Type-1A angiotensin II receptor - Rattus norvegicus (Rat)

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P25095 (AGTRA_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 117. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Type-1A angiotensin II receptor

Alternative name(s):
Angiotensin II type-1A receptor
Short name=AT1A

Gene names

Name:	Agtr1
Synonyms:	Agtr1a, At1a

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	359 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Subunit structure	Interacts with MAS1 By similarity. Interacts with ARRB1. Ref.8
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Is expressed in the liver, kidney, aorta, lung, uterus, ovary, spleen, heart, adrenal gland, and vascular smooth muscle cell.
Post-translational modification	C-terminal Ser or Thr residues may be phosphorylated.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	activation of Janus kinase activity Inferred from mutant phenotype PubMed 9314843. Source: RGD aging Inferred from expression pattern PubMed 21318332. Source: RGD blood vessel development Inferred from electronic annotation. Source: Compara brain renin-angiotensin system Inferred from electronic annotation. Source: Compara cellular response to dexamethasone stimulus Inferred from direct assay PubMed 17537984. Source: UniProtKB dopamine biosynthetic process Inferred from mutant phenotype PubMed 20097214. Source: RGD drinking behavior Inferred from electronic annotation. Source: Compara elevation of cytosolic calcium ion concentration Inferred from direct assay PubMed 12110004. Source: RGD heart development Inferred from electronic annotation. Source: Compara inflammatory response Inferred from electronic annotation. Source: Compara kidney development Inferred from electronic annotation. Source: Compara negative regulation of smooth muscle cell apoptotic process Inferred from electronic annotation. Source: Compara positive regulation of blood pressure Inferred from mutant phenotype PubMed 20702798. Source: RGD positive regulation of branching involved in ureteric bud morphogenesis Inferred from mutant phenotype PubMed 17537984. Source: UniProtKB positive regulation of cell proliferation Inferred from mutant phenotype PubMed 22645419. Source: RGD positive regulation of cytokine secretion Inferred from electronic annotation. Source: Compara positive regulation of receptor recycling Inferred from direct assay PubMed 14559250. Source: UniProtKB positive regulation of superoxide anion generation Inferred from mutant phenotype PubMed 21076237. Source: RGD regulation of pH Inferred from direct assay PubMed 11906170. Source: RGD regulation of renal output by angiotensin Inferred from electronic annotation. Source: Compara renin secretion into blood stream Inferred from electronic annotation. Source: Compara renin-angiotensin regulation of aldosterone production Inferred from mutant phenotype PubMed 21318332. Source: RGD response to estrogen stimulus Inferred from direct assay PubMed 12810582. Source: RGD vasoconstriction Inferred from mutant phenotype PubMed 20955746. Source: RGD
Cellular_component	Golgi apparatus Inferred from direct assay PubMed 14559250. Source: UniProtKB basolateral plasma membrane Inferred from direct assay PubMed 12110004. Source: RGD cytoplasmic vesicle Inferred from direct assay PubMed 14559250. Source: UniProtKB dendrite Inferred from direct assay PubMed 15590154. Source: RGD integral to membrane Traceable author statement PubMed 11906170. Source: RGD organelle outer membrane Inferred from direct assay PubMed 15590154. Source: RGD recycling endosome Inferred from direct assay PubMed 14559250. Source: RGD vesicle lumen Inferred from direct assay PubMed 12110004. Source: RGD vesicle membrane Inferred from direct assay PubMed 12110004. Source: RGD
Molecular_function	G-protein alpha-subunit binding Inferred from mutant phenotype PubMed 9092554. Source: RGD angiotensin type I receptor activity Inferred from direct assay PubMed 11906170. Source: RGD angiotensin type II receptor activity Inferred from electronic annotation. Source: InterPro peptide hormone binding Inferred from mutant phenotype PubMed 12110004 PubMed 12446719 PubMed 15569855. Source: RGD protein self-association Inferred from mutant phenotype PubMed 12446719. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 359

359

Type-1A angiotensin II receptor

PRO_0000069160

Regions

Topological domain

1 – 27

Extracellular Potential

Transmembrane

28 – 52

Helical; Name=1; Potential

Topological domain

53 – 64

Cytoplasmic Potential

Transmembrane

65 – 87

Helical; Name=2; Potential

Topological domain

88 – 102

Extracellular Potential

Transmembrane

103 – 124

Helical; Name=3; Potential

Topological domain

125 – 142

Cytoplasmic Potential

Transmembrane

143 – 162

Helical; Name=4; Potential

Topological domain

163 – 192

Extracellular Potential

Transmembrane

193 – 214

Helical; Name=5; Potential

Topological domain

215 – 240

Cytoplasmic Potential

Transmembrane

241 – 262

Helical; Name=6; Potential

Topological domain

263 – 275

Extracellular Potential

Transmembrane

276 – 296

Helical; Name=7; Potential

Topological domain

297 – 359

Cytoplasmic Potential

Amino acid modifications

Lipidation

355

S-palmitoyl cysteine Potential

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

176

N-linked (GlcNAc...) Potential

Glycosylation

188

N-linked (GlcNAc...) Potential

Disulfide bond

101 ↔ 180

By similarity

Experimental info

Sequence conflict

L → C in AAA40738. Ref.2

Sequence conflict

109

S → T Ref.2

Sequence conflict

109

S → T Ref.5

Sequences

Sequence

Length

Mass (Da)

Tools

P25095 [UniParc].

Last modified May 1, 1992. Version 1.
Checksum: 200EAE56DB4DA678
Show »

FASTA

359

40,890

        10         20         30         40         50         60 
MALNSSAEDG IKRIQDDCPK AGRHSYIFVM IPTLYSIIFV VGIFGNSLVV IVIYFYMKLK 

        70         80         90        100        110        120 
TVASVFLLNL ALADLCFLLT LPLWAVYTAM EYRWPFGNHL CKIASASVSF NLYASVFLLT 

       130        140        150        160        170        180 
CLSIDRYLAI VHPMKSRLRR TMLVAKVTCI IIWLMAGLAS LPAVIHRNVY FIENTNITVC 

       190        200        210        220        230        240 
AFHYESRNST LPIGLGLTKN ILGFLFPFLI ILTSYTLIWK ALKKAYEIQK NKPRNDDIFR 

       250        260        270        280        290        300 
IIMAIVLFFF FSWVPHQIFT FLDVLIQLGV IHDCKISDIV DTAMPITICI AYFNNCLNPL 

       310        320        330        340        350 
FYGFLGKKFK KYFLQLLKYI PPKAKSHSSL STKMSTLSYR PSDNMSSSAK KPASCFEVE

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor." Murphy T.J., Alexander R.W., Griendling K.K., Runge M.S., Bernstein K.E. Nature 351:233-236(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Vascular smooth muscle.
[2]	"Rat angiotensin II receptor: cDNA sequence and regulation of the gene expression." Iwai N., Yamano Y., Chaki S., Konishi F., Bardhan S., Tibbetts C., Sasaki K., Hasegawa M., Matsuda Y., Inagami T. Biochem. Biophys. Res. Commun. 177:299-304(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Kidney.
[3]	"The genomic organization of the rat AT1 angiotensin receptor." Langford K.G., Frenzel K., Martin B.M., Bernstein K.E. Biochem. Biophys. Res. Commun. 183:1025-1032(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[4]	"Identification of two subtypes in the rat type I angiotensin II receptor." Iwai N., Inagami T. FEBS Lett. 298:257-260(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Adrenal gland.
[5]	"Cloning, expression and regulation of angiotensin II receptors." Inagami T., Iwai N., Sasaki K., Yamano Y., Bardhan S., Chaki S., Guo D.F., Furuta H., Ohyama K., Kambayashi Y., Takahashi K., Ichiki T. Eur. Heart J. 15:104-107(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.
[7]	"Characterization of an angiotensin type-1 receptor partial cDNA from rat kidney: evidence for a novel AT1B receptor subtype." Ye M.Q., Healy D.P. Biochem. Biophys. Res. Commun. 185:204-210(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 84-259. Tissue: Kidney.
[8]	"Association of beta-Arrestin 1 with the type 1A angiotensin II receptor involves phosphorylation of the receptor carboxyl terminus and correlates with receptor internalization." Qian H., Pipolo L., Thomas W.G. Mol. Endocrinol. 15:1706-1719(2001) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH ARRB1.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X62295 mRNA. Translation: CAA44183.1.
M74054 mRNA. Translation: AAA40738.1.
BC078810 mRNA. Translation: AAH78810.1.
M86912 Genomic DNA. No translation available.

IPI

IPI00327967.

PIR

JC2134.

RefSeq

NP_112247.2. NM_030985.4.

UniGene

Rn.9814.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2AC6	model	-	A	1-359	[»]
2AH3	model	-	A	1-359	[»]

ProteinModelPortal

P25095.

ModBase

Search...

Protein-protein interaction databases

IntAct

P25095. 2 interactions.

MINT

MINT-1503145.

STRING

10116.ENSRNOP00000034687.

Protein family/group databases

GPCRDB

Search...

PTM databases

PhosphoSite

P25095.

Proteomic databases

PaxDb

P25095.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENSRNOT00000038532; ENSRNOP00000034687; ENSRNOG00000018346.

GeneID

24180.

KEGG

rno:24180.

UCSC

RGD:2070. rat.

Organism-specific databases

CTD

11607.

RGD

2070. Agtr1a.

Phylogenomic databases

eggNOG

NOG256015.

GeneTree

ENSGT00700000104167.

HOGENOM

HOG000234122.

HOVERGEN

HBG104998.

InParanoid

P25095.

K04166.

OMA

CIVIWLL.

OrthoDB

EOG48D0VX.

Gene expression databases

Genevestigator

P25095.

GermOnline

ENSRNOG00000018346. Rattus norvegicus.

Family and domain databases

InterPro

IPR000190. ATII_AT1_rcpt.
IPR000248. ATII_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]

Pfam

PF00001. 7tm_1. 1 hit.
[Graphical view]

PRINTS

PR00241. ANGIOTENSINR.
PR00635. ANGIOTENSN1R.
PR00237. GPCRRHODOPSN.

PROSITE

PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

BindingDB

P25095.

ChEMBL

CHEMBL329.

NextBio

602525.

Entry information

Entry name

AGTRA_RAT

Accession

Primary (citable) accession number: P25095
Secondary accession number(s): Q9QVS5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1992
Last sequence update:	May 1, 1992
Last modified:	April 3, 2013
This is version 117 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents