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P25025

- CXCR2_HUMAN

UniProt

P25025 - CXCR2_HUMAN

Protein

C-X-C chemokine receptor type 2

Gene

CXCR2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 150 (01 Oct 2014)
      Sequence version 2 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.

    GO - Molecular functioni

    1. C-X-C chemokine receptor activity Source: UniProtKB
    2. interleukin-8 binding Source: UniProtKB
    3. interleukin-8 receptor activity Source: UniProtKB
    4. protein binding Source: IntAct
    5. signal transducer activity Source: UniProtKB

    GO - Biological processi

    1. acute inflammatory response to antigenic stimulus Source: Ensembl
    2. cell surface receptor signaling pathway Source: UniProtKB
    3. cellular defense response Source: UniProtKB
    4. chemokine-mediated signaling pathway Source: GOC
    5. chemotaxis Source: UniProtKB
    6. dendritic cell chemotaxis Source: BHF-UCL
    7. inflammatory response Source: ProtInc
    8. interleukin-8-mediated signaling pathway Source: GOC
    9. metanephric tubule morphogenesis Source: Ensembl
    10. midbrain development Source: Ensembl
    11. negative regulation of neutrophil apoptotic process Source: Ensembl
    12. neutrophil activation Source: UniProtKB
    13. neutrophil chemotaxis Source: UniProtKB
    14. phospholipase C-activating G-protein coupled receptor signaling pathway Source: UniProtKB
    15. positive regulation of angiogenesis Source: Ensembl
    16. positive regulation of cardiac muscle cell apoptotic process Source: Ensembl
    17. positive regulation of cell proliferation Source: UniProtKB
    18. positive regulation of cytosolic calcium ion concentration Source: Ensembl
    19. positive regulation of neutrophil chemotaxis Source: Ensembl
    20. positive regulation of vascular permeability Source: Ensembl
    21. receptor internalization Source: UniProtKB
    22. signal transduction Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Chemotaxis

    Enzyme and pathway databases

    ReactomeiREACT_15344. Chemokine receptors bind chemokines.
    REACT_19231. G alpha (i) signalling events.
    SignaLinkiP25025.

    Protein family/group databases

    GPCRDBiSearch...

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-X-C chemokine receptor type 2
    Short name:
    CXC-R2
    Short name:
    CXCR-2
    Alternative name(s):
    CDw128b
    GRO/MGSA receptor
    High affinity interleukin-8 receptor B
    Short name:
    IL-8R B
    IL-8 receptor type 2
    CD_antigen: CD182
    Gene namesi
    Name:CXCR2
    Synonyms:IL8RB
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Organism-specific databases

    HGNCiHGNC:6027. CXCR2.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: UniProtKB
    2. integral component of plasma membrane Source: UniProtKB
    3. intracellular Source: UniProtKB
    4. mast cell granule Source: UniProtKB
    5. membrane Source: UniProtKB
    6. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29843.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 360360C-X-C chemokine receptor type 2PRO_0000069337Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi22 – 221N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi119 ↔ 196PROSITE-ProRule annotations
    Modified residuei347 – 3471Phosphoserine1 Publication
    Modified residuei351 – 3511Phosphoserine1 Publication
    Modified residuei352 – 3521Phosphoserine1 Publication
    Modified residuei353 – 3531Phosphoserine1 Publication

    Post-translational modificationi

    Phosphorylated upon ligand binding; which is required for desensitization.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiP25025.
    PRIDEiP25025.

    PTM databases

    PhosphoSiteiP25025.

    Expressioni

    Gene expression databases

    ArrayExpressiP25025.
    BgeeiP25025.
    CleanExiHS_IL8RB.
    GenevestigatoriP25025.

