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Protein

N-formyl peptide receptor 3

Gene

FPR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

  • complement receptor activity Source: GO_Central
  • N-formyl peptide receptor activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Chemotaxis

Enzyme and pathway databases

ReactomeiR-HSA-418594. G alpha (i) signalling events.
R-HSA-444473. Formyl peptide receptors bind formyl peptides and many other ligands.

Names & Taxonomyi

Protein namesi
Recommended name:
N-formyl peptide receptor 3
Alternative name(s):
FMLP-related receptor II
Short name:
FMLP-R-II
Formyl peptide receptor-like 2
Gene namesi
Name:FPR3
Synonyms:FPRH1, FPRL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:3828. FPR3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
Transmembranei28 – 50Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini51 – 61CytoplasmicSequence analysisAdd BLAST11
Transmembranei62 – 83Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini84 – 100ExtracellularSequence analysisAdd BLAST17
Transmembranei101 – 121Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini122 – 140CytoplasmicSequence analysisAdd BLAST19
Transmembranei141 – 162Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini163 – 205ExtracellularSequence analysisAdd BLAST43
Transmembranei206 – 226Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini227 – 242CytoplasmicSequence analysisAdd BLAST16
Transmembranei243 – 266Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini267 – 286ExtracellularSequence analysisAdd BLAST20
Transmembranei287 – 306Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini307 – 353CytoplasmicSequence analysisAdd BLAST47

GO - Cellular componenti

  • integral component of membrane Source: ProtInc
  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2359.
OpenTargetsiENSG00000187474.
PharmGKBiPA162388910.

Chemistry databases

GuidetoPHARMACOLOGYi224.

Polymorphism and mutation databases

BioMutaiFPR3.
DMDMi38258904.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000694571 – 353N-formyl peptide receptor 3Add BLAST353

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...)Sequence analysis1
Glycosylationi10N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi98 ↔ 176PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP25089.
PeptideAtlasiP25089.
PRIDEiP25089.
TopDownProteomicsiP25089.

PTM databases

iPTMnetiP25089.
PhosphoSitePlusiP25089.

Expressioni

Gene expression databases

BgeeiENSG00000187474.
CleanExiHS_FPR3.
ExpressionAtlasiP25089. baseline and differential.
GenevisibleiP25089. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000341821.

Chemistry databases

BindingDBiP25089.

Structurei

3D structure databases

ProteinModelPortaliP25089.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGAX. Eukaryota.
ENOG410XQ5U. LUCA.
GeneTreeiENSGT00760000118990.
HOGENOMiHOG000234122.
HOVERGENiHBG107927.
InParanoidiP25089.
KOiK04173.
OMAiVAMREKW.
OrthoDBiEOG091G09ZK.
PhylomeDBiP25089.
TreeFamiTF330976.

Family and domain databases

InterProiIPR027347. Formyl_pep_2/3_rcpt.
IPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 1 hit.
PTHR24225:SF16. PTHR24225:SF16. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25089-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METNFSIPLN ETEEVLPEPA GHTVLWIFSL LVHGVTFVFG VLGNGLVIWV
60 70 80 90 100
AGFRMTRTVN TICYLNLALA DFSFSAILPF RMVSVAMREK WPFGSFLCKL
110 120 130 140 150
VHVMIDINLF VSVYLITIIA LDRCICVLHP AWAQNHRTMS LAKRVMTGLW
160 170 180 190 200
IFTIVLTLPN FIFWTTISTT NGDTYCIFNF AFWGDTAVER LNVFITMAKV
210 220 230 240 250
FLILHFIIGF SVPMSIITVC YGIIAAKIHR NHMIKSSRPL RVFAAVVASF
260 270 280 290 300
FICWFPYELI GILMAVWLKE MLLNGKYKII LVLINPTSSL AFFNSCLNPI
310 320 330 340 350
LYVFMGRNFQ ERLIRSLPTS LERALTEVPD SAQTSNTDTT SASPPEETEL

