Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P25095

- AGTRA_RAT

UniProt

P25095 - AGTRA_RAT

Protein

Type-1A angiotensin II receptor

Gene

Agtr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 1 (01 May 1992)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

    GO - Molecular functioni

    1. angiotensin type II receptor activity Source: InterPro
    2. angiotensin type I receptor activity Source: RGD
    3. D1 dopamine receptor binding Source: RGD
    4. G-protein alpha-subunit binding Source: RGD
    5. peptide hormone binding Source: RGD
    6. protein binding Source: UniProtKB
    7. protein kinase binding Source: RGD
    8. protein self-association Source: RGD

    GO - Biological processi

    1. activation of Janus kinase activity Source: RGD
    2. aging Source: RGD
    3. blood vessel development Source: Ensembl
    4. brain renin-angiotensin system Source: Ensembl
    5. cellular response to dexamethasone stimulus Source: UniProtKB
    6. dopamine biosynthetic process Source: RGD
    7. drinking behavior Source: RGD
    8. G-protein coupled receptor signaling pathway Source: RGD
    9. heart development Source: Ensembl
    10. inflammatory response Source: Ensembl
    11. kidney development Source: Ensembl
    12. negative regulation of smooth muscle cell apoptotic process Source: Ensembl
    13. phospholipase C-activating angiotensin-activated signaling pathway Source: GOC
    14. phospholipase C-activating G-protein coupled receptor signaling pathway Source: RGD
    15. positive regulation of blood pressure Source: RGD
    16. positive regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
    17. positive regulation of cell proliferation Source: RGD
    18. positive regulation of cytokine secretion Source: Ensembl
    19. positive regulation of cytosolic calcium ion concentration Source: RGD
    20. positive regulation of receptor recycling Source: UniProtKB
    21. positive regulation of superoxide anion generation Source: RGD
    22. regulation of blood pressure Source: RGD
    23. regulation of pH Source: RGD
    24. regulation of renal output by angiotensin Source: Ensembl
    25. regulation of vasoconstriction Source: InterPro
    26. renin-angiotensin regulation of aldosterone production Source: RGD
    27. renin secretion into blood stream Source: Ensembl
    28. response to estrogen Source: RGD
    29. vasoconstriction Source: RGD

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Type-1A angiotensin II receptor
    Alternative name(s):
    Angiotensin II type-1A receptor
    Short name:
    AT1A
    Gene namesi
    Name:Agtr1
    Synonyms:Agtr1a, At1a
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 17

    Organism-specific databases

    RGDi2070. Agtr1a.

    Subcellular locationi

    GO - Cellular componenti

    1. basolateral plasma membrane Source: RGD
    2. cytoplasmic vesicle Source: UniProtKB
    3. dendrite Source: RGD
    4. endomembrane system Source: RGD
    5. Golgi apparatus Source: UniProtKB
    6. integral component of membrane Source: RGD
    7. membrane Source: RGD
    8. organelle outer membrane Source: RGD
    9. plasma membrane Source: UniProtKB
    10. recycling endosome Source: RGD
    11. vesicle lumen Source: RGD
    12. vesicle membrane Source: RGD

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 359359Type-1A angiotensin II receptorPRO_0000069160Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi101 ↔ 180PROSITE-ProRule annotation
    Glycosylationi176 – 1761N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence Analysis
    Lipidationi355 – 3551S-palmitoyl cysteineSequence Analysis

    Post-translational modificationi

    C-terminal Ser or Thr residues may be phosphorylated.

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

    Proteomic databases

    PaxDbiP25095.
    PRIDEiP25095.

    PTM databases

    PhosphoSiteiP25095.

    Expressioni

    Tissue specificityi

    Is expressed in the liver, kidney, aorta, lung, uterus, ovary, spleen, heart, adrenal gland, and vascular smooth muscle cell.

    Gene expression databases

    GenevestigatoriP25095.

    Interactioni

    Subunit structurei

    Interacts with MAS1 By similarity. Interacts with ARRB1.By similarity1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    AGTP0101910EBI-764979,EBI-751728From a different organism.

