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P25085

- IL1RA_MOUSE

UniProt

P25085 - IL1RA_MOUSE

Protein

Interleukin-1 receptor antagonist protein

Gene

Il1rn

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (01 May 1992)
      Previous versions | rss
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    Functioni

    Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity.

    GO - Biological processi

    1. carboxylic acid metabolic process Source: Ensembl
    2. chronic inflammatory response to antigenic stimulus Source: Ensembl
    3. female pregnancy Source: Ensembl
    4. fever generation Source: Ensembl
    5. insulin secretion Source: MGI
    6. lipid metabolic process Source: MGI
    7. memory Source: Ensembl
    8. negative regulation of apoptotic process Source: Ensembl
    9. negative regulation of cell migration Source: Ensembl
    10. negative regulation of glutamate secretion Source: Ensembl
    11. negative regulation of heterotypic cell-cell adhesion Source: Ensembl
    12. negative regulation of interleukin-1-mediated signaling pathway Source: Ensembl
    13. negative regulation of membrane potential Source: Ensembl
    14. positive regulation of JUN kinase activity Source: Ensembl
    15. response to drug Source: Ensembl
    16. response to glucocorticoid Source: Ensembl
    17. response to interleukin-4 Source: Ensembl
    18. response to lipopolysaccharide Source: Ensembl
    19. response to organonitrogen compound Source: Ensembl

    Enzyme and pathway databases

    ReactomeiREACT_224208. Interleukin-1 signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-1 receptor antagonist protein
    Short name:
    IL-1RN
    Short name:
    IL-1ra
    Short name:
    IRAP
    Alternative name(s):
    IL1 inhibitor
    Gene namesi
    Name:Il1rn
    Synonyms:Il-1ra
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:96547. Il1rn.

    Subcellular locationi

    GO - Cellular componenti

    1. centrosome Source: Ensembl
    2. cytoplasm Source: UniProtKB-SubCell
    3. extracellular region Source: MGI
    4. extracellular space Source: Ensembl
    5. nucleus Source: Ensembl
    6. vesicle Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626By similarityAdd
    BLAST
    Chaini27 – 178152Interleukin-1 receptor antagonist proteinPRO_0000015330Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi92 ↔ 142By similarity
    Glycosylationi110 – 1101N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiP25085.
    PaxDbiP25085.
    PRIDEiP25085.

    Expressioni

    Gene expression databases

    ArrayExpressiP25085.
    BgeeiP25085.
    CleanExiMM_IL1RN.
    GenevestigatoriP25085.

    Structurei

    3D structure databases

    ProteinModelPortaliP25085.
    SMRiP25085. Positions 35-177.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IL-1 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG46710.
    HOGENOMiHOG000231506.
    HOVERGENiHBG052099.
    KOiK05481.
    OMAiIHGGKLC.
    OrthoDBiEOG7X6M1M.
    PhylomeDBiP25085.
    TreeFamiTF300203.

    Family and domain databases

    InterProiIPR008996. Cytokine_IL1-like.
    IPR020877. IL-1_CS.
    IPR000975. IL-1_fam.
    IPR027166. IL-1RA.
    IPR003297. IL-1RA/IL-36.
    [Graphical view]
    PANTHERiPTHR10078:SF6. PTHR10078:SF6. 1 hit.
    PfamiPF00340. IL1. 1 hit.
    [Graphical view]
    PRINTSiPR00264. INTERLEUKIN1.
    PR01360. INTRLEUKIN1X.
    SUPFAMiSSF50353. SSF50353. 1 hit.
    PROSITEiPS00253. INTERLEUKIN_1. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P25085-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEICWGPYSH LISLLLILLF HSEAACRPSG KRPCKMQAFR IWDTNQKTFY    50
    LRNNQLIAGY LQGPNIKLEE KIDMVPIDLH SVFLGIHGGK LCLSCAKSGD 100
    DIKLQLEEVN ITDLSKNKEE DKRFTFIRSE KGPTTSFESA ACPGWFLCTT 150
    LEADRPVSLT NTPEEPLIVT KFYFQEDQ 178
    Length:178
    Mass (Da):20,274
    Last modified:May 1, 1992 - v1
    Checksum:i84AA002A3119C024
    GO
    Isoform 2 (identifier: P25085-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-21: MEICWGPYSHLISLLLILLFH → MA

    Show »
    Length:159
    Mass (Da):17,996
    Checksum:iA7CD35D137846222
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 2121MEICW…ILLFH → MA in isoform 2. 1 PublicationVSP_002652Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M74294 mRNA. Translation: AAA39309.1.
    M64404 mRNA. Translation: AAA39277.1.
    L32838 Genomic DNA. Translation: AAA20576.1.
    AF001795 mRNA. Translation: AAC15251.1.
    M57525 mRNA. Translation: AAA39278.1.
    M63100 Genomic DNA. Translation: AAA39310.1.
    S64082 mRNA. Translation: AAB20265.1.
    CCDSiCCDS15736.1. [P25085-2]
    CCDS38064.1. [P25085-1]
    PIRiA44610.
    RefSeqiNP_001034790.1. NM_001039701.3. [P25085-1]
    NP_112444.1. NM_031167.5. [P25085-2]
    UniGeneiMm.882.

