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P25063

- CD24_HUMAN

UniProt

P25063 - CD24_HUMAN

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Protein

Signal transducer CD24

Gene

CD24

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Modulates B-cell activation responses. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells.1 Publication

GO - Molecular functioni

  1. protein kinase binding Source: UniProtKB
  2. protein tyrosine kinase activator activity Source: UniProtKB
  3. signal transducer activity Source: UniProtKB

GO - Biological processi

  1. axon guidance Source: Reactome
  2. B cell receptor transport into membrane raft Source: UniProtKB
  3. cell activation Source: UniProtKB
  4. cell migration Source: UniProtKB
  5. chemokine receptor transport out of membrane raft Source: UniProtKB
  6. cholesterol homeostasis Source: UniProtKB
  7. glomerular parietal epithelial cell differentiation Source: UniProtKB
  8. glomerular visceral epithelial cell differentiation Source: UniProtKB
  9. immune response-regulating cell surface receptor signaling pathway Source: UniProtKB
  10. intrinsic apoptotic signaling pathway Source: UniProtKB
  11. negative regulation of transforming growth factor beta3 production Source: UniProtKB
  12. positive regulation of activated T cell proliferation Source: UniProtKB
  13. positive regulation of cytosolic calcium ion concentration Source: UniProtKB
  14. positive regulation of MAP kinase activity Source: UniProtKB
  15. positive regulation of nephron tubule epithelial cell differentiation Source: UniProtKB
  16. positive regulation of protein tyrosine kinase activity Source: GOC
  17. regulation of cytokine-mediated signaling pathway Source: UniProtKB
  18. regulation of epithelial cell differentiation Source: UniProtKB
  19. regulation of MAPK cascade Source: UniProtKB
  20. regulation of phosphorylation Source: UniProtKB
  21. respiratory burst Source: UniProtKB
  22. response to estrogen Source: UniProtKB
  23. response to hypoxia Source: UniProtKB
  24. response to molecule of bacterial origin Source: UniProtKB
  25. single organismal cell-cell adhesion Source: UniProtKB
  26. T cell costimulation Source: UniProtKB
  27. Wnt signaling pathway Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_22205. L1CAM interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transducer CD24
Alternative name(s):
Small cell lung carcinoma cluster 4 antigen
CD_antigen: CD24
Gene namesi
Name:CD24
Synonyms:CD24A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:1645. CD24.

Subcellular locationi

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. cell surface Source: UniProtKB
  3. membrane Source: UniProtKB
  4. membrane raft Source: UniProtKB
  5. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Multiple sclerosis (MS) [MIM:126200]: A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheath, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease.1 Publication
Note: Disease susceptibility may be associated with variations affecting the gene represented in this entry.

Organism-specific databases

MIMi126200. phenotype.
Orphaneti802. Multiple sclerosis.
PharmGKBiPA26202.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Peptidei27 – 5933Signal transducer CD24PRO_0000020893Add
BLAST
Propeptidei60 – 8021Removed in mature formSequence AnalysisPRO_0000020894Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi36 – 361N-linked (GlcNAc...)Sequence Analysis
Glycosylationi52 – 521N-linked (GlcNAc...)Sequence Analysis
Lipidationi59 – 591GPI-anchor amidated glycineSequence Analysis

Post-translational modificationi

Extensively O-glycosylated.

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiP25063.
PRIDEiP25063.

Expressioni

Tissue specificityi

B-cells. Expressed in a number of B-cell lines including P32/ISH and Namalwa. Expressed in erythroleukemia cell and small cell lung carcinoma cell lines. Also expressed on the surface of T-cells.2 Publications

Inductioni

Expression is lost when primary B-cells are induced to differentiate in antibody-forming cells.

Gene expression databases

CleanExiHS_CD24.
GenevestigatoriP25063.

Interactioni

Subunit structurei

Interacts with LYN and FGR in a cell-type specific manner. Binds FRG in a small cell cancer line, LYN in the erythroleukemia cell line K-562 and in Burkitt's lymphoma.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
LYNP079486EBI-6267018,EBI-79452

Protein-protein interaction databases

BioGridi107372. 3 interactions.
IntActiP25063. 1 interaction.
STRINGi9606.ENSP00000372291.

Structurei

3D structure databases

ProteinModelPortaliP25063.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CD24 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

InParanoidiP25063.
KOiK06469.

Family and domain databases

InterProiIPR028029. CD24.
[Graphical view]
PfamiPF14984. CD24. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25063-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGRAMVARLG LGLLLLALLL PTQIYSSETT TGTSSNSSQS TSNTGLAPNP
60 70 80
TNATTKAAGG ALQSTASLFV VSLSLLHLYS
Length:80
Mass (Da):8,097
Last modified:April 3, 2007 - v2
Checksum:iDB1988B684DEC62F
GO

Sequence cautioni

The sequence AAD14170.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti12 – 121G → W in AAD14170. (PubMed:7959762)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti44 – 441T → S.4 Publications
Corresponds to variant rs10465460 [ dbSNP | Ensembl ].
VAR_031576
Natural varianti57 – 571A → V May be associated with an increased risk for multiple sclerosis; homozygous patients express higher levels of CD24 on peripheral blood T-cells than homozygous controls. 3 Publications
Corresponds to variant rs8734 [ dbSNP | Ensembl ].
VAR_016156

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M58664 mRNA. Translation: AAA35665.1.
L33930 mRNA. Translation: AAB58807.1.
X69397 mRNA. Translation: CAA49195.1.
BT007404 mRNA. Translation: AAP36068.1.
BC064619 mRNA. Translation: AAH64619.1.
S75311 mRNA. Translation: AAD14170.1. Different initiation.
CCDSiCCDS75499.1.
PIRiI56114. A48996.
RefSeqiNP_001278666.1. NM_001291737.1.
NP_001278667.1. NM_001291738.1.
NP_037362.1. NM_013230.3.
UniGeneiHs.644105.
Hs.712050.

