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P25081

- MANA_SALTY

UniProt

P25081 - MANA_SALTY

Protein

Mannose-6-phosphate isomerase

Gene

manA

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 2 (23 Jan 2002)
      Previous versions | rss
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    Functioni

    Involved in the conversion of glucose to GDP-L-fucose, which can be converted to L-fucose, a capsular polysaccharide.

    Catalytic activityi

    D-mannose 6-phosphate = D-fructose 6-phosphate.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi97 – 971ZincBy similarity
    Metal bindingi99 – 991ZincBy similarity
    Metal bindingi134 – 1341ZincBy similarity
    Metal bindingi255 – 2551ZincBy similarity
    Active sitei274 – 2741By similarity

    GO - Molecular functioni

    1. mannose-6-phosphate isomerase activity Source: UniProtKB-EC
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. GDP-mannose biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Isomerase

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciSENT99287:GCTI-1477-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mannose-6-phosphate isomerase (EC:5.3.1.8)
    Alternative name(s):
    Phosphohexomutase
    Phosphomannose isomerase
    Short name:
    PMI
    Gene namesi
    Name:manA
    Synonyms:pmi
    Ordered Locus Names:STM1467
    OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
    Taxonomic identifieri99287 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000001014: Chromosome

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 391391Mannose-6-phosphate isomerasePRO_0000194231Add
    BLAST

    Proteomic databases

    PaxDbiP25081.
    PRIDEiP25081.

    Interactioni

    Protein-protein interaction databases

    STRINGi99287.STM1467.

    Structurei

    Secondary structure

    391
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi1 – 33
    Beta strandi7 – 93
    Beta strandi14 – 174
    Helixi18 – 236
    Beta strandi35 – 395
    Beta strandi47 – 493
    Beta strandi55 – 573
    Helixi58 – 647
    Helixi66 – 705
    Helixi72 – 776
    Beta strandi84 – 929
    Helixi102 – 11413
    Beta strandi134 – 1407
    Beta strandi142 – 1487
    Helixi151 – 1588
    Helixi159 – 1646
    Helixi166 – 1738
    Helixi177 – 18812
    Helixi192 – 20817
    Helixi214 – 22310
    Helixi228 – 2314
    Helixi232 – 2354
    Beta strandi236 – 2416
    Beta strandi246 – 2494
    Beta strandi255 – 26612
    Beta strandi276 – 2805
    Helixi284 – 2896
    Helixi298 – 3003
    Beta strandi306 – 3083
    Beta strandi311 – 3133
    Beta strandi317 – 3204
    Beta strandi322 – 3276
    Beta strandi333 – 3353
    Beta strandi341 – 35414
    Beta strandi357 – 3615
    Beta strandi366 – 3694
    Helixi371 – 3733
    Beta strandi376 – 38813

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2WFPX-ray1.67A1-391[»]
    3H1MX-ray2.50A1-391[»]
    3H1WX-ray1.94A1-391[»]
    3H1YX-ray2.04A1-391[»]
    ProteinModelPortaliP25081.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP25081.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1482.
    HOGENOMiHOG000241278.
    KOiK01809.
    OMAiQGEPWDT.
    OrthoDBiEOG6130B2.
    PhylomeDBiP25081.

