SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P25055

- PGKA_CRIFA

UniProt

P25055 - PGKA_CRIFA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Phosphoglycerate kinase, glycosomal
Gene
PGKA, PGK-A
Organism
Crithidia fasciculata
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei45 – 451Substrate By similarity
Binding sitei220 – 2201Substrate By similarity
Binding sitei257 – 2571Substrate By similarity
Binding sitei308 – 3081ATP By similarity
Binding sitei399 – 3991ATP; via carbonyl oxygen By similarity
Binding sitei430 – 4301ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi460 – 4634ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoglycerate kinase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase, glycosomal (EC:2.7.2.3)
Short name:
Phosphoglycerate kinase A
Gene namesi
Name:PGKA
Synonyms:PGK-A
OrganismiCrithidia fasciculata
Taxonomic identifieri5656 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeCrithidia

Subcellular locationi

Glycosome UniRule annotation

GO - Cellular componenti

  1. glycosome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Glycosome, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 505505Phosphoglycerate kinase, glycosomalUniRule annotation
PRO_0000145848Add
BLAST

Interactioni

Subunit structurei

Monomer.

Structurei

3D structure databases

ProteinModelPortaliP25055.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni30 – 323Substrate binding By similarity
Regioni68 – 714Substrate binding By similarity

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.1260. 2 hits.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR027250. Pgk_euglenozoa.
IPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PIRSF500126. Pgk_euglenozoa. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 2 hits.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25055-1 [UniParc]FASTAAdd to Basket

« Hide

MLLSTQSIPI KKSVDDIWPV AGKRVLIRVD FNVPTSSGGI DDDFRIRSAI    50
PTIRRIVDQG GICILISHLG RPTGVDYDTA HAEQEKRQTP VQLPNSRGKT 100
AFFSGLRGDA KATILAWSSQ REKAATLSNP YGSGKTAVFA RLPEEEKRRL 150
LLRFMSEHKE ELFPQLGSAG YEKEFSLEPV AVKLAELLDQ HVYFGHDCLG 200
AQADIAKLRC GEVMLLENLR FYTNENSSDE RKRMLMARIL ASYADVYIND 250
AFGTAHRDSA SLTGIPRVLQ QGAAGYLMEK EISYFSKVLN NPPRPLLAII 300
GGAKLSDKMQ VLENLLDCVD SLFIGGGLAY TFLRSQGYSI GTSHFEEAFV 350
PFAQALPLAG SGRQVRVVLP EDHVCHAHTR PAEAPLTTTS ANIPDGYAGL 400
DIGPLTIQSI THLVRQCSSV IWNGPLGMFE MPYYAFGTFS IARVVSQSSA 450
AKGTTSIVGG GDTASAMMKS GEAAHISHIS TGGNASLELL EGKVLAAVAV 500
LDNKE 505
Length:505
Mass (Da):54,758
Last modified:May 1, 1992 - v1
Checksum:iE184277AAB86D355
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X17251 Genomic DNA. Translation: CAA35114.1.
PIRiS14463. KICRGF.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X17251 Genomic DNA. Translation: CAA35114.1 .
PIRi S14463. KICRGF.

3D structure databases

ProteinModelPortali P25055.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00185 .

Family and domain databases

Gene3Di 3.40.50.1260. 2 hits.
3.40.50.1270. 1 hit.
HAMAPi MF_00145. Phosphoglyc_kinase.
InterProi IPR027250. Pgk_euglenozoa.
IPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view ]
PANTHERi PTHR11406. PTHR11406. 1 hit.
Pfami PF00162. PGK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000724. Pgk. 1 hit.
PIRSF500126. Pgk_euglenozoa. 1 hit.
PRINTSi PR00477. PHGLYCKINASE.
SUPFAMi SSF53748. SSF53748. 2 hits.
PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A phosphoglycerate kinase-related gene conserved between Trypanosoma brucei and Crithidia fasciculata."
    Swinkels B.W., Loiseau A., Opperdoes F.R., Borst P.A.
    Mol. Biochem. Parasitol. 50:69-78(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiPGKA_CRIFA
AccessioniPrimary (citable) accession number: P25055
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: June 11, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi