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Protein

C-X-C chemokine receptor type 2

Gene

CXCR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.

GO - Molecular functioni

  1. C-X-C chemokine receptor activity Source: UniProtKB
  2. interleukin-8 binding Source: UniProtKB
  3. interleukin-8 receptor activity Source: UniProtKB
  4. signal transducer activity Source: UniProtKB

GO - Biological processi

  1. acute inflammatory response to antigenic stimulus Source: Ensembl
  2. cell surface receptor signaling pathway Source: UniProtKB
  3. cellular defense response Source: UniProtKB
  4. chemokine-mediated signaling pathway Source: GOC
  5. chemotaxis Source: UniProtKB
  6. dendritic cell chemotaxis Source: BHF-UCL
  7. inflammatory response Source: ProtInc
  8. interleukin-8-mediated signaling pathway Source: GOC
  9. metanephric tubule morphogenesis Source: Ensembl
  10. midbrain development Source: Ensembl
  11. negative regulation of neutrophil apoptotic process Source: Ensembl
  12. neutrophil activation Source: UniProtKB
  13. neutrophil chemotaxis Source: UniProtKB
  14. phospholipase C-activating G-protein coupled receptor signaling pathway Source: UniProtKB
  15. positive regulation of angiogenesis Source: Ensembl
  16. positive regulation of cardiac muscle cell apoptotic process Source: Ensembl
  17. positive regulation of cell proliferation Source: UniProtKB
  18. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  19. positive regulation of neutrophil chemotaxis Source: Ensembl
  20. positive regulation of vascular permeability Source: Ensembl
  21. receptor internalization Source: UniProtKB
  22. signal transduction Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Chemotaxis

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.
SignaLinkiP25025.

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C chemokine receptor type 2
Short name:
CXC-R2
Short name:
CXCR-2
Alternative name(s):
CDw128b
GRO/MGSA receptor
High affinity interleukin-8 receptor B
Short name:
IL-8R B
IL-8 receptor type 2
CD_antigen: CD182
Gene namesi
Name:CXCR2
Synonyms:IL8RB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:6027. CXCR2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4848ExtracellularSequence AnalysisAdd
BLAST
Transmembranei49 – 7527Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini76 – 849CytoplasmicSequence Analysis
Transmembranei85 – 10521Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini106 – 12015ExtracellularSequence AnalysisAdd
BLAST
Transmembranei121 – 14222Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini143 – 16321CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei164 – 18320Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini184 – 20825ExtracellularSequence AnalysisAdd
BLAST
Transmembranei209 – 23123Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini232 – 25120CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei252 – 27322Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini274 – 29421ExtracellularSequence AnalysisAdd
BLAST
Transmembranei295 – 31521Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini316 – 36045CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: UniProtKB
  2. integral component of plasma membrane Source: UniProtKB
  3. intracellular Source: UniProtKB
  4. mast cell granule Source: UniProtKB
  5. membrane Source: UniProtKB
  6. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29843.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 360360C-X-C chemokine receptor type 2PRO_0000069337Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi22 – 221N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi119 ↔ 196PROSITE-ProRule annotation
Modified residuei347 – 3471Phosphoserine1 Publication
Modified residuei351 – 3511Phosphoserine1 Publication
Modified residuei352 – 3521Phosphoserine1 Publication
Modified residuei353 – 3531Phosphoserine1 Publication

Post-translational modificationi

Phosphorylated upon ligand binding; which is required for desensitization.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP25025.
PRIDEiP25025.

PTM databases

PhosphoSiteiP25025.

Expressioni

Gene expression databases

BgeeiP25025.
CleanExiHS_IL8RB.
ExpressionAtlasiP25025. baseline and differential.
GenevestigatoriP25025.

