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P25025

- CXCR2_HUMAN

UniProt

P25025 - CXCR2_HUMAN

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Protein
C-X-C chemokine receptor type 2
Gene
CXCR2, IL8RB
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.

GO - Molecular functioni

  1. C-X-C chemokine receptor activity Source: UniProtKB
  2. interleukin-8 binding Source: UniProtKB
  3. interleukin-8 receptor activity Source: UniProtKB
  4. protein binding Source: IntAct
  5. signal transducer activity Source: UniProtKB

GO - Biological processi

  1. acute inflammatory response to antigenic stimulus Source: Ensembl
  2. cell surface receptor signaling pathway Source: UniProtKB
  3. cellular defense response Source: UniProtKB
  4. chemokine-mediated signaling pathway Source: GOC
  5. chemotaxis Source: UniProtKB
  6. dendritic cell chemotaxis Source: BHF-UCL
  7. inflammatory response Source: ProtInc
  8. interleukin-8-mediated signaling pathway Source: GOC
  9. metanephric tubule morphogenesis Source: Ensembl
  10. midbrain development Source: Ensembl
  11. negative regulation of neutrophil apoptotic process Source: Ensembl
  12. neutrophil activation Source: UniProtKB
  13. neutrophil chemotaxis Source: UniProtKB
  14. phospholipase C-activating G-protein coupled receptor signaling pathway Source: UniProtKB
  15. positive regulation of angiogenesis Source: Ensembl
  16. positive regulation of cardiac muscle cell apoptotic process Source: Ensembl
  17. positive regulation of cell proliferation Source: UniProtKB
  18. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  19. positive regulation of neutrophil chemotaxis Source: Ensembl
  20. positive regulation of vascular permeability Source: Ensembl
  21. receptor internalization Source: UniProtKB
  22. signal transduction Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Chemotaxis

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.
SignaLinkiP25025.

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C chemokine receptor type 2
Short name:
CXC-R2
Short name:
CXCR-2
Alternative name(s):
CDw128b
GRO/MGSA receptor
High affinity interleukin-8 receptor B
Short name:
IL-8R B
IL-8 receptor type 2
CD_antigen: CD182
Gene namesi
Name:CXCR2
Synonyms:IL8RB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:6027. CXCR2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4848Extracellular Reviewed prediction
Add
BLAST
Transmembranei49 – 7527Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini76 – 849Cytoplasmic Reviewed prediction
Transmembranei85 – 10521Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini106 – 12015Extracellular Reviewed prediction
Add
BLAST
Transmembranei121 – 14222Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini143 – 16321Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei164 – 18320Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini184 – 20825Extracellular Reviewed prediction
Add
BLAST
Transmembranei209 – 23123Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini232 – 25120Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei252 – 27322Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini274 – 29421Extracellular Reviewed prediction
Add
BLAST
Transmembranei295 – 31521Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini316 – 36045Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell surface Source: UniProtKB
  2. integral component of plasma membrane Source: UniProtKB
  3. intracellular Source: UniProtKB
  4. mast cell granule Source: UniProtKB
  5. membrane Source: UniProtKB
  6. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29843.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 360360C-X-C chemokine receptor type 2
PRO_0000069337Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi22 – 221N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi119 ↔ 196 By similarity
Modified residuei347 – 3471Phosphoserine Inferred
Modified residuei351 – 3511Phosphoserine Inferred
Modified residuei352 – 3521Phosphoserine Inferred
Modified residuei353 – 3531Phosphoserine Inferred

Post-translational modificationi

Phosphorylated upon ligand binding; which is required for desensitization.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP25025.
PRIDEiP25025.

PTM databases

PhosphoSiteiP25025.

Expressioni

Gene expression databases

ArrayExpressiP25025.
BgeeiP25025.
CleanExiHS_IL8RB.
GenevestigatoriP25025.

