Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Alpha-1D adrenergic receptor

Gene

ADRA1D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.

GO - Molecular functioni

  1. alpha1-adrenergic receptor activity Source: ProtInc

GO - Biological processi

  1. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: ProtInc
  2. adrenergic receptor signaling pathway Source: GOC
  3. cell-cell signaling Source: ProtInc
  4. cell proliferation Source: ProtInc
  5. DNA metabolic process Source: ProtInc
  6. G-protein coupled receptor signaling pathway Source: ProtInc
  7. multicellular organismal development Source: ProtInc
  8. negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure Source: Ensembl
  9. norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure Source: Ensembl
  10. positive regulation of cell proliferation Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_16927. Adrenoceptors.
REACT_18283. G alpha (q) signalling events.
REACT_18407. G alpha (12/13) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1D adrenergic receptor
Alternative name(s):
Alpha-1A adrenergic receptor
Alpha-1D adrenoreceptor
Short name:
Alpha-1D adrenoceptor
Alpha-adrenergic receptor 1a
Gene namesi
Name:ADRA1D
Synonyms:ADRA1A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:280. ADRA1D.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9595ExtracellularBy similarityAdd
BLAST
Transmembranei96 – 12126Helical; Name=1By similarityAdd
BLAST
Topological domaini122 – 13312CytoplasmicBy similarityAdd
BLAST
Transmembranei134 – 15926Helical; Name=2By similarityAdd
BLAST
Topological domaini160 – 16910ExtracellularBy similarity
Transmembranei170 – 19223Helical; Name=3By similarityAdd
BLAST
Topological domaini193 – 21321CytoplasmicBy similarityAdd
BLAST
Transmembranei214 – 23825Helical; Name=4By similarityAdd
BLAST
Topological domaini239 – 25113ExtracellularBy similarityAdd
BLAST
Transmembranei252 – 27524Helical; Name=5By similarityAdd
BLAST
Topological domaini276 – 34873CytoplasmicBy similarityAdd
BLAST
Transmembranei349 – 37325Helical; Name=6By similarityAdd
BLAST
Topological domaini374 – 3807ExtracellularBy similarity
Transmembranei381 – 40525Helical; Name=7By similarityAdd
BLAST
Topological domaini406 – 572167CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24597.

Chemistry

DrugBankiDB00346. Alfuzosin.
DB00321. Amitriptyline.
DB00543. Amoxapine.
DB00182. Amphetamine.
DB01200. Bromocriptine.
DB00248. Cabergoline.
DB01136. Carvedilol.
DB00477. Chlorpromazine.
DB00575. Clonidine.
DB00298. Dapiprazole.
DB01151. Desipramine.
DB00590. Doxazosin.
DB01142. Doxepin.
DB04855. Dronedarone.
DB06262. Droxidopa.
DB00668. Epinephrine.
DB01049. Ergoloid mesylate.
DB00696. Ergotamine.
DB00800. Fenoldopam.
DB00458. Imipramine.
DB00598. Labetalol.
DB00934. Maprotiline.
DB01365. Mephentermine.
DB01403. Methotrimeprazine.
DB00723. Methoxamine.
DB06148. Mianserin.
DB00211. Midodrine.
DB00370. Mirtazapine.
DB00622. Nicardipine.
DB00368. Norepinephrine.
DB00540. Nortriptyline.
DB00935. Oxymetazoline.
DB01186. Pergolide.
DB00925. Phenoxybenzamine.
DB00388. Phenylephrine.
DB00457. Prazosin.
DB00420. Promazine.
DB00777. Propiomazine.
DB01224. Quetiapine.
DB06144. Sertindole.
DB06207. Silodosin.
DB00706. Tamsulosin.
DB01162. Terazosin.
DB06694. Xylometazoline.

Polymorphism and mutation databases

BioMutaiADRA1D.
DMDMi1168243.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 572572Alpha-1D adrenergic receptorPRO_0000069073Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi65 – 651N-linked (GlcNAc...)Sequence Analysis
Glycosylationi82 – 821N-linked (GlcNAc...)Sequence Analysis
Lipidationi419 – 4191S-palmitoyl cysteineSequence Analysis

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP25100.
PRIDEiP25100.

Expressioni

Gene expression databases

BgeeiP25100.
CleanExiHS_ADRA1A.
HS_ADRA1D.
ExpressionAtlasiP25100. baseline.
GenevestigatoriP25100.

Organism-specific databases

HPAiHPA038789.

Interactioni

Protein-protein interaction databases

BioGridi106656. 13 interactions.
IntActiP25100. 1 interaction.
STRINGi9606.ENSP00000368766.