    Protein-protein interaction databases

    BioGridi246370. 4 interactions.
    IntActiP25095. 6 interactions.
    MINTiMINT-1503145.
    STRINGi10116.ENSRNOP00000034687.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2AC6model-A1-359[»]
    2AH3model-A1-359[»]
    ProteinModelPortaliP25095.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2727ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini53 – 6412CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini88 – 10215ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini125 – 14218CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini163 – 19230ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini215 – 24026CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini263 – 27513ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini297 – 35963CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei28 – 5225Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei65 – 8723Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei103 – 12422Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei143 – 16220Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei193 – 21422Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei241 – 26222Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei276 – 29621Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG256015.
    GeneTreeiENSGT00720000108671.
    HOGENOMiHOG000234122.
    HOVERGENiHBG104998.
    InParanoidiP25095.
    KOiK04166.
    OMAiCIVIWLL.
    OrthoDBiEOG7J4473.
    PhylomeDBiP25095.
    TreeFamiTF330024.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000190. ATII_AT1_rcpt.
    IPR000248. ATII_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00241. ANGIOTENSINR.
    PR00635. ANGIOTENSN1R.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P25095-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALNSSAEDG IKRIQDDCPK AGRHSYIFVM IPTLYSIIFV VGIFGNSLVV    50
    IVIYFYMKLK TVASVFLLNL ALADLCFLLT LPLWAVYTAM EYRWPFGNHL 100
    CKIASASVSF NLYASVFLLT CLSIDRYLAI VHPMKSRLRR TMLVAKVTCI 150
    IIWLMAGLAS LPAVIHRNVY FIENTNITVC AFHYESRNST LPIGLGLTKN 200
    ILGFLFPFLI ILTSYTLIWK ALKKAYEIQK NKPRNDDIFR IIMAIVLFFF 250
    FSWVPHQIFT FLDVLIQLGV IHDCKISDIV DTAMPITICI AYFNNCLNPL 300
    FYGFLGKKFK KYFLQLLKYI PPKAKSHSSL STKMSTLSYR PSDNMSSSAK 350
    KPASCFEVE 359
    Length:359
    Mass (Da):40,890
    Last modified:May 1, 1992 - v1
    Checksum:i200EAE56DB4DA678
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti81 – 811L → C in AAA40738. (PubMed:2043116)Curated
    Sequence conflicti109 – 1091S → T(PubMed:2043116)Curated
    Sequence conflicti109 – 1091S → T(PubMed:7713098)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X62295 mRNA. Translation: CAA44183.1.
    M74054 mRNA. Translation: AAA40738.1.
    BC078810 mRNA. Translation: AAH78810.1.
    M86912 Genomic DNA. No translation available.
    PIRiJC2134.
    RefSeqiNP_112247.2. NM_030985.4.
    XP_006253944.1. XM_006253882.1.
    UniGeneiRn.9814.

    Genome annotation databases

    EnsembliENSRNOT00000038532; ENSRNOP00000034687; ENSRNOG00000018346.
    GeneIDi24180.
    KEGGirno:24180.
    UCSCiRGD:2070. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X62295 mRNA. Translation: CAA44183.1 .
    M74054 mRNA. Translation: AAA40738.1 .
    BC078810 mRNA. Translation: AAH78810.1 .
    M86912 Genomic DNA. No translation available.
    PIRi JC2134.
    RefSeqi NP_112247.2. NM_030985.4.
    XP_006253944.1. XM_006253882.1.
    UniGenei Rn.9814.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2AC6 model - A 1-359 [» ]
    2AH3 model - A 1-359 [» ]
    ProteinModelPortali P25095.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 246370. 4 interactions.
    IntActi P25095. 6 interactions.
    MINTi MINT-1503145.
    STRINGi 10116.ENSRNOP00000034687.

    Chemistry

    BindingDBi P25095.
    ChEMBLi CHEMBL329.
    GuidetoPHARMACOLOGYi 34.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P25095.

    Proteomic databases

    PaxDbi P25095.
    PRIDEi P25095.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000038532 ; ENSRNOP00000034687 ; ENSRNOG00000018346 .
    GeneIDi 24180.
    KEGGi rno:24180.
    UCSCi RGD:2070. rat.

    Organism-specific databases

    CTDi 11607.
    RGDi 2070. Agtr1a.

    Phylogenomic databases

    eggNOGi NOG256015.
    GeneTreei ENSGT00720000108671.
    HOGENOMi HOG000234122.
    HOVERGENi HBG104998.
    InParanoidi P25095.
    KOi K04166.
    OMAi CIVIWLL.
    OrthoDBi EOG7J4473.
    PhylomeDBi P25095.
    TreeFami TF330024.

    Miscellaneous databases

    NextBioi 602525.
    PROi P25095.

    Gene expression databases

    Genevestigatori P25095.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000190. ATII_AT1_rcpt.
    IPR000248. ATII_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00241. ANGIOTENSINR.
    PR00635. ANGIOTENSN1R.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor."
      Murphy T.J., Alexander R.W., Griendling K.K., Runge M.S., Bernstein K.E.
      Nature 351:233-236(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Vascular smooth muscle.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Kidney.
    3. Cited for: NUCLEOTIDE SEQUENCE.
    4. "Identification of two subtypes in the rat type I angiotensin II receptor."
      Iwai N., Inagami T.
      FEBS Lett. 298:257-260(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Adrenal gland.
    5. "Cloning, expression and regulation of angiotensin II receptors."
      Inagami T., Iwai N., Sasaki K., Yamano Y., Bardhan S., Chaki S., Guo D.F., Furuta H., Ohyama K., Kambayashi Y., Takahashi K., Ichiki T.
      Eur. Heart J. 15:104-107(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    7. "Characterization of an angiotensin type-1 receptor partial cDNA from rat kidney: evidence for a novel AT1B receptor subtype."
      Ye M.Q., Healy D.P.
      Biochem. Biophys. Res. Commun. 185:204-210(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 84-259.
      Tissue: Kidney.
    8. "Association of beta-Arrestin 1 with the type 1A angiotensin II receptor involves phosphorylation of the receptor carboxyl terminus and correlates with receptor internalization."
      Qian H., Pipolo L., Thomas W.G.
      Mol. Endocrinol. 15:1706-1719(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ARRB1.

    Entry informationi

    Entry nameiAGTRA_RAT
    AccessioniPrimary (citable) accession number: P25095
    Secondary accession number(s): Q9QVS5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: May 1, 1992
    Last modified: October 1, 2014
    This is version 128 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3