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P25098

- ARBK1_HUMAN

UniProt

P25098 - ARBK1_HUMAN

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Protein
Beta-adrenergic receptor kinase 1
Gene
ADRBK1, BARK, BARK1, GRK2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.1 Publication

Catalytic activityi

ATP + [beta-adrenergic receptor] = ADP + [beta-adrenergic receptor] phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei220 – 2201ATP By similarity
Active sitei317 – 3171Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi197 – 2059ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. Edg-2 lysophosphatidic acid receptor binding Source: UniProtKB
  3. G-protein coupled receptor kinase activity Source: BHF-UCL
  4. alpha-2A adrenergic receptor binding Source: BHF-UCL
  5. beta-adrenergic receptor kinase activity Source: UniProtKB-EC
  6. protein binding Source: UniProtKB
  7. protein kinase activity Source: BHF-UCL

GO - Biological processi

  1. G-protein coupled acetylcholine receptor signaling pathway Source: BHF-UCL
  2. activation of phospholipase C activity Source: Reactome
  3. cardiac muscle contraction Source: BHF-UCL
  4. desensitization of G-protein coupled receptor protein signaling pathway Source: BHF-UCL
  5. epidermal growth factor receptor signaling pathway Source: Reactome
  6. fibroblast growth factor receptor signaling pathway Source: Reactome
  7. heart development Source: Ensembl
  8. innate immune response Source: Reactome
  9. negative regulation of striated muscle contraction Source: BHF-UCL
  10. negative regulation of the force of heart contraction by chemical signal Source: BHF-UCL
  11. neurotrophin TRK receptor signaling pathway Source: Reactome
  12. peptidyl-serine phosphorylation Source: BHF-UCL
  13. peptidyl-threonine phosphorylation Source: Ensembl
  14. positive regulation of catecholamine secretion Source: BHF-UCL
  15. receptor internalization Source: UniProtKB
  16. signal transduction Source: Reactome
  17. tachykinin receptor signaling pathway Source: BHF-UCL
  18. termination of G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.15. 2681.
ReactomeiREACT_18283. G alpha (q) signalling events.
REACT_9000. Calmodulin induced events.
SignaLinkiP25098.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-adrenergic receptor kinase 1 (EC:2.7.11.15)
Short name:
Beta-ARK-1
Alternative name(s):
G-protein coupled receptor kinase 2
Gene namesi
Name:ADRBK1
Synonyms:BARK, BARK1, GRK2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:289. ADRBK1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: BHF-UCL
  2. cytosol Source: Reactome
  3. membrane Source: BHF-UCL
  4. plasma membrane Source: Reactome
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA40.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 689689Beta-adrenergic receptor kinase 1
PRO_0000085627Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei670 – 6701Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP25098.
PaxDbiP25098.
PRIDEiP25098.

PTM databases

PhosphoSiteiP25098.

Expressioni

Tissue specificityi

Expressed in peripheral blood leukocytes.1 Publication

Gene expression databases

ArrayExpressiP25098.
BgeeiP25098.
CleanExiHS_ADRBK1.
GenevestigatoriP25098.

Organism-specific databases

HPAiCAB005021.
CAB037248.
HPA048330.

Interactioni

Subunit structurei

Interacts with GIT1 By similarity. Interacts with, and phosphorylates chemokine-stimulated CCR5. Interacts with ARRB1. Interacts with LPAR1 and LPAR2. Interacts with RALA in response to LPAR1 activation. ADRBK1 and RALA mutually inhibit each other's binding to LPAR1.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
FPR1P214623EBI-3904795,EBI-2869495
GIT1Q9Y2X75EBI-3904795,EBI-466061
MDM2Q009874EBI-3904795,EBI-389668
UBCP0CG483EBI-3904795,EBI-3390054