Organism-specific databases

HPAiCAB016268.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
IL8P101452EBI-2835281,EBI-3917999

Protein-protein interaction databases

BioGridi109793. 8 interactions.
DIPiDIP-3782N.
IntActiP25025. 5 interactions.
MINTiMINT-271138.
STRINGi9606.ENSP00000319635.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4Q3HX-ray1.44A/B356-360[»]
ProteinModelPortaliP25025.
SMRiP25025. Positions 38-333.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146068.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP25025.
KOiK05050.
OMAiLFRRTIY.
PhylomeDBiP25025.
TreeFamiTF330966.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000057. Chemokine_CXCR2.
IPR000174. Chemokine_CXCR_1/2.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00427. INTRLEUKIN8R.
PR00573. INTRLEUKN8BR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25025-1 [UniParc]FASTAAdd to Basket

« Hide

MEDFNMESDS FEDFWKGEDL SNYSYSSTLP PFLLDAAPCE PESLEINKYF    50
VVIIYALVFL LSLLGNSLVM LVILYSRVGR SVTDVYLLNL ALADLLFALT 100
LPIWAASKVN GWIFGTFLCK VVSLLKEVNF YSGILLLACI SVDRYLAIVH 150
ATRTLTQKRY LVKFICLSIW GLSLLLALPV LLFRRTVYSS NVSPACYEDM 200
GNNTANWRML LRILPQSFGF IVPLLIMLFC YGFTLRTLFK AHMGQKHRAM 250
RVIFAVVLIF LLCWLPYNLV LLADTLMRTQ VIQETCERRN HIDRALDATE 300
ILGILHSCLN PLIYAFIGQK FRHGLLKILA IHGLISKDSL PKDSRPSFVG 350
SSSGHTSTTL 360
Length:360
Mass (Da):40,759
Last modified:February 1, 1996 - v2
Checksum:i564F04A8BCC0A197
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti80 – 801R → C.1 Publication
Corresponds to variant rs1805038 [ dbSNP | Ensembl ].
VAR_014679

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M73969 mRNA. Translation: AAA83148.1.
M94582 mRNA. Translation: AAA36108.1.
M99412 Genomic DNA. Translation: AAC14460.1.
L19593 mRNA. Translation: AAB59437.1.
U11869 Genomic DNA. Translation: AAB60656.1.
AY714242 Genomic DNA. Translation: AAT97985.1.
BC037961 mRNA. Translation: AAH37961.2.
AB032733 Genomic DNA. Translation: BAA92295.1.
AB032734 Genomic DNA. Translation: BAA92296.1.
CCDSiCCDS2408.1.
PIRiI37898. A53611.
RefSeqiNP_001161770.1. NM_001168298.1.
NP_001548.1. NM_001557.3.
XP_005246587.1. XM_005246530.1.
XP_005246588.1. XM_005246531.1.
UniGeneiHs.846.

Genome annotation databases

EnsembliENST00000318507; ENSP00000319635; ENSG00000180871.
GeneIDi3579.
KEGGihsa:3579.
UCSCiuc002vgz.2. human.

Polymorphism databases

DMDMi1352454.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

CXC chemokine receptors entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M73969 mRNA. Translation: AAA83148.1 .
M94582 mRNA. Translation: AAA36108.1 .
M99412 Genomic DNA. Translation: AAC14460.1 .
L19593 mRNA. Translation: AAB59437.1 .
U11869 Genomic DNA. Translation: AAB60656.1 .
AY714242 Genomic DNA. Translation: AAT97985.1 .
BC037961 mRNA. Translation: AAH37961.2 .
AB032733 Genomic DNA. Translation: BAA92295.1 .
AB032734 Genomic DNA. Translation: BAA92296.1 .
CCDSi CCDS2408.1.
PIRi I37898. A53611.
RefSeqi NP_001161770.1. NM_001168298.1.
NP_001548.1. NM_001557.3.
XP_005246587.1. XM_005246530.1.
XP_005246588.1. XM_005246531.1.
UniGenei Hs.846.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4Q3H X-ray 1.44 A/B 356-360 [» ]
ProteinModelPortali P25025.
SMRi P25025. Positions 38-333.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109793. 8 interactions.
DIPi DIP-3782N.
IntActi P25025. 5 interactions.
MINTi MINT-271138.
STRINGi 9606.ENSP00000319635.

