ID CD24_HUMAN Reviewed; 80 AA. AC P25063; Q16257; Q53XS0; DT 01-MAY-1992, integrated into UniProtKB/Swiss-Prot. DT 03-APR-2007, sequence version 2. DT 11-NOV-2015, entry version 137. DE RecName: Full=Signal transducer CD24; DE AltName: Full=Small cell lung carcinoma cluster 4 antigen; DE AltName: CD_antigen=CD24; DE Flags: Precursor; GN Name=CD24; Synonyms=CD24A; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT SER-44. RX PubMed=1831224; RA Kay R., Rosten P.M., Humphries R.K.; RT "CD24, a signal transducer modulating B cell activation responses, is RT a very short peptide with a glycosyl phosphatidylinositol membrane RT anchor."; RL J. Immunol. 147:1412-1416(1991). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANTS SER-44 AND VAL-57. RX PubMed=1327504; RA Jackson D., Waibel R., Weber E., Bell J., Stahel R.A.; RT "CD24, a signal-transducing molecule expressed on human B cells, is a RT major surface antigen on small cell lung carcinomas."; RL Cancer Res. 52:5264-5270(1992). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT SER-44. RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., RA Phelan M., Farmer A.; RT "Cloning of human full-length CDSs in BD Creator(TM) system donor RT vector."; RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT SER-44. RC TISSUE=Ovary; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [5] RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-76. RX PubMed=7959762; DOI=10.1006/geno.1994.1356; RA Hough M.R., Rosten P.M., Sexton T.L., Kay R., Humphries R.K.; RT "Mapping of CD24 and homologous sequences to multiple chromosomal RT loci."; RL Genomics 22:154-161(1994). RN [6] RP INTERACTION WITH LYN AND FGR, AND TISSUE SPECIFICITY. RX PubMed=8753773; DOI=10.1006/bbrc.1996.1184; RA Zarn J.A., Zimmermann S.M., Pass M.K., Waibel R., Stahel R.A.; RT "Association of CD24 with the kinase c-fgr in a small cell lung cancer RT cell line and with the kinase lyn in an erythroleukemia cell line."; RL Biochem. Biophys. Res. Commun. 225:384-391(1996). RN [7] RP INTERACTION WITH LYN, AND FUNCTION. RX PubMed=11313396; DOI=10.4049/jimmunol.166.9.5567; RA Suzuki T., Kiyokawa N., Taguchi T., Sekino T., Katagiri Y.U., RA Fujimoto J.; RT "CD24 induces apoptosis in human B cells via the glycolipid-enriched RT membrane domains/rafts-mediated signaling system."; RL J. Immunol. 166:5567-5577(2001). RN [8] RP VARIANT VAL-57, AND IDENTIFICATION. RX PubMed=7736776; RA Zarn J.A., Jackson D.G., Bell M.V., Jones T., Weber E., Sheer D., RA Waibel R., Stahel R.A.; RT "The small cell lung cancer antigen cluster-4 and the leukocyte RT antigen CD24 are allelic isoforms of the same gene (CD24) on RT chromosome band 6q21."; RL Cytogenet. Cell Genet. 70:119-125(1995). RN [9] RP VARIANT VAL-57, TISSUE SPECIFICITY, AND INVOLVEMENT IN SUSCEPTIBILITY RP TO MS. RX PubMed=14657362; DOI=10.1073/pnas.2533866100; RA Zhou Q., Rammohan K., Lin S., Robinson N., Li O., Liu X., Bai X.-F., RA Yin L., Scarberry B., Du P., You M., Guan K., Zheng P., Liu Y.; RT "CD24 is a genetic modifier for risk and progression of multiple RT sclerosis."; RL Proc. Natl. Acad. Sci. U.S.A. 100:15041-15046(2003). RN [10] RP ERRATUM. RA Zhou Q., Rammohan K., Lin S., Robinson N., Li O., Liu X., Bai X.-F., RA Yin L., Scarberry B., Du P., You M., Guan K., Zheng P., Liu Y.; RL Proc. Natl. Acad. Sci. U.S.A. 102:8392-8392(2005). CC -!