Organism-specific databases

HPAiCAB016268.
HPA031999.
HPA032017.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CXCL8P101452EBI-2835281,EBI-3917999

Protein-protein interaction databases

BioGridi109793. 8 interactions.
DIPiDIP-3782N.
IntActiP25025. 5 interactions.
MINTiMINT-271138.
STRINGi9606.ENSP00000319635.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4Q3HX-ray1.44A/B356-360[»]
ProteinModelPortaliP25025.
SMRiP25025. Positions 38-333.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146068.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP25025.
KOiK05050.
OMAiRRAIHPP.
PhylomeDBiP25025.
TreeFamiTF330966.

Family and domain databases

InterProiIPR000057. Chemokine_CXCR2.
IPR000174. Chemokine_CXCR_1/2.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00427. INTRLEUKIN8R.
PR00573. INTRLEUKN8BR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25025-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDFNMESDS FEDFWKGEDL SNYSYSSTLP PFLLDAAPCE PESLEINKYF
60 70 80 90 100
VVIIYALVFL LSLLGNSLVM LVILYSRVGR SVTDVYLLNL ALADLLFALT
110 120 130 140 150
LPIWAASKVN GWIFGTFLCK VVSLLKEVNF YSGILLLACI SVDRYLAIVH
160 170 180 190 200
ATRTLTQKRY LVKFICLSIW GLSLLLALPV LLFRRTVYSS NVSPACYEDM
210 220 230 240 250
GNNTANWRML LRILPQSFGF IVPLLIMLFC YGFTLRTLFK AHMGQKHRAM
260 270 280 290 300
RVIFAVVLIF LLCWLPYNLV LLADTLMRTQ VIQETCERRN HIDRALDATE
310 320 330 340 350
ILGILHSCLN PLIYAFIGQK FRHGLLKILA IHGLISKDSL PKDSRPSFVG
360
SSSGHTSTTL
Length:360
Mass (Da):40,759
Last modified:February 1, 1996 - v2
Checksum:i564F04A8BCC0A197
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti80 – 801R → C.1 Publication
Corresponds to variant rs1805038 [ dbSNP | Ensembl ].
VAR_014679

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73969 mRNA. Translation: AAA83148.1.
M94582 mRNA. Translation: AAA36108.1.
M99412 Genomic DNA. Translation: AAC14460.1.
L19593 mRNA. Translation: AAB59437.1.
U11869 Genomic DNA. Translation: AAB60656.1.
AY714242 Genomic DNA. Translation: AAT97985.1.
BC037961 mRNA. Translation: AAH37961.2.
AB032733 Genomic DNA. Translation: BAA92295.1.
AB032734 Genomic DNA. Translation: BAA92296.1.
CCDSiCCDS2408.1.
PIRiI37898. A53611.
RefSeqiNP_001161770.1. NM_001168298.1.
NP_001548.1. NM_001557.3.
XP_005246587.1. XM_005246530.1.
XP_005246588.1. XM_005246531.1.
UniGeneiHs.846.

Genome annotation databases

EnsembliENST00000318507; ENSP00000319635; ENSG00000180871.
GeneIDi3579.
KEGGihsa:3579.
UCSCiuc002vgz.2. human.

Polymorphism databases

DMDMi1352454.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

CXC chemokine receptors entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73969 mRNA. Translation: AAA83148.1.
M94582 mRNA. Translation: AAA36108.1.
M99412 Genomic DNA. Translation: AAC14460.1.
L19593 mRNA. Translation: AAB59437.1.
U11869 Genomic DNA. Translation: AAB60656.1.
AY714242 Genomic DNA. Translation: AAT97985.1.
BC037961 mRNA. Translation: AAH37961.2.
AB032733 Genomic DNA. Translation: BAA92295.1.
AB032734 Genomic DNA. Translation: BAA92296.1.
CCDSiCCDS2408.1.
PIRiI37898. A53611.
RefSeqiNP_001161770.1. NM_001168298.1.
NP_001548.1. NM_001557.3.
XP_005246587.1. XM_005246530.1.
XP_005246588.1. XM_005246531.1.
UniGeneiHs.846.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4Q3HX-ray1.44A/B356-360[»]
ProteinModelPortaliP25025.
SMRiP25025. Positions 38-333.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109793. 8 interactions.
DIPiDIP-3782N.
IntActiP25025. 5 interactions.
MINTiMINT-271138.
STRINGi9606.ENSP00000319635.

