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P25093 (FAAA_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fumarylacetoacetase
Short name=FAA
EC=3.7.1.2
Alternative name(s):
Beta-diketonase
Fumarylacetoacetate hydrolase
Gene names
Name:Fah
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length419 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

4-fumarylacetoacetate + H2O = acetoacetate + fumarate.

Cofactor

Calcium By similarity.

Magnesium By similarity.

Pathway

Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.

Subunit structure

Homodimer.

Tissue specificity

Mainly in liver and kidney.

Sequence similarities

Belongs to the FAH family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 419418Fumarylacetoacetase
PRO_0000156827

Sites

Active site1331Proton acceptor Probable
Metal binding1261Calcium By similarity
Metal binding1991Calcium By similarity
Metal binding2011Calcium By similarity
Metal binding2331Calcium By similarity
Metal binding2331Magnesium By similarity
Metal binding2531Magnesium By similarity
Metal binding2571Magnesium By similarity
Binding site1281Substrate By similarity
Binding site1421Substrate By similarity
Binding site2401Substrate By similarity
Binding site2441Substrate By similarity
Binding site3501Substrate By similarity

Amino acid modifications

Modified residue21N-acetylserine By similarity

Sequences

Sequence LengthMass (Da)Tools
P25093 [UniParc].

Last modified May 1, 1992. Version 1.
Checksum: AC099689591C6176

FASTA41945,976
        10         20         30         40         50         60 
MSFIPVAEDS DFPIQNLPYG VFSTQSNPKP RIGVAIGDQI LDLSVIKHLF TGPVLSKHQH 

        70         80         90        100        110        120 
VFDETTLNSF MGLGQAAWKE ARASLQNLLS ASQAQLRDDK ELRQRAFTSQ ASATMHLPAT 

       130        140        150        160        170        180 
IGDYTDFYSS LQHATNVGIM FRGKENALLP NWLHLPVGYH GRASSVVVSG TPIRRPMGQM 

       190        200        210        220        230        240 
RPDNSKPPVY GASKRLDMEL EMAFFVGPGN RFGEPIPISK AQEHIFGMVL MNDWSARDIQ 

       250        260        270        280        290        300 
QWEYVPLGPF LGKSFGTTIS PWVVPMDALM PFVVPNPKQD PKPLPYLCHS QPYTFDINLS 

       310        320        330        340        350        360 
VALKGEGMSQ AATICRSNFK HMYWTILQQL THHSVNGCNL RPGDLLASGT ISGSDPESFG 

       370        380        390        400        410 
SMLELSWKGT KAIDVGQGQT RTFLLDGDEV IITGHCQGDG YRVGFGQCAG KVLPALSPA

« Hide

References

« Hide 'large scale' references
[1]"Cloning and expression analysis of a cDNA encoding fumarylacetoacetate hydrolase: post-transcriptional modulation in rat liver and kidney."
Labelle Y., Phaneuf D., Tanguay R.M.
Gene 104:197-202(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
Tissue: Liver.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
[3]Lubec G., Afjehi-Sadat L.
Submitted (NOV-2006) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 32-47; 145-162 AND 382-402, MASS SPECTROMETRY.
Strain: Sprague-Dawley.
Tissue: Spinal cord.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M77694 mRNA. Translation: AAA41142.1.
BC076381 mRNA. Translation: AAH76381.1.
IPIIPI00214480.
PIRJH0467.
RefSeqNP_058877.1. NM_017181.2.
UniGeneRn.9195.

3D structure databases

ProteinModelPortalP25093.
SMRP25093. Positions 1-417.
ModBaseSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000061132.

PTM databases

PhosphoSiteP25093.

Proteomic databases

PaxDbP25093.
PRIDEP25093.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID29383.
KEGGrno:29383.
UCSCRGD:61932. rat.

Organism-specific databases

CTD2184.
RGD61932. Fah.

Phylogenomic databases

eggNOGCOG0179.
HOGENOMHOG000256845.
HOVERGENHBG001919.
InParanoidP25093.
KOK01555.
OrthoDBEOG4Q2DFM.

Enzyme and pathway databases

UniPathwayUPA00139; UER00341.

Gene expression databases

ArrayExpressP25093.
GenevestigatorP25093.
GermOnlineENSRNOG00000013223. Rattus norvegicus.

Family and domain databases

Gene3D2.30.30.230. 1 hit.
3.90.850.10. 1 hit.
InterProIPR005959. Fumarylacetoacetase.
IPR002529. Fumarylacetoacetase_C.
IPR011234. Fumarylacetoacetase_C-rel.
IPR015377. Fumarylacetoacetase_N.
[Graphical view]
PANTHERPTHR11820:SF1. PTHR11820:SF1. 1 hit.
PfamPF09298. DUF1969. 1 hit.
PF01557. FAA_hydrolase. 1 hit.
[Graphical view]
SUPFAMSSF56529. Fumarylacetoacetase_C-rel. 1 hit.
SSF63433. Fumarylacetoacetase_N. 1 hit.
TIGRFAMsTIGR01266. fum_ac_acetase. 1 hit.
ProtoNetSearch...

Other

NextBio608975.

Entry information

Entry nameFAAA_RAT
AccessionPrimary (citable) accession number: P25093
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: April 3, 2013
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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