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P25024

- CXCR1_HUMAN

UniProt

P25024 - CXCR1_HUMAN

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Protein

C-X-C chemokine receptor type 1

Gene

CXCR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.

GO - Molecular functioni

  1. chemokine receptor activity Source: ProtInc
  2. G-protein coupled receptor activity Source: ProtInc
  3. interleukin-8 binding Source: UniProtKB
  4. interleukin-8 receptor activity Source: UniProtKB

GO - Biological processi

  1. cell surface receptor signaling pathway Source: UniProtKB
  2. chemokine-mediated signaling pathway Source: GOC
  3. chemotaxis Source: ProtInc
  4. dendritic cell chemotaxis Source: BHF-UCL
  5. G-protein coupled receptor signaling pathway Source: ProtInc
  6. inflammatory response Source: ProtInc
  7. interleukin-8-mediated signaling pathway Source: GOC
  8. receptor internalization Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Chemotaxis

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C chemokine receptor type 1
Short name:
CXC-R1
Short name:
CXCR-1
Alternative name(s):
CDw128a
High affinity interleukin-8 receptor A
Short name:
IL-8R A
IL-8 receptor type 1
CD_antigen: CD181
Gene namesi
Name:CXCR1
Synonyms:CMKAR1, IL8RA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:6026. CXCR1.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. membrane Source: ProtInc
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29842.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 350350C-X-C chemokine receptor type 1PRO_0000069330Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
Glycosylationi16 – 161N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi110 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP25024.
PRIDEiP25024.

PTM databases

PhosphoSiteiP25024.

Expressioni

Gene expression databases

BgeeiP25024.
GenevestigatoriP25024.

Organism-specific databases

HPAiHPA031991.

Interactioni

Protein-protein interaction databases

BioGridi109791. 5 interactions.
DIPiDIP-3779N.
IntActiP25024. 4 interactions.
MINTiMINT-1516942.

Structurei

Secondary structure

1
350
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi38 – 6629
Helixi75 – 10026
Beta strandi101 – 1033
Helixi108 – 13831
Beta strandi139 – 1413
Beta strandi143 – 1464
Helixi149 – 17325
Turni195 – 1973
Helixi201 – 2044
Turni205 – 2073
Helixi208 – 22518
Turni226 – 2283
Beta strandi229 – 2313
Helixi235 – 2384
Helixi240 – 26728
Beta strandi270 – 2723
Helixi276 – 2827
Helixi285 – 2939
Helixi294 – 2985
Helixi300 – 3089
Helixi311 – 32212

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ILPNMR-C9-29[»]
1ILQNMR-C9-29[»]
2LNLNMR-A29-324[»]
ProteinModelPortaliP25024.
SMRiP25024. Positions 29-324.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP25024.

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3939ExtracellularSequence AnalysisAdd
BLAST
Topological domaini67 – 759CytoplasmicSequence Analysis
Topological domaini97 – 11115ExtracellularSequence AnalysisAdd
BLAST
Topological domaini134 – 15421CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini175 – 19925ExtracellularSequence AnalysisAdd
BLAST
Topological domaini221 – 24222CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini265 – 28521ExtracellularSequence AnalysisAdd
BLAST
Topological domaini309 – 35042CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei40 – 6627Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei76 – 9621Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei112 – 13322Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei155 – 17420Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei200 – 22021Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei243 – 26422Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei286 – 30823Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146068.
GeneTreeiENSGT00760000118785.
HOVERGENiHBG106917.
InParanoidiP25024.
KOiK04175.
OMAiPVCYEVL.
OrthoDBiEOG7ZPNK9.
PhylomeDBiP25024.
TreeFamiTF330966.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR001355. Chemokine_CXCR1.
IPR000174. Chemokine_CXCR_1/2.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF47. PTHR24227:SF47. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00427. INTRLEUKIN8R.
PR00572. INTRLEUKN8AR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25024-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSNITDPQMW DFDDLNFTGM PPADEDYSPC MLETETLNKY VVIIAYALVF
60 70 80 90 100
LLSLLGNSLV MLVILYSRVG RSVTDVYLLN LALADLLFAL TLPIWAASKV
110 120 130 140 150
NGWIFGTFLC KVVSLLKEVN FYSGILLLAC ISVDRYLAIV HATRTLTQKR
160 170 180 190 200
HLVKFVCLGC WGLSMNLSLP FFLFRQAYHP NNSSPVCYEV LGNDTAKWRM
210 220 230 240 250
VLRILPHTFG FIVPLFVMLF CYGFTLRTLF KAHMGQKHRA MRVIFAVVLI
260 270 280 290 300
FLLCWLPYNL VLLADTLMRT QVIQESCERR NNIGRALDAT EILGFLHSCL
310 320 330 340 350
NPIIYAFIGQ NFRHGFLKIL AMHGLVSKEF LARHRVTSYT SSSVNVSSNL
Length:350
Mass (Da):39,791
Last modified:May 30, 2006 - v2
Checksum:i2463E868C0EB0DE2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti154 – 1541K → N in AAH72397. (PubMed:15489334)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti31 – 311M → R.3 Publications
Corresponds to variant rs16858811 [ dbSNP | Ensembl ].
VAR_021061
Natural varianti71 – 711R → C.
Corresponds to variant rs1805038 [ dbSNP | Ensembl ].
VAR_016236
Natural varianti268 – 2681M → L.
Corresponds to variant rs9282752 [ dbSNP | Ensembl ].
VAR_026525
Natural varianti276 – 2761S → T Common polymorphism. 4 Publications
Corresponds to variant rs2234671 [ dbSNP | Ensembl ].
VAR_003479
Natural varianti306 – 3061A → T.1 Publication
VAR_016237
Natural varianti335 – 3351R → C.4 Publications
Corresponds to variant rs16858808 [ dbSNP | Ensembl ].
VAR_016238
Natural varianti342 – 3421S → L.1 Publication
Corresponds to variant rs16858806 [ dbSNP | Ensembl ].
VAR_021062