Chemistry

BindingDBiP25025.
ChEMBLiCHEMBL2096909.
GuidetoPHARMACOLOGYi69.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP25025.

Polymorphism databases

DMDMi1352454.

Proteomic databases

PaxDbiP25025.
PRIDEiP25025.

Protocols and materials databases

DNASUi3579.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318507; ENSP00000319635; ENSG00000180871.
GeneIDi3579.
KEGGihsa:3579.
UCSCiuc002vgz.2. human.

Organism-specific databases

CTDi3579.
GeneCardsiGC02P219021.
HGNCiHGNC:6027. CXCR2.
HPAiCAB016268.
HPA031999.
HPA032017.
MIMi146928. gene.
neXtProtiNX_P25025.
PharmGKBiPA29843.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG146068.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP25025.
KOiK05050.
OMAiRRAIHPP.
PhylomeDBiP25025.
TreeFamiTF330966.

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.
SignaLinkiP25025.

Miscellaneous databases

GenomeRNAii3579.
NextBioi13990.
PROiP25025.
SOURCEiSearch...

Gene expression databases

BgeeiP25025.
CleanExiHS_IL8RB.
ExpressionAtlasiP25025. baseline and differential.
GenevestigatoriP25025.

Family and domain databases

InterProiIPR000057. Chemokine_CXCR2.
IPR000174. Chemokine_CXCR_1/2.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00427. INTRLEUKIN8R.
PR00573. INTRLEUKN8BR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of complementary DNA encoding a functional human interleukin-8 receptor."
    Murphy P.M., Tiffany H.L.
    Science 253:1280-1283(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Molecular characterization of receptors for human interleukin-8, GRO/melanoma growth-stimulatory activity and neutrophil activating peptide-2."
    Cerretti D.P., Kozlosky C.J., Vanden Bos T., Nelson N., Gearing D.P., Beckmann M.P.
    Mol. Immunol. 30:359-367(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
  3. "Structure, genomic organization, and expression of the human interleukin-8 receptor B gene."
    Sprenger H., Lloyd A.R., Lautens L.L., Bonner T.I., Kelvin D.J.
    J. Biol. Chem. 269:11065-11072(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  4. "Comparison of the genomic organization and promoter function for human interleukin-8 receptors A and B."
    Ahuja S.K., Shetty A., Tiffany H.L., Murphy P.M.
    J. Biol. Chem. 269:26381-26389(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Placenta.
  5. SeattleSNPs variation discovery resource
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  7. "Single nucleotide polymorphisms in the coding regions of human CXC-chemokine receptors CXCR1, CXCR2 and CXCR3."
    Kato H., Tsuchiya N., Tokunaga K.
    Genes Immun. 1:330-337(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 52-162 AND 191-301, VARIANT CYS-80.
  8. "Characterization of two high affinity human interleukin-8 receptors."
    Lee J., Horuk R., Rice G.C., Bennett G.L., Camerato T., Wood W.I.
    J. Biol. Chem. 267:16283-16287(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  9. "Ligand-induced desensitization of the human CXC chemokine receptor-2 is modulated by multiple serine residues in the carboxyl-terminal domain of the receptor."
    Mueller S.G., White J.R., Schraw W.P., Lam V., Richmond A.
    J. Biol. Chem. 272:8207-8214(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-347; SER-351; SER-352 AND SER-353.

Entry informationi

Entry nameiCXCR2_HUMAN
AccessioniPrimary (citable) accession number: P25025
Secondary accession number(s): Q8IUZ1, Q9P2T6, Q9P2T7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: February 1, 1996
Last modified: March 4, 2015
This is version 153 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  8. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.