C-X-C chemokine receptor type 2 - Homo sapiens (Human)

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P25025 (CXCR2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 137. History...

Clusters with 100%, 90%, 50% identity |

Documents (7) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
C-X-C chemokine receptor type 2
Short name=CXC-R2
Short name=CXCR-2

Alternative name(s):
CDw128b
GRO/MGSA receptor
High affinity interleukin-8 receptor B
Short name=IL-8R B
IL-8 receptor type 2
CD_antigen=CD182

Gene names

Name:	CXCR2
Synonyms:	IL8RB

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	360 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Post-translational modification	Phosphorylated upon ligand binding; which is required for desensitization. Ref.9
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Chemotaxis
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	apoptotic process Inferred from electronic annotation. Source: Compara cellular defense response Inferred from direct assay PubMed 10725748. Source: UniProtKB dendritic cell chemotaxis Traceable author statement PubMed 16621978. Source: BHF-UCL elevation of cytosolic calcium ion concentration Inferred from electronic annotation. Source: Compara inflammatory response Traceable author statement PubMed 9725262. Source: ProtInc negative regulation of cAMP biosynthetic process Inferred from electronic annotation. Source: InterPro neutrophil activation Inferred from direct assay PubMed 10878382. Source: UniProtKB neutrophil chemotaxis Inferred from direct assay PubMed 10820279. Source: UniProtKB phospholipase C-activating G-protein coupled receptor signaling pathway Inferred from direct assay PubMed 10438939. Source: UniProtKB positive regulation of cell proliferation Inferred from direct assay PubMed 10438939. Source: UniProtKB receptor internalization Inferred from direct assay PubMed 10734056. Source: UniProtKB
Cellular_component	cell surface Inferred from direct assay PubMed 10878382. Source: UniProtKB integral to plasma membrane Traceable author statement PubMed 10438939. Source: UniProtKB mast cell granule Inferred from direct assay PubMed 9725262. Source: UniProtKB
Molecular_function	interleukin-8 receptor activity Inferred from direct assay PubMed 10820279. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 360

360

C-X-C chemokine receptor type 2

PRO_0000069337

Regions

Topological domain

1 – 48

Extracellular Potential

Transmembrane

49 – 75

Helical; Name=1; Potential

Topological domain

76 – 84

Cytoplasmic Potential

Transmembrane

85 – 105

Helical; Name=2; Potential

Topological domain

106 – 120

Extracellular Potential

Transmembrane

121 – 142

Helical; Name=3; Potential

Topological domain

143 – 163

Cytoplasmic Potential

Transmembrane

164 – 183

Helical; Name=4; Potential

Topological domain

184 – 208

Extracellular Potential

Transmembrane

209 – 231

Helical; Name=5; Potential

Topological domain

232 – 251

Cytoplasmic Potential

Transmembrane

252 – 273

Helical; Name=6; Potential

Topological domain

274 – 294

Extracellular Potential

Transmembrane

295 – 315

Helical; Name=7; Potential

Topological domain

316 – 360

Cytoplasmic Potential

Amino acid modifications

Modified residue

347

Phosphoserine Probable

Modified residue

351

Phosphoserine Probable

Modified residue

352

Phosphoserine Probable

Modified residue

353

Phosphoserine Probable

Glycosylation

N-linked (GlcNAc...) Potential

Disulfide bond

119 ↔ 196

By similarity

Natural variations

Natural variant

R → C. Ref.7
Corresponds to variant rs1805038 [ dbSNP | Ensembl ].

VAR_014679

Sequences

Sequence

Length

Mass (Da)

Tools

P25025 [UniParc].

Last modified February 1, 1996. Version 2.
Checksum: 564F04A8BCC0A197
Show »

FASTA

360

40,759

        10         20         30         40         50         60 
MEDFNMESDS FEDFWKGEDL SNYSYSSTLP PFLLDAAPCE PESLEINKYF VVIIYALVFL 

        70         80         90        100        110        120 
LSLLGNSLVM LVILYSRVGR SVTDVYLLNL ALADLLFALT LPIWAASKVN GWIFGTFLCK 

       130        140        150        160        170        180 
VVSLLKEVNF YSGILLLACI SVDRYLAIVH ATRTLTQKRY LVKFICLSIW GLSLLLALPV 

       190        200        210        220        230        240 
LLFRRTVYSS NVSPACYEDM GNNTANWRML LRILPQSFGF IVPLLIMLFC YGFTLRTLFK 

       250        260        270        280        290        300 
AHMGQKHRAM RVIFAVVLIF LLCWLPYNLV LLADTLMRTQ VIQETCERRN HIDRALDATE 

