P25090 (FPR2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-formyl peptide receptor 2

Alternative name(s):
FMLP-related receptor I
Short name=FMLP-R-I
Formyl peptide receptor-like 1
HM63
Lipoxin A4 receptor
Short name=LXA4 receptor
RFP

Gene names

Name:	FPR2
Synonyms:	FPRH1, FPRL1, LXA4R

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	351 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4).
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Expressed abundantly in the lung and neutrophils. Also found in the spleen and testis. Ref.13
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Chemotaxis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell adhesion Traceable author statement PubMed 9054386. Source: ProtInc cellular component movement Traceable author statement Ref.3. Source: ProtInc chemotaxis Traceable author statement PubMed 9054386. Source: ProtInc inflammatory response Traceable author statement PubMed 9054386. Source: ProtInc superoxide anion generation Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Traceable author statement PubMed 9054386. Source: ProtInc plasma membrane Traceable author statement. Source: Reactome
Molecular_function	N-formyl peptide receptor activity Traceable author statement Ref.3. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 351	351	N-formyl peptide receptor 2		PRO_0000069451
Regions
	Topological domain	1 – 27	27	Extracellular Potential
	Transmembrane	28 – 50	23	Helical; Name=1; Potential
	Topological domain	51 – 61	11	Cytoplasmic Potential
	Transmembrane	62 – 83	22	Helical; Name=2; Potential
	Topological domain	84 – 100	17	Extracellular Potential
	Transmembrane	101 – 121	21	Helical; Name=3; Potential
	Topological domain	122 – 140	19	Cytoplasmic Potential
	Transmembrane	141 – 162	22	Helical; Name=4; Potential
	Topological domain	163 – 205	43	Extracellular Potential
	Transmembrane	206 – 226	21	Helical; Name=5; Potential
	Topological domain	227 – 242	16	Cytoplasmic Potential
	Transmembrane	243 – 266	24	Helical; Name=6; Potential
	Topological domain	267 – 286	20	Extracellular Potential
	Transmembrane	287 – 306	20	Helical; Name=7; Potential
	Topological domain	307 – 351	45	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	4	1	N-linked (GlcNAc...) Potential
	Disulfide bond	98 ↔ 176		Potential
Experimental info
	Sequence conflict	339	1	S → C in AAA58481. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P25090 [UniParc]. Last modified July 1, 1993. Version 2. Checksum: DC6A1D77AFC0D780	FASTA	351	38,964
	10 20 30 40 50 60 METNFSTPLN EYEEVSYESA GYTVLRILPL VVLGVTFVLG VLGNGLVIWV AGFRMTRTVT 70 80 90 100 110 120 TICYLNLALA DFSFTATLPF LIVSMAMGEK WPFGWFLCKL IHIVVDINLF GSVFLIGFIA 130 140 150 160 170 180 LDRCICVLHP VWAQNHRTVS LAMKVIVGPW ILALVLTLPV FLFLTTVTIP NGDTYCTFNF 190 200 210 220 230 240 ASWGGTPEER LKVAITMLTA RGIIRFVIGF SLPMSIVAIC YGLIAAKIHK KGMIKSSRPL 250 260 270 280 290 300 RVLTAVVASF FICWFPFQLV ALLGTVWLKE MLFYGKYKII DILVNPTSSL AFFNSCLNPM 310 320 330 340 350 LYVFVGQDFR ERLIHSLPTS LERALSEDSA PTNDTAANSA SPPAETELQA M