Structurei

3D structure databases

ProteinModelPortaliP25100.
SMRiP25100. Positions 98-417.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi422 – 4287Poly-Arg

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1D sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG253615.
GeneTreeiENSGT00760000118795.
HOGENOMiHOG000239244.
HOVERGENiHBG106962.
InParanoidiP25100.
KOiK04137.
OMAiGATCQAY.
OrthoDBiEOG7H4DTB.
PhylomeDBiP25100.
TreeFamiTF331895.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR000363. ADRA1D_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24248:SF14. PTHR24248:SF14. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00240. ADRENRGCA1DR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25100-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTFRDLLSVS FEGPRPDSSA GGSSAGGGGG SAGGAAPSEG PAVGGVPGGA
60 70 80 90 100
GGGGGVVGAG SGEDNRSSAG EPGSAGAGGD VNGTAAVGGL VVSAQGVGVG
110 120 130 140 150
VFLAAFILMA VAGNLLVILS VACNRHLQTV TNYFIVNLAV ADLLLSATVL
160 170 180 190 200
PFSATMEVLG FWAFGRAFCD VWAAVDVLCC TASILSLCTI SVDRYVGVRH
210 220 230 240 250
SLKYPAIMTE RKAAAILALL WVVALVVSVG PLLGWKEPVP PDERFCGITE
260 270 280 290 300
EAGYAVFSSV CSFYLPMAVI VVMYCRVYVV ARSTTRSLEA GVKRERGKAS
310 320 330 340 350
EVVLRIHCRG AATGADGAHG MRSAKGHTFR SSLSVRLLKF SREKKAAKTL
360 370 380 390 400
AIVVGVFVLC WFPFFFVLPL GSLFPQLKPS EGVFKVIFWL GYFNSCVNPL
410 420 430 440 450
IYPCSSREFK RAFLRLLRCQ CRRRRRRRPL WRVYGHHWRA STSGLRQDCA
460 470 480 490 500
PSSGDAPPGA PLALTALPDP DPEPPGTPEM QAPVASRRKP PSAFREWRLL
510 520 530 540 550
GPFRRPTTQL RAKVSSLSHK IRAGGAQRAE AACAQRSEVE AVSLGVPHEV
560 570
AEGATCQAYE LADYSNLRET DI
Length:572
Mass (Da):60,463
Last modified:November 1, 1995 - v2
Checksum:iEBEB134CF20A4988
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1 – 8383MTFRD…GDVNG → MAAALRSVMMAGYLSEWRTP TYRSTEMVQRLRMEAVQHST S (PubMed:1656955).CuratedAdd
BLAST
Sequence conflicti31 – 311S → G in AAB31163 (PubMed:8024574).Curated
Sequence conflicti489 – 57284KPPSA…RETDI → SHPAPSASGGCWGRSGDPRP SCAPKSPACRTRSPPGARSA QRQRAPSAQRWRLCP (PubMed:1656955).CuratedAdd
BLAST
Sequence conflicti522 – 5221R → P in AAB31163 (PubMed:8024574).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M76446 mRNA. Translation: AAA35496.1.
U03864 mRNA. Translation: AAB60351.1.
L31772 mRNA. Translation: AAB59487.1.
S70782 mRNA. Translation: AAB31163.2.
D29952 Genomic DNA. Translation: BAA06222.1.
AL121675, AL357040 Genomic DNA. Translation: CAC00601.2.
CCDSiCCDS13079.1.
PIRiI39369.
JH0447.
RefSeqiNP_000669.1. NM_000678.3.
UniGeneiHs.557.

Genome annotation databases

EnsembliENST00000379453; ENSP00000368766; ENSG00000171873.
GeneIDi146.
KEGGihsa:146.
UCSCiuc002wkr.2. human.

Polymorphism and mutation databases

BioMutaiADRA1D.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M76446 mRNA. Translation: AAA35496.1.
U03864 mRNA. Translation: AAB60351.1.
L31772 mRNA. Translation: AAB59487.1.
S70782 mRNA. Translation: AAB31163.2.
D29952 Genomic DNA. Translation: BAA06222.1.
AL121675, AL357040 Genomic DNA. Translation: CAC00601.2.
CCDSiCCDS13079.1.
PIRiI39369.
JH0447.
RefSeqiNP_000669.1. NM_000678.3.
UniGeneiHs.557.

3D structure databases

ProteinModelPortaliP25100.
SMRiP25100. Positions 98-417.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106656. 13 interactions.
IntActiP25100. 1 interaction.
STRINGi9606.ENSP00000368766.

