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P25063

- CD24_HUMAN

UniProt

P25063 - CD24_HUMAN

Protein

Signal transducer CD24

Gene

CD24

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Modulates B-cell activation responses. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells.1 Publication

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. protein kinase binding Source: UniProtKB
    3. protein tyrosine kinase activator activity Source: UniProtKB
    4. signal transducer activity Source: UniProtKB

    GO - Biological processi

    1. axon guidance Source: Reactome
    2. B cell receptor transport into membrane raft Source: UniProtKB
    3. cell activation Source: UniProtKB
    4. cell migration Source: UniProtKB
    5. chemokine receptor transport out of membrane raft Source: UniProtKB
    6. cholesterol homeostasis Source: UniProtKB
    7. glomerular parietal epithelial cell differentiation Source: UniProtKB
    8. glomerular visceral epithelial cell differentiation Source: UniProtKB
    9. immune response-regulating cell surface receptor signaling pathway Source: UniProtKB
    10. intrinsic apoptotic signaling pathway Source: UniProtKB
    11. negative regulation of transforming growth factor beta3 production Source: UniProtKB
    12. positive regulation of activated T cell proliferation Source: UniProtKB
    13. positive regulation of cytosolic calcium ion concentration Source: UniProtKB
    14. positive regulation of MAP kinase activity Source: UniProtKB
    15. positive regulation of nephron tubule epithelial cell differentiation Source: UniProtKB
    16. positive regulation of protein tyrosine kinase activity Source: GOC
    17. regulation of cytokine-mediated signaling pathway Source: UniProtKB
    18. regulation of epithelial cell differentiation Source: UniProtKB
    19. regulation of MAPK cascade Source: UniProtKB
    20. regulation of phosphorylation Source: UniProtKB
    21. respiratory burst Source: UniProtKB
    22. response to estrogen Source: UniProtKB
    23. response to hypoxia Source: UniProtKB
    24. response to molecule of bacterial origin Source: UniProtKB
    25. single organismal cell-cell adhesion Source: UniProtKB
    26. T cell costimulation Source: UniProtKB
    27. Wnt signaling pathway Source: UniProtKB

    Enzyme and pathway databases

    ReactomeiREACT_22205. L1CAM interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Signal transducer CD24
    Alternative name(s):
    Small cell lung carcinoma cluster 4 antigen
    CD_antigen: CD24
    Gene namesi
    Name:CD24
    Synonyms:CD24A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:1645. CD24.

    Subcellular locationi

    GO - Cellular componenti

    1. anchored component of membrane Source: UniProtKB-KW
    2. cell surface Source: UniProtKB
    3. membrane Source: UniProtKB
    4. membrane raft Source: UniProtKB
    5. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Multiple sclerosis (MS) [MIM:126200]: A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheath, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease.1 Publication
    Note: Disease susceptibility may be associated with variations affecting the gene represented in this entry.

    Organism-specific databases

    MIMi126200. phenotype.
    Orphaneti802. Multiple sclerosis.
    PharmGKBiPA26202.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Peptidei27 – 5933Signal transducer CD24PRO_0000020893Add
    BLAST
    Propeptidei60 – 8021Removed in mature formSequence AnalysisPRO_0000020894Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi36 – 361N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi52 – 521N-linked (GlcNAc...)Sequence Analysis
    Lipidationi59 – 591GPI-anchor amidated glycineSequence Analysis

    Post-translational modificationi

    Extensively O-glycosylated.

    Keywords - PTMi

    Glycoprotein, GPI-anchor, Lipoprotein

    Proteomic databases

    PaxDbiP25063.
    PRIDEiP25063.

    Expressioni

    Tissue specificityi

    B-cells. Expressed in a number of B-cell lines including P32/ISH and Namalwa. Expressed in erythroleukemia cell and small cell lung carcinoma cell lines. Also expressed on the surface of T-cells.2 Publications

    Inductioni

    Expression is lost when primary B-cells are induced to differentiate in antibody-forming cells.

    Gene expression databases

    CleanExiHS_CD24.
    GenevestigatoriP25063.

    Interactioni

    Subunit structurei

    Interacts with LYN and FGR in a cell-type specific manner. Binds FRG in a small cell cancer line, LYN in the erythroleukemia cell line K-562 and in Burkitt's lymphoma.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    LYNP079486EBI-6267018,EBI-79452

    Protein-protein interaction databases

    BioGridi107372. 3 interactions.
    IntActiP25063. 1 interaction.
    STRINGi9606.ENSP00000372291.

    Structurei

    3D structure databases

    ProteinModelPortaliP25063.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CD24 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    InParanoidiP25063.
    KOiK06469.

    Family and domain databases

    InterProiIPR028029. CD24.
    [Graphical view]
    PfamiPF14984. CD24. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P25063-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGRAMVARLG LGLLLLALLL PTQIYSSETT TGTSSNSSQS TSNTGLAPNP   50
    TNATTKAAGG ALQSTASLFV VSLSLLHLYS 80
    Length:80
    Mass (Da):8,097
    Last modified:April 3, 2007 - v2
    Checksum:iDB1988B684DEC62F
    GO

    Sequence cautioni

    The sequence AAD14170.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti12 – 121G → W in AAD14170. (PubMed:7959762)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti44 – 441T → S.4 Publications
    Corresponds to variant rs10465460 [ dbSNP | Ensembl ].
    VAR_031576
    Natural varianti57 – 571A → V May be associated with an increased risk for multiple sclerosis; homozygous patients express higher levels of CD24 on peripheral blood T-cells than homozygous controls. 3 Publications
    Corresponds to variant rs8734 [ dbSNP | Ensembl ].
    VAR_016156

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M58664 mRNA. Translation: AAA35665.1.
    L33930 mRNA. Translation: AAB58807.1.
    X69397 mRNA. Translation: CAA49195.1.
    BT007404 mRNA. Translation: AAP36068.1.
    BC064619 mRNA. Translation: AAH64619.1.
    S75311 mRNA. Translation: AAD14170.1. Different initiation.
    PIRiI56114. A48996.
    RefSeqiNP_001278666.1. NM_001291737.1.
    NP_001278667.1. NM_001291738.1.
    NP_037362.1. NM_013230.3.
    UniGeneiHs.644105.
    Hs.712050.

    Genome annotation databases

    GeneIDi100133941.
    KEGGihsa:100133941.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M58664 mRNA. Translation: AAA35665.1 .
    L33930 mRNA. Translation: AAB58807.1 .
    X69397 mRNA. Translation: CAA49195.1 .
    BT007404 mRNA. Translation: AAP36068.1 .
    BC064619 mRNA. Translation: AAH64619.1 .
    S75311 mRNA. Translation: AAD14170.1 . Different initiation.
    PIRi I56114. A48996.
    RefSeqi NP_001278666.1. NM_001291737.1.
    NP_001278667.1. NM_001291738.1.
    NP_037362.1. NM_013230.3.
    UniGenei Hs.644105.
    Hs.712050.

    3D structure databases

    ProteinModelPortali P25063.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107372. 3 interactions.
    IntActi P25063. 1 interaction.
    STRINGi 9606.ENSP00000372291.

    Proteomic databases

    PaxDbi P25063.
    PRIDEi P25063.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100133941.
    KEGGi hsa:100133941.

    Organism-specific databases

    CTDi 100133941.
    GeneCardsi GC06U900001.
    HGNCi HGNC:1645. CD24.
    MIMi 126200. phenotype.
    600074. gene.
    neXtProti NX_P25063.
    Orphaneti 802. Multiple sclerosis.
    PharmGKBi PA26202.
    GenAtlasi Search...

    Phylogenomic databases

    InParanoidi P25063.
    KOi K06469.

    Enzyme and pathway databases

    Reactomei REACT_22205. L1CAM interactions.

    Miscellaneous databases

    GeneWikii CD24.
    GenomeRNAii 100133941.
    NextBioi 20789309.
    PROi P25063.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_CD24.
    Genevestigatori P25063.

    Family and domain databases

    InterProi IPR028029. CD24.
    [Graphical view ]
    Pfami PF14984. CD24. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "CD24, a signal transducer modulating B cell activation responses, is a very short peptide with a glycosyl phosphatidylinositol membrane anchor."
      Kay R., Rosten P.M., Humphries R.K.
      J. Immunol. 147:1412-1416(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-44.
    2. "CD24, a signal-transducing molecule expressed on human B cells, is a major surface antigen on small cell lung carcinomas."
      Jackson D., Waibel R., Weber E., Bell J., Stahel R.A.
      Cancer Res. 52:5264-5270(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS SER-44 AND VAL-57.
    3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-44.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-44.
      Tissue: Ovary.
    5. "Mapping of CD24 and homologous sequences to multiple chromosomal loci."
      Hough M.R., Rosten P.M., Sexton T.L., Kay R., Humphries R.K.
      Genomics 22:154-161(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-76.
    6. "Association of CD24 with the kinase c-fgr in a small cell lung cancer cell line and with the kinase lyn in an erythroleukemia cell line."
      Zarn J.A., Zimmermann S.M., Pass M.K., Waibel R., Stahel R.A.
      Biochem. Biophys. Res. Commun. 225:384-391(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH LYN AND FGR, TISSUE SPECIFICITY.
    7. "CD24 induces apoptosis in human B cells via the glycolipid-enriched membrane domains/rafts-mediated signaling system."
      Suzuki T., Kiyokawa N., Taguchi T., Sekino T., Katagiri Y.U., Fujimoto J.
      J. Immunol. 166:5567-5577(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH LYN, FUNCTION.
    8. "The small cell lung cancer antigen cluster-4 and the leukocyte antigen CD24 are allelic isoforms of the same gene (CD24) on chromosome band 6q21."
      Zarn J.A., Jackson D.G., Bell M.V., Jones T., Weber E., Sheer D., Waibel R., Stahel R.A.
      Cytogenet. Cell Genet. 70:119-125(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT VAL-57, IDENTIFICATION.
    9. Cited for: VARIANT VAL-57, TISSUE SPECIFICITY, INVOLVEMENT IN SUSCEPTIBILITY TO MS.
    10. Erratum
      Zhou Q., Rammohan K., Lin S., Robinson N., Li O., Liu X., Bai X.-F., Yin L., Scarberry B., Du P., You M., Guan K., Zheng P., Liu Y.
      Proc. Natl. Acad. Sci. U.S.A. 102:8392-8392(2005)

    Entry informationi

    Entry nameiCD24_HUMAN
    AccessioniPrimary (citable) accession number: P25063
    Secondary accession number(s): Q16257, Q53XS0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 129 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3