- FUNCTION: Modulates B-cell activation responses. Signaling could CC be triggered by the binding of a lectin-like ligand to the CD24 CC carbohydrates, and transduced by the release of second messengers CC derived from the GPI-anchor. Promotes AG-dependent proliferation CC of B-cells, and prevents their terminal differentiation into CC antibody-forming cells. {ECO:0000269|PubMed:11313396}. CC -!- SUBUNIT: Interacts with LYN and FGR in a cell-type specific CC manner. Binds FRG in a small cell cancer line, LYN in the CC erythroleukemia cell line K-562 and in Burkitt's lymphoma. CC {ECO:0000269|PubMed:11313396, ECO:0000269|PubMed:8753773}. CC -!- INTERACTION: CC P07948:LYN; NbExp=6; IntAct=EBI-6267018, EBI-79452; CC -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor. CC -!- TISSUE SPECIFICITY: B-cells. Expressed in a number of B-cell lines CC including P32/ISH and Namalwa. Expressed in erythroleukemia cell CC and small cell lung carcinoma cell lines. Also expressed on the CC surface of T-cells. {ECO:0000269|PubMed:14657362, CC ECO:0000269|PubMed:8753773}. CC -!- INDUCTION: Expression is lost when primary B-cells are induced to CC differentiate in antibody-forming cells. CC -!- PTM: Extensively O-glycosylated. CC -!- DISEASE: Multiple sclerosis (MS) [MIM:126200]: A multifactorial, CC inflammatory, demyelinating disease of the central nervous system. CC Sclerotic lesions are characterized by perivascular infiltration CC of monocytes and lymphocytes and appear as indurated areas in CC pathologic specimens (sclerosis in plaques). The pathological CC mechanism is regarded as an autoimmune attack of the myelin CC sheath, mediated by both cellular and humoral immunity. Clinical CC manifestations include visual loss, extra-ocular movement CC disorders, paresthesias, loss of sensation, weakness, dysarthria, CC spasticity, ataxia and bladder dysfunction. Genetic and CC environmental factors influence susceptibility to the disease. CC {ECO:0000269|PubMed:14657362}. Note=Disease susceptibility may be CC associated with variations affecting the gene represented in this CC entry. CC -!- SIMILARITY: Belongs to the CD24 family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=AAD14170.1; Type=Erroneous initiation; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M58664; AAA35665.1; -; mRNA. DR EMBL; L33930; AAB58807.1; -; mRNA. DR EMBL; X69397; CAA49195.1; -; mRNA. DR EMBL; BT007404; AAP36068.1; -; mRNA. DR EMBL; BC064619; AAH64619.1; -; mRNA. DR EMBL; S75311; AAD14170.1; ALT_INIT; mRNA. DR CCDS; CCDS75499.1; -. DR PIR; I56114; A48996. DR RefSeq; NP_001278666.1; NM_001291737.1. DR RefSeq; NP_001278667.1; NM_001291738.1. DR RefSeq; NP_037362.1; NM_013230.3. DR UniGene; Hs.644105; -. DR UniGene; Hs.712050; -. DR ProteinModelPortal; P25063; -. DR BioGrid; 107372; 3. DR IntAct; P25063; 1. DR BioMuta; CD24; -. DR PRIDE; P25063; -. DR GeneID; 100133941; -. DR KEGG; hsa:100133941; -. DR CTD; 100133941; -. DR GeneCards; CD24; -. DR HGNC; HGNC:1645; CD24. DR MIM; 126200; phenotype. DR MIM; 600074; gene. DR neXtProt; NX_P25063; -. DR Orphanet; 802; Multiple sclerosis. DR PharmGKB; PA26202; -. DR InParanoid; P25063; -. DR KO; K06469; -. DR Reactome; R-HSA-373760; L1CAM interactions. DR GeneWiki; CD24; -. DR GenomeRNAi; 100133941; -. DR NextBio; 20789309; -. DR PRO; PR:P25063; -. DR Proteomes; UP000005640; Unplaced. DR CleanEx; HS_CD24; -. DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW. DR GO; GO:0009986; C:cell surface; IDA:UniProtKB. DR GO; GO:0005829; C:cytosol; IDA:GOC. DR GO; GO:0005622; C:intracellular; IDA:GOC. DR GO; GO:0016020; C:membrane; IDA:UniProtKB. DR GO; GO:0045121; C:membrane raft; IDA:UniProtKB. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0019901; F:protein kinase binding; IPI:UniProtKB. DR GO; GO:0030296; F:protein tyrosine kinase activator activity; IDA:UniProtKB. DR GO; GO:0004871; F:signal transducer activity; NAS:UniProtKB. DR GO; GO:0007411; P:axon guidance; TAS:Reactome. DR GO; GO:0032597; P:B cell receptor transport into membrane raft; IDA:UniProtKB. DR GO; GO:0001775; P:cell activation; IDA:UniProtKB. DR GO; GO:0016477; P:cell migration; ISS:UniProtKB. DR GO; GO:0032600; P:chemokine receptor transport out of membrane raft; ISS:UniProtKB. DR GO; GO:0042632; P:cholesterol homeostasis; ISS:UniProtKB. DR GO; GO:0072139; P:glomerular parietal epithelial cell differentiation; IMP:UniProtKB. DR GO; GO:0072112; P:glomerular visceral epithelial cell differentiation; IMP:UniProtKB. DR GO; GO:0002768; P:immune response-regulating cell surface receptor signaling pathway; IC:UniProtKB. DR GO; GO:0097193; P:intrinsic apoptotic signaling pathway; NAS:UniProtKB. DR GO; GO:0032913; P:negative regulation of transforming growth factor beta3 production; IMP:UniProtKB. DR GO; GO:0042104; P:positive regulation of activated T cell proliferation; IDA:UniProtKB. DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IDA:UniProtKB. DR GO; GO:0043406; P:positive regulation of MAP kinase activity; IDA:UniProtKB. DR GO; GO:2000768; P:positive regulation of nephron tubule epithelial cell differentiation; IMP:UniProtKB. DR GO; GO:0061098; P:positive regulation of protein tyrosine kinase activity; IDA:GOC. DR GO; GO:0001959; P:regulation of cytokine-mediated signaling pathway; ISS:UniProtKB. DR GO; GO:0030856; P:regulation of epithelial cell differentiation; NAS:UniProtKB. DR GO; GO:0043408; P:regulation of MAPK cascade; IDA:UniProtKB. DR GO; GO:0042325; P:regulation of phosphorylation; IDA:UniProtKB. DR GO; GO:0045730; P:respiratory burst; IDA:UniProtKB. DR GO; GO:0043627; P:response to estrogen; IEP:UniProtKB. DR GO; GO:0001666; P:response to hypoxia; IEP:UniProtKB. DR GO; GO:0002237; P:response to molecule of bacterial origin; ISS:UniProtKB. DR GO; GO:0016337; P:single organismal cell-cell adhesion; NAS:UniProtKB. DR GO; GO:0031295; P:T cell costimulation; IDA:UniProtKB. DR GO; GO:0016055; P:Wnt signaling pathway; NAS:UniProtKB. DR InterPro; IPR028029; CD24. DR Pfam; PF14984; CD24; 1. PE 1: Evidence at protein level; KW Cell membrane; Complete proteome; Glycoprotein; GPI-anchor; KW Lipoprotein; Membrane; Polymorphism; Reference proteome; Signal. FT SIGNAL 1 26 {ECO:0000255}. FT PEPTIDE 27 59 Signal transducer CD24. FT /FTId=PRO_0000020893. FT PROPEP 60 80 Removed in mature form. {ECO:0000255}. FT /FTId=PRO_0000020894. FT LIPID 59 59 GPI-anchor amidated glycine. FT {ECO:0000255}. FT CARBOHYD 36 36 N-linked (GlcNAc...). {ECO:0000255}. FT CARBOHYD 52 52 N-linked (GlcNAc...). {ECO:0000255}. FT VARIANT 44 44 T -> S. {ECO:0000269|PubMed:1327504, FT ECO:0000269|PubMed:15489334, FT ECO:0000269|PubMed:1831224, FT ECO:0000269|Ref.3}. FT /FTId=VAR_031576. FT VARIANT 57 57 A -> V (may be associated with an FT increased risk for multiple sclerosis; FT homozygous patients express higher levels FT of CD24 on peripheral blood T-cells than FT homozygous controls). FT {ECO:0000269|PubMed:1327504, FT ECO:0000269|PubMed:14657362, FT ECO:0000269|PubMed:7736776}. FT /FTId=VAR_016156. FT CONFLICT 12 12 G -> W (in Ref. 5; AAD14170). FT {ECO:0000305}. SQ SEQUENCE 80 AA; 8097 MW; DB1988B684DEC62F CRC64; MGRAMVARLG LGLLLLALLL PTQIYSSETT TGTSSNSSQS TSNTGLAPNP TNATTKAAGG ALQSTASLFV VSLSLLHLYS //