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Protein

Adenosine receptor A1

Gene

Adora1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

GO - Molecular functioni

  • G-protein beta/gamma-subunit complex binding Source: RGD
  • G-protein coupled adenosine receptor activity Source: RGD
  • G-protein coupled receptor binding Source: BHF-UCL
  • heat shock protein binding Source: RGD
  • heterotrimeric G-protein binding Source: RGD
  • phospholipase C activity Source: RGD
  • protein heterodimerization activity Source: BHF-UCL
  • purine nucleoside binding Source: RGD

GO - Biological processi

  • activation of MAPKK activity Source: RGD
  • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: RGD
  • cognition Source: RGD
  • detection of temperature stimulus involved in sensory perception of pain Source: RGD
  • excitatory postsynaptic potential Source: RGD
  • G-protein coupled receptor signaling pathway Source: RGD
  • lipid catabolic process Source: RGD
  • negative regulation of acute inflammatory response Source: RGD
  • negative regulation of apoptotic process Source: RGD
  • negative regulation of blood pressure Source: RGD
  • negative regulation of cardiac muscle contraction Source: RGD
  • negative regulation of cell proliferation Source: RGD
  • negative regulation of circadian sleep/wake cycle, non-REM sleep Source: RGD
  • negative regulation of circadian sleep/wake cycle, sleep Source: RGD
  • negative regulation of glutamate secretion Source: RGD
  • negative regulation of heart contraction Source: RGD
  • negative regulation of hormone secretion Source: RGD
  • negative regulation of leukocyte migration Source: Ensembl
  • negative regulation of lipid catabolic process Source: RGD
  • negative regulation of long term synaptic depression Source: Ensembl
  • negative regulation of mucus secretion Source: Ensembl
  • negative regulation of neurotrophin production Source: RGD
  • negative regulation of renal sodium excretion Source: RGD
  • negative regulation of synaptic transmission, GABAergic Source: RGD
  • negative regulation of synaptic transmission, glutamatergic Source: RGD
  • negative regulation of vasodilation Source: RGD
  • positive regulation of blood pressure Source: RGD
  • positive regulation of epidermal growth factor-activated receptor activity Source: RGD
  • positive regulation of nucleoside transport Source: RGD
  • positive regulation of peptide secretion Source: RGD
  • positive regulation of potassium ion transport Source: RGD
  • positive regulation of protein dephosphorylation Source: RGD
  • protein targeting to membrane Source: RGD
  • regulation of cardiac muscle contraction Source: RGD
  • regulation of glomerular filtration Source: Ensembl
  • regulation of respiratory gaseous exchange by neurological system process Source: RGD
  • regulation of sensory perception of pain Source: Ensembl
  • regulation of synaptic plasticity Source: RGD
  • relaxation of vascular smooth muscle Source: RGD
  • response to hypoxia Source: RGD
  • temperature homeostasis Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-417973. Adenosine P1 receptors.
R-RNO-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine receptor A1
Gene namesi
Name:Adora1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi2048. Adora1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010ExtracellularSequence analysis
Transmembranei11 – 3323Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini34 – 4613CytoplasmicSequence analysisAdd
BLAST
Transmembranei47 – 6923Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini70 – 8011ExtracellularSequence analysisAdd
BLAST
Transmembranei81 – 10222Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini103 – 12321CytoplasmicSequence analysisAdd
BLAST
Transmembranei124 – 14623Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini147 – 17630ExtracellularSequence analysisAdd
BLAST
Transmembranei177 – 20125Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini202 – 23534CytoplasmicSequence analysisAdd
BLAST
Transmembranei236 – 25924Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini260 – 2678ExtracellularSequence analysis
Transmembranei268 – 29225Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini293 – 32634CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • asymmetric synapse Source: RGD
  • axolemma Source: RGD
  • basolateral plasma membrane Source: RGD
  • cell body Source: BHF-UCL
  • dendrite Source: BHF-UCL
  • dendritic spine Source: Ensembl
  • endomembrane system Source: RGD
  • endoplasmic reticulum Source: RGD
  • integral component of membrane Source: UniProtKB-KW
  • neuronal cell body Source: RGD
  • plasma membrane Source: RGD
  • postsynaptic density Source: RGD
  • postsynaptic membrane Source: RGD
  • presynaptic active zone Source: RGD
  • presynaptic membrane Source: RGD
  • terminal bouton Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2111386.
GuidetoPHARMACOLOGYi18.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326Adenosine receptor A1PRO_0000068994Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi80 ↔ 169PROSITE-ProRule annotation
Glycosylationi148 – 1481N-linked (GlcNAc...)Sequence analysis
Glycosylationi159 – 1591N-linked (GlcNAc...)Sequence analysis
Lipidationi309 – 3091S-palmitoyl cysteineSequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP25099.

PTM databases

iPTMnetiP25099.
PhosphoSiteiP25099.

Expressioni

Tissue specificityi

Widely expressed in brain and spinal cord.

Gene expression databases

BgeeiENSRNOG00000003442.
GenevisibleiP25099. RN.

