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P25085 (IL1RA_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-1 receptor antagonist protein

Short name=IL-1RN
Short name=IL-1ra
Short name=IRAP
Alternative name(s):
IL1 inhibitor
Gene names
Name:Il1rn
Synonyms:Il-1ra
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length178 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity.

Subcellular location

Isoform 1: Secreted.

Isoform 2: Cytoplasm.

Sequence similarities

Belongs to the IL-1 family.

Ontologies

Keywords
   Cellular componentCytoplasm
Secreted
   Coding sequence diversityAlternative splicing
   DomainSignal
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcarboxylic acid metabolic process

Inferred from electronic annotation. Source: Ensembl

chronic inflammatory response to antigenic stimulus

Inferred from electronic annotation. Source: Ensembl

female pregnancy

Inferred from electronic annotation. Source: Ensembl

fever generation

Inferred from electronic annotation. Source: Ensembl

insulin secretion

Inferred from mutant phenotype PubMed 12975454. Source: MGI

lipid metabolic process

Inferred from mutant phenotype PubMed 12975454. Source: MGI

memory

Inferred from electronic annotation. Source: Ensembl

negative regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell migration

Inferred from electronic annotation. Source: Ensembl

negative regulation of glutamate secretion

Inferred from electronic annotation. Source: Ensembl

negative regulation of heterotypic cell-cell adhesion

Inferred from electronic annotation. Source: Ensembl

negative regulation of interleukin-1-mediated signaling pathway

Inferred from electronic annotation. Source: Ensembl

negative regulation of membrane potential

Inferred from electronic annotation. Source: Ensembl

positive regulation of JUN kinase activity

Inferred from electronic annotation. Source: Ensembl

response to drug

Inferred from electronic annotation. Source: Ensembl

response to glucocorticoid

Inferred from electronic annotation. Source: Ensembl

response to interleukin-4

Inferred from electronic annotation. Source: Ensembl

response to lipopolysaccharide

Inferred from electronic annotation. Source: Ensembl

response to organonitrogen compound

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcentrosome

Inferred from electronic annotation. Source: Ensembl

cytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

extracellular region

Inferred from direct assay PubMed 15240711. Source: MGI

extracellular space

Inferred from electronic annotation. Source: Ensembl

nucleus

Inferred from electronic annotation. Source: Ensembl

vesicle

Inferred from direct assay PubMed 15240711. Source: MGI

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P25085-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P25085-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MEICWGPYSHLISLLLILLFH → MA

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 By similarity
Chain27 – 178152Interleukin-1 receptor antagonist protein
PRO_0000015330

Amino acid modifications

Glycosylation1101N-linked (GlcNAc...) Potential
Disulfide bond92 ↔ 142 By similarity

Natural variations

Alternative sequence1 – 2121MEICW…ILLFH → MA in isoform 2.
VSP_002652

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 1, 1992. Version 1.
Checksum: 84AA002A3119C024

FASTA17820,274
        10         20         30         40         50         60 
MEICWGPYSH LISLLLILLF HSEAACRPSG KRPCKMQAFR IWDTNQKTFY LRNNQLIAGY 

        70         80         90        100        110        120 
LQGPNIKLEE KIDMVPIDLH SVFLGIHGGK LCLSCAKSGD DIKLQLEEVN ITDLSKNKEE 

       130        140        150        160        170 
DKRFTFIRSE KGPTTSFESA ACPGWFLCTT LEADRPVSLT NTPEEPLIVT KFYFQEDQ 

« Hide

Isoform 2 [UniParc].

