Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Adenosine receptor A1

Gene

Adora1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

GO - Molecular functioni

  • G-protein beta/gamma-subunit complex binding Source: RGD
  • G-protein coupled adenosine receptor activity Source: RGD
  • G-protein coupled receptor binding Source: BHF-UCL
  • heterotrimeric G-protein binding Source: RGD
  • phospholipase C activity Source: RGD
  • protein heterodimerization activity Source: BHF-UCL
  • purine nucleoside binding Source: RGD

GO - Biological processi

  • activation of MAPKK activity Source: RGD
  • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: RGD
  • cognition Source: RGD
  • detection of temperature stimulus involved in sensory perception of pain Source: RGD
  • excitatory postsynaptic potential Source: RGD
  • G-protein coupled receptor signaling pathway Source: RGD
  • lipid catabolic process Source: RGD
  • negative regulation of acute inflammatory response Source: RGD
  • negative regulation of apoptotic process Source: RGD
  • negative regulation of blood pressure Source: RGD
  • negative regulation of blood vessel diameter Source: RGD
  • negative regulation of cardiac muscle contraction Source: RGD
  • negative regulation of cell proliferation Source: RGD
  • negative regulation of circadian sleep/wake cycle, non-REM sleep Source: RGD
  • negative regulation of circadian sleep/wake cycle, sleep Source: RGD
  • negative regulation of glutamate secretion Source: RGD
  • negative regulation of heart contraction Source: RGD
  • negative regulation of hormone secretion Source: RGD
  • negative regulation of leukocyte migration Source: Ensembl
  • negative regulation of lipid catabolic process Source: RGD
  • negative regulation of long term synaptic depression Source: Ensembl
  • negative regulation of mucus secretion Source: Ensembl
  • negative regulation of neurotrophin production Source: RGD
  • negative regulation of renal sodium excretion Source: RGD
  • negative regulation of synaptic transmission, GABAergic Source: RGD
  • negative regulation of synaptic transmission, glutamatergic Source: RGD
  • positive regulation of blood pressure Source: RGD
  • positive regulation of epidermal growth factor-activated receptor activity Source: RGD
  • positive regulation of nucleoside transport Source: RGD
  • positive regulation of peptide secretion Source: RGD
  • positive regulation of potassium ion transport Source: RGD
  • positive regulation of protein dephosphorylation Source: RGD
  • protein targeting to membrane Source: RGD
  • regulation of cardiac muscle contraction Source: RGD
  • regulation of glomerular filtration Source: Ensembl
  • regulation of respiratory gaseous exchange by neurological system process Source: RGD
  • regulation of sensory perception of pain Source: Ensembl
  • regulation of synaptic plasticity Source: RGD
  • relaxation of vascular smooth muscle Source: RGD
  • response to hypoxia Source: RGD
  • temperature homeostasis Source: RGD

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-417973 Adenosine P1 receptors
R-RNO-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine receptor A1
Gene namesi
Name:Adora1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi2048 Adora1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10ExtracellularSequence analysis10
Transmembranei11 – 33Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini34 – 46CytoplasmicSequence analysisAdd BLAST13
Transmembranei47 – 69Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini70 – 80ExtracellularSequence analysisAdd BLAST11
Transmembranei81 – 102Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini103 – 123CytoplasmicSequence analysisAdd BLAST21
Transmembranei124 – 146Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini147 – 176ExtracellularSequence analysisAdd BLAST30
Transmembranei177 – 201Helical; Name=5Sequence analysisAdd BLAST25
Topological domaini202 – 235CytoplasmicSequence analysisAdd BLAST34
Transmembranei236 – 259Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini260 – 267ExtracellularSequence analysis8
Transmembranei268 – 292Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini293 – 326CytoplasmicSequence analysisAdd BLAST34

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL318
GuidetoPHARMACOLOGYi18

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000689941 – 326Adenosine receptor A1Add BLAST326

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi80 ↔ 169PROSITE-ProRule annotation
Glycosylationi148N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi159N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi309S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP25099
PRIDEiP25099

PTM databases

iPTMnetiP25099
PhosphoSitePlusiP25099

Expressioni

Tissue specificityi

Widely expressed in brain and spinal cord.

Gene expression databases

BgeeiENSRNOG00000003442
GenevisibleiP25099 RN

Interactioni

GO - Molecular functioni

  • G-protein coupled receptor binding Source: BHF-UCL
  • protein heterodimerization activity Source: BHF-UCL

Protein-protein interaction databases

BioGridi247960, 2 interactors
IntActiP25099, 1 interactor
MINTiP25099
STRINGi10116.ENSRNOP00000004602

Chemistry databases

BindingDBiP25099

Structurei

3D structure databases

ProteinModelPortaliP25099
SMRiP25099
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00550000074524
HOGENOMiHOG000015770
HOVERGENiHBG106962
InParanoidiP25099
KOiK04265
OMAiVWAVRIN
PhylomeDBiP25099
TreeFamiTF325296

Family and domain databases

InterProiView protein in InterPro
IPR001068 Adeno_A1_rcpt
IPR001634 Adenosn_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00552 ADENOSINEA1R
PR00424 ADENOSINER
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P25099-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPYISAFQA AYIGIEVLIA LVSVPGNVLV IWAVKVNQAL RDATFCFIVS
60 70 80 90 100
LAVADVAVGA LVIPLAILIN IGPQTYFHTC LMVACPVLIL TQSSILALLA
110 120 130 140 150
IAVDRYLRVK IPLRYKTVVT QRRAAVAIAG CWILSLVVGL TPMFGWNNLS
160 170 180 190 200
VVEQDWRANG SVGEPVIKCE FEKVISMEYM VYFNFFVWVL PPLLLMVLIY
210 220 230 240 250
LEVFYLIRKQ LNKKVSASSG DPQKYYGKEL KIAKSLALIL FLFALSWLPL
260 270 280 290 300
HILNCITLFC PTCQKPSILI YIAIFLTHGN SAMNPIVYAF RIHKFRVTFL
310 320
KIWNDHFRCQ PKPPIDEDLP EEKAED
Length:326
Mass (Da):36,695
Last modified:November 1, 1997 - v2
Checksum:iE43785CA993CFF15
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti229 – 230EL → DV (PubMed:1658635).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M69045 mRNA Translation: AAB07231.1
M64299 mRNA Translation: AAA74471.1
AB001089 mRNA Translation: BAA19231.1
AF042079 mRNA Translation: AAC03772.1
PIRiA40376
RefSeqiNP_058851.2, NM_017155.2
XP_006249921.1, XM_006249859.3
XP_006249923.1, XM_006249861.3
UniGeneiRn.32078

Genome annotation databases

EnsembliENSRNOT00000004602; ENSRNOP00000004602; ENSRNOG00000003442
ENSRNOT00000078993; ENSRNOP00000073958; ENSRNOG00000003442
GeneIDi29290
KEGGirno:29290
UCSCiRGD:2048 rat

Similar proteinsi

Entry informationi

Entry nameiAA1R_RAT
AccessioniPrimary (citable) accession number: P25099
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health