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P25098

- ARBK1_HUMAN

UniProt

P25098 - ARBK1_HUMAN

Protein

Beta-adrenergic receptor kinase 1

Gene

ADRBK1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 166 (01 Oct 2014)
      Sequence version 2 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.1 Publication

    Catalytic activityi

    ATP + [beta-adrenergic receptor] = ADP + [beta-adrenergic receptor] phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei220 – 2201ATPPROSITE-ProRule annotation
    Active sitei317 – 3171Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi197 – 2059ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. alpha-2A adrenergic receptor binding Source: BHF-UCL
    2. ATP binding Source: UniProtKB-KW
    3. beta-adrenergic receptor kinase activity Source: UniProtKB-EC
    4. Edg-2 lysophosphatidic acid receptor binding Source: UniProtKB
    5. G-protein coupled receptor kinase activity Source: BHF-UCL
    6. protein binding Source: UniProtKB
    7. protein kinase activity Source: BHF-UCL

    GO - Biological processi

    1. activation of phospholipase C activity Source: Reactome
    2. cardiac muscle contraction Source: BHF-UCL
    3. desensitization of G-protein coupled receptor protein signaling pathway Source: BHF-UCL
    4. epidermal growth factor receptor signaling pathway Source: Reactome
    5. fibroblast growth factor receptor signaling pathway Source: Reactome
    6. G-protein coupled acetylcholine receptor signaling pathway Source: BHF-UCL
    7. heart development Source: Ensembl
    8. innate immune response Source: Reactome
    9. negative regulation of striated muscle contraction Source: BHF-UCL
    10. negative regulation of the force of heart contraction by chemical signal Source: BHF-UCL
    11. neurotrophin TRK receptor signaling pathway Source: Reactome
    12. peptidyl-serine phosphorylation Source: BHF-UCL
    13. peptidyl-threonine phosphorylation Source: Ensembl
    14. positive regulation of catecholamine secretion Source: BHF-UCL
    15. receptor internalization Source: UniProtKB
    16. signal transduction Source: Reactome
    17. tachykinin receptor signaling pathway Source: BHF-UCL
    18. termination of G-protein coupled receptor signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.11.15. 2681.
    ReactomeiREACT_18283. G alpha (q) signalling events.
    REACT_9000. Calmodulin induced events.
    SignaLinkiP25098.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-adrenergic receptor kinase 1 (EC:2.7.11.15)
    Short name:
    Beta-ARK-1
    Alternative name(s):
    G-protein coupled receptor kinase 2
    Gene namesi
    Name:ADRBK1
    Synonyms:BARK, BARK1, GRK2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:289. ADRBK1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: BHF-UCL
    2. cytosol Source: Reactome
    3. membrane Source: UniProtKB
    4. plasma membrane Source: Reactome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA40.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 689689Beta-adrenergic receptor kinase 1PRO_0000085627Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei670 – 6701Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP25098.
    PaxDbiP25098.
    PRIDEiP25098.

    PTM databases

    PhosphoSiteiP25098.

    Expressioni

    Tissue specificityi

    Expressed in peripheral blood leukocytes.1 Publication

    Gene expression databases

    ArrayExpressiP25098.
    BgeeiP25098.
    CleanExiHS_ADRBK1.
    GenevestigatoriP25098.

    Organism-specific databases

    HPAiCAB005021.
    CAB037248.
    HPA048330.

    Interactioni

    Subunit structurei

    Interacts with GIT1 By similarity. Interacts with, and phosphorylates chemokine-stimulated CCR5. Interacts with ARRB1. Interacts with LPAR1 and LPAR2. Interacts with RALA in response to LPAR1 activation. ADRBK1 and RALA mutually inhibit each other's binding to LPAR1.By similarity3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    FPR1P214623EBI-3904795,EBI-2869495
    GIT1Q9Y2X75EBI-3904795,EBI-466061
    MDM2Q009874EBI-3904795,EBI-389668
    UBCP0CG483EBI-3904795,EBI-3390054

    Protein-protein interaction databases

    BioGridi106665. 38 interactions.
    DIPiDIP-42429N.
    IntActiP25098. 15 interactions.
    MINTiMINT-1214643.
    STRINGi9606.ENSP00000312262.

