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P25063 (CD24_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 127. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Signal transducer CD24
Alternative name(s):
Small cell lung carcinoma cluster 4 antigen
CD_antigen=CD24
Gene names
Name:CD24
Synonyms:CD24A
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length80 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Modulates B-cell activation responses. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells. Ref.7

Subunit structure

Interacts with LYN and FGR in a cell-type specific manner. Binds FRG in a small cell cancer line, LYN in the erythroleukemia cell line K-562 and in Burkitt's lymphoma. Ref.6 Ref.7

Subcellular location

Cell membrane; Lipid-anchorGPI-anchor.

Tissue specificity

B-cells. Expressed in a number of B-cell lines including P32/ISH and Namalwa. Expressed in erythroleukemia cell and small cell lung carcinoma cell lines. Also expressed on the surface of T-cells. Ref.6 Ref.9

Induction

Expression is lost when primary B-cells are induced to differentiate in antibody-forming cells.

Post-translational modification

Extensively O-glycosylated.

Involvement in disease

Multiple sclerosis (MS) [MIM:126200]: A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheath, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease.
Note: Disease susceptibility may be associated with variations affecting the gene represented in this entry. Ref.9

Sequence similarities

Belongs to the CD24 family.

Sequence caution

The sequence AAD14170.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   Coding sequence diversityPolymorphism
   DomainSignal
   PTMGlycoprotein
GPI-anchor
Lipoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processB cell receptor transport into membrane raft

Inferred from direct assay Ref.7. Source: UniProtKB

T cell costimulation

Inferred from direct assay PubMed 11272271. Source: UniProtKB

Wnt signaling pathway

Non-traceable author statement PubMed 16532032. Source: UniProtKB

axon guidance

Traceable author statement. Source: Reactome

cell activation

Inferred from direct assay PubMed 8223854. Source: UniProtKB

cell migration

Inferred from sequence or structural similarity PubMed 16390867. Source: UniProtKB

chemokine receptor transport out of membrane raft

Inferred from sequence or structural similarity. Source: UniProtKB

cholesterol homeostasis

Inferred from sequence or structural similarity PubMed 16390867. Source: UniProtKB

glomerular parietal epithelial cell differentiation

Inferred from mutant phenotype PubMed 19092120. Source: UniProtKB

glomerular visceral epithelial cell differentiation

Inferred from mutant phenotype PubMed 19092120. Source: UniProtKB

immune response-regulating cell surface receptor signaling pathway

Inferred by curator Ref.7. Source: UniProtKB

intrinsic apoptotic signaling pathway

Non-traceable author statement Ref.7. Source: UniProtKB

negative regulation of transforming growth factor beta3 production

Inferred from mutant phenotype PubMed 16930538. Source: UniProtKB

positive regulation of MAP kinase activity

Inferred from direct assay PubMed 12496407. Source: UniProtKB

positive regulation of activated T cell proliferation

Inferred from direct assay PubMed 11272271. Source: UniProtKB

positive regulation of cytosolic calcium ion concentration

Inferred from direct assay PubMed 2153173PubMed 8223854. Source: UniProtKB

positive regulation of nephron tubule epithelial cell differentiation

Inferred from mutant phenotype PubMed 16885410. Source: UniProtKB

positive regulation of protein tyrosine kinase activity

Inferred from direct assay Ref.7. Source: GOC

regulation of MAPK cascade

Inferred from direct assay Ref.7. Source: UniProtKB

regulation of cytokine-mediated signaling pathway

Inferred from sequence or structural similarity PubMed 16390867. Source: UniProtKB

regulation of epithelial cell differentiation

Non-traceable author statement PubMed 16930538. Source: UniProtKB

regulation of phosphorylation

Inferred from direct assay Ref.7. Source: UniProtKB

respiratory burst

Inferred from direct assay PubMed 8223854. Source: UniProtKB

response to estrogen

Inferred from expression pattern PubMed 10037815. Source: UniProtKB

response to hypoxia

Inferred from expression pattern PubMed 15174142. Source: UniProtKB

response to molecule of bacterial origin

Inferred from sequence or structural similarity PubMed 15493995. Source: UniProtKB

single organismal cell-cell adhesion

Non-traceable author statement PubMed 15633604. Source: UniProtKB

   Cellular_componentanchored component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

cell surface

Inferred from direct assay PubMed 16532032. Source: UniProtKB

membrane

Inferred from direct assay PubMed 10037815. Source: UniProtKB

membrane raft

Inferred from direct assay Ref.7. Source: UniProtKB

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionprotein binding

Inferred from physical interaction PubMed 15633604Ref.6PubMed 9129046. Source: UniProtKB

protein kinase binding

Inferred from physical interaction Ref.6. Source: UniProtKB

protein tyrosine kinase activator activity

Inferred from direct assay Ref.7. Source: UniProtKB

signal transducer activity

Non-traceable author statement PubMed 8213086. Source: UniProtKB

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

LYNP079486EBI-6267018,EBI-79452

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Peptide27 – 5933Signal transducer CD24
PRO_0000020893
Propeptide60 – 8021Removed in mature form Potential
PRO_0000020894

Amino acid modifications

Lipidation591GPI-anchor amidated glycine Potential
Glycosylation361N-linked (GlcNAc...) Potential
Glycosylation521N-linked (GlcNAc...) Potential

Natural variations

Natural variant441T → S. Ref.1 Ref.2 Ref.3 Ref.4
Corresponds to variant rs10465460 [ dbSNP | Ensembl ].
VAR_031576
Natural variant571A → V May be associated with an increased risk for multiple sclerosis; homozygous patients express higher levels of CD24 on peripheral blood T-cells than homozygous controls. Ref.2 Ref.8 Ref.9
Corresponds to variant rs8734 [ dbSNP | Ensembl ].
VAR_016156

Experimental info

Sequence conflict121G → W in AAD14170. Ref.5

Sequences

Sequence LengthMass (Da)Tools
P25063 [UniParc].

Last modified April 3, 2007. Version 2.
Checksum: DB1988B684DEC62F

FASTA808,097
        10         20         30         40         50         60 
MGRAMVARLG LGLLLLALLL PTQIYSSETT TGTSSNSSQS TSNTGLAPNP TNATTKAAGG 

        70         80 
ALQSTASLFV VSLSLLHLYS 

« Hide

References

« Hide 'large scale' references
[1]"CD24, a signal transducer modulating B cell activation responses, is a very short peptide with a glycosyl phosphatidylinositol membrane anchor."
Kay R., Rosten P.M., Humphries R.K.
J. Immunol. 147:1412-1416(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-44.
[2]"CD24, a signal-transducing molecule expressed on human B cells, is a major surface antigen on small cell lung carcinomas."
Jackson D., Waibel R., Weber E., Bell J., Stahel R.A.
Cancer Res. 52:5264-5270(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS SER-44 AND VAL-57.
[3]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-44.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-44.
Tissue: Ovary.
[5]"Mapping of CD24 and homologous sequences to multiple chromosomal loci."
Hough M.R., Rosten P.M., Sexton T.L., Kay R., Humphries R.K.
Genomics 22:154-161(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-76.
[6]"Association of CD24 with the kinase c-fgr in a small cell lung cancer cell line and with the kinase lyn in an erythroleukemia cell line."
Zarn J.A., Zimmermann S.M., Pass M.K., Waibel R., Stahel R.A.
Biochem. Biophys. Res. Commun. 225:384-391(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH LYN AND FGR, TISSUE SPECIFICITY.
[7]"CD24 induces apoptosis in human B cells via the glycolipid-enriched membrane domains/rafts-mediated signaling system."
Suzuki T., Kiyokawa N., Taguchi T., Sekino T., Katagiri Y.U., Fujimoto J.
J. Immunol. 166:5567-5577(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH LYN, FUNCTION.
[8]"The small cell lung cancer antigen cluster-4 and the leukocyte antigen CD24 are allelic isoforms of the same gene (CD24) on chromosome band 6q21."
Zarn J.A., Jackson D.G., Bell M.V., Jones T., Weber E., Sheer D., Waibel R., Stahel R.A.
Cytogenet. Cell Genet. 70:119-125(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT VAL-57, IDENTIFICATION.
[9]"CD24 is a genetic modifier for risk and progression of multiple sclerosis."
Zhou Q., Rammohan K., Lin S., Robinson N., Li O., Liu X., Bai X.-F., Yin L., Scarberry B., Du P., You M., Guan K., Zheng P., Liu Y.
Proc. Natl. Acad. Sci. U.S.A. 100:15041-15046(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT VAL-57, TISSUE SPECIFICITY, INVOLVEMENT IN SUSCEPTIBILITY TO MS.
[10]Erratum
Zhou Q., Rammohan K., Lin S., Robinson N., Li O., Liu X., Bai X.-F., Yin L., Scarberry B., Du P., You M., Guan K., Zheng P., Liu Y.
Proc. Natl. Acad. Sci. U.S.A. 102:8392-8392(2005)
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M58664 mRNA. Translation: AAA35665.1.
L33930 mRNA. Translation: AAB58807.1.
X69397 mRNA. Translation: CAA49195.1.
BT007404 mRNA. Translation: AAP36068.1.
BC064619 mRNA. Translation: AAH64619.1.
S75311 mRNA. Translation: AAD14170.1. Different initiation.
PIRA48996. I56114.
RefSeqNP_001278666.1. NM_001291737.1.
NP_001278667.1. NM_001291738.1.
NP_037362.1. NM_013230.3.
UniGeneHs.644105.
Hs.712050.

3D structure databases

ProteinModelPortalP25063.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107372. 3 interactions.
IntActP25063. 1 interaction.
STRING9606.ENSP00000372291.

Proteomic databases

PaxDbP25063.
PRIDEP25063.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100133941.
KEGGhsa:100133941.

Organism-specific databases

CTD100133941.
GeneCardsGC06U900001.
HGNCHGNC:1645. CD24.
MIM126200. phenotype.
600074. gene.
neXtProtNX_P25063.
Orphanet802. Multiple sclerosis.
PharmGKBPA26202.
GenAtlasSearch...

Phylogenomic databases

InParanoidP25063.
KOK06469.

Enzyme and pathway databases

ReactomeREACT_111045. Developmental Biology.

Gene expression databases

CleanExHS_CD24.
GenevestigatorP25063.

Family and domain databases

InterProIPR028029. CD24.
[Graphical view]
PfamPF14984. CD24. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCD24.
GenomeRNAi100133941.
NextBio20789309.
PROP25063.
SOURCESearch...

Entry information

Entry nameCD24_HUMAN
AccessionPrimary (citable) accession number: P25063
Secondary accession number(s): Q16257, Q53XS0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: April 3, 2007
Last modified: July 9, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

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