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P25055

- PGKA_CRIFA

UniProt

P25055 - PGKA_CRIFA

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Protein

Phosphoglycerate kinase, glycosomal

Gene

PGKA

Organism
Crithidia fasciculata
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei45 – 451SubstrateBy similarity
Binding sitei220 – 2201SubstrateBy similarity
Binding sitei257 – 2571SubstrateBy similarity
Binding sitei308 – 3081ATPBy similarity
Binding sitei399 – 3991ATP; via carbonyl oxygenBy similarity
Binding sitei430 – 4301ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi460 – 4634ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoglycerate kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase, glycosomal (EC:2.7.2.3)
Short name:
Phosphoglycerate kinase A
Gene namesi
Name:PGKA
Synonyms:PGK-A
OrganismiCrithidia fasciculata
Taxonomic identifieri5656 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeCrithidia

Subcellular locationi

GO - Cellular componenti

  1. glycosome Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Glycosome, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 505505Phosphoglycerate kinase, glycosomalPRO_0000145848Add
BLAST

Interactioni

Subunit structurei

Monomer.

Structurei

3D structure databases

ProteinModelPortaliP25055.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni30 – 323Substrate bindingBy similarity
Regioni68 – 714Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.Curated

Family and domain databases

Gene3Di3.40.50.1260. 2 hits.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR027250. Pgk_euglenozoa.
IPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PIRSF500126. Pgk_euglenozoa. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 2 hits.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25055-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLLSTQSIPI KKSVDDIWPV AGKRVLIRVD FNVPTSSGGI DDDFRIRSAI
60 70 80 90 100
PTIRRIVDQG GICILISHLG RPTGVDYDTA HAEQEKRQTP VQLPNSRGKT
110 120 130 140 150
AFFSGLRGDA KATILAWSSQ REKAATLSNP YGSGKTAVFA RLPEEEKRRL
160 170 180 190 200
LLRFMSEHKE ELFPQLGSAG YEKEFSLEPV AVKLAELLDQ HVYFGHDCLG
210 220 230 240 250
AQADIAKLRC GEVMLLENLR FYTNENSSDE RKRMLMARIL ASYADVYIND
260 270 280 290 300
AFGTAHRDSA SLTGIPRVLQ QGAAGYLMEK EISYFSKVLN NPPRPLLAII
310 320 330 340 350
GGAKLSDKMQ VLENLLDCVD SLFIGGGLAY TFLRSQGYSI GTSHFEEAFV
360 370 380 390 400
PFAQALPLAG SGRQVRVVLP EDHVCHAHTR PAEAPLTTTS ANIPDGYAGL
410 420 430 440 450
DIGPLTIQSI THLVRQCSSV IWNGPLGMFE MPYYAFGTFS IARVVSQSSA
460 470 480 490 500
AKGTTSIVGG GDTASAMMKS GEAAHISHIS TGGNASLELL EGKVLAAVAV

LDNKE
Length:505
Mass (Da):54,758
Last modified:May 1, 1992 - v1
Checksum:iE184277AAB86D355
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X17251 Genomic DNA. Translation: CAA35114.1.
PIRiS14463. KICRGF.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X17251 Genomic DNA. Translation: CAA35114.1 .
PIRi S14463. KICRGF.

3D structure databases

ProteinModelPortali P25055.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00185 .

Family and domain databases

Gene3Di 3.40.50.1260. 2 hits.
3.40.50.1270. 1 hit.
HAMAPi MF_00145. Phosphoglyc_kinase.
InterProi IPR027250. Pgk_euglenozoa.
IPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view ]
PANTHERi PTHR11406. PTHR11406. 1 hit.
Pfami PF00162. PGK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000724. Pgk. 1 hit.
PIRSF500126. Pgk_euglenozoa. 1 hit.
PRINTSi PR00477. PHGLYCKINASE.
SUPFAMi SSF53748. SSF53748. 2 hits.
PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A phosphoglycerate kinase-related gene conserved between Trypanosoma brucei and Crithidia fasciculata."
    Swinkels B.W., Loiseau A., Opperdoes F.R., Borst P.A.
    Mol. Biochem. Parasitol. 50:69-78(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiPGKA_CRIFA
AccessioniPrimary (citable) accession number: P25055
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: October 29, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3