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L19591 mRNA. Translation: AAB59436.1.
L19592 Genomic DNA. Translation: AAA59160.1.
M68932 mRNA. Translation: AAA59159.1.
X65858 Genomic DNA. Translation: CAA46688.1.
U11870 Genomic DNA. Translation: AAA64378.1.
AY916762 Genomic DNA. Translation: AAY21512.1.
AY916763 Genomic DNA. Translation: AAY21513.1.
AY916764 Genomic DNA. Translation: AAY21514.1.
AY916765 Genomic DNA. Translation: AAY21515.1.
AY916766 Genomic DNA. Translation: AAY21516.1.
AY916769 Genomic DNA. Translation: AAY21519.1.
AY916772 Genomic DNA. Translation: AAY21522.1.
AY916773 Genomic DNA. Translation: AAY21523.1.
CR541994 mRNA. Translation: CAG46791.1.
CR542029 mRNA. Translation: CAG46826.1.
AK312668 mRNA. Translation: BAG35550.1.
AY651785 Genomic DNA. Translation: AAT46689.1.
AC097483 Genomic DNA. Translation: AAX93212.1.
CH471063 Genomic DNA. Translation: EAW70590.1.
BC028221 mRNA. Translation: AAH28221.1.
BC072397 mRNA. Translation: AAH72397.1.
AB032728 Genomic DNA. Translation: BAA92290.1.
AB032729 Genomic DNA. Translation: BAA92291.1.
AB032730 Genomic DNA. Translation: BAA92292.1.
AB032731 Genomic DNA. Translation: BAA92293.1.
AB032732 Genomic DNA. Translation: BAA92294.1.
CCDSiCCDS2409.1.
PIRiI37449. A39445.
RefSeqiNP_000625.1. NM_000634.2.
UniGeneiHs.194778.

Genome annotation databases

EnsembliENST00000295683; ENSP00000295683; ENSG00000163464.
GeneIDi3577.
KEGGihsa:3577.
UCSCiuc002vhc.3. human.

Polymorphism databases

DMDMi108936015.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

CXC chemokine receptors entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L19591 mRNA. Translation: AAB59436.1 .
L19592 Genomic DNA. Translation: AAA59160.1 .
M68932 mRNA. Translation: AAA59159.1 .
X65858 Genomic DNA. Translation: CAA46688.1 .
U11870 Genomic DNA. Translation: AAA64378.1 .
AY916762 Genomic DNA. Translation: AAY21512.1 .
AY916763 Genomic DNA. Translation: AAY21513.1 .
AY916764 Genomic DNA. Translation: AAY21514.1 .
AY916765 Genomic DNA. Translation: AAY21515.1 .
AY916766 Genomic DNA. Translation: AAY21516.1 .
AY916769 Genomic DNA. Translation: AAY21519.1 .
AY916772 Genomic DNA. Translation: AAY21522.1 .
AY916773 Genomic DNA. Translation: AAY21523.1 .
CR541994 mRNA. Translation: CAG46791.1 .
CR542029 mRNA. Translation: CAG46826.1 .
AK312668 mRNA. Translation: BAG35550.1 .
AY651785 Genomic DNA. Translation: AAT46689.1 .
AC097483 Genomic DNA. Translation: AAX93212.1 .
CH471063 Genomic DNA. Translation: EAW70590.1 .
BC028221 mRNA. Translation: AAH28221.1 .
BC072397 mRNA. Translation: AAH72397.1 .
AB032728 Genomic DNA. Translation: BAA92290.1 .
AB032729 Genomic DNA. Translation: BAA92291.1 .
AB032730 Genomic DNA. Translation: BAA92292.1 .
AB032731 Genomic DNA. Translation: BAA92293.1 .
AB032732 Genomic DNA. Translation: BAA92294.1 .
CCDSi CCDS2409.1.
PIRi I37449. A39445.
RefSeqi NP_000625.1. NM_000634.2.
UniGenei Hs.194778.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1ILP NMR - C 9-29 [» ]
1ILQ NMR - C 9-29 [» ]
2LNL NMR - A 29-324 [» ]
ProteinModelPortali P25024.
SMRi P25024. Positions 29-324.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109791. 5 interactions.
DIPi DIP-3779N.
IntActi P25024. 4 interactions.
MINTi MINT-1516942.

