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Protein

Interleukin-1 receptor antagonist protein

Gene

Il1rn

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity (By similarity).By similarity

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • interleukin-1, Type I receptor binding Source: RGD
  • interleukin-1 receptor binding Source: RGD

GO - Biological processi

  • carboxylic acid metabolic process Source: RGD
  • cellular response to norepinephrine stimulus Source: RGD
  • chronic inflammatory response to antigenic stimulus Source: RGD
  • cytokine-mediated signaling pathway Source: GO_Central
  • female pregnancy Source: RGD
  • fever generation Source: RGD
  • memory Source: RGD
  • negative regulation of apoptotic process Source: RGD
  • negative regulation of cell migration Source: RGD
  • negative regulation of cytokine-mediated signaling pathway Source: GOC
  • negative regulation of glutamate secretion Source: RGD
  • negative regulation of membrane potential Source: RGD
  • negative regulation of signal transduction Source: RGD
  • positive regulation of JUN kinase activity Source: RGD
  • response to activity Source: RGD
  • response to drug Source: RGD
  • response to interleukin-1 Source: RGD
  • response to interleukin-4 Source: RGD
  • response to lipopolysaccharide Source: RGD
  • response to organic cyclic compound Source: RGD
  • response to organonitrogen compound Source: RGD
  • response to starvation Source: RGD
  • sensory perception of pain Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 receptor antagonist protein
Short name:
IL-1RN
Short name:
IL-1ra
Short name:
IRAP
Alternative name(s):
IL1 inhibitor
Gene namesi
Name:Il1rn
Synonyms:Il-1ra
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621159. Il1rn.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626By similarityAdd
BLAST
Chaini27 – 178152Interleukin-1 receptor antagonist proteinPRO_0000015333Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi92 ↔ 142By similarity
Glycosylationi110 – 1101N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP25086.
PRIDEiP25086.

Expressioni

Gene expression databases

GenevisibleiP25086. RN.

Interactioni

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • interleukin-1, Type I receptor binding Source: RGD
  • interleukin-1 receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007949.

Structurei

3D structure databases

ProteinModelPortaliP25086.
SMRiP25086. Positions 28-178.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZQ4. Eukaryota.
ENOG41119SQ. LUCA.
HOGENOMiHOG000231506.
HOVERGENiHBG052099.
InParanoidiP25086.
KOiK05481.
OMAiIHGGKLC.
OrthoDBiEOG7X6M1M.
PhylomeDBiP25086.
TreeFamiTF300203.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR020877. IL-1_CS.
IPR000975. IL-1_fam.
IPR027166. IL-1RA.
IPR003297. IL-1RA/IL-36.
[Graphical view]
PANTHERiPTHR10078:SF21. PTHR10078:SF21. 1 hit.
PfamiPF00340. IL1. 1 hit.
[Graphical view]
PRINTSiPR00264. INTERLEUKIN1.
PR01360. INTRLEUKIN1X.
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00253. INTERLEUKIN_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25086-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEICRGPYSH LISLLLILLF RSESAGHPAG KRPCKMQAFR IWDTNQKTFY
60 70 80 90 100
LRNNQLIAGY LQGPNTKLEE KIDMVPIDFR NVFLGIHGGK LCLSCVKSGD
110 120 130 140 150
DTKLQLEEVN ITDLNKNKEE DKRFTFIRSE TGPTTSFESL ACPGWFLCTT
160 170
LEADHPVSLT NTPKEPCTVT KFYFQEDQ
Length:178
Mass (Da):20,282
Last modified:May 1, 1992 - v1
Checksum:iF3A5754FB6C51B03
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63101 Genomic DNA. Translation: AAA41434.1.
BC070930 mRNA. Translation: AAH70930.1.
PIRiC40956.
RefSeqiNP_071530.1. NM_022194.2.
UniGeneiRn.162640.

Genome annotation databases

GeneIDi60582.
KEGGirno:60582.
UCSCiRGD:621159. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63101 Genomic DNA. Translation: AAA41434.1.
BC070930 mRNA. Translation: AAH70930.1.
PIRiC40956.
RefSeqiNP_071530.1. NM_022194.2.
UniGeneiRn.162640.

3D structure databases

ProteinModelPortaliP25086.
SMRiP25086. Positions 28-178.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007949.

Proteomic databases

PaxDbiP25086.
PRIDEiP25086.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi60582.
KEGGirno:60582.
UCSCiRGD:621159. rat.

Organism-specific databases

CTDi3557.
RGDi621159. Il1rn.

Phylogenomic databases

eggNOGiENOG410IZQ4. Eukaryota.
ENOG41119SQ. LUCA.
HOGENOMiHOG000231506.
HOVERGENiHBG052099.
InParanoidiP25086.
KOiK05481.
OMAiIHGGKLC.
OrthoDBiEOG7X6M1M.
PhylomeDBiP25086.
TreeFamiTF300203.

Miscellaneous databases

PROiP25086.

Gene expression databases

GenevisibleiP25086. RN.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR020877. IL-1_CS.
IPR000975. IL-1_fam.
IPR027166. IL-1RA.
IPR003297. IL-1RA/IL-36.
[Graphical view]
PANTHERiPTHR10078:SF21. PTHR10078:SF21. 1 hit.
PfamiPF00340. IL1. 1 hit.
[Graphical view]
PRINTSiPR00264. INTERLEUKIN1.
PR01360. INTRLEUKIN1X.
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00253. INTERLEUKIN_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Interleukin 1 receptor antagonist is a member of the interleukin 1 gene family: evolution of a cytokine control mechanism."
    Eisenberg S.P., Brewer M.T., Verderber E., Heimdal P., Brandhuber B.J., Thompson R.C.
    Proc. Natl. Acad. Sci. U.S.A. 88:5232-5236(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiIL1RA_RAT
AccessioniPrimary (citable) accession number: P25086
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: July 6, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.