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Protein

Cellular tumor antigen p53

Gene

tp53

Organism
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity).By similarity

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi164ZincBy similarity1
Metal bindingi167ZincBy similarity1
Metal bindingi227ZincBy similarity1
Metal bindingi231ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi90 – 281By similarityAdd BLAST192

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processApoptosis, Cell cycle, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cellular tumor antigen p53
Alternative name(s):
Tumor suppressor p53
Gene namesi
Name:tp53
Synonyms:p53
OrganismiOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Taxonomic identifieri8022 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001857201 – 396Cellular tumor antigen p53Add BLAST396

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP25035

Interactioni

Subunit structurei

Binds DNA as a homotetramer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei108Interaction with DNABy similarity1

Structurei

3D structure databases

ProteinModelPortaliP25035
SMRiP25035
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 44Transcription activation (acidic)Add BLAST44
Regioni262 – 269Interaction with DNABy similarity8
Regioni325 – 356OligomerizationAdd BLAST32
Regioni369 – 392Basic (repression of DNA-binding)Add BLAST24

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi297 – 317Bipartite nuclear localization signalBy similarityAdd BLAST21
Motifi339 – 350Nuclear export signalBy similarityAdd BLAST12

Sequence similaritiesi

Belongs to the p53 family.Curated

Phylogenomic databases

HOVERGENiHBG005201

Family and domain databases

CDDicd08367 P53, 1 hit
Gene3Di2.60.40.720, 1 hit
4.10.170.10, 1 hit
InterProiView protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR012346 p53/RUNT-type_TF_DNA-bd_sf
IPR011615 p53_DNA-bd
IPR036674 p53_tetramer_sf
IPR010991 p53_tetrameristn
IPR013872 p53_transactivation_domain
IPR002117 p53_tumour_suppressor
PANTHERiPTHR11447 PTHR11447, 1 hit
PfamiView protein in Pfam
PF00870 P53, 1 hit
PF08563 P53_TAD, 1 hit
PF07710 P53_tetramer, 1 hit
PRINTSiPR00386 P53SUPPRESSR
SUPFAMiSSF47719 SSF47719, 1 hit
SSF49417 SSF49417, 1 hit
PROSITEiView protein in PROSITE
PS00348 P53, 1 hit

Sequencei

Sequence statusi: Complete.

P25035-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADLAENVSL PLSQESFEDL WKMNLNLVAV QPPETESWVG YDNFMMEAPL
60 70 80 90 100
QVEFDPSLFE VSATEPAPQP SISTLDTGSP PTSTVPTTSD YPGALGFQLR
110 120 130 140 150
FLQSSTAKSV TCTYSPDLNK LFCQLAKTCP VQIVVDHPPP PGAVVRALAI
160 170 180 190 200
YKKLSDVADV VRRCPHHQST SENNEGPAPR GHLVRVEGNQ RSEYMEDGNT
210 220 230 240 250
LRHSVLVPYE PPQVGSECTT VLYNFMCNSS CMGGMNRRPI LTIITLETQE
260 270 280 290 300
GQLLGRRSFE VRVCACPGRD RKTEEINLKK QQETTLETKT KPAQGIKRAM
310 320 330 340 350
KEASLPAPQP GASKKTKSSP AVSDDEIYTL QIRGKEKYEM LKKFNDSLEL
360 370 380 390
SELVPVADAD KYRQKCLTKR VAKRDFGVGP KKRKKLLVKE EKSDSD
Length:396
Mass (Da):43,966
Last modified:May 1, 1992 - v1
Checksum:i8422250765545A1C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M75145 mRNA Translation: AAA49605.1
PIRiJH0631
RefSeqiNP_001118164.1, NM_001124692.1
UniGeneiOmy.11581

Genome annotation databases

GeneIDi100136737

Similar proteinsi

Entry informationi

Entry nameiP53_ONCMY
AccessioniPrimary (citable) accession number: P25035
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: May 23, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

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