P25089 (FPR3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-formyl peptide receptor 3

Alternative name(s):
FMLP-related receptor II
Short name=FMLP-R-II
Formyl peptide receptor-like 2

Gene names

Name:	FPR3
Synonyms:	FPRH1, FPRL2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	353 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Chemotaxis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell migration Inferred from electronic annotation. Source: InterPro cellular component movement Traceable author statement Ref.2. Source: ProtInc chemotaxis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Traceable author statement Ref.2. Source: ProtInc plasma membrane Traceable author statement. Source: Reactome
Molecular_function	N-formyl peptide receptor activity Traceable author statement Ref.2. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 353	353	N-formyl peptide receptor 3		PRO_0000069457
Regions
	Topological domain	1 – 27	27	Extracellular Potential
	Transmembrane	28 – 50	23	Helical; Name=1; Potential
	Topological domain	51 – 61	11	Cytoplasmic Potential
	Transmembrane	62 – 83	22	Helical; Name=2; Potential
	Topological domain	84 – 100	17	Extracellular Potential
	Transmembrane	101 – 121	21	Helical; Name=3; Potential
	Topological domain	122 – 140	19	Cytoplasmic Potential
	Transmembrane	141 – 162	22	Helical; Name=4; Potential
	Topological domain	163 – 205	43	Extracellular Potential
	Transmembrane	206 – 226	21	Helical; Name=5; Potential
	Topological domain	227 – 242	16	Cytoplasmic Potential
	Transmembrane	243 – 266	24	Helical; Name=6; Potential
	Topological domain	267 – 286	20	Extracellular Potential
	Transmembrane	287 – 306	20	Helical; Name=7; Potential
	Topological domain	307 – 353	47	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	4	1	N-linked (GlcNAc...) Potential
	Glycosylation	10	1	N-linked (GlcNAc...) Potential
	Disulfide bond	98 ↔ 176		Potential
Experimental info
	Sequence conflict	94	1	G → A in AAA58482. Ref.1
	Sequence conflict	211	1	S → T in AAA58482. Ref.1
	Sequence conflict	338	1	D → H in AAA58482. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P25089 [UniParc]. Last modified November 7, 2003. Version 2. Checksum: FFB7150B6A833F4C	FASTA	353	39,965
	10 20 30 40 50 60 METNFSIPLN ETEEVLPEPA GHTVLWIFSL LVHGVTFVFG VLGNGLVIWV AGFRMTRTVN 70 80 90 100 110 120 TICYLNLALA DFSFSAILPF RMVSVAMREK WPFGSFLCKL VHVMIDINLF VSVYLITIIA 130 140 150 160 170 180 LDRCICVLHP AWAQNHRTMS LAKRVMTGLW IFTIVLTLPN FIFWTTISTT NGDTYCIFNF 190 200 210 220 230 240 AFWGDTAVER LNVFITMAKV FLILHFIIGF SVPMSIITVC YGIIAAKIHR NHMIKSSRPL 250 260 270 280 290 300 RVFAAVVASF FICWFPYELI GILMAVWLKE MLLNGKYKII LVLINPTSSL AFFNSCLNPI 310 320 330 340 350 LYVFMGRNFQ ERLIRSLPTS LERALTEVPD SAQTSNTDTT SASPPEETEL QAM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19." Bao L., Gerard N.P., Eddy R.L. Jr., Shows T.B., Gerard C. Genomics 13:437-440(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Differential expression of members of the N-formylpeptide receptor gene cluster in human phagocytes." Durstin M., Gao J.-L., Tiffany H.L., McDermott D., Murphy P.M. Biochem. Biophys. Res. Commun. 201:174-179(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Kopatz S.A., Aronstam R.S., Sharma S.V. Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M76673 mRNA. Translation: AAA58482.1. L14061 Genomic DNA. Translation: AAA52474.1. AY262690 Genomic DNA. Translation: AAP20654.1. BC059388 mRNA. Translation: AAH59388.1. BC069070 mRNA. Translation: AAH69070.1. BC069593 mRNA. Translation: AAH69593.1. BC069812 mRNA. Translation: AAH69812.1.
IPI	IPI00012478.
PIR	C42009.
RefSeq	NP_002021.3. NM_002030.3.
UniGene	Hs.445466.
3D structure databases
ProteinModelPortal	P25089.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000341821.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P25089.
Polymorphism databases
DMDM	38258904.
Proteomic databases
PRIDE	P25089.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000339223; ENSP00000341821; ENSG00000187474. ENST00000595991; ENSP00000470471; ENSG00000187474.
GeneID	2359.
KEGG	hsa:2359.
UCSC	uc002pxt.1. human.
Organism-specific databases
CTD	2359.
GeneCards	GC19P052298.
HGNC	HGNC:3828. FPR3.
MIM	136539. gene.
neXtProt	NX_P25089.
PharmGKB	PA162388910.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG150376.
HOGENOM	HOG000234122.
HOVERGEN	HBG107927.
InParanoid	P25089.
KO	K04173.
OMA	VAMREKW.
OrthoDB	EOG4SQWWZ.
PhylomeDB	P25089.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	P25089.
Bgee	P25089.
CleanEx	HS_FPR3.
Genevestigator	P25089.
GermOnline	ENSG00000187474. Homo sapiens.
Family and domain databases
InterPro	IPR027347. Formyl_pep_3_rcpt. IPR000826. Formyl_pep_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
PANTHER	PTHR24225. PTHR24225. 1 hit. PTHR24225:SF16. PTHR24225:SF16. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00526. FMETLEUPHER. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P25089.
GenomeRNAi	2359.
NextBio	9571.
SOURCE	Search...

Entry information

Entry name

FPR3_HUMAN

Accession

Primary (citable) accession number: P25089

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1992
Last sequence update:	November 7, 2003
Last modified:	May 1, 2013
This is version 113 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.