Interactioni

GO - Molecular functioni

  • G-protein beta/gamma-subunit complex binding Source: RGD
  • G-protein coupled receptor binding Source: BHF-UCL
  • heat shock protein binding Source: RGD
  • heterotrimeric G-protein binding Source: RGD
  • protein heterodimerization activity Source: BHF-UCL

Protein-protein interaction databases

BioGridi247960. 1 interaction.
IntActiP25099. 1 interaction.
MINTiMINT-242252.
STRINGi10116.ENSRNOP00000004602.

Chemistry

BindingDBiP25099.

Structurei

3D structure databases

ProteinModelPortaliP25099.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00550000074524.
HOGENOMiHOG000015770.
HOVERGENiHBG106962.
InParanoidiP25099.
KOiK04265.
OMAiVYAFRIH.
PhylomeDBiP25099.
TreeFamiTF325296.

Family and domain databases

InterProiIPR001068. Adeno_A1_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00552. ADENOSINEA1R.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25099-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPYISAFQA AYIGIEVLIA LVSVPGNVLV IWAVKVNQAL RDATFCFIVS
60 70 80 90 100
LAVADVAVGA LVIPLAILIN IGPQTYFHTC LMVACPVLIL TQSSILALLA
110 120 130 140 150
IAVDRYLRVK IPLRYKTVVT QRRAAVAIAG CWILSLVVGL TPMFGWNNLS
160 170 180 190 200
VVEQDWRANG SVGEPVIKCE FEKVISMEYM VYFNFFVWVL PPLLLMVLIY
210 220 230 240 250
LEVFYLIRKQ LNKKVSASSG DPQKYYGKEL KIAKSLALIL FLFALSWLPL
260 270 280 290 300
HILNCITLFC PTCQKPSILI YIAIFLTHGN SAMNPIVYAF RIHKFRVTFL
310 320
KIWNDHFRCQ PKPPIDEDLP EEKAED
Length:326
Mass (Da):36,695
Last modified:November 1, 1997 - v2
Checksum:iE43785CA993CFF15
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti229 – 2302EL → DV (PubMed:1658635).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M69045 mRNA. Translation: AAB07231.1.
M64299 mRNA. Translation: AAA74471.1.
AB001089 mRNA. Translation: BAA19231.1.
AF042079 mRNA. Translation: AAC03772.1.
PIRiA40376.
RefSeqiNP_058851.2. NM_017155.2.
XP_006249921.1. XM_006249859.2.
XP_006249922.1. XM_006249860.2.
XP_006249923.1. XM_006249861.2.
XP_008767774.1. XM_008769552.1.
XP_008767775.1. XM_008769553.1.
UniGeneiRn.32078.

Genome annotation databases

EnsembliENSRNOT00000004602; ENSRNOP00000004602; ENSRNOG00000003442.
ENSRNOT00000078993; ENSRNOP00000073958; ENSRNOG00000003442.
GeneIDi29290.
KEGGirno:29290.
UCSCiRGD:2048. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M69045 mRNA. Translation: AAB07231.1.
M64299 mRNA. Translation: AAA74471.1.
AB001089 mRNA. Translation: BAA19231.1.
AF042079 mRNA. Translation: AAC03772.1.
PIRiA40376.
RefSeqiNP_058851.2. NM_017155.2.
XP_006249921.1. XM_006249859.2.
XP_006249922.1. XM_006249860.2.
XP_006249923.1. XM_006249861.2.
XP_008767774.1. XM_008769552.1.
XP_008767775.1. XM_008769553.1.
UniGeneiRn.32078.

3D structure databases

ProteinModelPortaliP25099.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247960. 1 interaction.
IntActiP25099. 1 interaction.
MINTiMINT-242252.
STRINGi10116.ENSRNOP00000004602.

Chemistry

BindingDBiP25099.
ChEMBLiCHEMBL2111386.
GuidetoPHARMACOLOGYi18.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP25099.
PhosphoSiteiP25099.

Proteomic databases

PaxDbiP25099.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000004602; ENSRNOP00000004602; ENSRNOG00000003442.
ENSRNOT00000078993; ENSRNOP00000073958; ENSRNOG00000003442.
GeneIDi29290.
KEGGirno:29290.
UCSCiRGD:2048. rat.

Organism-specific databases

CTDi134.
RGDi2048. Adora1.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00550000074524.
HOGENOMiHOG000015770.
HOVERGENiHBG106962.
InParanoidiP25099.
KOiK04265.
OMAiVYAFRIH.
PhylomeDBiP25099.
TreeFamiTF325296.

Enzyme and pathway databases

ReactomeiR-RNO-417973. Adenosine P1 receptors.
R-RNO-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiP25099.

Gene expression databases

BgeeiENSRNOG00000003442.
GenevisibleiP25099. RN.

Family and domain databases

InterProiIPR001068. Adeno_A1_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00552. ADENOSINEA1R.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAA1R_RAT
AccessioniPrimary (citable) accession number: P25099
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: November 1, 1997
Last modified: September 7, 2016
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.