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Protein

Cellular tumor antigen p53

Gene

tp53

Organism
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity).By similarity

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi164 – 1641ZincBy similarity
Metal bindingi167 – 1671ZincBy similarity
Metal bindingi227 – 2271ZincBy similarity
Metal bindingi231 – 2311ZincBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi90 – 281192By similarityAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • cell cycle Source: UniProtKB-KW
  • negative regulation of apoptotic process Source: AgBase
  • protein tetramerization Source: InterPro
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Apoptosis, Cell cycle, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cellular tumor antigen p53
Alternative name(s):
Tumor suppressor p53
Gene namesi
Name:tp53
Synonyms:p53
OrganismiOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Taxonomic identifieri8022 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 396396Cellular tumor antigen p53PRO_0000185720Add
BLAST

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Binds DNA as a homotetramer.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei108 – 1081Interaction with DNABy similarity

Structurei

3D structure databases

ProteinModelPortaliP25035.
SMRiP25035. Positions 82-283.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 4444Transcription activation (acidic)Add
BLAST
Regioni262 – 2698Interaction with DNABy similarity
Regioni325 – 35632OligomerizationAdd
BLAST
Regioni369 – 39224Basic (repression of DNA-binding)Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi297 – 31721Bipartite nuclear localization signalBy similarityAdd
BLAST
Motifi339 – 35012Nuclear export signalBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the p53 family.Curated

Phylogenomic databases

HOVERGENiHBG005201.

Family and domain databases

Gene3Di2.60.40.720. 1 hit.
4.10.170.10. 1 hit.
InterProiIPR008967. p53-like_TF_DNA-bd.
IPR012346. p53/RUNT-type_TF_DNA-bd.
IPR011615. p53_DNA-bd.
IPR010991. p53_tetrameristn.
IPR013872. p53_transactivation_domain.
IPR002117. p53_tumour_suppressor.
[Graphical view]
PANTHERiPTHR11447. PTHR11447. 1 hit.
PfamiPF00870. P53. 1 hit.
PF08563. P53_TAD. 1 hit.
PF07710. P53_tetramer. 1 hit.
[Graphical view]
PRINTSiPR00386. P53SUPPRESSR.
SUPFAMiSSF47719. SSF47719. 1 hit.
SSF49417. SSF49417. 1 hit.
PROSITEiPS00348. P53. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25035-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADLAENVSL PLSQESFEDL WKMNLNLVAV QPPETESWVG YDNFMMEAPL
60 70 80 90 100
QVEFDPSLFE VSATEPAPQP SISTLDTGSP PTSTVPTTSD YPGALGFQLR
110 120 130 140 150
FLQSSTAKSV TCTYSPDLNK LFCQLAKTCP VQIVVDHPPP PGAVVRALAI
160 170 180 190 200
YKKLSDVADV VRRCPHHQST SENNEGPAPR GHLVRVEGNQ RSEYMEDGNT
210 220 230 240 250
LRHSVLVPYE PPQVGSECTT VLYNFMCNSS CMGGMNRRPI LTIITLETQE
260 270 280 290 300
GQLLGRRSFE VRVCACPGRD RKTEEINLKK QQETTLETKT KPAQGIKRAM
310 320 330 340 350
KEASLPAPQP GASKKTKSSP AVSDDEIYTL QIRGKEKYEM LKKFNDSLEL
360 370 380 390
SELVPVADAD KYRQKCLTKR VAKRDFGVGP KKRKKLLVKE EKSDSD
Length:396
Mass (Da):43,966
Last modified:May 1, 1992 - v1
Checksum:i8422250765545A1C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M75145 mRNA. Translation: AAA49605.1.
PIRiJH0631.
RefSeqiNP_001118164.1. NM_001124692.1.
UniGeneiOmy.11581.

Genome annotation databases

GeneIDi100136737.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M75145 mRNA. Translation: AAA49605.1.
PIRiJH0631.
RefSeqiNP_001118164.1. NM_001124692.1.
UniGeneiOmy.11581.

3D structure databases

ProteinModelPortaliP25035.
SMRiP25035. Positions 82-283.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100136737.

Organism-specific databases

CTDi7157.

Phylogenomic databases

HOVERGENiHBG005201.

Family and domain databases

Gene3Di2.60.40.720. 1 hit.
4.10.170.10. 1 hit.
InterProiIPR008967. p53-like_TF_DNA-bd.
IPR012346. p53/RUNT-type_TF_DNA-bd.
IPR011615. p53_DNA-bd.
IPR010991. p53_tetrameristn.
IPR013872. p53_transactivation_domain.
IPR002117. p53_tumour_suppressor.
[Graphical view]
PANTHERiPTHR11447. PTHR11447. 1 hit.
PfamiPF00870. P53. 1 hit.
PF08563. P53_TAD. 1 hit.
PF07710. P53_tetramer. 1 hit.
[Graphical view]
PRINTSiPR00386. P53SUPPRESSR.
SUPFAMiSSF47719. SSF47719. 1 hit.
SSF49417. SSF49417. 1 hit.
PROSITEiPS00348. P53. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Rainbow trout p53: cDNA cloning and biochemical characterization."
    de Fromentel C.C., Padkel F., Chapus A., Baney C., May P., Soussi T.
    Gene 112:241-245(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiP53_ONCMY
AccessioniPrimary (citable) accession number: P25035
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: October 14, 2015
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.