    Genome annotation databases

    EnsembliENSMUST00000114482; ENSMUSP00000110126; ENSMUSG00000026981. [P25085-1]
    ENSMUST00000114487; ENSMUSP00000110131; ENSMUSG00000026981. [P25085-2]
    GeneIDi16181.
    KEGGimmu:16181.
    UCSCiuc008iox.2. mouse. [P25085-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M74294 mRNA. Translation: AAA39309.1 .
    M64404 mRNA. Translation: AAA39277.1 .
    L32838 Genomic DNA. Translation: AAA20576.1 .
    AF001795 mRNA. Translation: AAC15251.1 .
    M57525 mRNA. Translation: AAA39278.1 .
    M63100 Genomic DNA. Translation: AAA39310.1 .
    S64082 mRNA. Translation: AAB20265.1 .
    CCDSi CCDS15736.1. [P25085-2 ]
    CCDS38064.1. [P25085-1 ]
    PIRi A44610.
    RefSeqi NP_001034790.1. NM_001039701.3. [P25085-1 ]
    NP_112444.1. NM_031167.5. [P25085-2 ]
    UniGenei Mm.882.

    3D structure databases

    ProteinModelPortali P25085.
    SMRi P25085. Positions 35-177.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    MaxQBi P25085.
    PaxDbi P25085.
    PRIDEi P25085.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000114482 ; ENSMUSP00000110126 ; ENSMUSG00000026981 . [P25085-1 ]
    ENSMUST00000114487 ; ENSMUSP00000110131 ; ENSMUSG00000026981 . [P25085-2 ]
    GeneIDi 16181.
    KEGGi mmu:16181.
    UCSCi uc008iox.2. mouse. [P25085-1 ]

    Organism-specific databases

    CTDi 3557.
    MGIi MGI:96547. Il1rn.

    Phylogenomic databases

    eggNOGi NOG46710.
    HOGENOMi HOG000231506.
    HOVERGENi HBG052099.
    KOi K05481.
    OMAi IHGGKLC.
    OrthoDBi EOG7X6M1M.
    PhylomeDBi P25085.
    TreeFami TF300203.

    Enzyme and pathway databases

    Reactomei REACT_224208. Interleukin-1 signaling.

    Miscellaneous databases

    NextBioi 289059.
    PROi P25085.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P25085.
    Bgeei P25085.
    CleanExi MM_IL1RN.
    Genevestigatori P25085.

    Family and domain databases

    InterProi IPR008996. Cytokine_IL1-like.
    IPR020877. IL-1_CS.
    IPR000975. IL-1_fam.
    IPR027166. IL-1RA.
    IPR003297. IL-1RA/IL-36.
    [Graphical view ]
    PANTHERi PTHR10078:SF6. PTHR10078:SF6. 1 hit.
    Pfami PF00340. IL1. 1 hit.
    [Graphical view ]
    PRINTSi PR00264. INTERLEUKIN1.
    PR01360. INTRLEUKIN1X.
    SUPFAMi SSF50353. SSF50353. 1 hit.
    PROSITEi PS00253. INTERLEUKIN_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse IL-1 receptor antagonist protein. Molecular characterization, gene mapping, and expression of mRNA in vitro and in vivo."
      Zahedi K., Seldin M.F., Rits M., Ezekowitz R.A., Whitehead A.S.
      J. Immunol. 146:4228-4233(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1).
    2. "Cloning and expression of murine interleukin-1 receptor antagonist in macrophages stimulated by colony-stimulating factor 1."
      Matsushime H., Roussel M.F., Matsushima K., Hishinuma A., Sherr C.J.
      Blood 78:616-623(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "The mouse interleukin 1 receptor antagonist protein: gene structure and regulation in vitro."
      Zahedi K.A., Uhlar C.M., Rits M., Prada A.E., Whitehead A.S.
      Cytokine 6:1-9(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
      Strain: Swiss.
    4. "Mouse IL-1 receptor antagonist isoforms: complementary DNA cloning and protein expression of intracellular isoform and tissue distribution of secreted and intracellular IL-1 receptor antagonist in vivo."
      Gabay C., Porter B., Fantuzzi G., Arend W.P.
      J. Immunol. 159:5905-5913(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Strain: FVB X DBA/1 LACJ.
    5. "Interleukin 1 receptor antagonist is a member of the interleukin 1 gene family: evolution of a cytokine control mechanism."
      Eisenberg S.P., Brewer M.T., Verderber E., Heimdal P., Brandhuber B.J., Thompson R.C.
      Proc. Natl. Acad. Sci. U.S.A. 88:5232-5236(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 7-178.
    6. "Cloning, heterologous expression and characterization of murine interleukin 1 receptor antagonist protein."
      Shuck M.E., Eessalu T.E., Tracey D.E., Bienkowski M.J.
      Eur. J. Immunol. 21:2775-2780(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 23-178.

    Entry informationi

    Entry nameiIL1RA_MOUSE
    AccessioniPrimary (citable) accession number: P25085
    Secondary accession number(s): O70207
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: May 1, 1992
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3