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P25055

- PGKA_CRIFA

UniProt

P25055 - PGKA_CRIFA

Protein

Phosphoglycerate kinase, glycosomal

Gene

PGKA

Organism
Crithidia fasciculata
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 May 1992)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei45 – 451SubstrateBy similarity
    Binding sitei220 – 2201SubstrateBy similarity
    Binding sitei257 – 2571SubstrateBy similarity
    Binding sitei308 – 3081ATPBy similarity
    Binding sitei399 – 3991ATP; via carbonyl oxygenBy similarity
    Binding sitei430 – 4301ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi460 – 4634ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoglycerate kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00185.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoglycerate kinase, glycosomal (EC:2.7.2.3)
    Short name:
    Phosphoglycerate kinase A
    Gene namesi
    Name:PGKA
    Synonyms:PGK-A
    OrganismiCrithidia fasciculata
    Taxonomic identifieri5656 [NCBI]
    Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeCrithidia

    Subcellular locationi

    GO - Cellular componenti

    1. glycosome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Glycosome, Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 505505Phosphoglycerate kinase, glycosomalPRO_0000145848Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.

    Structurei

    3D structure databases

    ProteinModelPortaliP25055.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni30 – 323Substrate bindingBy similarity
    Regioni68 – 714Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the phosphoglycerate kinase family.Curated

    Family and domain databases

    Gene3Di3.40.50.1260. 2 hits.
    3.40.50.1270. 1 hit.
    HAMAPiMF_00145. Phosphoglyc_kinase.
    InterProiIPR027250. Pgk_euglenozoa.
    IPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view]
    PANTHERiPTHR11406. PTHR11406. 1 hit.
    PfamiPF00162. PGK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000724. Pgk. 1 hit.
    PIRSF500126. Pgk_euglenozoa. 1 hit.
    PRINTSiPR00477. PHGLYCKINASE.
    SUPFAMiSSF53748. SSF53748. 2 hits.
    PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P25055-1 [UniParc]FASTAAdd to Basket

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    MLLSTQSIPI KKSVDDIWPV AGKRVLIRVD FNVPTSSGGI DDDFRIRSAI    50
    PTIRRIVDQG GICILISHLG RPTGVDYDTA HAEQEKRQTP VQLPNSRGKT 100
    AFFSGLRGDA KATILAWSSQ REKAATLSNP YGSGKTAVFA RLPEEEKRRL 150
    LLRFMSEHKE ELFPQLGSAG YEKEFSLEPV AVKLAELLDQ HVYFGHDCLG 200
    AQADIAKLRC GEVMLLENLR FYTNENSSDE RKRMLMARIL ASYADVYIND 250
    AFGTAHRDSA SLTGIPRVLQ QGAAGYLMEK EISYFSKVLN NPPRPLLAII 300
    GGAKLSDKMQ VLENLLDCVD SLFIGGGLAY TFLRSQGYSI GTSHFEEAFV 350
    PFAQALPLAG SGRQVRVVLP EDHVCHAHTR PAEAPLTTTS ANIPDGYAGL 400
    DIGPLTIQSI THLVRQCSSV IWNGPLGMFE MPYYAFGTFS IARVVSQSSA 450
    AKGTTSIVGG GDTASAMMKS GEAAHISHIS TGGNASLELL EGKVLAAVAV 500
    LDNKE 505
    Length:505
    Mass (Da):54,758
    Last modified:May 1, 1992 - v1
    Checksum:iE184277AAB86D355
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X17251 Genomic DNA. Translation: CAA35114.1.
    PIRiS14463. KICRGF.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X17251 Genomic DNA. Translation: CAA35114.1 .
    PIRi S14463. KICRGF.

    3D structure databases

    ProteinModelPortali P25055.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00185 .

    Family and domain databases

    Gene3Di 3.40.50.1260. 2 hits.
    3.40.50.1270. 1 hit.
    HAMAPi MF_00145. Phosphoglyc_kinase.
    InterProi IPR027250. Pgk_euglenozoa.
    IPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view ]
    PANTHERi PTHR11406. PTHR11406. 1 hit.
    Pfami PF00162. PGK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000724. Pgk. 1 hit.
    PIRSF500126. Pgk_euglenozoa. 1 hit.
    PRINTSi PR00477. PHGLYCKINASE.
    SUPFAMi SSF53748. SSF53748. 2 hits.
    PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A phosphoglycerate kinase-related gene conserved between Trypanosoma brucei and Crithidia fasciculata."
      Swinkels B.W., Loiseau A., Opperdoes F.R., Borst P.A.
      Mol. Biochem. Parasitol. 50:69-78(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiPGKA_CRIFA
    AccessioniPrimary (citable) accession number: P25055
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: May 1, 1992
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3