ID   POL_BLVAU               Reviewed;         852 AA.
AC   P25059;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1992, sequence version 1.
DT   16-JUN-2009, entry version 60.
DE   RecName: Full=Pol polyprotein;
DE   Contains:
DE     RecName: Full=Reverse transcriptase/ribonuclease H;
DE              Short=RT;
DE              EC=2.7.7.49;
DE              EC=2.7.7.7;
DE              EC=3.1.26.4;
DE   Contains:
DE     RecName: Full=Integrase;
DE              Short=IN;
GN   Name=pol;
OS   Bovine leukemia virus (isolate Australian) (BLV).
OC   Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae;
OC   Deltaretrovirus.
OX   NCBI_TaxID=11903;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=90362060; PubMed=2167927;
RA   Coulston J., Naif H., Brandon R., Kumar S., Khan S., Daniel R.C.W.,
RA   Lavin M.F.;
RT   "Molecular cloning and sequencing of an Australian isolate of proviral
RT   bovine leukaemia virus DNA: comparison with other isolates.";
RL   J. Gen. Virol. 71:1737-1746(1990).
CC   -!- FUNCTION: During replicative cycle of retroviruses, the reverse-
CC       transcribed viral DNA is integrated into the host chromosome by
CC       the viral integrase enzyme. RNase H activity is associated with
CC       the reverse transcriptase.
CC   -!- CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) =
CC       diphosphate + DNA(n+1).
CC   -!- CATALYTIC ACTIVITY: Endonucleolytic cleavage to 5'-
CC       phosphomonoester.
CC   -!- PTM: Specific enzymatic cleavages in vivo yield mature proteins.
CC   -!- SIMILARITY: Belongs to the retroviral Pol polyprotein family.
CC   -!- SIMILARITY: Contains 1 integrase catalytic domain.
CC   -!- SIMILARITY: Contains 1 integrase-type DNA-binding domain.
CC   -!- SIMILARITY: Contains 1 reverse transcriptase domain.
CC   -!- SIMILARITY: Contains 1 RNase H domain.
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DR   EMBL; D00647; BAA00544.1; -; Genomic_DNA.
DR   PIR; JQ0555; GNLJGA.
DR   HSSP; P03354; 1C1A.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:EC.
DR   GO; GO:0008907; F:integrase activity; IEA:InterPro.
DR   GO; GO:0004523; F:ribonuclease H activity; IEA:EC.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006278; P:RNA-dependent DNA replication; IEA:InterPro.
DR   GO; GO:0032196; P:transposition; IEA:UniProtKB-KW.
DR   InterPro; IPR000477; DNA_pol_RVTase.
DR   InterPro; IPR001037; Integrase_C_retrovir.
DR   InterPro; IPR001584; Integrase_cat-core.
DR   InterPro; IPR002156; RNase_H.
DR   InterPro; IPR010661; RVT_thumb.
DR   Pfam; PF00552; Integrase; 1.
DR   Pfam; PF00075; RnaseH; 1.
DR   Pfam; PF00665; rve; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   Pfam; PF06817; RVT_thumb; 1.
DR   PROSITE; PS50994; INTEGRASE; 1.
DR   PROSITE; PS51027; INTEGRASE_DBD; 1.
DR   PROSITE; PS50879; RNASE_H; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   3: Inferred from homology;
KW   DNA integration; DNA recombination; Endonuclease; Hydrolase;
KW   Multifunctional enzyme; Nuclease; Nucleotidyltransferase;
KW   RNA-directed DNA polymerase; Transferase.
FT   CHAIN         1    852       Pol polyprotein.
FT                                /FTId=PRO_0000125481.
FT   DOMAIN       22    212       Reverse transcriptase.
FT   DOMAIN      432    562       RNase H.
FT   DOMAIN      615    779       Integrase catalytic.
FT   DNA_BIND    788    836       Integrase-type.
SQ   SEQUENCE   852 AA;  95441 MW;  CD69FE59E1208A08 CRC64;
     GTSIPFKLER LQALQDLVHR SLEAGYISPW DGPGNNPVFP VRKPNGAWRF VHDLRVTNAL
     TKPIPALSPG PPDLTAIPTH LPHIICLDLK DAFFQIPVED RFRSYFAFTL PTPGGLQPHR
     RFAWRVLPQG FINSPALFER ALQEPLRQVS AAFSQSLLVS YMDDILYVSP TEEQRLQCYQ
     TMAAHLRDLG FQVASEKTRQ TPSPVPFLGQ MVHERMVTYQ SLPTLQISSP ISLHQLQTVL
     GDLQWVSRGT PTTRRPLQLL YSSLKGIDDP RAIIHLSPEQ QQGIAELRQA LSHNARSRYN
     EQEPLLAYVH LTRAGSTLVL FQKGAQFPLA YFQTPLTDNQ ASPWGLLLLL GCQYLQAQAL
     SSYAKTILKY YHNLPKTSLD NWIQSSEDPR VQELLQLWPQ ISSQGIQPPG PWKTLVTRAE
     VFLTPQFSPE PIPAALCLFS DGAARRGAYC LWKDHLLDFQ AVPAPESAQK GELAGLLAGL
     AAAPPEPLNI WVDSKYLYSL LRTLVLGAWL QPDPVPSYAL LYKSLLRHPA IFVGHVRSHS
     SASHPIASLN NYVDQLLPLE TPEQWHKLTH CNSRALSRWP NPRISAWDPR SPATLCETCQ
     RLNPTGGGKM RTIQRGWAPN HIWQADITHY KYKQFTYALH VFVDTYSGAT HASAKRGLTT
     QTTIEGLLEA IVHLGRPKKL NTDQGANYTS KTFVRFCQQF GISLSHHVPY NPTSSGLVER
     TNGLLKLLLS KYHLDEPHLP MTQALSRALW THNQINLLPI LKTRWELHHS PPLAVISEGG
     ETPKGSDKLF LYKLPGQNNR RWLGPLPALV EASGGALLAT NPPVWVPWRL LKAFKCLKND
     GPEDAPNRSS DG
//