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Protein

Type-1A angiotensin II receptor

Gene

Agtr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

  • angiotensin type II receptor activity Source: InterPro
  • angiotensin type I receptor activity Source: RGD
  • D1 dopamine receptor binding Source: RGD
  • G-protein alpha-subunit binding Source: RGD
  • peptide hormone binding Source: RGD
  • protein kinase binding Source: RGD
  • protein self-association Source: RGD

GO - Biological processi

  • activation of Janus kinase activity Source: RGD
  • aging Source: RGD
  • angiotensin-activated signaling pathway Source: BHF-UCL
  • blood vessel development Source: Ensembl
  • brain renin-angiotensin system Source: Ensembl
  • cellular response to dexamethasone stimulus Source: UniProtKB
  • dopamine biosynthetic process Source: RGD
  • drinking behavior Source: RGD
  • G-protein coupled receptor signaling pathway Source: RGD
  • heart development Source: Ensembl
  • inflammatory response Source: Ensembl
  • kidney development Source: Ensembl
  • negative regulation of smooth muscle cell apoptotic process Source: Ensembl
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: RGD
  • positive regulation of blood pressure Source: BHF-UCL
  • positive regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
  • positive regulation of cell proliferation Source: RGD
  • positive regulation of cytokine secretion Source: Ensembl
  • positive regulation of cytosolic calcium ion concentration Source: RGD
  • positive regulation of receptor recycling Source: UniProtKB
  • positive regulation of superoxide anion generation Source: RGD
  • regulation of blood pressure Source: RGD
  • regulation of pH Source: RGD
  • regulation of renal output by angiotensin Source: Ensembl
  • regulation of vasoconstriction Source: InterPro
  • renin-angiotensin regulation of aldosterone production Source: RGD
  • renin secretion into blood stream Source: Ensembl
  • response to activity Source: RGD
  • response to angiotensin Source: RGD
  • response to corticosterone Source: RGD
  • response to estrogen Source: RGD
  • response to salt stress Source: RGD
  • vasoconstriction Source: RGD

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-375276 Peptide ligand-binding receptors
R-RNO-416476 G alpha (q) signalling events
R-RNO-8856825 Cargo recognition for clathrin-mediated endocytosis
R-RNO-8856828 Clathrin-mediated endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Type-1A angiotensin II receptor
Alternative name(s):
Angiotensin II type-1A receptor
Short name:
AT1A
Gene namesi
Name:Agtr1
Synonyms:Agtr1a, At1a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi2070 Agtr1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
Transmembranei28 – 52Helical; Name=1Sequence analysisAdd BLAST25
Topological domaini53 – 64CytoplasmicSequence analysisAdd BLAST12
Transmembranei65 – 87Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini88 – 102ExtracellularSequence analysisAdd BLAST15
Transmembranei103 – 124Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini125 – 142CytoplasmicSequence analysisAdd BLAST18
Transmembranei143 – 162Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini163 – 192ExtracellularSequence analysisAdd BLAST30
Transmembranei193 – 214Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini215 – 240CytoplasmicSequence analysisAdd BLAST26
Transmembranei241 – 262Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini263 – 275ExtracellularSequence analysisAdd BLAST13
Transmembranei276 – 296Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini297 – 359CytoplasmicSequence analysisAdd BLAST63

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL329
GuidetoPHARMACOLOGYi34

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000691601 – 359Type-1A angiotensin II receptorAdd BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi101 ↔ 180PROSITE-ProRule annotation
Glycosylationi176N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi355S-palmitoyl cysteineSequence analysis1

Post-translational modificationi

C-terminal Ser or Thr residues may be phosphorylated.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP25095
PRIDEiP25095

PTM databases

iPTMnetiP25095
PhosphoSitePlusiP25095

Expressioni

Tissue specificityi

Is expressed in the liver, kidney, aorta, lung, uterus, ovary, spleen, heart, adrenal gland, and vascular smooth muscle cell.

Gene expression databases

BgeeiENSRNOG00000018346
GenevisibleiP25095 RN

Interactioni

Subunit structurei

Interacts with MAS1 (By similarity). Interacts with ARRB1 (PubMed:11579203). Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA (By similarity).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
AGTP0101910EBI-764979,EBI-751728From Homo sapiens.

GO - Molecular functioni

  • D1 dopamine receptor binding Source: RGD
  • G-protein alpha-subunit binding Source: RGD
  • protein kinase binding Source: RGD
  • protein self-association Source: RGD

Protein-protein interaction databases

BioGridi246370, 8 interactors
IntActiP25095, 6 interactors
MINTiP25095
STRINGi10116.ENSRNOP00000034687

Chemistry databases

BindingDBiP25095

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2AC6model-A1-359[»]
2AH3model-A1-359[»]
ProteinModelPortaliP25095
SMRiP25095
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000119055
HOGENOMiHOG000234122
HOVERGENiHBG104998
InParanoidiP25095
KOiK04166
OMAiYTLIWKT
OrthoDBiEOG091G0C1Y
PhylomeDBiP25095
TreeFamiTF330024

Family and domain databases

CDDicd15192 7tmA_AT1R, 1 hit
InterProiView protein in InterPro
IPR000190 ATII_AT1_rcpt
IPR000248 ATII_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00241 ANGIOTENSINR
PR00635 ANGIOTENSN1R
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P25095-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALNSSAEDG IKRIQDDCPK AGRHSYIFVM IPTLYSIIFV VGIFGNSLVV
60 70 80 90 100
IVIYFYMKLK TVASVFLLNL ALADLCFLLT LPLWAVYTAM EYRWPFGNHL
110 120 130 140 150
CKIASASVSF NLYASVFLLT CLSIDRYLAI VHPMKSRLRR TMLVAKVTCI
160 170 180 190 200
IIWLMAGLAS LPAVIHRNVY FIENTNITVC AFHYESRNST LPIGLGLTKN
210 220 230 240 250
ILGFLFPFLI ILTSYTLIWK ALKKAYEIQK NKPRNDDIFR IIMAIVLFFF
260 270 280 290 300
FSWVPHQIFT FLDVLIQLGV IHDCKISDIV DTAMPITICI AYFNNCLNPL
310 320 330 340 350
FYGFLGKKFK KYFLQLLKYI PPKAKSHSSL STKMSTLSYR PSDNMSSSAK

KPASCFEVE
Length:359
Mass (Da):40,890
Last modified:May 1, 1992 - v1
Checksum:i200EAE56DB4DA678
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti81L → C in AAA40738 (PubMed:2043116).Curated1
Sequence conflicti109S → T (PubMed:2043116).Curated1
Sequence conflicti109S → T (PubMed:7713098).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62295 mRNA Translation: CAA44183.1
M74054 mRNA Translation: AAA40738.1
BC078810 mRNA Translation: AAH78810.1
M86912 Genomic DNA No translation available.
PIRiJC2134
RefSeqiNP_112247.2, NM_030985.4
XP_006253944.1, XM_006253882.3
XP_008769816.1, XM_008771594.2
UniGeneiRn.9814

Genome annotation databases

EnsembliENSRNOT00000038532; ENSRNOP00000034687; ENSRNOG00000018346
GeneIDi24180
KEGGirno:24180
UCSCiRGD:2070 rat

Similar proteinsi

Entry informationi

Entry nameiAGTRA_RAT
AccessioniPrimary (citable) accession number: P25095
Secondary accession number(s): Q9QVS5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: June 20, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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