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P25089

- FPR3_HUMAN

UniProt

P25089 - FPR3_HUMAN

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Protein

N-formyl peptide receptor 3

Gene

FPR3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

  1. N-formyl peptide receptor activity Source: ProtInc

GO - Biological processi

  1. cellular component movement Source: ProtInc
  2. chemotaxis Source: UniProtKB-KW
  3. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Chemotaxis

Enzyme and pathway databases

ReactomeiREACT_19231. G alpha (i) signalling events.
REACT_21264. Formyl peptide receptors bind formyl peptides and many other ligands.

Names & Taxonomyi

Protein namesi
Recommended name:
N-formyl peptide receptor 3
Alternative name(s):
FMLP-related receptor II
Short name:
FMLP-R-II
Formyl peptide receptor-like 2
Gene namesi
Name:FPR3
Synonyms:FPRH1, FPRL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:3828. FPR3.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: ProtInc
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162388910.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 353353N-formyl peptide receptor 3PRO_0000069457Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi98 ↔ 176PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP25089.

PTM databases

PhosphoSiteiP25089.

Expressioni

Gene expression databases

BgeeiP25089.
CleanExiHS_FPR3.
ExpressionAtlasiP25089. baseline and differential.
GenevestigatoriP25089.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000341821.

Structurei

3D structure databases

ProteinModelPortaliP25089.
SMRiP25089. Positions 4-344.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727ExtracellularSequence AnalysisAdd
BLAST
Topological domaini51 – 6111CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini84 – 10017ExtracellularSequence AnalysisAdd
BLAST
Topological domaini122 – 14019CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini163 – 20543ExtracellularSequence AnalysisAdd
BLAST
Topological domaini227 – 24216CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini267 – 28620ExtracellularSequence AnalysisAdd
BLAST
Topological domaini307 – 35347CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei28 – 5023Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei62 – 8322Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei101 – 12121Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei141 – 16222Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei206 – 22621Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei243 – 26624Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei287 – 30620Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG150376.
HOGENOMiHOG000234122.
HOVERGENiHBG107927.
InParanoidiP25089.
KOiK04173.
OMAiTVSTICY.
OrthoDBiEOG77DJ6B.
PhylomeDBiP25089.
TreeFamiTF330976.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR027347. Formyl_pep_2/3_rcpt.
IPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 1 hit.
PTHR24225:SF16. PTHR24225:SF16. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25089-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
METNFSIPLN ETEEVLPEPA GHTVLWIFSL LVHGVTFVFG VLGNGLVIWV
60 70 80 90 100
AGFRMTRTVN TICYLNLALA DFSFSAILPF RMVSVAMREK WPFGSFLCKL
110 120 130 140 150
VHVMIDINLF VSVYLITIIA LDRCICVLHP AWAQNHRTMS LAKRVMTGLW
160 170 180 190 200
IFTIVLTLPN FIFWTTISTT NGDTYCIFNF AFWGDTAVER LNVFITMAKV
210 220 230 240 250
FLILHFIIGF SVPMSIITVC YGIIAAKIHR NHMIKSSRPL RVFAAVVASF
260 270 280 290 300
FICWFPYELI GILMAVWLKE MLLNGKYKII LVLINPTSSL AFFNSCLNPI
310 320 330 340 350
LYVFMGRNFQ ERLIRSLPTS LERALTEVPD SAQTSNTDTT SASPPEETEL

QAM
Length:353
Mass (Da):39,965
Last modified:November 7, 2003 - v2
Checksum:iFFB7150B6A833F4C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti94 – 941G → A in AAA58482. (PubMed:1612600)Curated
Sequence conflicti211 – 2111S → T in AAA58482. (PubMed:1612600)Curated
Sequence conflicti338 – 3381D → H in AAA58482. (PubMed:1612600)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M76673 mRNA. Translation: AAA58482.1.
L14061 Genomic DNA. Translation: AAA52474.1.
AY262690 Genomic DNA. Translation: AAP20654.1.
BC059388 mRNA. Translation: AAH59388.1.
BC069070 mRNA. Translation: AAH69070.1.
BC069593 mRNA. Translation: AAH69593.1.
BC069812 mRNA. Translation: AAH69812.1.
CCDSiCCDS12841.1.
PIRiC42009.
RefSeqiNP_002021.3. NM_002030.3.
UniGeneiHs.445466.

Genome annotation databases

EnsembliENST00000339223; ENSP00000341821; ENSG00000187474.
ENST00000595991; ENSP00000470471; ENSG00000187474.
GeneIDi2359.
KEGGihsa:2359.
UCSCiuc002pxt.1. human.

Polymorphism databases

DMDMi38258904.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M76673 mRNA. Translation: AAA58482.1 .
L14061 Genomic DNA. Translation: AAA52474.1 .
AY262690 Genomic DNA. Translation: AAP20654.1 .
BC059388 mRNA. Translation: AAH59388.1 .
BC069070 mRNA. Translation: AAH69070.1 .
BC069593 mRNA. Translation: AAH69593.1 .
BC069812 mRNA. Translation: AAH69812.1 .
CCDSi CCDS12841.1.
PIRi C42009.
RefSeqi NP_002021.3. NM_002030.3.
UniGenei Hs.445466.

3D structure databases

ProteinModelPortali P25089.
SMRi P25089. Positions 4-344.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000341821.

Chemistry

BindingDBi P25089.
GuidetoPHARMACOLOGYi 224.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P25089.

Polymorphism databases

DMDMi 38258904.

Proteomic databases

PRIDEi P25089.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000339223 ; ENSP00000341821 ; ENSG00000187474 .
ENST00000595991 ; ENSP00000470471 ; ENSG00000187474 .
GeneIDi 2359.
KEGGi hsa:2359.
UCSCi uc002pxt.1. human.

Organism-specific databases

CTDi 2359.
GeneCardsi GC19P052298.
HGNCi HGNC:3828. FPR3.
MIMi 136539. gene.
neXtProti NX_P25089.
PharmGKBi PA162388910.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG150376.
HOGENOMi HOG000234122.
HOVERGENi HBG107927.
InParanoidi P25089.
KOi K04173.
OMAi TVSTICY.
OrthoDBi EOG77DJ6B.
PhylomeDBi P25089.
TreeFami TF330976.

Enzyme and pathway databases

Reactomei REACT_19231. G alpha (i) signalling events.
REACT_21264. Formyl peptide receptors bind formyl peptides and many other ligands.

Miscellaneous databases

GeneWikii Formyl_peptide_receptor_3.
GenomeRNAii 2359.
NextBioi 9571.
PROi P25089.
SOURCEi Search...

Gene expression databases

Bgeei P25089.
CleanExi HS_FPR3.
ExpressionAtlasi P25089. baseline and differential.
Genevestigatori P25089.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR027347. Formyl_pep_2/3_rcpt.
IPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24225. PTHR24225. 1 hit.
PTHR24225:SF16. PTHR24225:SF16. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19."
    Bao L., Gerard N.P., Eddy R.L. Jr., Shows T.B., Gerard C.
    Genomics 13:437-440(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Differential expression of members of the N-formylpeptide receptor gene cluster in human phagocytes."
    Durstin M., Gao J.-L., Tiffany H.L., McDermott D., Murphy P.M.
    Biochem. Biophys. Res. Commun. 201:174-179(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Kopatz S.A., Aronstam R.S., Sharma S.V.
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.

Entry informationi

Entry nameiFPR3_HUMAN
AccessioniPrimary (citable) accession number: P25089
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: November 7, 2003
Last modified: October 29, 2014
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3