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Protein

Phosphoglycerate kinase, glycosomal

Gene

PGKA

Organism
Crithidia fasciculata
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase, glycosomal (GAPDG)
  2. Phosphoglycerate kinase, glycosomal (PGKA), Phosphoglycerate kinase, glycosomal (PGKC), Phosphoglycerate kinase, cytosolic (PGKB)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei45SubstrateBy similarity1
Binding sitei220SubstrateBy similarity1
Binding sitei257SubstrateBy similarity1
Binding sitei308ATPBy similarity1
Binding sitei399ATP; via carbonyl oxygenBy similarity1
Binding sitei430ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi460 – 463ATPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase, glycosomal (EC:2.7.2.3)
Short name:
Phosphoglycerate kinase A
Gene namesi
Name:PGKA
Synonyms:PGK-A
OrganismiCrithidia fasciculata
Taxonomic identifieri5656 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeCrithidia

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Glycosome, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001458481 – 505Phosphoglycerate kinase, glycosomalAdd BLAST505

Proteomic databases

PRIDEiP25055

Interactioni

Subunit structurei

Monomer.

Structurei

3D structure databases

ProteinModelPortaliP25055
SMRiP25055
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni30 – 32Substrate bindingBy similarity3
Regioni68 – 71Substrate bindingBy similarity4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.Curated

Family and domain databases

CDDicd00318 Phosphoglycerate_kinase, 1 hit
Gene3Di3.40.50.1260, 4 hits
HAMAPiMF_00145 Phosphoglyc_kinase, 1 hit
InterProiView protein in InterPro
IPR001576 Phosphoglycerate_kinase
IPR015911 Phosphoglycerate_kinase_CS
IPR015824 Phosphoglycerate_kinase_N
IPR036043 Phosphoglycerate_kinase_sf
PANTHERiPTHR11406 PTHR11406, 1 hit
PfamiView protein in Pfam
PF00162 PGK, 1 hit
PRINTSiPR00477 PHGLYCKINASE
SUPFAMiSSF53748 SSF53748, 2 hits
PROSITEiView protein in PROSITE
PS00111 PGLYCERATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

P25055-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLSTQSIPI KKSVDDIWPV AGKRVLIRVD FNVPTSSGGI DDDFRIRSAI
60 70 80 90 100
PTIRRIVDQG GICILISHLG RPTGVDYDTA HAEQEKRQTP VQLPNSRGKT
110 120 130 140 150
AFFSGLRGDA KATILAWSSQ REKAATLSNP YGSGKTAVFA RLPEEEKRRL
160 170 180 190 200
LLRFMSEHKE ELFPQLGSAG YEKEFSLEPV AVKLAELLDQ HVYFGHDCLG
210 220 230 240 250
AQADIAKLRC GEVMLLENLR FYTNENSSDE RKRMLMARIL ASYADVYIND
260 270 280 290 300
AFGTAHRDSA SLTGIPRVLQ QGAAGYLMEK EISYFSKVLN NPPRPLLAII
310 320 330 340 350
GGAKLSDKMQ VLENLLDCVD SLFIGGGLAY TFLRSQGYSI GTSHFEEAFV
360 370 380 390 400
PFAQALPLAG SGRQVRVVLP EDHVCHAHTR PAEAPLTTTS ANIPDGYAGL
410 420 430 440 450
DIGPLTIQSI THLVRQCSSV IWNGPLGMFE MPYYAFGTFS IARVVSQSSA
460 470 480 490 500
AKGTTSIVGG GDTASAMMKS GEAAHISHIS TGGNASLELL EGKVLAAVAV

LDNKE
Length:505
Mass (Da):54,758
Last modified:May 1, 1992 - v1
Checksum:iE184277AAB86D355
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17251 Genomic DNA Translation: CAA35114.1
PIRiS14463 KICRGF

Similar proteinsi

Entry informationi

Entry nameiPGKA_CRIFA
AccessioniPrimary (citable) accession number: P25055
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: May 23, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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