    Structurei

    Secondary structure

    1
    689
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi39 – 4911
    Helixi55 – 595
    Helixi62 – 7514
    Helixi77 – 793
    Helixi80 – 9314
    Helixi98 – 10912
    Helixi112 – 1187
    Beta strandi119 – 1224
    Helixi126 – 13712
    Turni143 – 1464
    Helixi147 – 15711
    Helixi160 – 1678
    Helixi169 – 18113
    Helixi188 – 1903
    Beta strandi191 – 1999
    Beta strandi201 – 21010
    Turni211 – 2133
    Beta strandi216 – 2238
    Helixi224 – 2296
    Helixi233 – 24614
    Beta strandi247 – 2493
    Beta strandi252 – 2543
    Beta strandi257 – 2626
    Beta strandi264 – 2718
    Helixi279 – 2868
    Helixi291 – 30919
    Turni310 – 3123
    Helixi320 – 3223
    Beta strandi323 – 3253
    Beta strandi331 – 3333
    Helixi336 – 3383
    Beta strandi343 – 3453
    Helixi354 – 3563
    Helixi359 – 3624
    Helixi371 – 38616
    Helixi393 – 3953
    Helixi399 – 40810
    Beta strandi415 – 4173
    Helixi419 – 42810
    Helixi433 – 4353
    Beta strandi440 – 4423
    Helixi444 – 4474
    Helixi451 – 4533
    Helixi458 – 4625
    Helixi500 – 5034
    Turni504 – 5085
    Helixi514 – 5229
    Turni523 – 5253
    Helixi526 – 54621
    Beta strandi555 – 5573
    Beta strandi561 – 5688
    Helixi571 – 5733
    Beta strandi577 – 5848
    Beta strandi587 – 5915
    Beta strandi593 – 5953
    Beta strandi599 – 6024
    Helixi603 – 6053
    Beta strandi606 – 61611
    Beta strandi618 – 6247
    Turni625 – 6273
    Beta strandi628 – 6336
    Helixi637 – 65822
    Turni662 – 6643

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1BAKNMR-A556-670[»]
    3CIKX-ray2.75A1-689[»]
    3KRWX-ray2.90A2-689[»]
    3KRXX-ray3.10A2-689[»]
    3V5WX-ray2.07A1-689[»]
    4MK0X-ray2.40A30-668[»]
    ProteinModelPortaliP25098.
    SMRiP25098. Positions 30-670.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP25098.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini54 – 175122RGSPROSITE-ProRule annotationAdd
    BLAST
    Domaini191 – 453263Protein kinasePROSITE-ProRule annotationAdd
    BLAST
    Domaini454 – 52168AGC-kinase C-terminalAdd
    BLAST
    Domaini558 – 65295PHPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 190190N-terminalAdd
    BLAST

