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P25024

- CXCR1_HUMAN

UniProt

P25024 - CXCR1_HUMAN

Protein

C-X-C chemokine receptor type 1

Gene

CXCR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 152 (01 Oct 2014)
      Sequence version 2 (30 May 2006)
      Previous versions | rss
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    Functioni

    Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.

    GO - Molecular functioni

    1. chemokine receptor activity Source: ProtInc
    2. G-protein coupled receptor activity Source: ProtInc
    3. interleukin-8 binding Source: UniProtKB
    4. interleukin-8 receptor activity Source: UniProtKB

    GO - Biological processi

    1. cell surface receptor signaling pathway Source: UniProtKB
    2. chemokine-mediated signaling pathway Source: GOC
    3. chemotaxis Source: ProtInc
    4. dendritic cell chemotaxis Source: BHF-UCL
    5. G-protein coupled receptor signaling pathway Source: ProtInc
    6. inflammatory response Source: ProtInc
    7. interleukin-8-mediated signaling pathway Source: GOC
    8. receptor internalization Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Chemotaxis

    Enzyme and pathway databases

    ReactomeiREACT_15344. Chemokine receptors bind chemokines.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-X-C chemokine receptor type 1
    Short name:
    CXC-R1
    Short name:
    CXCR-1
    Alternative name(s):
    CDw128a
    High affinity interleukin-8 receptor A
    Short name:
    IL-8R A
    IL-8 receptor type 1
    CD_antigen: CD181
    Gene namesi
    Name:CXCR1
    Synonyms:CMKAR1, IL8RA
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:6026. CXCR1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. membrane Source: ProtInc
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29842.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 350350C-X-C chemokine receptor type 1PRO_0000069330Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi16 – 161N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi110 ↔ 187PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP25024.
    PRIDEiP25024.

    PTM databases

    PhosphoSiteiP25024.

    Expressioni

    Gene expression databases

    BgeeiP25024.
    GenevestigatoriP25024.

    Organism-specific databases

    HPAiHPA031991.

    Interactioni

    Protein-protein interaction databases

    BioGridi109791. 5 interactions.
    DIPiDIP-3779N.
    IntActiP25024. 4 interactions.
    MINTiMINT-1516942.

    Structurei

    Secondary structure

    1
    350
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi38 – 6629
    Helixi75 – 10026
    Beta strandi101 – 1033
    Helixi108 – 13831
    Beta strandi139 – 1413
    Beta strandi143 – 1464
    Helixi149 – 17325
    Turni195 – 1973
    Helixi201 – 2044
    Turni205 – 2073
    Helixi208 – 22518
    Turni226 – 2283
    Beta strandi229 – 2313
    Helixi235 – 2384
    Helixi240 – 26728
    Beta strandi270 – 2723
    Helixi276 – 2827
    Helixi285 – 2939
    Helixi294 – 2985
    Helixi300 – 3089
    Helixi311 – 32212

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1ILPNMR-C9-29[»]
    1ILQNMR-C9-29[»]
    2LNLNMR-A29-324[»]
    ProteinModelPortaliP25024.
    SMRiP25024. Positions 29-324.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP25024.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3939ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini67 – 759CytoplasmicSequence Analysis
    Topological domaini97 – 11115ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini134 – 15421CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini175 – 19925ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini221 – 24222CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini265 – 28521ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini309 – 35042CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei40 – 6627Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei76 – 9621Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei112 – 13322Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei155 – 17420Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei200 – 22021Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei243 – 26422Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei286 – 30823Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG146068.
    HOVERGENiHBG106917.
    InParanoidiP25024.
    KOiK04175.
    OMAiPVCYEVL.
    OrthoDBiEOG7ZPNK9.
    PhylomeDBiP25024.
    TreeFamiTF330966.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR001355. Chemokine_CXCR1.
    IPR000174. Chemokine_CXCR_1/2.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24227. PTHR24227. 1 hit.
    PTHR24227:SF47. PTHR24227:SF47. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00427. INTRLEUKIN8R.
    PR00572. INTRLEUKN8AR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P25024-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNITDPQMW DFDDLNFTGM PPADEDYSPC MLETETLNKY VVIIAYALVF    50
    LLSLLGNSLV MLVILYSRVG RSVTDVYLLN LALADLLFAL TLPIWAASKV 100
    NGWIFGTFLC KVVSLLKEVN FYSGILLLAC ISVDRYLAIV HATRTLTQKR 150
    HLVKFVCLGC WGLSMNLSLP FFLFRQAYHP NNSSPVCYEV LGNDTAKWRM 200
    VLRILPHTFG FIVPLFVMLF CYGFTLRTLF KAHMGQKHRA MRVIFAVVLI 250
    FLLCWLPYNL VLLADTLMRT QVIQESCERR NNIGRALDAT EILGFLHSCL 300
    NPIIYAFIGQ NFRHGFLKIL AMHGLVSKEF LARHRVTSYT SSSVNVSSNL 350
    Length:350
    Mass (Da):39,791
    Last modified:May 30, 2006 - v2
    Checksum:i2463E868C0EB0DE2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti154 – 1541K → N in AAH72397. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti31 – 311M → R.3 Publications
    Corresponds to variant rs16858811 [ dbSNP | Ensembl ].
    VAR_021061
    Natural varianti71 – 711R → C.
    Corresponds to variant rs1805038 [ dbSNP | Ensembl ].
    VAR_016236
    Natural varianti268 – 2681M → L.
    Corresponds to variant rs9282752 [ dbSNP | Ensembl ].
    VAR_026525
    Natural varianti276 – 2761S → T Common polymorphism. 4 Publications
    Corresponds to variant rs2234671 [ dbSNP | Ensembl ].
    VAR_003479
    Natural varianti306 – 3061A → T.1 Publication
    VAR_016237
    Natural varianti335 – 3351R → C.4 Publications
    Corresponds to variant rs16858808 [ dbSNP | Ensembl ].
    VAR_016238
    Natural varianti342 – 3421S → L.1 Publication
    Corresponds to variant rs16858806 [ dbSNP | Ensembl ].
    VAR_021062

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L19591 mRNA. Translation: AAB59436.1.
    L19592 Genomic DNA. Translation: AAA59160.1.
    M68932 mRNA. Translation: AAA59159.1.
    X65858 Genomic DNA. Translation: CAA46688.1.
    U11870 Genomic DNA. Translation: AAA64378.1.
    AY916762 Genomic DNA. Translation: AAY21512.1.
    AY916763 Genomic DNA. Translation: AAY21513.1.
    AY916764 Genomic DNA. Translation: AAY21514.1.
    AY916765 Genomic DNA. Translation: AAY21515.1.
    AY916766 Genomic DNA. Translation: AAY21516.1.
    AY916769 Genomic DNA. Translation: AAY21519.1.
    AY916772 Genomic DNA. Translation: AAY21522.1.
    AY916773 Genomic DNA. Translation: AAY21523.1.
    CR541994 mRNA. Translation: CAG46791.1.
    CR542029 mRNA. Translation: CAG46826.1.
    AK312668 mRNA. Translation: BAG35550.1.
    AY651785 Genomic DNA. Translation: AAT46689.1.
    AC097483 Genomic DNA. Translation: AAX93212.1.
    CH471063 Genomic DNA. Translation: EAW70590.1.
    BC028221 mRNA. Translation: AAH28221.1.
    BC072397 mRNA. Translation: AAH72397.1.
    AB032728 Genomic DNA. Translation: BAA92290.1.
    AB032729 Genomic DNA. Translation: BAA92291.1.
    AB032730 Genomic DNA. Translation: BAA92292.1.
    AB032731 Genomic DNA. Translation: BAA92293.1.
    AB032732 Genomic DNA. Translation: BAA92294.1.
    CCDSiCCDS2409.1.
    PIRiI37449. A39445.
    RefSeqiNP_000625.1. NM_000634.2.
    UniGeneiHs.194778.

    Genome annotation databases

    EnsembliENST00000295683; ENSP00000295683; ENSG00000163464.
    GeneIDi3577.
    KEGGihsa:3577.
    UCSCiuc002vhc.3. human.

    Polymorphism databases

    DMDMi108936015.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    CXC chemokine receptors entry

    SeattleSNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L19591 mRNA. Translation: AAB59436.1 .
    L19592 Genomic DNA. Translation: AAA59160.1 .
    M68932 mRNA. Translation: AAA59159.1 .
    X65858 Genomic DNA. Translation: CAA46688.1 .
    U11870 Genomic DNA. Translation: AAA64378.1 .
    AY916762 Genomic DNA. Translation: AAY21512.1 .
    AY916763 Genomic DNA. Translation: AAY21513.1 .
    AY916764 Genomic DNA. Translation: AAY21514.1 .
    AY916765 Genomic DNA. Translation: AAY21515.1 .
    AY916766 Genomic DNA. Translation: AAY21516.1 .
    AY916769 Genomic DNA. Translation: AAY21519.1 .
    AY916772 Genomic DNA. Translation: AAY21522.1 .
    AY916773 Genomic DNA. Translation: AAY21523.1 .
    CR541994 mRNA. Translation: CAG46791.1 .
    CR542029 mRNA. Translation: CAG46826.1 .
    AK312668 mRNA. Translation: BAG35550.1 .
    AY651785 Genomic DNA. Translation: AAT46689.1 .
    AC097483 Genomic DNA. Translation: AAX93212.1 .
    CH471063 Genomic DNA. Translation: EAW70590.1 .
    BC028221 mRNA. Translation: AAH28221.1 .
    BC072397 mRNA. Translation: AAH72397.1 .
    AB032728 Genomic DNA. Translation: BAA92290.1 .
    AB032729 Genomic DNA. Translation: BAA92291.1 .
    AB032730 Genomic DNA. Translation: BAA92292.1 .
    AB032731 Genomic DNA. Translation: BAA92293.1 .
    AB032732 Genomic DNA. Translation: BAA92294.1 .
    CCDSi CCDS2409.1.
    PIRi I37449. A39445.
    RefSeqi NP_000625.1. NM_000634.2.
    UniGenei Hs.194778.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1ILP NMR - C 9-29 [» ]
    1ILQ NMR - C 9-29 [» ]
    2LNL NMR - A 29-324 [» ]
    ProteinModelPortali P25024.
    SMRi P25024. Positions 29-324.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109791. 5 interactions.
    DIPi DIP-3779N.
    IntActi P25024. 4 interactions.
    MINTi MINT-1516942.

    Chemistry

    BindingDBi P25024.
    ChEMBLi CHEMBL2096909.
    GuidetoPHARMACOLOGYi 68.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P25024.

    Polymorphism databases

    DMDMi 108936015.

    Proteomic databases

    PaxDbi P25024.
    PRIDEi P25024.

    Protocols and materials databases

    DNASUi 3577.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000295683 ; ENSP00000295683 ; ENSG00000163464 .
    GeneIDi 3577.
    KEGGi hsa:3577.
    UCSCi uc002vhc.3. human.

    Organism-specific databases

    CTDi 3577.
    GeneCardsi GC02M219028.
    H-InvDB HIX0203926.
    HGNCi HGNC:6026. CXCR1.
    HPAi HPA031991.
    MIMi 146929. gene.
    neXtProti NX_P25024.
    PharmGKBi PA29842.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG146068.
    HOVERGENi HBG106917.
    InParanoidi P25024.
    KOi K04175.
    OMAi PVCYEVL.
    OrthoDBi EOG7ZPNK9.
    PhylomeDBi P25024.
    TreeFami TF330966.

    Enzyme and pathway databases

    Reactomei REACT_15344. Chemokine receptors bind chemokines.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    EvolutionaryTracei P25024.
    GeneWikii Interleukin_8_receptor,_alpha.
    GenomeRNAii 3577.
    NextBioi 13982.
    PROi P25024.
    SOURCEi Search...

    Gene expression databases

    Bgeei P25024.
    Genevestigatori P25024.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR001355. Chemokine_CXCR1.
    IPR000174. Chemokine_CXCR_1/2.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24227. PTHR24227. 1 hit.
    PTHR24227:SF47. PTHR24227:SF47. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00427. INTRLEUKIN8R.
    PR00572. INTRLEUKN8AR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure and functional expression of a human interleukin-8 receptor."
      Holmes W.E., Lee J., Kuang W.-J., Rice G.C., Wood W.I.
      Science 253:1278-1280(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANT THR-276.
    2. "Molecular characterization of receptors for human interleukin-8, GRO/melanoma growth-stimulatory activity and neutrophil activating peptide-2."
      Cerretti D.P., Kozlosky C.J., Vanden Bos T., Nelson N., Gearing D.P., Beckmann M.P.
      Mol. Immunol. 30:359-367(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
    3. "The high-affinity interleukin 8 receptor gene (IL8RA) maps to the 2q33-q36 region of the human genome: cloning of a pseudogene (IL8RBP) for the low-affinity receptor."
      Mollereau C., Passage E., Mattei M.-G., Vassart G., Parmentier M.
      Genomics 16:248-251(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Comparison of the genomic organization and promoter function for human interleukin-8 receptors A and B."
      Ahuja S.K., Shetty A., Tiffany H.L., Murphy P.M.
      J. Biol. Chem. 269:26381-26389(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Placenta.
    5. "Molecular evolution of CXCR1, a G protein-coupled receptor involved in signal transduction of neutrophils."
      Liu Y., Yang S., Lin A.A., Cavalli-Sforza L.L., Su B.
      J. Mol. Evol. 61:691-696(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ARG-31; THR-276 AND CYS-335.
    6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    8. SeattleSNPs variation discovery resource
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ARG-31; THR-276; CYS-335 AND LEU-342.
    9. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ARG-31 AND CYS-335.
      Tissue: Blood.
    12. "Single nucleotide polymorphisms in the coding regions of human CXC-chemokine receptors CXCR1, CXCR2 and CXCR3."
      Kato H., Tsuchiya N., Tokunaga K.
      Genes Immun. 1:330-337(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 223-350, VARIANTS THR-276; THR-306 AND CYS-335.
    13. "Characterization of two high affinity human interleukin-8 receptors."
      Lee J., Horuk R., Rice G.C., Bennett G.L., Camerato T., Wood W.I.
      J. Biol. Chem. 267:16283-16287(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    14. "Structure of a CXC chemokine-receptor fragment in complex with interleukin-8."
      Skelton N.J., Quan C., Reilly D., Lowman H.
      Structure 7:157-168(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 9-29 IN COMPLEX WITH IL-8.

    Entry informationi

    Entry nameiCXCR1_HUMAN
    AccessioniPrimary (citable) accession number: P25024
    Secondary accession number(s): B2R6Q3
    , Q2YEF8, Q2YEG4, Q2YEG5, Q2YEG7, Q2YEG8, Q53R18, Q6IN95, Q8N6T6, Q9P2T8, Q9P2T9, Q9P2U0, Q9P2U1, Q9P2U2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: May 30, 2006
    Last modified: October 1, 2014
    This is version 152 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    3. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    4. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    5. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    6. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    7. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    8. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3