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Protein

Tyrosine-protein phosphatase 1

Gene

PTP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Is not required for vegetative growth.

Miscellaneous

Present with 2690 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei252Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

  • protein tyrosine phosphatase activity Source: SGD

GO - Biological processi

  • invasive growth in response to glucose limitation Source: SGD
  • protein dephosphorylation Source: SGD
  • pseudohyphal growth Source: SGD

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

BioCyciYEAST:G3O-29609-MONOMER.
ReactomeiR-SCE-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase 1 (EC:3.1.3.48)
Alternative name(s):
Protein-tyrosine phosphatase 1
Short name:
PTPase 1
Gene namesi
Name:PTP1
Ordered Locus Names:YDL230W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDL230W.
SGDiS000002389. PTP1.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4452.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000948551 – 335Tyrosine-protein phosphatase 1Add BLAST335

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei83Phosphoserine; by CLK11 Publication1

Post-translational modificationi

Activated by phosphorylation at Ser-83.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP25044.
PRIDEiP25044.

PTM databases

iPTMnetiP25044.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
RSP5P399402EBI-14183,EBI-16219

Protein-protein interaction databases

BioGridi31881. 90 interactors.
DIPiDIP-2765N.
IntActiP25044. 13 interactors.
MINTiMINT-490206.
STRINGi4932.YDL230W.

Chemistry databases

BindingDBiP25044.

Structurei

3D structure databases

ProteinModelPortaliP25044.
SMRiP25044.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 328Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST314

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00880000137873.
HOGENOMiHOG000243992.
InParanoidiP25044.
KOiK01104.
OMAiTFRSQRI.
OrthoDBiEOG092C49KM.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiView protein in InterPro
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016277. Ptp1.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
PfamiView protein in Pfam
PF00102. Y_phosphatase. 1 hit.
PIRSFiPIRSF000938. PTPN1_yeast. 1 hit.
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiView protein in SMART
SM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiView protein in PROSITE
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.

Sequencei

Sequence statusi: Complete.

P25044-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAPWYIRQ RDTDLLGKFK FIQNQEDGRL REATNGTVNS RWSLGVSIEP
60 70 80 90 100
RNDARNRYVN IMPYERNRVH LKTLSGNDYI NASYVKVNVP GQSIEPGYYI
110 120 130 140 150
ATQGPTRKTW DQFWQMCYHN CPLDNIVIVM VTPLVEYNRE KCYQYWPRGG
160 170 180 190 200
VDDTVRIASK WESPGGANDM TQFPSDLKIE FVNVHKVKDY YTVTDIKLTP
210 220 230 240 250
TDPLVGPVKT VHHFYFDLWK DMNKPEEVVP IMELCAHSHS LNSRGNPIIV
260 270 280 290 300
HCSAGVGRTG TFIALDHLMH DTLDFKNITE RSRHSDRATE EYTRDLIEQI
310 320 330
VLQLRSQRMK MVQTKDQFLF IYHAAKYLNS LSVNQ
Length:335
Mass (Da):38,868
Last modified:May 1, 1992 - v1
Checksum:i15F71E50694BE562
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64062 Genomic DNA. Translation: AAA34923.1.
Z74278 Genomic DNA. Translation: CAA98809.1.
BK006938 Genomic DNA. Translation: DAA11636.1.
PIRiA39862.
RefSeqiNP_010051.1. NM_001180290.1.

Genome annotation databases

EnsemblFungiiYDL230W; YDL230W; YDL230W.
GeneIDi851368.
KEGGisce:YDL230W.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPTP1_YEAST
AccessioniPrimary (citable) accession number: P25044
Secondary accession number(s): D6VRC6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: July 5, 2017
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names