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P25089 (FPR3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 125. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
N-formyl peptide receptor 3
Alternative name(s):
FMLP-related receptor II
Short name=FMLP-R-II
Formyl peptide receptor-like 2
Gene names
Name:FPR3
Synonyms:FPRH1, FPRL2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length353 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 353353N-formyl peptide receptor 3
PRO_0000069457

Regions

Topological domain1 – 2727Extracellular Potential
Transmembrane28 – 5023Helical; Name=1; Potential
Topological domain51 – 6111Cytoplasmic Potential
Transmembrane62 – 8322Helical; Name=2; Potential
Topological domain84 – 10017Extracellular Potential
Transmembrane101 – 12121Helical; Name=3; Potential
Topological domain122 – 14019Cytoplasmic Potential
Transmembrane141 – 16222Helical; Name=4; Potential
Topological domain163 – 20543Extracellular Potential
Transmembrane206 – 22621Helical; Name=5; Potential
Topological domain227 – 24216Cytoplasmic Potential
Transmembrane243 – 26624Helical; Name=6; Potential
Topological domain267 – 28620Extracellular Potential
Transmembrane287 – 30620Helical; Name=7; Potential
Topological domain307 – 35347Cytoplasmic Potential

Amino acid modifications

Glycosylation41N-linked (GlcNAc...) Potential
Glycosylation101N-linked (GlcNAc...) Potential
Disulfide bond98 ↔ 176 Potential

Experimental info

Sequence conflict941G → A in AAA58482. Ref.1
Sequence conflict2111S → T in AAA58482. Ref.1
Sequence conflict3381D → H in AAA58482. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P25089 [UniParc].

Last modified November 7, 2003. Version 2.
Checksum: FFB7150B6A833F4C

FASTA35339,965
        10         20         30         40         50         60 
METNFSIPLN ETEEVLPEPA GHTVLWIFSL LVHGVTFVFG VLGNGLVIWV AGFRMTRTVN 

        70         80         90        100        110        120 
TICYLNLALA DFSFSAILPF RMVSVAMREK WPFGSFLCKL VHVMIDINLF VSVYLITIIA 

       130        140        150        160        170        180 
LDRCICVLHP AWAQNHRTMS LAKRVMTGLW IFTIVLTLPN FIFWTTISTT NGDTYCIFNF 

       190        200        210        220        230        240 
AFWGDTAVER LNVFITMAKV FLILHFIIGF SVPMSIITVC YGIIAAKIHR NHMIKSSRPL 

       250        260        270        280        290        300 
RVFAAVVASF FICWFPYELI GILMAVWLKE MLLNGKYKII LVLINPTSSL AFFNSCLNPI 

       310        320        330        340        350 
LYVFMGRNFQ ERLIRSLPTS LERALTEVPD SAQTSNTDTT SASPPEETEL QAM 

« Hide

References

« Hide 'large scale' references
[1]"Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19."
Bao L., Gerard N.P., Eddy R.L. Jr., Shows T.B., Gerard C.
Genomics 13:437-440(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Differential expression of members of the N-formylpeptide receptor gene cluster in human phagocytes."
Durstin M., Gao J.-L., Tiffany H.L., McDermott D., Murphy P.M.
Biochem. Biophys. Res. Commun. 201:174-179(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Kopatz S.A., Aronstam R.S., Sharma S.V.
Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M76673 mRNA. Translation: AAA58482.1.
L14061 Genomic DNA. Translation: AAA52474.1.
AY262690 Genomic DNA. Translation: AAP20654.1.
BC059388 mRNA. Translation: AAH59388.1.
BC069070 mRNA. Translation: AAH69070.1.
BC069593 mRNA. Translation: AAH69593.1.
BC069812 mRNA. Translation: AAH69812.1.
CCDSCCDS12841.1.
PIRC42009.
RefSeqNP_002021.3. NM_002030.3.
UniGeneHs.445466.

3D structure databases

ProteinModelPortalP25089.
SMRP25089. Positions 4-344.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000341821.

Chemistry

BindingDBP25089.
GuidetoPHARMACOLOGY224.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP25089.

Polymorphism databases

DMDM38258904.

Proteomic databases

PRIDEP25089.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000339223; ENSP00000341821; ENSG00000187474.
ENST00000595991; ENSP00000470471; ENSG00000187474.
GeneID2359.
KEGGhsa:2359.
UCSCuc002pxt.1. human.

Organism-specific databases

CTD2359.
GeneCardsGC19P052298.
HGNCHGNC:3828. FPR3.
MIM136539. gene.
neXtProtNX_P25089.
PharmGKBPA162388910.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG150376.
HOGENOMHOG000234122.
HOVERGENHBG107927.
InParanoidP25089.
KOK04173.
OMATVSTICY.
OrthoDBEOG77DJ6B.
PhylomeDBP25089.
TreeFamTF330976.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressP25089.
BgeeP25089.
CleanExHS_FPR3.
GenevestigatorP25089.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR027347. Formyl_pep_2/3_rcpt.
IPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24225. PTHR24225. 1 hit.
PTHR24225:SF16. PTHR24225:SF16. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiFormyl_peptide_receptor_3.
GenomeRNAi2359.
NextBio9571.
PROP25089.
SOURCESearch...

Entry information

Entry nameFPR3_HUMAN
AccessionPrimary (citable) accession number: P25089
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: November 7, 2003
Last modified: July 9, 2014
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries