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Protein

C-X-C chemokine receptor type 1

Gene

CXCR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.

GO - Molecular functioni

  • chemokine receptor activity Source: ProtInc
  • G-protein coupled receptor activity Source: ProtInc
  • interleukin-8 binding Source: UniProtKB
  • interleukin-8 receptor activity Source: UniProtKB

GO - Biological processi

  • cell surface receptor signaling pathway Source: UniProtKB
  • chemotaxis Source: ProtInc
  • dendritic cell chemotaxis Source: BHF-UCL
  • G-protein coupled receptor signaling pathway Source: ProtInc
  • inflammatory response Source: ProtInc
  • receptor internalization Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Chemotaxis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163464-MONOMER.
ReactomeiR-HSA-380108. Chemokine receptors bind chemokines.
R-HSA-418594. G alpha (i) signalling events.
R-HSA-6798695. Neutrophil degranulation.
SIGNORiP25024.

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C chemokine receptor type 1
Short name:
CXC-R1
Short name:
CXCR-1
Alternative name(s):
CDw128a
High affinity interleukin-8 receptor A
Short name:
IL-8R A
IL-8 receptor type 1
CD_antigen: CD181
Gene namesi
Name:CXCR1
Synonyms:CMKAR1, IL8RA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:6026. CXCR1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 39ExtracellularSequence analysisAdd BLAST39
Transmembranei40 – 66Helical; Name=1Sequence analysisAdd BLAST27
Topological domaini67 – 75CytoplasmicSequence analysis9
Transmembranei76 – 96Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini97 – 111ExtracellularSequence analysisAdd BLAST15
Transmembranei112 – 133Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini134 – 154CytoplasmicSequence analysisAdd BLAST21
Transmembranei155 – 174Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini175 – 199ExtracellularSequence analysisAdd BLAST25
Transmembranei200 – 220Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini221 – 242CytoplasmicSequence analysisAdd BLAST22
Transmembranei243 – 264Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini265 – 285ExtracellularSequence analysisAdd BLAST21
Transmembranei286 – 308Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini309 – 350CytoplasmicSequence analysisAdd BLAST42

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3577.
MalaCardsiCXCR1.
OpenTargetsiENSG00000163464.
PharmGKBiPA29842.

Chemistry databases

ChEMBLiCHEMBL4029.
DrugBankiDB01009. Ketoprofen.
GuidetoPHARMACOLOGYi68.

Polymorphism and mutation databases

BioMutaiCXCR1.
DMDMi108936015.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000693301 – 350C-X-C chemokine receptor type 1Add BLAST350

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...)Sequence analysis1
Glycosylationi16N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi110 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP25024.
PeptideAtlasiP25024.
PRIDEiP25024.

PTM databases

iPTMnetiP25024.
PhosphoSitePlusiP25024.

Expressioni

Gene expression databases

BgeeiENSG00000163464.
GenevisibleiP25024. HS.

Organism-specific databases

HPAiHPA031991.

Interactioni

GO - Molecular functioni

  • interleukin-8 binding Source: UniProtKB

Protein-protein interaction databases

BioGridi109791. 5 interactors.
DIPiDIP-3779N.
IntActiP25024. 5 interactors.
MINTiMINT-1516942.
STRINGi9606.ENSP00000295683.

Chemistry databases

BindingDBiP25024.

Structurei

Secondary structure

1350
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi38 – 66Combined sources29
Helixi75 – 100Combined sources26
Beta strandi101 – 103Combined sources3
Helixi108 – 138Combined sources31
Beta strandi139 – 141Combined sources3
Beta strandi143 – 146Combined sources4
Helixi149 – 173Combined sources25
Turni195 – 197Combined sources3
Helixi201 – 204Combined sources4
Turni205 – 207Combined sources3
Helixi208 – 225Combined sources18
Turni226 – 228Combined sources3
Beta strandi229 – 231Combined sources3
Helixi235 – 238Combined sources4
Helixi240 – 267Combined sources28
Beta strandi270 – 272Combined sources3
Helixi276 – 282Combined sources7
Helixi285 – 293Combined sources9
Helixi294 – 298Combined sources5
Helixi300 – 308Combined sources9
Helixi311 – 322Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ILPNMR-C9-29[»]
1ILQNMR-C9-29[»]
2LNLNMR-A20-328[»]
ProteinModelPortaliP25024.
SMRiP25024.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP25024.

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEHI. Eukaryota.
ENOG410Y9Y6. LUCA.
GeneTreeiENSGT00760000118785.
HOVERGENiHBG106917.
InParanoidiP25024.
KOiK04175.
OMAiLFRQAYH.
OrthoDBiEOG091G0C7W.
PhylomeDBiP25024.
TreeFamiTF330966.

Family and domain databases

InterProiIPR001355. Chemokine_CXCR1.
IPR000174. Chemokine_CXCR_1/2.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00427. INTRLEUKIN8R.
PR00572. INTRLEUKN8AR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25024-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNITDPQMW DFDDLNFTGM PPADEDYSPC MLETETLNKY VVIIAYALVF
60 70 80 90 100
LLSLLGNSLV MLVILYSRVG RSVTDVYLLN LALADLLFAL TLPIWAASKV
110 120 130 140 150
NGWIFGTFLC KVVSLLKEVN FYSGILLLAC ISVDRYLAIV HATRTLTQKR
160 170 180 190 200
HLVKFVCLGC WGLSMNLSLP FFLFRQAYHP NNSSPVCYEV LGNDTAKWRM
210 220 230 240 250
VLRILPHTFG FIVPLFVMLF CYGFTLRTLF KAHMGQKHRA MRVIFAVVLI
260 270 280 290 300
FLLCWLPYNL VLLADTLMRT QVIQESCERR NNIGRALDAT EILGFLHSCL
310 320 330 340 350
NPIIYAFIGQ NFRHGFLKIL AMHGLVSKEF LARHRVTSYT SSSVNVSSNL
Length:350
Mass (Da):39,791
Last modified:May 30, 2006 - v2
Checksum:i2463E868C0EB0DE2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti154K → N in AAH72397 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02106131M → R.3 PublicationsCorresponds to variant rs16858811dbSNPEnsembl.1
Natural variantiVAR_01623671R → C.Corresponds to variant rs1805038dbSNPEnsembl.1
Natural variantiVAR_026525268M → L.Corresponds to variant rs9282752dbSNPEnsembl.1
Natural variantiVAR_003479276S → T Common polymorphism. 4 PublicationsCorresponds to variant rs2234671dbSNPEnsembl.1
Natural variantiVAR_016237306A → T.1 PublicationCorresponds to variant rs201583693dbSNPEnsembl.1
Natural variantiVAR_016238335R → C.4 PublicationsCorresponds to variant rs16858808dbSNPEnsembl.1
Natural variantiVAR_021062342S → L.1 PublicationCorresponds to variant rs16858806dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19591 mRNA. Translation: AAB59436.1.
L19592 Genomic DNA. Translation: AAA59160.1.
M68932 mRNA. Translation: AAA59159.1.
X65858 Genomic DNA. Translation: CAA46688.1.
U11870 Genomic DNA. Translation: AAA64378.1.
AY916762 Genomic DNA. Translation: AAY21512.1.
AY916763 Genomic DNA. Translation: AAY21513.1.
AY916764 Genomic DNA. Translation: AAY21514.1.
AY916765 Genomic DNA. Translation: AAY21515.1.
AY916766 Genomic DNA. Translation: AAY21516.1.
AY916769 Genomic DNA. Translation: AAY21519.1.
AY916772 Genomic DNA. Translation: AAY21522.1.
AY916773 Genomic DNA. Translation: AAY21523.1.
CR541994 mRNA. Translation: CAG46791.1.
CR542029 mRNA. Translation: CAG46826.1.
AK312668 mRNA. Translation: BAG35550.1.
AY651785 Genomic DNA. Translation: AAT46689.1.
AC097483 Genomic DNA. Translation: AAX93212.1.
CH471063 Genomic DNA. Translation: EAW70590.1.
BC028221 mRNA. Translation: AAH28221.1.
BC072397 mRNA. Translation: AAH72397.1.
AB032728 Genomic DNA. Translation: BAA92290.1.
AB032729 Genomic DNA. Translation: BAA92291.1.
AB032730 Genomic DNA. Translation: BAA92292.1.
AB032731 Genomic DNA. Translation: BAA92293.1.
AB032732 Genomic DNA. Translation: BAA92294.1.
CCDSiCCDS2409.1.
PIRiI37449. A39445.
RefSeqiNP_000625.1. NM_000634.2.
UniGeneiHs.194778.