Chemistry

BindingDBi P25025.
ChEMBLi CHEMBL2434.
GuidetoPHARMACOLOGYi 69.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P25025.

Polymorphism databases

DMDMi 1352454.

Proteomic databases

PaxDbi P25025.
PRIDEi P25025.

Protocols and materials databases

DNASUi 3579.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000318507 ; ENSP00000319635 ; ENSG00000180871 .
GeneIDi 3579.
KEGGi hsa:3579.
UCSCi uc002vgz.2. human.

Organism-specific databases

CTDi 3579.
GeneCardsi GC02P219012.
HGNCi HGNC:6027. CXCR2.
HPAi CAB016268.
MIMi 146928. gene.
neXtProti NX_P25025.
PharmGKBi PA29843.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG146068.
HOGENOMi HOG000234122.
HOVERGENi HBG106917.
InParanoidi P25025.
KOi K05050.
OMAi LFRRTIY.
PhylomeDBi P25025.
TreeFami TF330966.

Enzyme and pathway databases

Reactomei REACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.
SignaLinki P25025.

Miscellaneous databases

GenomeRNAii 3579.
NextBioi 13990.
PROi P25025.
SOURCEi Search...

Gene expression databases

ArrayExpressi P25025.
Bgeei P25025.
CleanExi HS_IL8RB.
Genevestigatori P25025.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000057. Chemokine_CXCR2.
IPR000174. Chemokine_CXCR_1/2.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24227. PTHR24227. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00427. INTRLEUKIN8R.
PR00573. INTRLEUKN8BR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of complementary DNA encoding a functional human interleukin-8 receptor."
    Murphy P.M., Tiffany H.L.
    Science 253:1280-1283(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Molecular characterization of receptors for human interleukin-8, GRO/melanoma growth-stimulatory activity and neutrophil activating peptide-2."
    Cerretti D.P., Kozlosky C.J., Vanden Bos T., Nelson N., Gearing D.P., Beckmann M.P.
    Mol. Immunol. 30:359-367(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
  3. "Structure, genomic organization, and expression of the human interleukin-8 receptor B gene."
    Sprenger H., Lloyd A.R., Lautens L.L., Bonner T.I., Kelvin D.J.
    J. Biol. Chem. 269:11065-11072(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  4. "Comparison of the genomic organization and promoter function for human interleukin-8 receptors A and B."
    Ahuja S.K., Shetty A., Tiffany H.L., Murphy P.M.
    J. Biol. Chem. 269:26381-26389(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Placenta.
  5. SeattleSNPs variation discovery resource
    Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  7. "Single nucleotide polymorphisms in the coding regions of human CXC-chemokine receptors CXCR1, CXCR2 and CXCR3."
    Kato H., Tsuchiya N., Tokunaga K.
    Genes Immun. 1:330-337(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 52-162 AND 191-301, VARIANT CYS-80.
  8. "Characterization of two high affinity human interleukin-8 receptors."
    Lee J., Horuk R., Rice G.C., Bennett G.L., Camerato T., Wood W.I.
    J. Biol. Chem. 267:16283-16287(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  9. "Ligand-induced desensitization of the human CXC chemokine receptor-2 is modulated by multiple serine residues in the carboxyl-terminal domain of the receptor."
    Mueller S.G., White J.R., Schraw W.P., Lam V., Richmond A.
    J. Biol. Chem. 272:8207-8214(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-347; SER-351; SER-352 AND SER-353.

Entry informationi

Entry nameiCXCR2_HUMAN
AccessioniPrimary (citable) accession number: P25025
Secondary accession number(s): Q8IUZ1, Q9P2T6, Q9P2T7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: February 1, 1996
Last modified: September 3, 2014
This is version 149 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  8. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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