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Protein

Type-1A angiotensin II receptor

Gene

Agtr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

  1. angiotensin type II receptor activity Source: InterPro
  2. angiotensin type I receptor activity Source: RGD
  3. D1 dopamine receptor binding Source: RGD
  4. G-protein alpha-subunit binding Source: RGD
  5. peptide hormone binding Source: RGD
  6. protein kinase binding Source: RGD
  7. protein self-association Source: RGD

GO - Biological processi

  1. activation of Janus kinase activity Source: RGD
  2. aging Source: RGD
  3. blood vessel development Source: Ensembl
  4. brain renin-angiotensin system Source: Ensembl
  5. cellular response to dexamethasone stimulus Source: UniProtKB
  6. dopamine biosynthetic process Source: RGD
  7. drinking behavior Source: RGD
  8. G-protein coupled receptor signaling pathway Source: RGD
  9. heart development Source: Ensembl
  10. inflammatory response Source: Ensembl
  11. kidney development Source: Ensembl
  12. negative regulation of smooth muscle cell apoptotic process Source: Ensembl
  13. phospholipase C-activating angiotensin-activated signaling pathway Source: GOC
  14. phospholipase C-activating G-protein coupled receptor signaling pathway Source: RGD
  15. positive regulation of blood pressure Source: RGD
  16. positive regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
  17. positive regulation of cell proliferation Source: RGD
  18. positive regulation of cytokine secretion Source: Ensembl
  19. positive regulation of cytosolic calcium ion concentration Source: RGD
  20. positive regulation of receptor recycling Source: UniProtKB
  21. positive regulation of superoxide anion generation Source: RGD
  22. regulation of blood pressure Source: RGD
  23. regulation of pH Source: RGD
  24. regulation of renal output by angiotensin Source: Ensembl
  25. regulation of vasoconstriction Source: InterPro
  26. renin-angiotensin regulation of aldosterone production Source: RGD
  27. renin secretion into blood stream Source: Ensembl
  28. response to estrogen Source: RGD
  29. vasoconstriction Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_250028. Peptide ligand-binding receptors.
REACT_263374. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Type-1A angiotensin II receptor
Alternative name(s):
Angiotensin II type-1A receptor
Short name:
AT1A
Gene namesi
Name:Agtr1
Synonyms:Agtr1a, At1a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 17

Organism-specific databases

RGDi2070. Agtr1a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727ExtracellularSequence AnalysisAdd
BLAST
Transmembranei28 – 5225Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini53 – 6412CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei65 – 8723Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini88 – 10215ExtracellularSequence AnalysisAdd
BLAST
Transmembranei103 – 12422Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini125 – 14218CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei143 – 16220Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini163 – 19230ExtracellularSequence AnalysisAdd
BLAST
Transmembranei193 – 21422Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini215 – 24026CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei241 – 26222Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini263 – 27513ExtracellularSequence AnalysisAdd
BLAST
Transmembranei276 – 29621Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini297 – 35963CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. basolateral plasma membrane Source: RGD
  2. cytoplasmic vesicle Source: UniProtKB
  3. dendrite Source: RGD
  4. endomembrane system Source: RGD
  5. Golgi apparatus Source: UniProtKB
  6. integral component of membrane Source: RGD
  7. membrane Source: RGD
  8. organelle outer membrane Source: RGD
  9. plasma membrane Source: UniProtKB
  10. recycling endosome Source: RGD
  11. vesicle lumen Source: RGD
  12. vesicle membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359Type-1A angiotensin II receptorPRO_0000069160Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi101 ↔ 180PROSITE-ProRule annotation
Glycosylationi176 – 1761N-linked (GlcNAc...)Sequence Analysis
Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence Analysis
Lipidationi355 – 3551S-palmitoyl cysteineSequence Analysis

Post-translational modificationi

C-terminal Ser or Thr residues may be phosphorylated.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP25095.
PRIDEiP25095.

PTM databases

PhosphoSiteiP25095.

Expressioni

Tissue specificityi

Is expressed in the liver, kidney, aorta, lung, uterus, ovary, spleen, heart, adrenal gland, and vascular smooth muscle cell.

Gene expression databases

GenevestigatoriP25095.

Interactioni

Subunit structurei

Interacts with MAS1 (By similarity). Interacts with ARRB1.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
AGTP0101910EBI-764979,EBI-751728From a different organism.

Protein-protein interaction databases

BioGridi246370. 4 interactions.
IntActiP25095. 6 interactions.
MINTiMINT-1503145.
STRINGi10116.ENSRNOP00000034687.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2AC6model-A1-359[»]
2AH3model-A1-359[»]
ProteinModelPortaliP25095.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG256015.
GeneTreeiENSGT00760000119055.
HOGENOMiHOG000234122.
HOVERGENiHBG104998.
InParanoidiP25095.
KOiK04166.
OMAiCIVIWLL.
OrthoDBiEOG7J4473.
PhylomeDBiP25095.
TreeFamiTF330024.