       310        320        330        340        350        360 
ILGILHSCLN PLIYAFIGQK FRHGLLKILA IHGLISKDSL PKDSRPSFVG SSSGHTSTTL

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of complementary DNA encoding a functional human interleukin-8 receptor." Murphy P.M., Tiffany H.L. Science 253:1280-1283(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Molecular characterization of receptors for human interleukin-8, GRO/melanoma growth-stimulatory activity and neutrophil activating peptide-2." Cerretti D.P., Kozlosky C.J., Vanden Bos T., Nelson N., Gearing D.P., Beckmann M.P. Mol. Immunol. 30:359-367(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
[3]	"Structure, genomic organization, and expression of the human interleukin-8 receptor B gene." Sprenger H., Lloyd A.R., Lautens L.L., Bonner T.I., Kelvin D.J. J. Biol. Chem. 269:11065-11072(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[4]	"Comparison of the genomic organization and promoter function for human interleukin-8 receptors A and B." Ahuja S.K., Shetty A., Tiffany H.L., Murphy P.M. J. Biol. Chem. 269:26381-26389(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Placenta.
[5]	SeattleSNPs variation discovery resource Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[7]	"Single nucleotide polymorphisms in the coding regions of human CXC-chemokine receptors CXCR1, CXCR2 and CXCR3." Kato H., Tsuchiya N., Tokunaga K. Genes Immun. 1:330-337(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 52-162 AND 191-301, VARIANT CYS-80.
[8]	"Characterization of two high affinity human interleukin-8 receptors." Lee J., Horuk R., Rice G.C., Bennett G.L., Camerato T., Wood W.I. J. Biol. Chem. 267:16283-16287(1992) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION.
[9]	"Ligand-induced desensitization of the human CXC chemokine receptor-2 is modulated by multiple serine residues in the carboxyl-terminal domain of the receptor." Mueller S.G., White J.R., Schraw W.P., Lam V., Richmond A. J. Biol. Chem. 272:8207-8214(1997) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION AT SER-347; SER-351; SER-352 AND SER-353.
+	Additional computationally mapped references.

Web resources

Wikipedia

CXC chemokine receptors entry

SeattleSNPs

Cross-references

Sequence databases
EMBL GenBank DDBJ	M73969 mRNA. Translation: AAA83148.1. M94582 mRNA. Translation: AAA36108.1. M99412 Genomic DNA. Translation: AAC14460.1. L19593 mRNA. Translation: AAB59437.1. U11869 Genomic DNA. Translation: AAB60656.1. AY714242 Genomic DNA. Translation: AAT97985.1. BC037961 mRNA. Translation: AAH37961.2. AB032733 Genomic DNA. Translation: BAA92295.1. AB032734 Genomic DNA. Translation: BAA92296.1.
IPI	IPI00012320.
PIR	A53611. I37898.
RefSeq	NP_001161770.1. NM_001168298.1. NP_001548.1. NM_001557.3.
UniGene	Hs.846.
3D structure databases
ProteinModelPortal	P25025.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-3782N.
IntAct	P25025. 4 interactions.
MINT	MINT-271138.
STRING	9606.ENSP00000319635.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P25025.
Polymorphism databases
DMDM	1352454.
Proteomic databases
PaxDb	P25025.
PRIDE	P25025.
Protocols and materials databases
DNASU	3579.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000318507; ENSP00000319635; ENSG00000180871.
GeneID	3579.
KEGG	hsa:3579.
UCSC	uc002vgz.2. human.
Organism-specific databases
CTD	3579.
GeneCards	GC02P218994.
HGNC	HGNC:6027. CXCR2.
HPA	CAB016268.
MIM	146928. gene.
neXtProt	NX_P25025.
PharmGKB	PA29843.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG146068.
HOGENOM	HOG000234122.
HOVERGEN	HBG106917.
InParanoid	P25025.
KO	K05050.
OMA	THGLISK.
PhylomeDB	P25025.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	P25025.
Bgee	P25025.
CleanEx	HS_IL8RB.
Genevestigator	P25025.
GermOnline	ENSG00000180871. Homo sapiens.
Family and domain databases
InterPro	IPR000174. Chemokine_CXCR. IPR000057. Chemokine_CXCR2. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00427. INTRLEUKIN8R. PR00573. INTRLEUKN8BR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P25025.
ChEMBL	CHEMBL2434.
GenomeRNAi	3579.
NextBio	13990.
SOURCE	Search...

Entry information

Entry name

CXCR2_HUMAN

Accession

Primary (citable) accession number: P25025
Secondary accession number(s): Q8IUZ1, Q9P2T6, Q9P2T7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1992
Last sequence update:	February 1, 1996
Last modified:	May 1, 2013
This is version 137 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.