Checksum: A7CD35D137846222
Show »

FASTA15917,996

References

[1]"Mouse IL-1 receptor antagonist protein. Molecular characterization, gene mapping, and expression of mRNA in vitro and in vivo."
Zahedi K., Seldin M.F., Rits M., Ezekowitz R.A., Whitehead A.S.
J. Immunol. 146:4228-4233(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1).
[2]"Cloning and expression of murine interleukin-1 receptor antagonist in macrophages stimulated by colony-stimulating factor 1."
Matsushime H., Roussel M.F., Matsushima K., Hishinuma A., Sherr C.J.
Blood 78:616-623(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]"The mouse interleukin 1 receptor antagonist protein: gene structure and regulation in vitro."
Zahedi K.A., Uhlar C.M., Rits M., Prada A.E., Whitehead A.S.
Cytokine 6:1-9(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
Strain: Swiss.
[4]"Mouse IL-1 receptor antagonist isoforms: complementary DNA cloning and protein expression of intracellular isoform and tissue distribution of secreted and intracellular IL-1 receptor antagonist in vivo."
Gabay C., Porter B., Fantuzzi G., Arend W.P.
J. Immunol. 159:5905-5913(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Strain: FVB X DBA/1 LACJ.
[5]"Interleukin 1 receptor antagonist is a member of the interleukin 1 gene family: evolution of a cytokine control mechanism."
Eisenberg S.P., Brewer M.T., Verderber E., Heimdal P., Brandhuber B.J., Thompson R.C.
Proc. Natl. Acad. Sci. U.S.A. 88:5232-5236(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 7-178.
[6]"Cloning, heterologous expression and characterization of murine interleukin 1 receptor antagonist protein."
Shuck M.E., Eessalu T.E., Tracey D.E., Bienkowski M.J.
Eur. J. Immunol. 21:2775-2780(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 23-178.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M74294 mRNA. Translation: AAA39309.1.
M64404 mRNA. Translation: AAA39277.1.
L32838 Genomic DNA. Translation: AAA20576.1.
AF001795 mRNA. Translation: AAC15251.1.
M57525 mRNA. Translation: AAA39278.1.
M63100 Genomic DNA. Translation: AAA39310.1.
S64082 mRNA. Translation: AAB20265.1.
PIRA44610.
RefSeqNP_001034790.1. NM_001039701.3.
NP_112444.1. NM_031167.5.
UniGeneMm.882.

3D structure databases

ProteinModelPortalP25085.
SMRP25085. Positions 35-177.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbP25085.
PRIDEP25085.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000114482; ENSMUSP00000110126; ENSMUSG00000026981. [P25085-1]
ENSMUST00000114487; ENSMUSP00000110131; ENSMUSG00000026981. [P25085-2]
GeneID16181.
KEGGmmu:16181.
UCSCuc008iox.2. mouse. [P25085-1]

Organism-specific databases

CTD3557.
MGIMGI:96547. Il1rn.

Phylogenomic databases

eggNOGNOG46710.
HOGENOMHOG000231506.
HOVERGENHBG052099.
KOK05481.
OMAIHGGKLC.
OrthoDBEOG7X6M1M.
PhylomeDBP25085.
TreeFamTF300203.

Gene expression databases

ArrayExpressP25085.
BgeeP25085.
CleanExMM_IL1RN.
GenevestigatorP25085.

Family and domain databases

InterProIPR008996. Cytokine_IL1-like.
IPR000975. IL-1.
IPR020877. IL-1_CS.
IPR027166. IL-1RA.
IPR003297. IL-1RA/IL-36.
[Graphical view]
PANTHERPTHR10078:SF6. PTHR10078:SF6. 1 hit.
PfamPF00340. IL1. 1 hit.
[Graphical view]
PRINTSPR00264. INTERLEUKIN1.
PR01360. INTRLEUKIN1X.
SMARTSM00125. IL1. 1 hit.
[Graphical view]
SUPFAMSSF50353. SSF50353. 1 hit.
PROSITEPS00253. INTERLEUKIN_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio289059.
PROP25085.
SOURCESearch...

Entry information

Entry nameIL1RA_MOUSE
AccessionPrimary (citable) accession number: P25085
Secondary accession number(s): O70207
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: April 16, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot