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Protein

Tyrosine-protein phosphatase 1

Gene

PTP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Is not required for vegetative growth.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei252 – 2521Phosphocysteine intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: SGD

GO - Biological processi

  1. invasive growth in response to glucose limitation Source: SGD
  2. peptidyl-tyrosine dephosphorylation Source: GOC
  3. protein dephosphorylation Source: SGD
  4. pseudohyphal growth Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

BioCyciYEAST:G3O-29609-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase 1 (EC:3.1.3.48)
Alternative name(s):
Protein-tyrosine phosphatase 1
Short name:
PTPase 1
Gene namesi
Name:PTP1
Ordered Locus Names:YDL230W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome IV

Organism-specific databases

CYGDiYDL230w.
SGDiS000002389. PTP1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 335335Tyrosine-protein phosphatase 1PRO_0000094855Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei83 – 831Phosphoserine; by CLK11 Publication

Post-translational modificationi

Activated by phosphorylation at Ser-83.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP25044.
PaxDbiP25044.
PeptideAtlasiP25044.

Expressioni

Gene expression databases

GenevestigatoriP25044.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
RSP5P399402EBI-14183,EBI-16219

Protein-protein interaction databases

BioGridi31881. 71 interactions.
DIPiDIP-2765N.
IntActiP25044. 13 interactions.
MINTiMINT-490206.
STRINGi4932.YDL230W.

Structurei

3D structure databases

ProteinModelPortaliP25044.
SMRiP25044. Positions 18-330.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini15 – 328314Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5599.
GeneTreeiENSGT00780000121879.
HOGENOMiHOG000243992.
InParanoidiP25044.
KOiK01104.
OMAiNDARNRY.
OrthoDBiEOG7R573B.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR016277. Ptp1.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PIRSFiPIRSF000938. PTPN1_yeast. 1 hit.
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25044-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAPWYIRQ RDTDLLGKFK FIQNQEDGRL REATNGTVNS RWSLGVSIEP
60 70 80 90 100
RNDARNRYVN IMPYERNRVH LKTLSGNDYI NASYVKVNVP GQSIEPGYYI
110 120 130 140 150
ATQGPTRKTW DQFWQMCYHN CPLDNIVIVM VTPLVEYNRE KCYQYWPRGG
160 170 180 190 200
VDDTVRIASK WESPGGANDM TQFPSDLKIE FVNVHKVKDY YTVTDIKLTP
210 220 230 240 250
TDPLVGPVKT VHHFYFDLWK DMNKPEEVVP IMELCAHSHS LNSRGNPIIV
260 270 280 290 300
HCSAGVGRTG TFIALDHLMH DTLDFKNITE RSRHSDRATE EYTRDLIEQI
310 320 330
VLQLRSQRMK MVQTKDQFLF IYHAAKYLNS LSVNQ
Length:335
Mass (Da):38,868
Last modified:May 1, 1992 - v1
Checksum:i15F71E50694BE562
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64062 Genomic DNA. Translation: AAA34923.1.
Z74278 Genomic DNA. Translation: CAA98809.1.
BK006938 Genomic DNA. Translation: DAA11636.1.
PIRiA39862.
RefSeqiNP_010051.1. NM_001180290.1.

Genome annotation databases

EnsemblFungiiYDL230W; YDL230W; YDL230W.
GeneIDi851368.
KEGGisce:YDL230W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64062 Genomic DNA. Translation: AAA34923.1.
Z74278 Genomic DNA. Translation: CAA98809.1.
BK006938 Genomic DNA. Translation: DAA11636.1.
PIRiA39862.
RefSeqiNP_010051.1. NM_001180290.1.

3D structure databases

ProteinModelPortaliP25044.
SMRiP25044. Positions 18-330.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31881. 71 interactions.
DIPiDIP-2765N.
IntActiP25044. 13 interactions.
MINTiMINT-490206.
STRINGi4932.YDL230W.

Chemistry

BindingDBiP25044.
ChEMBLiCHEMBL4452.

Proteomic databases

MaxQBiP25044.
PaxDbiP25044.
PeptideAtlasiP25044.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDL230W; YDL230W; YDL230W.
GeneIDi851368.
KEGGisce:YDL230W.

Organism-specific databases

CYGDiYDL230w.
SGDiS000002389. PTP1.

Phylogenomic databases

eggNOGiCOG5599.
GeneTreeiENSGT00780000121879.
HOGENOMiHOG000243992.
InParanoidiP25044.
KOiK01104.
OMAiNDARNRY.
OrthoDBiEOG7R573B.

Enzyme and pathway databases

BioCyciYEAST:G3O-29609-MONOMER.

Miscellaneous databases

NextBioi968486.

Gene expression databases

GenevestigatoriP25044.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR016277. Ptp1.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PIRSFiPIRSF000938. PTPN1_yeast. 1 hit.
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of a yeast protein tyrosine phosphatase."
    Guan K., Deschenes R.J., Qiu H., Dixon J.E.
    J. Biol. Chem. 266:12964-12970(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
    Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
    , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
    Nature 387:75-78(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "The CLK family kinases, CLK1 and CLK2, phosphorylate and activate the tyrosine phosphatase, PTP-1B."
    Moeslein F.M., Myers M.P., Landreth G.E.
    J. Biol. Chem. 274:26697-26704(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-83.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPTP1_YEAST
AccessioniPrimary (citable) accession number: P25044
Secondary accession number(s): D6VRC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: April 1, 2015
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2690 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.