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19." Bao L., Gerard N.P., Eddy R.L. Jr., Shows T.B., Gerard C. Genomics 13:437-440(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cloning of a cDNA encoding a receptor related to the formyl peptide receptor of human neutrophils." Perez H.D., Holmes R., Kelly E., McClary J., Andrews W.H. Gene 118:303-304(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Bone marrow.
[3]	"Isolation of a cDNA that encodes a novel granulocyte N-formyl peptide receptor." Ye R.D., Cavanagh S.L., Quehenberger O., Prossnitz E.R., Cochrane C.G. Biochem. Biophys. Res. Commun. 184:582-589(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Granulocyte.
[4]	"A structural homologue of the N-formyl peptide receptor. Characterization and chromosome mapping of a peptide chemoattractant receptor family." Murphy P.M., Ozcelik T., Kenney R.T., Tiffany H.L., McDermott D., Francke U. J. Biol. Chem. 267:7637-7643(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]	"Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors." Nomura H., Nielsen B.W., Matsushima K. Int. Immunol. 5:1239-1249(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Monocyte.
[6]	Maddox J.F., Hachicha M., Takano T., Petasis N.A., Fokin V.V., Serhan C.N. Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[7]	"Identification of a human enterocyte lipoxin A4 receptor that is regulated by interleukin (IL)-13 and interferon gamma and inhibits tumor necrosis factor alpha-induced IL-8 release." Gronert K., Gewirtz A., Madara J.L., Serhan C.N. J. Exp. Med. 187:1285-1294(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[8]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Kopatz S.A., Aronstam R.S., Sharma S.V. Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[9]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Heart.
[10]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[11]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[12]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Blood.
[13]	"Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues are potent inhibitors of acute inflammation: evidence for anti-inflammatory receptors." Takano T., Fiore S., Maddox J.F., Brady H.R., Petasis N.A., Serhan C.N. J. Exp. Med. 185:1693-1704(1997) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M76672 mRNA. Translation: AAA58481.1. X63819 mRNA. Translation: CAA45319.1. M88107 mRNA. Translation: AAA60070.1. M84562 mRNA. Translation: AAA52473.1. D10922 mRNA. Translation: BAA01720.1. U81501 mRNA. Translation: AAB51133.1. AF054013 mRNA. Translation: AAC13684.1. AY225226 Genomic DNA. Translation: AAO67711.1. AK290557 mRNA. Translation: BAF83246.1. AC018755 Genomic DNA. Translation: AAF87844.1. CH471135 Genomic DNA. Translation: EAW72043.1. BC029125 mRNA. Translation: AAH29125.1. BC071722 mRNA. Translation: AAH71722.1.
IPI	IPI00012487.
PIR	B42009.
RefSeq	NP_001005738.1. NM_001005738.1. NP_001453.1. NM_001462.3.
UniGene	Hs.99855.
3D structure databases
ProteinModelPortal	P25090.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000340191.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P25090.
Polymorphism databases
DMDM	399504.
Proteomic databases
PaxDb	P25090.
PRIDE	P25090.
Protocols and materials databases
DNASU	2358.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000340023; ENSP00000340191; ENSG00000171049. ENST00000598776; ENSP00000468897; ENSG00000171049. ENST00000598953; ENSP00000468876; ENSG00000171049.
GeneID	2358.
KEGG	hsa:2358.
UCSC	uc002pxr.3. human.
Organism-specific databases
CTD	2358.
GeneCards	GC19P052264.
HGNC	HGNC:3827. FPR2.
HPA	HPA029154.
MIM	136538. gene.
neXtProt	NX_P25090.
PharmGKB	PA162388901.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG150376.
HOGENOM	HOG000234122.
HOVERGEN	HBG107927.
InParanoid	P25090.
KO	K04173.
OMA	VHIVVDI.
OrthoDB	EOG4SQWWZ.
PhylomeDB	P25090.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
Bgee	P25090.
CleanEx	HS_FPR2.
Genevestigator	P25090.
GermOnline	ENSG00000171049. Homo sapiens.
Family and domain databases
InterPro	IPR027346. Formyl_pep_2_rcpt. IPR000826. Formyl_pep_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
PANTHER	PTHR24225. PTHR24225. 1 hit. PTHR24225:SF7. PTHR24225:SF7. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00526. FMETLEUPHER. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P25090.
ChEMBL	CHEMBL4227.
GenomeRNAi	2358.
NextBio	9565.
SOURCE	Search...

Entry information

Entry name

FPR2_HUMAN

Accession

Primary (citable) accession number: P25090
Secondary accession number(s): A8K3E2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1992
Last sequence update:	July 1, 1993
Last modified:	May 1, 2013
This is version 125 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.