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Protein

Peripheral myelin protein 22

Gene

Pmp22

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Might be involved in growth regulation, and in myelinization in the peripheral nervous system.

GO - Biological processi

  • bleb assembly Source: Ensembl
  • cell cycle arrest Source: UniProtKB-KW
  • cell death Source: Ensembl
  • cell differentiation Source: RGD
  • myelination Source: RGD
  • negative regulation of cell proliferation Source: BHF-UCL
  • negative regulation of neuron projection development Source: BHF-UCL
  • peripheral nervous system development Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Growth arrest

Names & Taxonomyi

Protein namesi
Recommended name:
Peripheral myelin protein 22
Short name:
PMP-22
Alternative name(s):
Protein CD25
SR13 myelin protein
Schwann cell membrane glycoprotein
Short name:
SAG
Gene namesi
Name:Pmp22
Synonyms:Cd25, Pmp-22
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi3359. Pmp22.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1CytoplasmicSequence analysis1
Transmembranei2 – 31HelicalBy similarityAdd BLAST30
Topological domaini32 – 64ExtracellularSequence analysisAdd BLAST33
Transmembranei65 – 91HelicalBy similarityAdd BLAST27
Topological domaini92 – 95CytoplasmicSequence analysis4
Transmembranei96 – 119HelicalBy similarityAdd BLAST24
Topological domaini120 – 133ExtracellularSequence analysisAdd BLAST14
Transmembranei134 – 156HelicalBy similarityAdd BLAST23
Topological domaini157 – 160CytoplasmicSequence analysis4

GO - Cellular componenti

  • bicellular tight junction Source: RGD
  • compact myelin Source: RGD
  • integral component of membrane Source: RGD
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2007624.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001646521 – 160Peripheral myelin protein 22Add BLAST160

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi41N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP25094.

Expressioni

Tissue specificityi

Found exclusively in the peripheral nervous system. Present in both myelinating and nonmyelinating Schwann cells. Found in the tumors of Schwann cell lineage where axons are present (neurofibromas) but not where axons are absent (schwannomas).1 Publication

Developmental stagei

Levels increase between embryonic day 21 (E21) and postnatal day 0 (PND0) and then gradually increase up to PND15. There is a slight increase between PND15 and adulthood.1 Publication

Inductioni

Strongly down-regulated in the initial phase after sciatic nerve injury.

Gene expression databases

BgeeiENSRNOG00000003338.
GenevisibleiP25094. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051201.

Structurei

3D structure databases

ProteinModelPortaliP25094.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWVJ. Eukaryota.
ENOG4111SX3. LUCA.
GeneTreeiENSGT00510000046328.
HOGENOMiHOG000059542.
HOVERGENiHBG001690.
InParanoidiP25094.
KOiK19289.
OMAiAIFTVRH.
OrthoDBiEOG091G0RF4.
PhylomeDBiP25094.
TreeFamiTF330414.

Family and domain databases

InterProiIPR003936. PMP22.
IPR004031. PMP22/EMP/MP20/Claudin.
IPR004032. PMP22_EMP_MP20.
[Graphical view]
PANTHERiPTHR10671:SF7. PTHR10671:SF7. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01453. EPMEMFAMILY.
PR01458. PMYELIN22.
PROSITEiPS01221. PMP22_1. 1 hit.
PS01222. PMP22_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25094-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLLLLGILF LHIAVLVLLF VSTIVSQWLV GNGHRTDLWQ NCTTSALGAV
60 70 80 90 100
QHCYSSSVSE WLQSVQATMI LSVIFSVLSL FLFFCQLFTL TKGGRFYITG
110 120 130 140 150
VFQILAGLCV MSAAAIYTVR HSEWHVNNDY SYGFAYILAW VAFPLALLSG
160
IIYVILRKRE
Length:160
Mass (Da):17,946
Last modified:May 1, 1992 - v1
Checksum:i8DB9B2F2CF6D4903
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22S → K AA sequence (PubMed:1376775).Curated1
Sequence conflicti30V → E in CAA44297 (PubMed:1935894).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62431 mRNA. Translation: CAA44297.1.
M69139 mRNA. Translation: AAA73063.1.
S55427 mRNA. Translation: AAB25374.1.
PIRiA41144.
RefSeqiNP_058733.1. NM_017037.1.
XP_006246646.1. XM_006246584.3.
UniGeneiRn.1476.

Genome annotation databases

EnsembliENSRNOT00000041606; ENSRNOP00000051201; ENSRNOG00000003338.
ENSRNOT00000081415; ENSRNOP00000069909; ENSRNOG00000003338.
GeneIDi24660.
KEGGirno:24660.
UCSCiRGD:3359. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62431 mRNA. Translation: CAA44297.1.
M69139 mRNA. Translation: AAA73063.1.
S55427 mRNA. Translation: AAB25374.1.
PIRiA41144.
RefSeqiNP_058733.1. NM_017037.1.
XP_006246646.1. XM_006246584.3.
UniGeneiRn.1476.

3D structure databases

ProteinModelPortaliP25094.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051201.

Chemistry databases

ChEMBLiCHEMBL2007624.

Proteomic databases

PaxDbiP25094.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000041606; ENSRNOP00000051201; ENSRNOG00000003338.
ENSRNOT00000081415; ENSRNOP00000069909; ENSRNOG00000003338.
GeneIDi24660.
KEGGirno:24660.
UCSCiRGD:3359. rat.

Organism-specific databases

CTDi5376.
RGDi3359. Pmp22.

Phylogenomic databases

eggNOGiENOG410IWVJ. Eukaryota.
ENOG4111SX3. LUCA.
GeneTreeiENSGT00510000046328.
HOGENOMiHOG000059542.
HOVERGENiHBG001690.
InParanoidiP25094.
KOiK19289.
OMAiAIFTVRH.
OrthoDBiEOG091G0RF4.
PhylomeDBiP25094.
TreeFamiTF330414.

Miscellaneous databases

PROiP25094.

Gene expression databases

BgeeiENSRNOG00000003338.
GenevisibleiP25094. RN.

Family and domain databases

InterProiIPR003936. PMP22.
IPR004031. PMP22/EMP/MP20/Claudin.
IPR004032. PMP22_EMP_MP20.
[Graphical view]
PANTHERiPTHR10671:SF7. PTHR10671:SF7. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01453. EPMEMFAMILY.
PR01458. PMYELIN22.
PROSITEiPS01221. PMP22_1. 1 hit.
PS01222. PMP22_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPMP22_RAT
AccessioniPrimary (citable) accession number: P25094
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: November 2, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.