    Family and domain databases

    Gene3Di2.60.120.10. 3 hits.
    InterProiIPR001250. Man6P_Isoase-1.
    IPR016305. Mannose-6-P_Isomerase.
    IPR018050. Pmannose_isomerase-type1_CS.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view]
    PANTHERiPTHR10309. PTHR10309. 1 hit.
    PfamiPF01238. PMI_typeI. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001480. Mannose-6-phosphate_isomerase. 1 hit.
    PRINTSiPR00714. MAN6PISMRASE.
    SUPFAMiSSF51182. SSF51182. 1 hit.
    TIGRFAMsiTIGR00218. manA. 1 hit.
    PROSITEiPS00965. PMI_I_1. 1 hit.
    PS00966. PMI_I_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P25081-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQKLINSVQN YAWGSKTALT ELYGIANPQQ QPMAELWMGA HPKSSSRITT    50
    ANGETVSLRD AIEKNKTAML GEAVANRFGE LPFLFKVLCA AQPLSIQVHP 100
    NKRNSEIGFA KENAAGIPMD AAERNYKDPN HKPELVFALT PFLAMNAFRE 150
    FSDIVSLLQP VAGAHSAIAH FLQVPNAERL SQLFASLLNM QGEEKSRALA 200
    VLKAALNSQQ GEPWQTIRVI SEYYPDDSGL FSPLLLNVVK LNPGEAMFLF 250
    AETPHAYLQG VALEVMANSD NVLRAGLTPK YIDIPELVAN VKFEPKPAGE 300
    LLTAPVKSGA ELDFPIPVDD FAFSLHDLAL QETSIGQHSA AILFCVEGEA 350
    VLRKDEQRLV LKPGESAFIG ADESPVNASG TGRLARVYNK L 391
    Length:391
    Mass (Da):42,591
    Last modified:January 23, 2002 - v2
    Checksum:i61E7355146DBEF5A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti92 – 921Q → K in CAA40399. (PubMed:1879695)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X57117 Genomic DNA. Translation: CAA40399.1.
    AE006468 Genomic DNA. Translation: AAL20387.1.
    PIRiJQ1192.
    RefSeqiNP_460428.1. NC_003197.1.

    Genome annotation databases

    EnsemblBacteriaiAAL20387; AAL20387; STM1467.
    GeneIDi1252985.
    KEGGistm:STM1467.
    PATRICi32381417. VBISalEnt20916_1549.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X57117 Genomic DNA. Translation: CAA40399.1 .
    AE006468 Genomic DNA. Translation: AAL20387.1 .
    PIRi JQ1192.
    RefSeqi NP_460428.1. NC_003197.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2WFP X-ray 1.67 A 1-391 [» ]
    3H1M X-ray 2.50 A 1-391 [» ]
    3H1W X-ray 1.94 A 1-391 [» ]
    3H1Y X-ray 2.04 A 1-391 [» ]
    ProteinModelPortali P25081.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 99287.STM1467.

    Proteomic databases

    PaxDbi P25081.
    PRIDEi P25081.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL20387 ; AAL20387 ; STM1467 .
    GeneIDi 1252985.
    KEGGi stm:STM1467.
    PATRICi 32381417. VBISalEnt20916_1549.

    Phylogenomic databases

    eggNOGi COG1482.
    HOGENOMi HOG000241278.
    KOi K01809.
    OMAi QGEPWDT.
    OrthoDBi EOG6130B2.
    PhylomeDBi P25081.

    Enzyme and pathway databases

    BioCyci SENT99287:GCTI-1477-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P25081.

    Family and domain databases

    Gene3Di 2.60.120.10. 3 hits.
    InterProi IPR001250. Man6P_Isoase-1.
    IPR016305. Mannose-6-P_Isomerase.
    IPR018050. Pmannose_isomerase-type1_CS.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view ]
    PANTHERi PTHR10309. PTHR10309. 1 hit.
    Pfami PF01238. PMI_typeI. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001480. Mannose-6-phosphate_isomerase. 1 hit.
    PRINTSi PR00714. MAN6PISMRASE.
    SUPFAMi SSF51182. SSF51182. 1 hit.
    TIGRFAMsi TIGR00218. manA. 1 hit.
    PROSITEi PS00965. PMI_I_1. 1 hit.
    PS00966. PMI_I_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence of the phosphomannose isomerase-encoding gene of Salmonella typhimurium."
      Collins L.V., Hackett J.
      Gene 103:135-136(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: C5.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LT2 / SGSC1412 / ATCC 700720.

    Entry informationi

    Entry nameiMANA_SALTY
    AccessioniPrimary (citable) accession number: P25081
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: January 23, 2002
    Last modified: October 1, 2014
    This is version 115 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3