Protein-protein interaction databases

BioGridi106665. 38 interactions.
DIPiDIP-42429N.
IntActiP25098. 14 interactions.
MINTiMINT-1214643.
STRINGi9606.ENSP00000312262.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi39 – 4911
Helixi55 – 595
Helixi62 – 7514
Helixi77 – 793
Helixi80 – 9314
Helixi98 – 10912
Helixi112 – 1187
Beta strandi119 – 1224
Helixi126 – 13712
Turni143 – 1464
Helixi147 – 15711
Helixi160 – 1678
Helixi169 – 18113
Helixi188 – 1903
Beta strandi191 – 1999
Beta strandi201 – 21010
Turni211 – 2133
Beta strandi216 – 2238
Helixi224 – 2296
Helixi233 – 24614
Beta strandi247 – 2493
Beta strandi252 – 2543
Beta strandi257 – 2626
Beta strandi264 – 2718
Helixi279 – 2868
Helixi291 – 30919
Turni310 – 3123
Helixi320 – 3223
Beta strandi323 – 3253
Beta strandi331 – 3333
Helixi336 – 3383
Beta strandi343 – 3453
Helixi354 – 3563
Helixi359 – 3624
Helixi371 – 38616
Helixi393 – 3953
Helixi399 – 40810
Beta strandi415 – 4173
Helixi419 – 42810
Helixi433 – 4353
Beta strandi440 – 4423
Helixi444 – 4474
Helixi451 – 4533
Helixi458 – 4625
Helixi500 – 5034
Turni504 – 5085
Helixi514 – 5229
Turni523 – 5253
Helixi526 – 54621
Beta strandi555 – 5573
Beta strandi561 – 5688
Helixi571 – 5733
Beta strandi577 – 5848
Beta strandi587 – 5915
Beta strandi593 – 5953
Beta strandi599 – 6024
Helixi603 – 6053
Beta strandi606 – 61611
Beta strandi618 – 6247
Turni625 – 6273
Beta strandi628 – 6336
Helixi637 – 65822
Turni662 – 6643

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BAKNMR-A556-670[»]
3CIKX-ray2.75A1-689[»]
3KRWX-ray2.90A2-689[»]
3KRXX-ray3.10A2-689[»]
3V5WX-ray2.07A1-689[»]
4MK0X-ray2.40A30-668[»]
ProteinModelPortaliP25098.
SMRiP25098. Positions 30-670.

Miscellaneous databases

EvolutionaryTraceiP25098.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini54 – 175122RGS
Add
BLAST
Domaini191 – 453263Protein kinase
Add
BLAST
Domaini454 – 52168AGC-kinase C-terminal
Add
BLAST
Domaini558 – 65295PH
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 190190N-terminal
Add
BLAST

Sequence similaritiesi

Contains 1 PH domain.
Contains 1 RGS domain.

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000006742.
HOVERGENiHBG050559.
InParanoidiP25098.
KOiK00910.
OMAiDFCLKHL.
OrthoDBiEOG7FV3PP.
PhylomeDBiP25098.
TreeFamiTF313940.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR000961. AGC-kinase_C.
IPR000239. GPCR_kinase.
IPR011009. Kinase-like_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF00069. Pkinase. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR00717. GPCRKINASE.
SMARTiSM00233. PH. 1 hit.
SM00315. RGS. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25098-1 [UniParc]FASTAAdd to Basket

« Hide

MADLEAVLAD VSYLMAMEKS KATPAARASK KILLPEPSIR SVMQKYLEDR    50
GEVTFEKIFS QKLGYLLFRD FCLNHLEEAR PLVEFYEEIK KYEKLETEEE 100
RVARSREIFD SYIMKELLAC SHPFSKSATE HVQGHLGKKQ VPPDLFQPYI 150
EEICQNLRGD VFQKFIESDK FTRFCQWKNV ELNIHLTMND FSVHRIIGRG 200
GFGEVYGCRK ADTGKMYAMK CLDKKRIKMK QGETLALNER IMLSLVSTGD 250
CPFIVCMSYA FHTPDKLSFI LDLMNGGDLH YHLSQHGVFS EADMRFYAAE 300
IILGLEHMHN RFVVYRDLKP ANILLDEHGH VRISDLGLAC DFSKKKPHAS 350
VGTHGYMAPE VLQKGVAYDS SADWFSLGCM LFKLLRGHSP FRQHKTKDKH 400
EIDRMTLTMA VELPDSFSPE LRSLLEGLLQ RDVNRRLGCL GRGAQEVKES 450
PFFRSLDWQM VFLQKYPPPL IPPRGEVNAA DAFDIGSFDE EDTKGIKLLD 500
SDQELYRNFP LTISERWQQE VAETVFDTIN AETDRLEARK KAKNKQLGHE 550
EDYALGKDCI MHGYMSKMGN PFLTQWQRRY FYLFPNRLEW RGEGEAPQSL 600
LTMEEIQSVE ETQIKERKCL LLKIRGGKQF ILQCDSDPEL VQWKKELRDA 650
YREAQQLVQR VPKMKNKPRS PVVELSKVPL VQRGSANGL 689
Length:689
Mass (Da):79,574
Last modified:February 20, 2007 - v2
Checksum:i4DB68F62841AFA7D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti184 – 1841I → T.1 Publication
Corresponds to variant rs55696045 [ dbSNP | Ensembl ].
VAR_040378
Natural varianti578 – 5781R → Q in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication
VAR_040379

