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P25081

- MANA_SALTY

UniProt

P25081 - MANA_SALTY

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Protein

Mannose-6-phosphate isomerase

Gene

manA

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Involved in the conversion of glucose to GDP-L-fucose, which can be converted to L-fucose, a capsular polysaccharide.

Catalytic activityi

D-mannose 6-phosphate = D-fructose 6-phosphate.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi97 – 971ZincBy similarity
Metal bindingi99 – 991ZincBy similarity
Metal bindingi134 – 1341ZincBy similarity
Metal bindingi255 – 2551ZincBy similarity
Active sitei274 – 2741By similarity

GO - Molecular functioni

  1. mannose-6-phosphate isomerase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. GDP-mannose biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciSENT99287:GCTI-1477-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Mannose-6-phosphate isomerase (EC:5.3.1.8)
Alternative name(s):
Phosphohexomutase
Phosphomannose isomerase
Short name:
PMI
Gene namesi
Name:manA
Synonyms:pmi
Ordered Locus Names:STM1467
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014: Chromosome

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 391391Mannose-6-phosphate isomerasePRO_0000194231Add
BLAST

Proteomic databases

PaxDbiP25081.
PRIDEiP25081.

Interactioni

Protein-protein interaction databases

STRINGi99287.STM1467.

Structurei

Secondary structure

391
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi1 – 33Combined sources
Beta strandi7 – 93Combined sources
Beta strandi14 – 174Combined sources
Helixi18 – 236Combined sources
Beta strandi35 – 395Combined sources
Beta strandi47 – 493Combined sources
Beta strandi55 – 573Combined sources
Helixi58 – 647Combined sources
Helixi66 – 705Combined sources
Helixi72 – 776Combined sources
Beta strandi84 – 929Combined sources
Helixi102 – 11413Combined sources
Beta strandi134 – 1407Combined sources
Beta strandi142 – 1487Combined sources
Helixi151 – 1588Combined sources
Helixi159 – 1646Combined sources
Helixi166 – 1738Combined sources
Helixi177 – 18812Combined sources
Helixi192 – 20817Combined sources
Helixi214 – 22310Combined sources
Helixi228 – 2314Combined sources
Helixi232 – 2354Combined sources
Beta strandi236 – 2416Combined sources
Beta strandi246 – 2494Combined sources
Beta strandi255 – 26612Combined sources
Beta strandi276 – 2805Combined sources
Helixi284 – 2896Combined sources
Helixi298 – 3003Combined sources
Beta strandi306 – 3083Combined sources
Beta strandi311 – 3133Combined sources
Beta strandi317 – 3204Combined sources
Beta strandi322 – 3276Combined sources
Beta strandi333 – 3353Combined sources
Beta strandi341 – 35414Combined sources
Beta strandi357 – 3615Combined sources
Beta strandi366 – 3694Combined sources
Helixi371 – 3733Combined sources
Beta strandi376 – 38813Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2WFPX-ray1.67A1-391[»]
3H1MX-ray2.50A1-391[»]
3H1WX-ray1.94A1-391[»]
3H1YX-ray2.04A1-391[»]
ProteinModelPortaliP25081.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP25081.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1482.
HOGENOMiHOG000241278.
KOiK01809.
OMAiQGEPWDT.
OrthoDBiEOG6130B2.
PhylomeDBiP25081.