QAM
Length:353
Mass (Da):39,965
Last modified:November 7, 2003 - v2
Checksum:iFFB7150B6A833F4C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti94G → A in AAA58482 (PubMed:1612600).Curated1
Sequence conflicti211S → T in AAA58482 (PubMed:1612600).Curated1
Sequence conflicti338D → H in AAA58482 (PubMed:1612600).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M76673 mRNA. Translation: AAA58482.1.
L14061 Genomic DNA. Translation: AAA52474.1.
AY262690 Genomic DNA. Translation: AAP20654.1.
BC059388 mRNA. Translation: AAH59388.1.
BC069070 mRNA. Translation: AAH69070.1.
BC069593 mRNA. Translation: AAH69593.1.
BC069812 mRNA. Translation: AAH69812.1.
CCDSiCCDS12841.1.
PIRiC42009.
RefSeqiNP_002021.3. NM_002030.4.
XP_011524989.1. XM_011526687.2.
UniGeneiHs.445466.

Genome annotation databases

EnsembliENST00000339223; ENSP00000341821; ENSG00000187474.
ENST00000595991; ENSP00000470471; ENSG00000187474.
GeneIDi2359.
KEGGihsa:2359.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M76673 mRNA. Translation: AAA58482.1.
L14061 Genomic DNA. Translation: AAA52474.1.
AY262690 Genomic DNA. Translation: AAP20654.1.
BC059388 mRNA. Translation: AAH59388.1.
BC069070 mRNA. Translation: AAH69070.1.
BC069593 mRNA. Translation: AAH69593.1.
BC069812 mRNA. Translation: AAH69812.1.
CCDSiCCDS12841.1.
PIRiC42009.
RefSeqiNP_002021.3. NM_002030.4.
XP_011524989.1. XM_011526687.2.
UniGeneiHs.445466.

3D structure databases

ProteinModelPortaliP25089.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000341821.

Chemistry databases

BindingDBiP25089.
GuidetoPHARMACOLOGYi224.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP25089.
PhosphoSitePlusiP25089.

Polymorphism and mutation databases

BioMutaiFPR3.
DMDMi38258904.

Proteomic databases

PaxDbiP25089.
PeptideAtlasiP25089.
PRIDEiP25089.
TopDownProteomicsiP25089.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339223; ENSP00000341821; ENSG00000187474.
ENST00000595991; ENSP00000470471; ENSG00000187474.
GeneIDi2359.
KEGGihsa:2359.

Organism-specific databases

CTDi2359.
DisGeNETi2359.
GeneCardsiFPR3.
HGNCiHGNC:3828. FPR3.
MIMi136539. gene.
neXtProtiNX_P25089.
OpenTargetsiENSG00000187474.
PharmGKBiPA162388910.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGAX. Eukaryota.
ENOG410XQ5U. LUCA.
GeneTreeiENSGT00760000118990.
HOGENOMiHOG000234122.
HOVERGENiHBG107927.
InParanoidiP25089.
KOiK04173.
OMAiVAMREKW.
OrthoDBiEOG091G09ZK.
PhylomeDBiP25089.
TreeFamiTF330976.

Enzyme and pathway databases

ReactomeiR-HSA-418594. G alpha (i) signalling events.
R-HSA-444473. Formyl peptide receptors bind formyl peptides and many other ligands.

Miscellaneous databases

GeneWikiiFormyl_peptide_receptor_3.
GenomeRNAii2359.
PROiP25089.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000187474.
CleanExiHS_FPR3.
ExpressionAtlasiP25089. baseline and differential.
GenevisibleiP25089. HS.

Family and domain databases

InterProiIPR027347. Formyl_pep_2/3_rcpt.
IPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 1 hit.
PTHR24225:SF16. PTHR24225:SF16. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFPR3_HUMAN
AccessioniPrimary (citable) accession number: P25089
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: November 7, 2003
Last modified: November 2, 2016
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.