Methoxamine.
DB06148. Mianserin.
DB00211. Midodrine.
DB00370. Mirtazapine.
DB00622. Nicardipine.
DB00368. Norepinephrine.
DB00540. Nortriptyline.
DB00935. Oxymetazoline.
DB01186. Pergolide.
DB00925. Phenoxybenzamine.
DB00388. Phenylephrine.
DB00457. Prazosin.
DB00420. Promazine.
DB00777. Propiomazine.
DB01224. Quetiapine.
DB06144. Sertindole.
DB06207. Silodosin.
DB00706. Tamsulosin.
DB01162. Terazosin.
DB06694. Xylometazoline.
GuidetoPHARMACOLOGYi24.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP25100.
PhosphoSitePlusiP25100.

Polymorphism and mutation databases

BioMutaiADRA1D.
DMDMi1168243.

Proteomic databases

PaxDbiP25100.
PRIDEiP25100.

Protocols and materials databases

DNASUi146.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379453; ENSP00000368766; ENSG00000171873.
GeneIDi146.
KEGGihsa:146.
UCSCiuc002wkr.3. human.

Organism-specific databases

CTDi146.
DisGeNETi146.
GeneCardsiADRA1D.
HGNCiHGNC:280. ADRA1D.
HPAiHPA038789.
MIMi104219. gene.
neXtProtiNX_P25100.
OpenTargetsiENSG00000171873.
PharmGKBiPA24597.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118795.
HOGENOMiHOG000239244.
HOVERGENiHBG106962.
InParanoidiP25100.
KOiK04137.
OMAiGATCQAY.
OrthoDBiEOG091G06VI.
PhylomeDBiP25100.
TreeFamiTF331895.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171873-MONOMER.
ReactomeiR-HSA-390696. Adrenoceptors.
R-HSA-416476. G alpha (q) signalling events.
R-HSA-416482. G alpha (12/13) signalling events.
SIGNORiP25100.

Miscellaneous databases

ChiTaRSiADRA1D. human.
GeneWikiiAlpha-1D_adrenergic_receptor.
GenomeRNAii146.
PROiP25100.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171873.
CleanExiHS_ADRA1A.
HS_ADRA1D.
ExpressionAtlasiP25100. baseline and differential.
GenevisibleiP25100. HS.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR000363. ADRA1D_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24248:SF14. PTHR24248:SF14. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00240. ADRENRGCA1DR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADA1D_HUMAN
AccessioniPrimary (citable) accession number: P25100
Secondary accession number(s): Q9NPY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 144 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.