Family and domain databases

InterProiIPR000190. ATII_AT1_rcpt.
IPR000248. ATII_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00241. ANGIOTENSINR.
PR00635. ANGIOTENSN1R.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25095-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALNSSAEDG IKRIQDDCPK AGRHSYIFVM IPTLYSIIFV VGIFGNSLVV
60 70 80 90 100
IVIYFYMKLK TVASVFLLNL ALADLCFLLT LPLWAVYTAM EYRWPFGNHL
110 120 130 140 150
CKIASASVSF NLYASVFLLT CLSIDRYLAI VHPMKSRLRR TMLVAKVTCI
160 170 180 190 200
IIWLMAGLAS LPAVIHRNVY FIENTNITVC AFHYESRNST LPIGLGLTKN
210 220 230 240 250
ILGFLFPFLI ILTSYTLIWK ALKKAYEIQK NKPRNDDIFR IIMAIVLFFF
260 270 280 290 300
FSWVPHQIFT FLDVLIQLGV IHDCKISDIV DTAMPITICI AYFNNCLNPL
310 320 330 340 350
FYGFLGKKFK KYFLQLLKYI PPKAKSHSSL STKMSTLSYR PSDNMSSSAK

KPASCFEVE
Length:359
Mass (Da):40,890
Last modified:May 1, 1992 - v1
Checksum:i200EAE56DB4DA678
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti81 – 811L → C in AAA40738. (PubMed:2043116)Curated
Sequence conflicti109 – 1091S → T(PubMed:2043116)Curated
Sequence conflicti109 – 1091S → T(PubMed:7713098)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62295 mRNA. Translation: CAA44183.1.
M74054 mRNA. Translation: AAA40738.1.
BC078810 mRNA. Translation: AAH78810.1.
M86912 Genomic DNA. No translation available.
PIRiJC2134.
RefSeqiNP_112247.2. NM_030985.4.
XP_006253944.1. XM_006253882.2.
XP_008769816.1. XM_008771594.1.
UniGeneiRn.9814.

Genome annotation databases

EnsembliENSRNOT00000038532; ENSRNOP00000034687; ENSRNOG00000018346.
GeneIDi24180.
KEGGirno:24180.
UCSCiRGD:2070. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62295 mRNA. Translation: CAA44183.1.
M74054 mRNA. Translation: AAA40738.1.
BC078810 mRNA. Translation: AAH78810.1.
M86912 Genomic DNA. No translation available.
PIRiJC2134.
RefSeqiNP_112247.2. NM_030985.4.
XP_006253944.1. XM_006253882.2.
XP_008769816.1. XM_008771594.1.
UniGeneiRn.9814.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2AC6model-A1-359[»]
2AH3model-A1-359[»]
ProteinModelPortaliP25095.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi246370. 4 interactions.
IntActiP25095. 6 interactions.
MINTiMINT-1503145.
STRINGi10116.ENSRNOP00000034687.

Chemistry

BindingDBiP25095.
ChEMBLiCHEMBL329.
GuidetoPHARMACOLOGYi34.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP25095.

Proteomic databases

PaxDbiP25095.
PRIDEiP25095.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000038532; ENSRNOP00000034687; ENSRNOG00000018346.
GeneIDi24180.
KEGGirno:24180.
UCSCiRGD:2070. rat.

Organism-specific databases

CTDi11607.
RGDi2070. Agtr1a.

Phylogenomic databases

eggNOGiNOG256015.
GeneTreeiENSGT00760000119055.
HOGENOMiHOG000234122.
HOVERGENiHBG104998.
InParanoidiP25095.
KOiK04166.
OMAiCIVIWLL.
OrthoDBiEOG7J4473.
PhylomeDBiP25095.
TreeFamiTF330024.

Enzyme and pathway databases

ReactomeiREACT_250028. Peptide ligand-binding receptors.
REACT_263374. G alpha (q) signalling events.

Miscellaneous databases

NextBioi602525.
PROiP25095.

Gene expression databases

GenevestigatoriP25095.

Family and domain databases

InterProiIPR000190. ATII_AT1_rcpt.
IPR000248. ATII_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00241. ANGIOTENSINR.
PR00635. ANGIOTENSN1R.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor."
    Murphy T.J., Alexander R.W., Griendling K.K., Runge M.S., Bernstein K.E.
    Nature 351:233-236(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Vascular smooth muscle.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney.
  3. Cited for: NUCLEOTIDE SEQUENCE.
  4. "Identification of two subtypes in the rat type I angiotensin II receptor."
    Iwai N., Inagami T.
    FEBS Lett. 298:257-260(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Adrenal gland.
  5. "Cloning, expression and regulation of angiotensin II receptors."
    Inagami T., Iwai N., Sasaki K., Yamano Y., Bardhan S., Chaki S., Guo D.F., Furuta H., Ohyama K., Kambayashi Y., Takahashi K., Ichiki T.
    Eur. Heart J. 15:104-107(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  7. "Characterization of an angiotensin type-1 receptor partial cDNA from rat kidney: evidence for a novel AT1B receptor subtype."
    Ye M.Q., Healy D.P.
    Biochem. Biophys. Res. Commun. 185:204-210(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 84-259.
    Tissue: Kidney.
  8. "Association of beta-Arrestin 1 with the type 1A angiotensin II receptor involves phosphorylation of the receptor carboxyl terminus and correlates with receptor internalization."
    Qian H., Pipolo L., Thomas W.G.
    Mol. Endocrinol. 15:1706-1719(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ARRB1.

Entry informationi

Entry nameiAGTRA_RAT
AccessioniPrimary (citable) accession number: P25095
Secondary accession number(s): Q9QVS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: January 7, 2015
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.