    Sequence similaritiesi

    Contains 1 AGC-kinase C-terminal domain.Curated
    Contains 1 PH domain.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation
    Contains 1 RGS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000006742.
    HOVERGENiHBG050559.
    InParanoidiP25098.
    KOiK00910.
    OMAiDFCLKHL.
    OrthoDBiEOG7FV3PP.
    PhylomeDBiP25098.
    TreeFamiTF313940.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    InterProiIPR000961. AGC-kinase_C.
    IPR000239. GPCR_kinase.
    IPR011009. Kinase-like_dom.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00169. PH. 1 hit.
    PF00069. Pkinase. 1 hit.
    PF00615. RGS. 1 hit.
    [Graphical view]
    PRINTSiPR00717. GPCRKINASE.
    SMARTiSM00233. PH. 1 hit.
    SM00315. RGS. 1 hit.
    SM00133. S_TK_X. 1 hit.
    SM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF48097. SSF48097. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P25098-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADLEAVLAD VSYLMAMEKS KATPAARASK KILLPEPSIR SVMQKYLEDR    50
    GEVTFEKIFS QKLGYLLFRD FCLNHLEEAR PLVEFYEEIK KYEKLETEEE 100
    RVARSREIFD SYIMKELLAC SHPFSKSATE HVQGHLGKKQ VPPDLFQPYI 150
    EEICQNLRGD VFQKFIESDK FTRFCQWKNV ELNIHLTMND FSVHRIIGRG 200
    GFGEVYGCRK ADTGKMYAMK CLDKKRIKMK QGETLALNER IMLSLVSTGD 250
    CPFIVCMSYA FHTPDKLSFI LDLMNGGDLH YHLSQHGVFS EADMRFYAAE 300
    IILGLEHMHN RFVVYRDLKP ANILLDEHGH VRISDLGLAC DFSKKKPHAS 350
    VGTHGYMAPE VLQKGVAYDS SADWFSLGCM LFKLLRGHSP FRQHKTKDKH 400
    EIDRMTLTMA VELPDSFSPE LRSLLEGLLQ RDVNRRLGCL GRGAQEVKES 450
    PFFRSLDWQM VFLQKYPPPL IPPRGEVNAA DAFDIGSFDE EDTKGIKLLD 500
    SDQELYRNFP LTISERWQQE VAETVFDTIN AETDRLEARK KAKNKQLGHE 550
    EDYALGKDCI MHGYMSKMGN PFLTQWQRRY FYLFPNRLEW RGEGEAPQSL 600
    LTMEEIQSVE ETQIKERKCL LLKIRGGKQF ILQCDSDPEL VQWKKELRDA 650
    YREAQQLVQR VPKMKNKPRS PVVELSKVPL VQRGSANGL 689
    Length:689
    Mass (Da):79,574
    Last modified:February 20, 2007 - v2
    Checksum:i4DB68F62841AFA7D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti168 – 18518SDKFT…ELNIH → RISSHGFASGRMWSSTST in AAB60689. (PubMed:8195124)CuratedAdd
    BLAST
    Sequence conflicti211 – 2111A → R in CAA43470. (PubMed:2037065)Curated
    Sequence conflicti211 – 2111A → R in AAB60689. (PubMed:8195124)Curated
    Sequence conflicti422 – 4221R → H in CAA43470. (PubMed:2037065)Curated
    Sequence conflicti422 – 4221R → H in AAB60689. (PubMed:8195124)Curated
    Sequence conflicti465 – 4651K → R in CAA43470. (PubMed:2037065)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti184 – 1841I → T.1 Publication
    Corresponds to variant rs55696045 [ dbSNP | Ensembl ].
    VAR_040378
    Natural varianti578 – 5781R → Q in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication
    VAR_040379

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X61157 mRNA. Translation: CAA43470.1.
    M80776 mRNA. Translation: AAA58391.1.
    U08438
    , U08435, U08436, U08437 Genomic DNA. Translation: AAB60689.1.
    EU326303 Genomic DNA. Translation: ACA05909.1.
    BC037963 mRNA. Translation: AAH37963.1.
    BC090863 mRNA. Translation: AAH90863.1.
    CCDSiCCDS8156.1.
    PIRiA53791.
    RefSeqiNP_001610.2. NM_001619.3.
    UniGeneiHs.83636.

    Genome annotation databases

    EnsembliENST00000308595; ENSP00000312262; ENSG00000173020.
    GeneIDi156.
    KEGGihsa:156.
    UCSCiuc009yrn.1. human.

    Polymorphism databases

    DMDMi126302521.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Beta adrenergic receptor kinase entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X61157 mRNA. Translation: CAA43470.1 .
    M80776 mRNA. Translation: AAA58391.1 .
    U08438
    , U08435 , U08436 , U08437 Genomic DNA. Translation: AAB60689.1 .
    EU326303 Genomic DNA. Translation: ACA05909.1 .
    BC037963 mRNA. Translation: AAH37963.1 .
    BC090863 mRNA. Translation: AAH90863.1 .
    CCDSi CCDS8156.1.
    PIRi A53791.
    RefSeqi NP_001610.2. NM_001619.3.
    UniGenei Hs.83636.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1BAK NMR - A 556-670 [» ]
    3CIK X-ray 2.75 A 1-689 [» ]
    3KRW X-ray 2.90 A 2-689 [» ]
    3KRX X-ray 3.10 A 2-689 [» ]
    3V5W X-ray 2.07 A 1-689 [» ]
    4MK0 X-ray 2.40 A 30-668 [» ]
    ProteinModelPortali P25098.
    SMRi P25098. Positions 30-670.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106665. 38 interactions.
    DIPi DIP-42429N.
    IntActi P25098. 15 interactions.
    MINTi MINT-1214643.
    STRINGi 9606.ENSP00000312262.

    Chemistry

    BindingDBi P25098.
    ChEMBLi CHEMBL4079.
    DrugBanki DB00171. Adenosine triphosphate.
    GuidetoPHARMACOLOGYi 1466.

    PTM databases

    PhosphoSitei P25098.

    Polymorphism databases

    DMDMi 126302521.

    Proteomic databases

    MaxQBi P25098.
    PaxDbi P25098.
    PRIDEi P25098.