    Organism-specific databases

    HPAiCAB016268.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CXCL8P101452EBI-2835281,EBI-3917999

    Protein-protein interaction databases

    BioGridi109793. 8 interactions.
    DIPiDIP-3782N.
    IntActiP25025. 5 interactions.
    MINTiMINT-271138.
    STRINGi9606.ENSP00000319635.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4Q3HX-ray1.44A/B356-360[»]
    ProteinModelPortaliP25025.
    SMRiP25025. Positions 38-333.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4848ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini76 – 849CytoplasmicSequence Analysis
    Topological domaini106 – 12015ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini143 – 16321CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini184 – 20825ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini232 – 25120CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini274 – 29421ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini316 – 36045CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei49 – 7527Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei85 – 10521Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei121 – 14222Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei164 – 18320Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei209 – 23123Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei252 – 27322Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei295 – 31521Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotations

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG146068.
    HOGENOMiHOG000234122.
    HOVERGENiHBG106917.
    InParanoidiP25025.
    KOiK05050.
    OMAiLFRRTIY.
    PhylomeDBiP25025.
    TreeFamiTF330966.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000057. Chemokine_CXCR2.
    IPR000174. Chemokine_CXCR_1/2.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24227. PTHR24227. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00427. INTRLEUKIN8R.
    PR00573. INTRLEUKN8BR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]
    ProtoNetiSearch...

    Sequencei

    Sequence statusi: Complete.

    P25025-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEDFNMESDS FEDFWKGEDL SNYSYSSTLP PFLLDAAPCE PESLEINKYF    50
    VVIIYALVFL LSLLGNSLVM LVILYSRVGR SVTDVYLLNL ALADLLFALT 100
    LPIWAASKVN GWIFGTFLCK VVSLLKEVNF YSGILLLACI SVDRYLAIVH 150
    ATRTLTQKRY LVKFICLSIW GLSLLLALPV LLFRRTVYSS NVSPACYEDM 200
    GNNTANWRML LRILPQSFGF IVPLLIMLFC YGFTLRTLFK AHMGQKHRAM 250
    RVIFAVVLIF LLCWLPYNLV LLADTLMRTQ VIQETCERRN HIDRALDATE 300
    ILGILHSCLN PLIYAFIGQK FRHGLLKILA IHGLISKDSL PKDSRPSFVG 350
    SSSGHTSTTL 360
    Length:360
    Mass (Da):40,759
    Last modified:February 1, 1996 - v2
    Checksum:i564F04A8BCC0A197
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti80 – 801R → C.1 Publication
    Corresponds to variant rs1805038 [ dbSNP | Ensembl ].
    VAR_014679

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M73969 mRNA. Translation: AAA83148.1.
    M94582 mRNA. Translation: AAA36108.1.
    M99412 Genomic DNA. Translation: AAC14460.1.
    L19593 mRNA. Translation: AAB59437.1.
    U11869 Genomic DNA. Translation: AAB60656.1.
    AY714242 Genomic DNA. Translation: AAT97985.1.
    BC037961 mRNA. Translation: AAH37961.2.
    AB032733 Genomic DNA. Translation: BAA92295.1.
    AB032734 Genomic DNA. Translation: BAA92296.1.
    CCDSiCCDS2408.1.
    PIRiI37898. A53611.
    RefSeqiNP_001161770.1. NM_001168298.1.
    NP_001548.1. NM_001557.3.
    XP_005246587.1. XM_005246530.1.
    XP_005246588.1. XM_005246531.1.
    UniGeneiHs.846.

    Genome annotation databases

    EnsembliENST00000318507; ENSP00000319635; ENSG00000180871.
    GeneIDi3579.
    KEGGihsa:3579.
    UCSCiuc002vgz.2. human.

    Polymorphism databases

    DMDMi1352454.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    CXC chemokine receptors entry

    SeattleSNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M73969 mRNA. Translation: AAA83148.1 .
    M94582 mRNA. Translation: AAA36108.1 .
    M99412 Genomic DNA. Translation: AAC14460.1 .
    L19593 mRNA. Translation: AAB59437.1 .
    U11869 Genomic DNA. Translation: AAB60656.1 .
    AY714242 Genomic DNA. Translation: AAT97985.1 .
    BC037961 mRNA. Translation: AAH37961.2 .
    AB032733 Genomic DNA. Translation: BAA92295.1 .
    AB032734 Genomic DNA. Translation: BAA92296.1 .
    CCDSi CCDS2408.1.
    PIRi I37898. A53611.
    RefSeqi NP_001161770.1. NM_001168298.1.
    NP_001548.1. NM_001557.3.
    XP_005246587.1. XM_005246530.1.
    XP_005246588.1. XM_005246531.1.
    UniGenei Hs.846.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4Q3H X-ray 1.44 A/B 356-360 [» ]
    ProteinModelPortali P25025.
    SMRi P25025. Positions 38-333.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109793. 8 interactions.
    DIPi DIP-3782N.
    IntActi P25025. 5 interactions.
    MINTi MINT-271138.
    STRINGi 9606.ENSP00000319635.

    Chemistry

    BindingDBi P25025.
    ChEMBLi CHEMBL2434.
    GuidetoPHARMACOLOGYi 69.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P25025.

    Polymorphism databases

    DMDMi 1352454.

    Proteomic databases

    PaxDbi P25025.
    PRIDEi P25025.

    Protocols and materials databases

    DNASUi 3579.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000318507 ; ENSP00000319635 ; ENSG00000180871 .
    GeneIDi 3579.
    KEGGi hsa:3579.
    UCSCi uc002vgz.2. human.

    Organism-specific databases

    CTDi 3579.
    GeneCardsi GC02P219012.
    HGNCi HGNC:6027. CXCR2.
    HPAi CAB016268.
    MIMi 146928. gene.
    neXtProti NX_P25025.
    PharmGKBi PA29843.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG146068.
    HOGENOMi HOG000234122.
    HOVERGENi HBG106917.
    InParanoidi P25025.
    KOi K05050.
    OMAi LFRRTIY.
    PhylomeDBi P25025.
    TreeFami TF330966.

    Enzyme and pathway databases

    Reactomei REACT_15344. Chemokine receptors bind chemokines.
    REACT_19231. G alpha (i) signalling events.
    SignaLinki P25025.

    Miscellaneous databases

    GenomeRNAii 3579.
    NextBioi 13990.
    PROi P25025.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P25025.
    Bgeei P25025.
    CleanExi HS_IL8RB.
    Genevestigatori P25025.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000057. Chemokine_CXCR2.
    IPR000174. Chemokine_CXCR_1/2.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24227. PTHR24227. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00427. INTRLEUKIN8R.
    PR00573. INTRLEUKN8BR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of complementary DNA encoding a functional human interleukin-8 receptor."
      Murphy P.M., Tiffany H.L.
      Science 253:1280-1283(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Molecular characterization of receptors for human interleukin-8, GRO/melanoma growth-stimulatory activity and neutrophil activating peptide-2."
      Cerretti D.P., Kozlosky C.J., Vanden Bos T., Nelson N., Gearing D.P., Beckmann M.P.
      Mol. Immunol. 30:359-367(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
    3. "Structure, genomic organization, and expression of the human interleukin-8 receptor B gene."
      Sprenger H., Lloyd A.R., Lautens L.L., Bonner T.I., Kelvin D.J.
      J. Biol. Chem. 269:11065-11072(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    4. "Comparison of the genomic organization and promoter function for human interleukin-8 receptors A and B."
      Ahuja S.K., Shetty A., Tiffany H.L., Murphy P.M.
      J. Biol. Chem. 269:26381-26389(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Placenta.
    5. SeattleSNPs variation discovery resource
      Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    7. "Single nucleotide polymorphisms in the coding regions of human CXC-chemokine receptors CXCR1, CXCR2 and CXCR3."
      Kato H., Tsuchiya N., Tokunaga K.
      Genes Immun. 1:330-337(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 52-162 AND 191-301, VARIANT CYS-80.
    8. "Characterization of two high affinity human interleukin-8 receptors."
      Lee J., Horuk R., Rice G.C., Bennett G.L., Camerato T., Wood W.I.
      J. Biol. Chem. 267:16283-16287(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    9. "Ligand-induced desensitization of the human CXC chemokine receptor-2 is modulated by multiple serine residues in the carboxyl-terminal domain of the receptor."
      Mueller S.G., White J.R., Schraw W.P., Lam V., Richmond A.
      J. Biol. Chem. 272:8207-8214(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-347; SER-351; SER-352 AND SER-353.

    Entry informationi

    Entry nameiCXCR2_HUMAN
    AccessioniPrimary (citable) accession number: P25025
    Secondary accession number(s): Q8IUZ1, Q9P2T6, Q9P2T7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 150 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    3. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    4. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    5. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    6. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    7. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    8. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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