Family and domain databases

Gene3Di2.60.120.10. 3 hits.
InterProiIPR001250. Man6P_Isoase-1.
IPR016305. Mannose-6-P_Isomerase.
IPR018050. Pmannose_isomerase-type1_CS.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR10309. PTHR10309. 1 hit.
PfamiPF01238. PMI_typeI. 1 hit.
[Graphical view]
PIRSFiPIRSF001480. Mannose-6-phosphate_isomerase. 1 hit.
PRINTSiPR00714. MAN6PISMRASE.
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR00218. manA. 1 hit.
PROSITEiPS00965. PMI_I_1. 1 hit.
PS00966. PMI_I_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25081-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQKLINSVQN YAWGSKTALT ELYGIANPQQ QPMAELWMGA HPKSSSRITT
60 70 80 90 100
ANGETVSLRD AIEKNKTAML GEAVANRFGE LPFLFKVLCA AQPLSIQVHP
110 120 130 140 150
NKRNSEIGFA KENAAGIPMD AAERNYKDPN HKPELVFALT PFLAMNAFRE
160 170 180 190 200
FSDIVSLLQP VAGAHSAIAH FLQVPNAERL SQLFASLLNM QGEEKSRALA
210 220 230 240 250
VLKAALNSQQ GEPWQTIRVI SEYYPDDSGL FSPLLLNVVK LNPGEAMFLF
260 270 280 290 300
AETPHAYLQG VALEVMANSD NVLRAGLTPK YIDIPELVAN VKFEPKPAGE
310 320 330 340 350
LLTAPVKSGA ELDFPIPVDD FAFSLHDLAL QETSIGQHSA AILFCVEGEA
360 370 380 390
VLRKDEQRLV LKPGESAFIG ADESPVNASG TGRLARVYNK L
Length:391
Mass (Da):42,591
Last modified:January 23, 2002 - v2
Checksum:i61E7355146DBEF5A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti92 – 921Q → K in CAA40399. (PubMed:1879695)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57117 Genomic DNA. Translation: CAA40399.1.
AE006468 Genomic DNA. Translation: AAL20387.1.
PIRiJQ1192.
RefSeqiNP_460428.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL20387; AAL20387; STM1467.
GeneIDi1252985.
KEGGistm:STM1467.
PATRICi32381417. VBISalEnt20916_1549.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57117 Genomic DNA. Translation: CAA40399.1 .
AE006468 Genomic DNA. Translation: AAL20387.1 .
PIRi JQ1192.
RefSeqi NP_460428.1. NC_003197.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2WFP X-ray 1.67 A 1-391 [» ]
3H1M X-ray 2.50 A 1-391 [» ]
3H1W X-ray 1.94 A 1-391 [» ]
3H1Y X-ray 2.04 A 1-391 [» ]
ProteinModelPortali P25081.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 99287.STM1467.

Proteomic databases

PaxDbi P25081.
PRIDEi P25081.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL20387 ; AAL20387 ; STM1467 .
GeneIDi 1252985.
KEGGi stm:STM1467.
PATRICi 32381417. VBISalEnt20916_1549.

Phylogenomic databases

eggNOGi COG1482.
HOGENOMi HOG000241278.
KOi K01809.
OMAi QGEPWDT.
OrthoDBi EOG6130B2.
PhylomeDBi P25081.

Enzyme and pathway databases

BioCyci SENT99287:GCTI-1477-MONOMER.

Miscellaneous databases

EvolutionaryTracei P25081.

Family and domain databases

Gene3Di 2.60.120.10. 3 hits.
InterProi IPR001250. Man6P_Isoase-1.
IPR016305. Mannose-6-P_Isomerase.
IPR018050. Pmannose_isomerase-type1_CS.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR10309. PTHR10309. 1 hit.
Pfami PF01238. PMI_typeI. 1 hit.
[Graphical view ]
PIRSFi PIRSF001480. Mannose-6-phosphate_isomerase. 1 hit.
PRINTSi PR00714. MAN6PISMRASE.
SUPFAMi SSF51182. SSF51182. 1 hit.
TIGRFAMsi TIGR00218. manA. 1 hit.
PROSITEi PS00965. PMI_I_1. 1 hit.
PS00966. PMI_I_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of the phosphomannose isomerase-encoding gene of Salmonella typhimurium."
    Collins L.V., Hackett J.
    Gene 103:135-136(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C5.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.

Entry informationi

Entry nameiMANA_SALTY
AccessioniPrimary (citable) accession number: P25081
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: January 23, 2002
Last modified: November 26, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3