Chemistry

BindingDBiP25100.
ChEMBLiCHEMBL2095203.
DrugBankiDB00346. Alfuzosin.
DB00321. Amitriptyline.
DB00543. Amoxapine.
DB00182. Amphetamine.
DB01200. Bromocriptine.
DB00248. Cabergoline.
DB01136. Carvedilol.
DB00477. Chlorpromazine.
DB00575. Clonidine.
DB00298. Dapiprazole.
DB01151. Desipramine.
DB00590. Doxazosin.
DB01142. Doxepin.
DB04855. Dronedarone.
DB06262. Droxidopa.
DB00668. Epinephrine.
DB01049. Ergoloid mesylate.
DB00696. Ergotamine.
DB00800. Fenoldopam.
DB00458. Imipramine.
DB00598. Labetalol.
DB00934. Maprotiline.
DB01365. Mephentermine.
DB01403. Methotrimeprazine.
DB00723. Methoxamine.
DB06148. Mianserin.
DB00211. Midodrine.
DB00370. Mirtazapine.
DB00622. Nicardipine.
DB00368. Norepinephrine.
DB00540. Nortriptyline.
DB00935. Oxymetazoline.
DB01186. Pergolide.
DB00925. Phenoxybenzamine.
DB00388. Phenylephrine.
DB00457. Prazosin.
DB00420. Promazine.
DB00777. Propiomazine.
DB01224. Quetiapine.
DB06144. Sertindole.
DB06207. Silodosin.
DB00706. Tamsulosin.
DB01162. Terazosin.
DB06694. Xylometazoline.
GuidetoPHARMACOLOGYi24.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiADRA1D.
DMDMi1168243.

Proteomic databases

PaxDbiP25100.
PRIDEiP25100.

Protocols and materials databases

DNASUi146.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379453; ENSP00000368766; ENSG00000171873.
GeneIDi146.
KEGGihsa:146.
UCSCiuc002wkr.2. human.

Organism-specific databases

CTDi146.
GeneCardsiGC20M004149.
HGNCiHGNC:280. ADRA1D.
HPAiHPA038789.
MIMi104219. gene.
neXtProtiNX_P25100.
PharmGKBiPA24597.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG253615.
GeneTreeiENSGT00760000118795.
HOGENOMiHOG000239244.
HOVERGENiHBG106962.
InParanoidiP25100.
KOiK04137.
OMAiGATCQAY.
OrthoDBiEOG7H4DTB.
PhylomeDBiP25100.
TreeFamiTF331895.

Enzyme and pathway databases

ReactomeiREACT_16927. Adrenoceptors.
REACT_18283. G alpha (q) signalling events.
REACT_18407. G alpha (12/13) signalling events.

Miscellaneous databases

ChiTaRSiADRA1D. human.
GeneWikiiAlpha-1D_adrenergic_receptor.
GenomeRNAii146.
NextBioi577.
PROiP25100.
SOURCEiSearch...

Gene expression databases

BgeeiP25100.
CleanExiHS_ADRA1A.
HS_ADRA1D.
ExpressionAtlasiP25100. baseline.
GenevestigatoriP25100.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR000363. ADRA1D_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24248:SF14. PTHR24248:SF14. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00240. ADRENRGCA1DR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and sequencing of a cDNA encoding a human alpha 1A adrenergic receptor."
    Bruno J.F., Whittaker J., Song J., Berelowitz M.
    Biochem. Biophys. Res. Commun. 179:1485-1490(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Hippocampus.
  2. "The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype."
    Forray C., Bard J.A., Wetzel J.M., Chiu G., Shapiro E., Tang R., Lepor H., Hartig P.R., Weinshank R.L., Branchek T.A., Gluchowski C.
    Mol. Pharmacol. 45:703-708(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Hippocampus.
  3. "Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues."
    Schwinn D.A., Johnston G.I., Page S.O., Mosley M.J., Wilson K.H., Worman N.P., Campbell S., Fidock M.D., Furness L.M., Parry-Smith D.J., Peter B., Bailey D.S.
    J. Pharmacol. Exp. Ther. 272:134-142(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c."
    Weinberg D.H., Trivedi P., Tan C.P., Mitra S., Perkins-Barrow A., Borkowski D., Strader C.D., Bayne M.
    Biochem. Biophys. Res. Commun. 201:1296-1304(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "Cloning of the human alpha 1d-adrenergic receptor and inducible expression of three human subtypes in SK-N-MC cells."
    Esbenshade T.A., Hirasawa A., Tsujimoto G., Tanaka T., Yano J., Minneman K.P., Murphy T.J.
    Mol. Pharmacol. 47:977-985(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Placenta and Prostate.
  6. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiADA1D_HUMAN
AccessioniPrimary (citable) accession number: P25100
Secondary accession number(s): Q9NPY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: November 1, 1995
Last modified: April 29, 2015
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.