    Protocols and materials databases

    DNASUi 156.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000308595 ; ENSP00000312262 ; ENSG00000173020 .
    GeneIDi 156.
    KEGGi hsa:156.
    UCSCi uc009yrn.1. human.

    Organism-specific databases

    CTDi 156.
    GeneCardsi GC11P067033.
    HGNCi HGNC:289. ADRBK1.
    HPAi CAB005021.
    CAB037248.
    HPA048330.
    MIMi 109635. gene.
    neXtProti NX_P25098.
    PharmGKBi PA40.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000006742.
    HOVERGENi HBG050559.
    InParanoidi P25098.
    KOi K00910.
    OMAi DFCLKHL.
    OrthoDBi EOG7FV3PP.
    PhylomeDBi P25098.
    TreeFami TF313940.

    Enzyme and pathway databases

    BRENDAi 2.7.11.15. 2681.
    Reactomei REACT_18283. G alpha (q) signalling events.
    REACT_9000. Calmodulin induced events.
    SignaLinki P25098.

    Miscellaneous databases

    ChiTaRSi ADRBK1. human.
    EvolutionaryTracei P25098.
    GeneWikii Beta_adrenergic_receptor_kinase.
    GenomeRNAii 156.
    NextBioi 621.
    PROi P25098.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P25098.
    Bgeei P25098.
    CleanExi HS_ADRBK1.
    Genevestigatori P25098.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    InterProi IPR000961. AGC-kinase_C.
    IPR000239. GPCR_kinase.
    IPR011009. Kinase-like_dom.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00169. PH. 1 hit.
    PF00069. Pkinase. 1 hit.
    PF00615. RGS. 1 hit.
    [Graphical view ]
    PRINTSi PR00717. GPCRKINASE.
    SMARTi SM00233. PH. 1 hit.
    SM00315. RGS. 1 hit.
    SM00133. S_TK_X. 1 hit.
    SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48097. SSF48097. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS51285. AGC_KINASE_CTER. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning and chromosomal localization of the human beta-adrenergic receptor kinase."
      Benovic J.L., Stone W.C., Huebner K., Croce C., Caron M.G., Lefkowitz R.J.
      FEBS Lett. 283:122-126(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "High expression of beta-adrenergic receptor kinase in human peripheral blood leukocytes. Isoproterenol and platelet activating factor can induce kinase translocation."
      Chuang T.T., Sallese M., Ambrosini G., Parruti G., de Blasi A.
      J. Biol. Chem. 267:6886-6892(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Blood.
    3. "Structure of the human gene encoding the beta-adrenergic receptor kinase."
      Penn R.B., Benovic J.L.
      J. Biol. Chem. 269:14924-14930(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. NHLBI resequencing and genotyping service (RS&G)
      Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: PNS and Testis.
    6. "Monocyte chemoattractant protein-1-induced CCR2B receptor desensitization mediated by the G protein-coupled receptor kinase 2."
      Aragay A.M., Mellado M., Frade J.M., Martin A.M., Jimenez-Sainz M.C., Martinez-A C., Mayor F. Jr.
      Proc. Natl. Acad. Sci. U.S.A. 95:2985-2990(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ARRB1.
    7. "Differential effects of CC chemokines on CC chemokine receptor 5 (CCR5) phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl terminus."
      Oppermann M., Mack M., Proudfoot A.E., Olbrich H.
      J. Biol. Chem. 274:8875-8885(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CCR5, TISSUE SPECIFICITY.
    8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-670, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Platelet.
    9. "Dual regulation of lysophosphatidic acid (LPA1) receptor signalling by Ral and GRK."
      Aziziyeh A.I., Li T.T., Pape C., Pampillo M., Chidiac P., Possmayer F., Babwah A.V., Bhattacharya M.
      Cell. Signal. 21:1207-1217(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH LPAR1; LPAR2 AND RALA.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "The solution structure and dynamics of the pleckstrin homology domain of G protein-coupled receptor kinase 2 (beta-adrenergic receptor kinase 1). A binding partner of Gbetagamma subunits."
      Fushman D., Najmabadi-Haske T., Cahill S., Zheng J., Levine H. III, Cowburn D.
      J. Biol. Chem. 273:2835-2843(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 552-670.
    12. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] THR-184 AND GLN-578.

    Entry informationi

    Entry nameiARBK1_HUMAN
    AccessioniPrimary (citable) accession number: P25098
    Secondary accession number(s): B0ZBE1, Q13837, Q6GTT3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 166 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3