Genome annotation databases

GeneIDi100133941.
KEGGihsa:100133941.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M58664 mRNA. Translation: AAA35665.1 .
L33930 mRNA. Translation: AAB58807.1 .
X69397 mRNA. Translation: CAA49195.1 .
BT007404 mRNA. Translation: AAP36068.1 .
BC064619 mRNA. Translation: AAH64619.1 .
S75311 mRNA. Translation: AAD14170.1 . Different initiation.
CCDSi CCDS75499.1.
PIRi I56114. A48996.
RefSeqi NP_001278666.1. NM_001291737.1.
NP_001278667.1. NM_001291738.1.
NP_037362.1. NM_013230.3.
UniGenei Hs.644105.
Hs.712050.

3D structure databases

ProteinModelPortali P25063.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107372. 3 interactions.
IntActi P25063. 1 interaction.
STRINGi 9606.ENSP00000372291.

Proteomic databases

PaxDbi P25063.
PRIDEi P25063.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100133941.
KEGGi hsa:100133941.

Organism-specific databases

CTDi 100133941.
GeneCardsi GC06U900001.
HGNCi HGNC:1645. CD24.
MIMi 126200. phenotype.
600074. gene.
neXtProti NX_P25063.
Orphaneti 802. Multiple sclerosis.
PharmGKBi PA26202.
GenAtlasi Search...

Phylogenomic databases

InParanoidi P25063.
KOi K06469.

Enzyme and pathway databases

Reactomei REACT_22205. L1CAM interactions.

Miscellaneous databases

GeneWikii CD24.
GenomeRNAii 100133941.
NextBioi 20789309.
PROi P25063.
SOURCEi Search...

Gene expression databases

CleanExi HS_CD24.
Genevestigatori P25063.

Family and domain databases

InterProi IPR028029. CD24.
[Graphical view ]
Pfami PF14984. CD24. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "CD24, a signal transducer modulating B cell activation responses, is a very short peptide with a glycosyl phosphatidylinositol membrane anchor."
    Kay R., Rosten P.M., Humphries R.K.
    J. Immunol. 147:1412-1416(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-44.
  2. "CD24, a signal-transducing molecule expressed on human B cells, is a major surface antigen on small cell lung carcinomas."
    Jackson D., Waibel R., Weber E., Bell J., Stahel R.A.
    Cancer Res. 52:5264-5270(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS SER-44 AND VAL-57.
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-44.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-44.
    Tissue: Ovary.
  5. "Mapping of CD24 and homologous sequences to multiple chromosomal loci."
    Hough M.R., Rosten P.M., Sexton T.L., Kay R., Humphries R.K.
    Genomics 22:154-161(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-76.
  6. "Association of CD24 with the kinase c-fgr in a small cell lung cancer cell line and with the kinase lyn in an erythroleukemia cell line."
    Zarn J.A., Zimmermann S.M., Pass M.K., Waibel R., Stahel R.A.
    Biochem. Biophys. Res. Commun. 225:384-391(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH LYN AND FGR, TISSUE SPECIFICITY.
  7. "CD24 induces apoptosis in human B cells via the glycolipid-enriched membrane domains/rafts-mediated signaling system."
    Suzuki T., Kiyokawa N., Taguchi T., Sekino T., Katagiri Y.U., Fujimoto J.
    J. Immunol. 166:5567-5577(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH LYN, FUNCTION.
  8. "The small cell lung cancer antigen cluster-4 and the leukocyte antigen CD24 are allelic isoforms of the same gene (CD24) on chromosome band 6q21."
    Zarn J.A., Jackson D.G., Bell M.V., Jones T., Weber E., Sheer D., Waibel R., Stahel R.A.
    Cytogenet. Cell Genet. 70:119-125(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT VAL-57, IDENTIFICATION.
  9. Cited for: VARIANT VAL-57, TISSUE SPECIFICITY, INVOLVEMENT IN SUSCEPTIBILITY TO MS.
  10. Erratum
    Zhou Q., Rammohan K., Lin S., Robinson N., Li O., Liu X., Bai X.-F., Yin L., Scarberry B., Du P., You M., Guan K., Zheng P., Liu Y.
    Proc. Natl. Acad. Sci. U.S.A. 102:8392-8392(2005)

Entry informationi

Entry nameiCD24_HUMAN
AccessioniPrimary (citable) accession number: P25063
Secondary accession number(s): Q16257, Q53XS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: April 3, 2007
Last modified: October 29, 2014
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3