Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P25089

- FPR3_HUMAN

UniProt

P25089 - FPR3_HUMAN

Protein

N-formyl peptide receptor 3

Gene

FPR3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 2 (07 Nov 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system.

    GO - Molecular functioni

    1. N-formyl peptide receptor activity Source: ProtInc

    GO - Biological processi

    1. cellular component movement Source: ProtInc
    2. chemotaxis Source: UniProtKB-KW
    3. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Chemotaxis

    Enzyme and pathway databases

    ReactomeiREACT_19231. G alpha (i) signalling events.
    REACT_21264. Formyl peptide receptors bind formyl peptides and many other ligands.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N-formyl peptide receptor 3
    Alternative name(s):
    FMLP-related receptor II
    Short name:
    FMLP-R-II
    Formyl peptide receptor-like 2
    Gene namesi
    Name:FPR3
    Synonyms:FPRH1, FPRL2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:3828. FPR3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: ProtInc
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162388910.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 353353N-formyl peptide receptor 3PRO_0000069457Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi98 ↔ 176PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP25089.

    PTM databases

    PhosphoSiteiP25089.

    Expressioni

    Gene expression databases

    ArrayExpressiP25089.
    BgeeiP25089.
    CleanExiHS_FPR3.
    GenevestigatoriP25089.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000341821.

    Structurei

    3D structure databases

    ProteinModelPortaliP25089.
    SMRiP25089. Positions 4-344.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2727ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini51 – 6111CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini84 – 10017ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini122 – 14019CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini163 – 20543ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini227 – 24216CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini267 – 28620ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini307 – 35347CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei28 – 5023Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei62 – 8322Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei101 – 12121Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei141 – 16222Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei206 – 22621Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei243 – 26624Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei287 – 30620Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG150376.
    HOGENOMiHOG000234122.
    HOVERGENiHBG107927.
    InParanoidiP25089.
    KOiK04173.
    OMAiTVSTICY.
    OrthoDBiEOG77DJ6B.
    PhylomeDBiP25089.
    TreeFamiTF330976.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR027347. Formyl_pep_2/3_rcpt.
    IPR000826. Formyl_rcpt-rel.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24225. PTHR24225. 1 hit.
    PTHR24225:SF16. PTHR24225:SF16. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P25089-1 [UniParc]FASTAAdd to Basket

    « Hide

    METNFSIPLN ETEEVLPEPA GHTVLWIFSL LVHGVTFVFG VLGNGLVIWV    50
    AGFRMTRTVN TICYLNLALA DFSFSAILPF RMVSVAMREK WPFGSFLCKL 100
    VHVMIDINLF VSVYLITIIA LDRCICVLHP AWAQNHRTMS LAKRVMTGLW 150
    IFTIVLTLPN FIFWTTISTT NGDTYCIFNF AFWGDTAVER LNVFITMAKV 200
    FLILHFIIGF SVPMSIITVC YGIIAAKIHR NHMIKSSRPL RVFAAVVASF 250
    FICWFPYELI GILMAVWLKE MLLNGKYKII LVLINPTSSL AFFNSCLNPI 300
    LYVFMGRNFQ ERLIRSLPTS LERALTEVPD SAQTSNTDTT SASPPEETEL 350
    QAM 353
    Length:353
    Mass (Da):39,965
    Last modified:November 7, 2003 - v2
    Checksum:iFFB7150B6A833F4C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti94 – 941G → A in AAA58482. (PubMed:1612600)Curated
    Sequence conflicti211 – 2111S → T in AAA58482. (PubMed:1612600)Curated
    Sequence conflicti338 – 3381D → H in AAA58482. (PubMed:1612600)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M76673 mRNA. Translation: AAA58482.1.
    L14061 Genomic DNA. Translation: AAA52474.1.
    AY262690 Genomic DNA. Translation: AAP20654.1.
    BC059388 mRNA. Translation: AAH59388.1.
    BC069070 mRNA. Translation: AAH69070.1.
    BC069593 mRNA. Translation: AAH69593.1.
    BC069812 mRNA. Translation: AAH69812.1.
    CCDSiCCDS12841.1.
    PIRiC42009.
    RefSeqiNP_002021.3. NM_002030.3.
    UniGeneiHs.445466.

    Genome annotation databases

    EnsembliENST00000339223; ENSP00000341821; ENSG00000187474.
    ENST00000595991; ENSP00000470471; ENSG00000187474.
    GeneIDi2359.
    KEGGihsa:2359.
    UCSCiuc002pxt.1. human.

    Polymorphism databases

    DMDMi38258904.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M76673 mRNA. Translation: AAA58482.1 .
    L14061 Genomic DNA. Translation: AAA52474.1 .
    AY262690 Genomic DNA. Translation: AAP20654.1 .
    BC059388 mRNA. Translation: AAH59388.1 .
    BC069070 mRNA. Translation: AAH69070.1 .
    BC069593 mRNA. Translation: AAH69593.1 .
    BC069812 mRNA. Translation: AAH69812.1 .
    CCDSi CCDS12841.1.
    PIRi C42009.
    RefSeqi NP_002021.3. NM_002030.3.
    UniGenei Hs.445466.

    3D structure databases

    ProteinModelPortali P25089.
    SMRi P25089. Positions 4-344.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000341821.

    Chemistry

    BindingDBi P25089.
    GuidetoPHARMACOLOGYi 224.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P25089.

    Polymorphism databases

    DMDMi 38258904.

    Proteomic databases

    PRIDEi P25089.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000339223 ; ENSP00000341821 ; ENSG00000187474 .
    ENST00000595991 ; ENSP00000470471 ; ENSG00000187474 .
    GeneIDi 2359.
    KEGGi hsa:2359.
    UCSCi uc002pxt.1. human.

    Organism-specific databases

    CTDi 2359.
    GeneCardsi GC19P052298.
    HGNCi HGNC:3828. FPR3.
    MIMi 136539. gene.
    neXtProti NX_P25089.
    PharmGKBi PA162388910.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG150376.
    HOGENOMi HOG000234122.
    HOVERGENi HBG107927.
    InParanoidi P25089.
    KOi K04173.
    OMAi TVSTICY.
    OrthoDBi EOG77DJ6B.
    PhylomeDBi P25089.
    TreeFami TF330976.

    Enzyme and pathway databases

    Reactomei REACT_19231. G alpha (i) signalling events.
    REACT_21264. Formyl peptide receptors bind formyl peptides and many other ligands.

    Miscellaneous databases

    GeneWikii Formyl_peptide_receptor_3.
    GenomeRNAii 2359.
    NextBioi 9571.
    PROi P25089.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P25089.
    Bgeei P25089.
    CleanExi HS_FPR3.
    Genevestigatori P25089.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR027347. Formyl_pep_2/3_rcpt.
    IPR000826. Formyl_rcpt-rel.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24225. PTHR24225. 1 hit.
    PTHR24225:SF16. PTHR24225:SF16. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19."
      Bao L., Gerard N.P., Eddy R.L. Jr., Shows T.B., Gerard C.
      Genomics 13:437-440(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Differential expression of members of the N-formylpeptide receptor gene cluster in human phagocytes."
      Durstin M., Gao J.-L., Tiffany H.L., McDermott D., Murphy P.M.
      Biochem. Biophys. Res. Commun. 201:174-179(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Kopatz S.A., Aronstam R.S., Sharma S.V.
      Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.

    Entry informationi

    Entry nameiFPR3_HUMAN
    AccessioniPrimary (citable) accession number: P25089
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: November 7, 2003
    Last modified: October 1, 2014
    This is version 127 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3