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P25090

- FPR2_HUMAN

UniProt

P25090 - FPR2_HUMAN

Protein

N-formyl peptide receptor 2

Gene

FPR2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 138 (01 Oct 2014)
      Sequence version 2 (01 Jul 1993)
      Previous versions | rss
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    Functioni

    Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4).

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: ProtInc
    2. N-formyl peptide receptor activity Source: ProtInc

    GO - Biological processi

    1. cell adhesion Source: ProtInc
    2. cellular component movement Source: ProtInc
    3. chemotaxis Source: ProtInc
    4. G-protein coupled receptor signaling pathway Source: ProtInc
    5. inflammatory response Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Chemotaxis

    Enzyme and pathway databases

    ReactomeiREACT_18283. G alpha (q) signalling events.
    REACT_19231. G alpha (i) signalling events.
    REACT_21264. Formyl peptide receptors bind formyl peptides and many other ligands.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N-formyl peptide receptor 2
    Alternative name(s):
    FMLP-related receptor I
    Short name:
    FMLP-R-I
    Formyl peptide receptor-like 1
    HM63
    Lipoxin A4 receptor
    Short name:
    LXA4 receptor
    RFP
    Gene namesi
    Name:FPR2
    Synonyms:FPRH1, FPRL1, LXA4R
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:3827. FPR2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: ProtInc
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162388901.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 351351N-formyl peptide receptor 2PRO_0000069451Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi98 ↔ 176PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP25090.
    PRIDEiP25090.

    PTM databases

    PhosphoSiteiP25090.

    Expressioni

    Tissue specificityi

    Expressed abundantly in the lung and neutrophils. Also found in the spleen and testis.1 Publication

    Gene expression databases

    ArrayExpressiP25090.
    BgeeiP25090.
    CleanExiHS_FPR2.
    GenevestigatoriP25090.

    Organism-specific databases

    HPAiHPA029154.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000340191.

    Structurei

    3D structure databases

    ProteinModelPortaliP25090.
    SMRiP25090. Positions 26-310.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2727ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini51 – 6111CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini84 – 10017ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini122 – 14019CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini163 – 20543ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini227 – 24216CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini267 – 28620ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini307 – 35145CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei28 – 5023Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei62 – 8322Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei101 – 12121Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei141 – 16222Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei206 – 22621Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei243 – 26624Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei287 – 30620Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG150376.
    HOGENOMiHOG000234122.
    HOVERGENiHBG107927.
    InParanoidiP25090.
    KOiK04173.
    OMAiMAMGEKW.
    PhylomeDBiP25090.
    TreeFamiTF330976.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR027347. Formyl_pep_2/3_rcpt.
    IPR000826. Formyl_rcpt-rel.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24225. PTHR24225. 1 hit.
    PTHR24225:SF16. PTHR24225:SF16. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P25090-1 [UniParc]FASTAAdd to Basket

    « Hide

    METNFSTPLN EYEEVSYESA GYTVLRILPL VVLGVTFVLG VLGNGLVIWV    50
    AGFRMTRTVT TICYLNLALA DFSFTATLPF LIVSMAMGEK WPFGWFLCKL 100
    IHIVVDINLF GSVFLIGFIA LDRCICVLHP VWAQNHRTVS LAMKVIVGPW 150
    ILALVLTLPV FLFLTTVTIP NGDTYCTFNF ASWGGTPEER LKVAITMLTA 200
    RGIIRFVIGF SLPMSIVAIC YGLIAAKIHK KGMIKSSRPL RVLTAVVASF 250
    FICWFPFQLV ALLGTVWLKE MLFYGKYKII DILVNPTSSL AFFNSCLNPM 300
    LYVFVGQDFR ERLIHSLPTS LERALSEDSA PTNDTAANSA SPPAETELQA 350
    M 351
    Length:351
    Mass (Da):38,964
    Last modified:July 1, 1993 - v2
    Checksum:iDC6A1D77AFC0D780
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti339 – 3391S → C in AAA58481. (PubMed:1612600)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M76672 mRNA. Translation: AAA58481.1.
    X63819 mRNA. Translation: CAA45319.1.
    M88107 mRNA. Translation: AAA60070.1.
    M84562 mRNA. Translation: AAA52473.1.
    D10922 mRNA. Translation: BAA01720.1.
    U81501 mRNA. Translation: AAB51133.1.
    AF054013 mRNA. Translation: AAC13684.1.
    AY225226 Genomic DNA. Translation: AAO67711.1.
    AK290557 mRNA. Translation: BAF83246.1.
    AC018755 Genomic DNA. Translation: AAF87844.1.
    CH471135 Genomic DNA. Translation: EAW72043.1.
    BC029125 mRNA. Translation: AAH29125.1.
    BC071722 mRNA. Translation: AAH71722.1.
    CCDSiCCDS12840.1.
    PIRiB42009.
    RefSeqiNP_001005738.1. NM_001005738.1.
    NP_001453.1. NM_001462.3.
    XP_006723183.1. XM_006723120.1.
    UniGeneiHs.99855.

    Genome annotation databases

    EnsembliENST00000340023; ENSP00000340191; ENSG00000171049.
    ENST00000598776; ENSP00000468897; ENSG00000171049.
    ENST00000598953; ENSP00000468876; ENSG00000171049.
    GeneIDi2358.
    KEGGihsa:2358.
    UCSCiuc002pxr.3. human.

    Polymorphism databases

    DMDMi399504.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M76672 mRNA. Translation: AAA58481.1 .
    X63819 mRNA. Translation: CAA45319.1 .
    M88107 mRNA. Translation: AAA60070.1 .
    M84562 mRNA. Translation: AAA52473.1 .
    D10922 mRNA. Translation: BAA01720.1 .
    U81501 mRNA. Translation: AAB51133.1 .
    AF054013 mRNA. Translation: AAC13684.1 .
    AY225226 Genomic DNA. Translation: AAO67711.1 .
    AK290557 mRNA. Translation: BAF83246.1 .
    AC018755 Genomic DNA. Translation: AAF87844.1 .
    CH471135 Genomic DNA. Translation: EAW72043.1 .
    BC029125 mRNA. Translation: AAH29125.1 .
    BC071722 mRNA. Translation: AAH71722.1 .
    CCDSi CCDS12840.1.
    PIRi B42009.
    RefSeqi NP_001005738.1. NM_001005738.1.
    NP_001453.1. NM_001462.3.
    XP_006723183.1. XM_006723120.1.
    UniGenei Hs.99855.

    3D structure databases

    ProteinModelPortali P25090.
    SMRi P25090. Positions 26-310.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000340191.

    Chemistry

    BindingDBi P25090.
    ChEMBLi CHEMBL4227.
    GuidetoPHARMACOLOGYi 223.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P25090.

    Polymorphism databases

    DMDMi 399504.

    Proteomic databases

    PaxDbi P25090.
    PRIDEi P25090.

    Protocols and materials databases

    DNASUi 2358.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000340023 ; ENSP00000340191 ; ENSG00000171049 .
    ENST00000598776 ; ENSP00000468897 ; ENSG00000171049 .
    ENST00000598953 ; ENSP00000468876 ; ENSG00000171049 .
    GeneIDi 2358.
    KEGGi hsa:2358.
    UCSCi uc002pxr.3. human.

    Organism-specific databases

    CTDi 2358.
    GeneCardsi GC19P052264.
    HGNCi HGNC:3827. FPR2.
    HPAi HPA029154.
    MIMi 136538. gene.
    neXtProti NX_P25090.
    PharmGKBi PA162388901.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG150376.
    HOGENOMi HOG000234122.
    HOVERGENi HBG107927.
    InParanoidi P25090.
    KOi K04173.
    OMAi MAMGEKW.
    PhylomeDBi P25090.
    TreeFami TF330976.

    Enzyme and pathway databases

    Reactomei REACT_18283. G alpha (q) signalling events.
    REACT_19231. G alpha (i) signalling events.
    REACT_21264. Formyl peptide receptors bind formyl peptides and many other ligands.

    Miscellaneous databases

    GeneWikii Formyl_peptide_receptor_2.
    GenomeRNAii 2358.
    NextBioi 9565.
    PROi P25090.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P25090.
    Bgeei P25090.
    CleanExi HS_FPR2.
    Genevestigatori P25090.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR027347. Formyl_pep_2/3_rcpt.
    IPR000826. Formyl_rcpt-rel.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24225. PTHR24225. 1 hit.
    PTHR24225:SF16. PTHR24225:SF16. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19."
      Bao L., Gerard N.P., Eddy R.L. Jr., Shows T.B., Gerard C.
      Genomics 13:437-440(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Cloning of a cDNA encoding a receptor related to the formyl peptide receptor of human neutrophils."
      Perez H.D., Holmes R., Kelly E., McClary J., Andrews W.H.
      Gene 118:303-304(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Bone marrow.
    3. "Isolation of a cDNA that encodes a novel granulocyte N-formyl peptide receptor."
      Ye R.D., Cavanagh S.L., Quehenberger O., Prossnitz E.R., Cochrane C.G.
      Biochem. Biophys. Res. Commun. 184:582-589(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Granulocyte.
    4. "A structural homologue of the N-formyl peptide receptor. Characterization and chromosome mapping of a peptide chemoattractant receptor family."
      Murphy P.M., Ozcelik T., Kenney R.T., Tiffany H.L., McDermott D., Francke U.
      J. Biol. Chem. 267:7637-7643(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    5. "Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors."
      Nomura H., Nielsen B.W., Matsushima K.
      Int. Immunol. 5:1239-1249(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Monocyte.
    6. Maddox J.F., Hachicha M., Takano T., Petasis N.A., Fokin V.V., Serhan C.N.
      Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    7. "Identification of a human enterocyte lipoxin A4 receptor that is regulated by interleukin (IL)-13 and interferon gamma and inhibits tumor necrosis factor alpha-induced IL-8 release."
      Gronert K., Gewirtz A., Madara J.L., Serhan C.N.
      J. Exp. Med. 187:1285-1294(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    8. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Kopatz S.A., Aronstam R.S., Sharma S.V.
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    9. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Heart.
    10. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    11. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    12. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Blood.
    13. "Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues are potent inhibitors of acute inflammation: evidence for anti-inflammatory receptors."
      Takano T., Fiore S., Maddox J.F., Brady H.R., Petasis N.A., Serhan C.N.
      J. Exp. Med. 185:1693-1704(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiFPR2_HUMAN
    AccessioniPrimary (citable) accession number: P25090
    Secondary accession number(s): A8K3E2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 138 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3