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P25044 (PTP1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein phosphatase 1

EC=3.1.3.48
Alternative name(s):
Protein-tyrosine phosphatase 1
Short name=PTPase 1
Gene names
Name:PTP1
Ordered Locus Names:YDL230W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length335 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Is not required for vegetative growth.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Subcellular location

Cytoplasm.

Post-translational modification

Activated by phosphorylation at Ser-83.

Miscellaneous

Present with 2690 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.

Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

RSP5P399402EBI-14183,EBI-16219

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 335335Tyrosine-protein phosphatase 1
PRO_0000094855

Regions

Domain15 – 328314Tyrosine-protein phosphatase

Sites

Active site2521Phosphocysteine intermediate By similarity

Amino acid modifications

Modified residue831Phosphoserine; by CLK1 Ref.4

Sequences

Sequence LengthMass (Da)Tools
P25044 [UniParc].

Last modified May 1, 1992. Version 1.
Checksum: 15F71E50694BE562

FASTA33538,868
        10         20         30         40         50         60 
MAAAPWYIRQ RDTDLLGKFK FIQNQEDGRL REATNGTVNS RWSLGVSIEP RNDARNRYVN 

        70         80         90        100        110        120 
IMPYERNRVH LKTLSGNDYI NASYVKVNVP GQSIEPGYYI ATQGPTRKTW DQFWQMCYHN 

       130        140        150        160        170        180 
CPLDNIVIVM VTPLVEYNRE KCYQYWPRGG VDDTVRIASK WESPGGANDM TQFPSDLKIE 

       190        200        210        220        230        240 
FVNVHKVKDY YTVTDIKLTP TDPLVGPVKT VHHFYFDLWK DMNKPEEVVP IMELCAHSHS 

       250        260        270        280        290        300 
LNSRGNPIIV HCSAGVGRTG TFIALDHLMH DTLDFKNITE RSRHSDRATE EYTRDLIEQI 

       310        320        330 
VLQLRSQRMK MVQTKDQFLF IYHAAKYLNS LSVNQ 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and expression of a yeast protein tyrosine phosphatase."
Guan K., Deschenes R.J., Qiu H., Dixon J.E.
J. Biol. Chem. 266:12964-12970(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T. expand/collapse author list , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"The CLK family kinases, CLK1 and CLK2, phosphorylate and activate the tyrosine phosphatase, PTP-1B."
Moeslein F.M., Myers M.P., Landreth G.E.
J. Biol. Chem. 274:26697-26704(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION AT SER-83.
[5]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M64062 Genomic DNA. Translation: AAA34923.1.
Z74278 Genomic DNA. Translation: CAA98809.1.
BK006938 Genomic DNA. Translation: DAA11636.1.
PIRA39862.
RefSeqNP_010051.1. NM_001180290.1.

3D structure databases

ProteinModelPortalP25044.
SMRP25044. Positions 18-330.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31881. 69 interactions.
DIPDIP-2765N.
IntActP25044. 13 interactions.
MINTMINT-490206.
STRING4932.YDL230W.

Chemistry

BindingDBP25044.
ChEMBLCHEMBL4452.

Proteomic databases

PaxDbP25044.
PeptideAtlasP25044.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYDL230W; YDL230W; YDL230W.
GeneID851368.
KEGGsce:YDL230W.

Organism-specific databases

CYGDYDL230w.
SGDS000002389. PTP1.

Phylogenomic databases

eggNOGCOG5599.
GeneTreeENSGT00740000114913.
HOGENOMHOG000243992.
KOK01104.
OMANDARNRY.
OrthoDBEOG7R573B.

Enzyme and pathway databases

BioCycYEAST:G3O-29609-MONOMER.

Gene expression databases

GenevestigatorP25044.

Family and domain databases

InterProIPR016277. Non-rcpt_Tyr_Pase_T1_fun.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PIRSFPIRSF000938. PTPN1_yeast. 1 hit.
PRINTSPR00700. PRTYPHPHTASE.
SMARTSM00194. PTPc. 1 hit.
[Graphical view]
PROSITEPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio968486.

Entry information

Entry namePTP1_YEAST
AccessionPrimary (citable) accession number: P25044
Secondary accession number(s): D6VRC6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: February 19, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome IV

Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families