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti168 – 18518SDKFT…ELNIH → RISSHGFASGRMWSSTST in AAB60689. 1 Publication
Add
BLAST
Sequence conflicti211 – 2111A → R in CAA43470. 1 Publication
Sequence conflicti211 – 2111A → R in AAB60689. 1 Publication
Sequence conflicti422 – 4221R → H in CAA43470. 1 Publication
Sequence conflicti422 – 4221R → H in AAB60689. 1 Publication
Sequence conflicti465 – 4651K → R in CAA43470. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X61157 mRNA. Translation: CAA43470.1.
M80776 mRNA. Translation: AAA58391.1.
U08438
, U08435, U08436, U08437 Genomic DNA. Translation: AAB60689.1.
EU326303 Genomic DNA. Translation: ACA05909.1.
BC037963 mRNA. Translation: AAH37963.1.
BC090863 mRNA. Translation: AAH90863.1.
CCDSiCCDS8156.1.
PIRiA53791.
RefSeqiNP_001610.2. NM_001619.3.
UniGeneiHs.83636.

Genome annotation databases

EnsembliENST00000308595; ENSP00000312262; ENSG00000173020.
GeneIDi156.
KEGGihsa:156.
UCSCiuc009yrn.1. human.

Polymorphism databases

DMDMi126302521.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Beta adrenergic receptor kinase entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X61157 mRNA. Translation: CAA43470.1 .
M80776 mRNA. Translation: AAA58391.1 .
U08438
, U08435 , U08436 , U08437 Genomic DNA. Translation: AAB60689.1 .
EU326303 Genomic DNA. Translation: ACA05909.1 .
BC037963 mRNA. Translation: AAH37963.1 .
BC090863 mRNA. Translation: AAH90863.1 .
CCDSi CCDS8156.1.
PIRi A53791.
RefSeqi NP_001610.2. NM_001619.3.
UniGenei Hs.83636.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1BAK NMR - A 556-670 [» ]
3CIK X-ray 2.75 A 1-689 [» ]
3KRW X-ray 2.90 A 2-689 [» ]
3KRX X-ray 3.10 A 2-689 [» ]
3V5W X-ray 2.07 A 1-689 [» ]
4MK0 X-ray 2.40 A 30-668 [» ]
ProteinModelPortali P25098.
SMRi P25098. Positions 30-670.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 106665. 38 interactions.
DIPi DIP-42429N.
IntActi P25098. 14 interactions.
MINTi MINT-1214643.
STRINGi 9606.ENSP00000312262.

Chemistry

BindingDBi P25098.
ChEMBLi CHEMBL4079.
DrugBanki DB00171. Adenosine triphosphate.
GuidetoPHARMACOLOGYi 1466.

PTM databases

PhosphoSitei P25098.

Polymorphism databases

DMDMi 126302521.

Proteomic databases

MaxQBi P25098.
PaxDbi P25098.
PRIDEi P25098.

Protocols and materials databases

DNASUi 156.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000308595 ; ENSP00000312262 ; ENSG00000173020 .
GeneIDi 156.
KEGGi hsa:156.
UCSCi uc009yrn.1. human.

Organism-specific databases

CTDi 156.
GeneCardsi GC11P067033.
HGNCi HGNC:289. ADRBK1.
HPAi CAB005021.
CAB037248.
HPA048330.
MIMi 109635. gene.
neXtProti NX_P25098.
PharmGKBi PA40.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000006742.
HOVERGENi HBG050559.
InParanoidi P25098.
KOi K00910.
OMAi DFCLKHL.
OrthoDBi EOG7FV3PP.
PhylomeDBi P25098.
TreeFami TF313940.

Enzyme and pathway databases

BRENDAi 2.7.11.15. 2681.
Reactomei REACT_18283. G alpha (q) signalling events.
REACT_9000. Calmodulin induced events.
SignaLinki P25098.

Miscellaneous databases

ChiTaRSi ADRBK1. human.
EvolutionaryTracei P25098.
GeneWikii Beta_adrenergic_receptor_kinase.
GenomeRNAii 156.
NextBioi 621.
PROi P25098.
SOURCEi Search...

Gene expression databases

ArrayExpressi P25098.
Bgeei P25098.
CleanExi HS_ADRBK1.
Genevestigatori P25098.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
InterProi IPR000961. AGC-kinase_C.
IPR000239. GPCR_kinase.
IPR011009. Kinase-like_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00169. PH. 1 hit.
PF00069. Pkinase. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view ]
PRINTSi PR00717. GPCRKINASE.
SMARTi SM00233. PH. 1 hit.
SM00315. RGS. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF48097. SSF48097. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS51285. AGC_KINASE_CTER. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning and chromosomal localization of the human beta-adrenergic receptor kinase."
    Benovic J.L., Stone W.C., Huebner K., Croce C., Caron M.G., Lefkowitz R.J.
    FEBS Lett. 283:122-126(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "High expression of beta-adrenergic receptor kinase in human peripheral blood leukocytes. Isoproterenol and platelet activating factor can induce kinase translocation."
    Chuang T.T., Sallese M., Ambrosini G., Parruti G., de Blasi A.
    J. Biol. Chem. 267:6886-6892(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Blood.
  3. "Structure of the human gene encoding the beta-adrenergic receptor kinase."
    Penn R.B., Benovic J.L.
    J. Biol. Chem. 269:14924-14930(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. NHLBI resequencing and genotyping service (RS&G)
    Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PNS and Testis.
  6. "Monocyte chemoattractant protein-1-induced CCR2B receptor desensitization mediated by the G protein-coupled receptor kinase 2."
    Aragay A.M., Mellado M., Frade J.M., Martin A.M., Jimenez-Sainz M.C., Martinez-A C., Mayor F. Jr.
    Proc. Natl. Acad. Sci. U.S.A. 95:2985-2990(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ARRB1.
  7. "Differential effects of CC chemokines on CC chemokine receptor 5 (CCR5) phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl terminus."
    Oppermann M., Mack M., Proudfoot A.E., Olbrich H.
    J. Biol. Chem. 274:8875-8885(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CCR5, TISSUE SPECIFICITY.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-670, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Platelet.
  9. "Dual regulation of lysophosphatidic acid (LPA1) receptor signalling by Ral and GRK."
    Aziziyeh A.I., Li T.T., Pape C., Pampillo M., Chidiac P., Possmayer F., Babwah A.V., Bhattacharya M.
    Cell. Signal. 21:1207-1217(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH LPAR1; LPAR2 AND RALA.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "The solution structure and dynamics of the pleckstrin homology domain of G protein-coupled receptor kinase 2 (beta-adrenergic receptor kinase 1). A binding partner of Gbetagamma subunits."
    Fushman D., Najmabadi-Haske T., Cahill S., Zheng J., Levine H. III, Cowburn D.
    J. Biol. Chem. 273:2835-2843(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 552-670.
  12. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] THR-184 AND GLN-578.

Entry informationi

Entry nameiARBK1_HUMAN
AccessioniPrimary (citable) accession number: P25098
Secondary accession number(s): B0ZBE1, Q13837, Q6GTT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: February 20, 2007
Last modified: September 3, 2014
This is version 165 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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