Chemistry

BindingDBi P25024.
ChEMBLi CHEMBL4029.
DrugBanki DB01009. Ketoprofen.
GuidetoPHARMACOLOGYi 68.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P25024.

Polymorphism databases

DMDMi 108936015.

Proteomic databases

PaxDbi P25024.
PRIDEi P25024.

Protocols and materials databases

DNASUi 3577.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000295683 ; ENSP00000295683 ; ENSG00000163464 .
GeneIDi 3577.
KEGGi hsa:3577.
UCSCi uc002vhc.3. human.

Organism-specific databases

CTDi 3577.
GeneCardsi GC02M219028.
H-InvDB HIX0203926.
HGNCi HGNC:6026. CXCR1.
HPAi HPA031991.
MIMi 146929. gene.
neXtProti NX_P25024.
PharmGKBi PA29842.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG146068.
GeneTreei ENSGT00760000118785.
HOVERGENi HBG106917.
InParanoidi P25024.
KOi K04175.
OMAi PVCYEVL.
OrthoDBi EOG7ZPNK9.
PhylomeDBi P25024.
TreeFami TF330966.

Enzyme and pathway databases

Reactomei REACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

EvolutionaryTracei P25024.
GeneWikii Interleukin_8_receptor,_alpha.
GenomeRNAii 3577.
NextBioi 13982.
PROi P25024.
SOURCEi Search...

Gene expression databases

Bgeei P25024.
Genevestigatori P25024.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR001355. Chemokine_CXCR1.
IPR000174. Chemokine_CXCR_1/2.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24227. PTHR24227. 1 hit.
PTHR24227:SF47. PTHR24227:SF47. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00427. INTRLEUKIN8R.
PR00572. INTRLEUKN8AR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and functional expression of a human interleukin-8 receptor."
    Holmes W.E., Lee J., Kuang W.-J., Rice G.C., Wood W.I.
    Science 253:1278-1280(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANT THR-276.
  2. "Molecular characterization of receptors for human interleukin-8, GRO/melanoma growth-stimulatory activity and neutrophil activating peptide-2."
    Cerretti D.P., Kozlosky C.J., Vanden Bos T., Nelson N., Gearing D.P., Beckmann M.P.
    Mol. Immunol. 30:359-367(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
  3. "The high-affinity interleukin 8 receptor gene (IL8RA) maps to the 2q33-q36 region of the human genome: cloning of a pseudogene (IL8RBP) for the low-affinity receptor."
    Mollereau C., Passage E., Mattei M.-G., Vassart G., Parmentier M.
    Genomics 16:248-251(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Comparison of the genomic organization and promoter function for human interleukin-8 receptors A and B."
    Ahuja S.K., Shetty A., Tiffany H.L., Murphy P.M.
    J. Biol. Chem. 269:26381-26389(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Placenta.
  5. "Molecular evolution of CXCR1, a G protein-coupled receptor involved in signal transduction of neutrophils."
    Liu Y., Yang S., Lin A.A., Cavalli-Sforza L.L., Su B.
    J. Mol. Evol. 61:691-696(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ARG-31; THR-276 AND CYS-335.
  6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  8. SeattleSNPs variation discovery resource
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ARG-31; THR-276; CYS-335 AND LEU-342.
  9. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ARG-31 AND CYS-335.
    Tissue: Blood.
  12. "Single nucleotide polymorphisms in the coding regions of human CXC-chemokine receptors CXCR1, CXCR2 and CXCR3."
    Kato H., Tsuchiya N., Tokunaga K.
    Genes Immun. 1:330-337(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 223-350, VARIANTS THR-276; THR-306 AND CYS-335.
  13. "Characterization of two high affinity human interleukin-8 receptors."
    Lee J., Horuk R., Rice G.C., Bennett G.L., Camerato T., Wood W.I.
    J. Biol. Chem. 267:16283-16287(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  14. "Structure of a CXC chemokine-receptor fragment in complex with interleukin-8."
    Skelton N.J., Quan C., Reilly D., Lowman H.
    Structure 7:157-168(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 9-29 IN COMPLEX WITH IL-8.

Entry informationi

Entry nameiCXCR1_HUMAN
AccessioniPrimary (citable) accession number: P25024
Secondary accession number(s): B2R6Q3
, Q2YEF8, Q2YEG4, Q2YEG5, Q2YEG7, Q2YEG8, Q53R18, Q6IN95, Q8N6T6, Q9P2T8, Q9P2T9, Q9P2U0, Q9P2U1, Q9P2U2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 30, 2006
Last modified: October 29, 2014
This is version 153 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  8. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3