Genome annotation databases

EnsembliENST00000295683; ENSP00000295683; ENSG00000163464.
GeneIDi3577.
KEGGihsa:3577.
UCSCiuc002vhc.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

CXC chemokine receptors entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19591 mRNA. Translation: AAB59436.1.
L19592 Genomic DNA. Translation: AAA59160.1.
M68932 mRNA. Translation: AAA59159.1.
X65858 Genomic DNA. Translation: CAA46688.1.
U11870 Genomic DNA. Translation: AAA64378.1.
AY916762 Genomic DNA. Translation: AAY21512.1.
AY916763 Genomic DNA. Translation: AAY21513.1.
AY916764 Genomic DNA. Translation: AAY21514.1.
AY916765 Genomic DNA. Translation: AAY21515.1.
AY916766 Genomic DNA. Translation: AAY21516.1.
AY916769 Genomic DNA. Translation: AAY21519.1.
AY916772 Genomic DNA. Translation: AAY21522.1.
AY916773 Genomic DNA. Translation: AAY21523.1.
CR541994 mRNA. Translation: CAG46791.1.
CR542029 mRNA. Translation: CAG46826.1.
AK312668 mRNA. Translation: BAG35550.1.
AY651785 Genomic DNA. Translation: AAT46689.1.
AC097483 Genomic DNA. Translation: AAX93212.1.
CH471063 Genomic DNA. Translation: EAW70590.1.
BC028221 mRNA. Translation: AAH28221.1.
BC072397 mRNA. Translation: AAH72397.1.
AB032728 Genomic DNA. Translation: BAA92290.1.
AB032729 Genomic DNA. Translation: BAA92291.1.
AB032730 Genomic DNA. Translation: BAA92292.1.
AB032731 Genomic DNA. Translation: BAA92293.1.
AB032732 Genomic DNA. Translation: BAA92294.1.
CCDSiCCDS2409.1.
PIRiI37449. A39445.
RefSeqiNP_000625.1. NM_000634.2.
UniGeneiHs.194778.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ILPNMR-C9-29[»]
1ILQNMR-C9-29[»]
2LNLNMR-A20-328[»]
ProteinModelPortaliP25024.
SMRiP25024.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109791. 5 interactors.
DIPiDIP-3779N.
IntActiP25024. 5 interactors.
MINTiMINT-1516942.
STRINGi9606.ENSP00000295683.

Chemistry databases

BindingDBiP25024.
ChEMBLiCHEMBL4029.
DrugBankiDB01009. Ketoprofen.
GuidetoPHARMACOLOGYi68.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP25024.
PhosphoSitePlusiP25024.

Polymorphism and mutation databases

BioMutaiCXCR1.
DMDMi108936015.

Proteomic databases

PaxDbiP25024.
PeptideAtlasiP25024.
PRIDEiP25024.

Protocols and materials databases

DNASUi3577.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295683; ENSP00000295683; ENSG00000163464.
GeneIDi3577.
KEGGihsa:3577.
UCSCiuc002vhc.4. human.

Organism-specific databases

CTDi3577.
DisGeNETi3577.
GeneCardsiCXCR1.
H-InvDBHIX0203926.
HGNCiHGNC:6026. CXCR1.
HPAiHPA031991.
MalaCardsiCXCR1.
MIMi146929. gene.
neXtProtiNX_P25024.
OpenTargetsiENSG00000163464.
PharmGKBiPA29842.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEHI. Eukaryota.
ENOG410Y9Y6. LUCA.
GeneTreeiENSGT00760000118785.
HOVERGENiHBG106917.
InParanoidiP25024.
KOiK04175.
OMAiLFRQAYH.
OrthoDBiEOG091G0C7W.
PhylomeDBiP25024.
TreeFamiTF330966.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163464-MONOMER.
ReactomeiR-HSA-380108. Chemokine receptors bind chemokines.
R-HSA-418594. G alpha (i) signalling events.
R-HSA-6798695. Neutrophil degranulation.
SIGNORiP25024.

Miscellaneous databases

ChiTaRSiCXCR1. human.
EvolutionaryTraceiP25024.
GeneWikiiInterleukin_8_receptor,_alpha.
GenomeRNAii3577.
PROiP25024.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163464.
GenevisibleiP25024. HS.

Family and domain databases

InterProiIPR001355. Chemokine_CXCR1.
IPR000174. Chemokine_CXCR_1/2.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00427. INTRLEUKIN8R.
PR00572. INTRLEUKN8AR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCXCR1_HUMAN
AccessioniPrimary (citable) accession number: P25024
Secondary accession number(s): B2R6Q3
, Q2YEF8, Q2YEG4, Q2YEG5, Q2YEG7, Q2YEG8, Q53R18, Q6IN95, Q8N6T6, Q9P2T8, Q9P2T9, Q9P2U0, Q9P2U1, Q9P2U2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 30, 2006
Last modified: November 30, 2016
This is version 171 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  8. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.