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P25055 (PGKA_CRIFA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase, glycosomal

Short name=Phosphoglycerate kinase A
EC=2.7.2.3
Gene names
Name:PGKA
Synonyms:PGK-A
OrganismCrithidia fasciculata
Taxonomic identifier5656 [NCBI]
Taxonomic lineageEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeCrithidia

Protein attributes

Sequence length505 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145

Subunit structure

Monomer.

Subcellular location

Glycosome HAMAP-Rule MF_00145.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentGlycosome
Peroxisome
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
Gene Ontology (GO)
   Biological_processglycolytic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentglycosome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoglycerate kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 505505Phosphoglycerate kinase, glycosomal HAMAP-Rule MF_00145
PRO_0000145848

Regions

Nucleotide binding460 – 4634ATP By similarity
Region30 – 323Substrate binding By similarity
Region68 – 714Substrate binding By similarity

Sites

Binding site451Substrate By similarity
Binding site2201Substrate By similarity
Binding site2571Substrate By similarity
Binding site3081ATP By similarity
Binding site3991ATP; via carbonyl oxygen By similarity
Binding site4301ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P25055 [UniParc].

Last modified May 1, 1992. Version 1.
Checksum: E184277AAB86D355

FASTA50554,758
        10         20         30         40         50         60 
MLLSTQSIPI KKSVDDIWPV AGKRVLIRVD FNVPTSSGGI DDDFRIRSAI PTIRRIVDQG 

        70         80         90        100        110        120 
GICILISHLG RPTGVDYDTA HAEQEKRQTP VQLPNSRGKT AFFSGLRGDA KATILAWSSQ 

       130        140        150        160        170        180 
REKAATLSNP YGSGKTAVFA RLPEEEKRRL LLRFMSEHKE ELFPQLGSAG YEKEFSLEPV 

       190        200        210        220        230        240 
AVKLAELLDQ HVYFGHDCLG AQADIAKLRC GEVMLLENLR FYTNENSSDE RKRMLMARIL 

       250        260        270        280        290        300 
ASYADVYIND AFGTAHRDSA SLTGIPRVLQ QGAAGYLMEK EISYFSKVLN NPPRPLLAII 

       310        320        330        340        350        360 
GGAKLSDKMQ VLENLLDCVD SLFIGGGLAY TFLRSQGYSI GTSHFEEAFV PFAQALPLAG 

       370        380        390        400        410        420 
SGRQVRVVLP EDHVCHAHTR PAEAPLTTTS ANIPDGYAGL DIGPLTIQSI THLVRQCSSV 

       430        440        450        460        470        480 
IWNGPLGMFE MPYYAFGTFS IARVVSQSSA AKGTTSIVGG GDTASAMMKS GEAAHISHIS 

       490        500 
TGGNASLELL EGKVLAAVAV LDNKE 

« Hide

References

[1]"A phosphoglycerate kinase-related gene conserved between Trypanosoma brucei and Crithidia fasciculata."
Swinkels B.W., Loiseau A., Opperdoes F.R., Borst P.A.
Mol. Biochem. Parasitol. 50:69-78(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X17251 Genomic DNA. Translation: CAA35114.1.
PIRKICRGF. S14463.

3D structure databases

ProteinModelPortalP25055.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 2 hits.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR027250. Pgk_euglenozoa.
IPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PIRSF500126. Pgk_euglenozoa. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 2 hits.
PROSITEPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGKA_CRIFA
AccessionPrimary (citable) accession number: P25055
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: June 11, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways